|
CA1270837A
(en)
*
|
1984-12-21 |
1990-06-26 |
Hoffmann-La Roche Limited |
Oxetanones
|
|
ZA859574B
(en)
*
|
1984-12-21 |
1986-08-27 |
Hoffmann La Roche |
Process for the manufacture of oxetanones
|
|
CA1328881C
(en)
*
|
1984-12-21 |
1994-04-26 |
Pierre Barbier |
Process for the manufacture of oxetanones
|
|
JPH0618793Y2
(ja)
*
|
1986-06-13 |
1994-05-18 |
パイオニア株式会社 |
作業台
|
|
US4816477A
(en)
*
|
1987-05-26 |
1989-03-28 |
Merck & Co., Inc. |
Antihypercholesterolemic β-lactones
|
|
US4806564A
(en)
*
|
1987-05-26 |
1989-02-21 |
Merck & Co., Inc. |
Antihypercholesterolemic beta-lactones
|
|
US5484777A
(en)
*
|
1989-04-20 |
1996-01-16 |
Lange, Iii; Louis G. |
Pancreatic cholesterol esterase inhibitor
|
|
US5063210A
(en)
*
|
1989-04-20 |
1991-11-05 |
Lange Iii Louis G |
Use of sulfated polysaccharides to decrease cholesterol and fatty acid absorption
|
|
US5017565A
(en)
*
|
1989-04-20 |
1991-05-21 |
Lange Iii Louis G |
Use of sulfated polysaccharides to inhibit pancreatic cholesterol esterase
|
|
US5376640A
(en)
*
|
1989-12-25 |
1994-12-27 |
Nisshin Flour Milling Co., Ltd. |
Lipolytic enzyme inhibitors
|
|
JP2960947B2
(ja)
*
|
1989-12-25 |
1999-10-12 |
日清製粉株式会社 |
脂質分解酵素阻害剤
|
|
CA2098167C
(en)
*
|
1992-06-24 |
2006-12-19 |
Dorothea Isler |
Foodstuffs and feedstuffs containing a lipase inhibitor
|
|
TW381025B
(en)
*
|
1993-08-05 |
2000-02-01 |
Hoffmann La Roche |
Pharmaceutical composition containing a glucosidase inhibitor and a lipase inhibitor
|
|
US6268392B1
(en)
|
1994-09-13 |
2001-07-31 |
G. D. Searle & Co. |
Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors
|
|
US6642268B2
(en)
|
1994-09-13 |
2003-11-04 |
G.D. Searle & Co. |
Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors
|
|
US6262277B1
(en)
|
1994-09-13 |
2001-07-17 |
G.D. Searle And Company |
Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
|
|
MY116591A
(en)
*
|
1996-04-26 |
2004-02-28 |
Hoffmann La Roche |
Process for the production of lipstatin and tetrahydrolipstatin
|
|
BR9807655A
(pt)
*
|
1997-02-05 |
2000-02-15 |
Hoffmann La Roche |
Uso de inibidores de lipase gastrintestinal.
|
|
US6004996A
(en)
*
|
1997-02-05 |
1999-12-21 |
Hoffman-La Roche Inc. |
Tetrahydrolipstatin containing compositions
|
|
US7344713B1
(en)
*
|
1997-07-07 |
2008-03-18 |
Pimentel Julio L |
Decreased fat absorption with an anti-lipase antibody
|
|
RU2234917C2
(ru)
*
|
1997-12-24 |
2004-08-27 |
Кнолль Акциенгезелльшафт |
Терапевтические средства
|
|
GB9727131D0
(en)
*
|
1997-12-24 |
1998-02-25 |
Knoll Ag |
Therapeutic agents
|
|
US6299868B1
(en)
|
1999-07-14 |
2001-10-09 |
Geltex Pharmaceuticals, Inc. |
Fat-binding polymers
|
|
US6264937B1
(en)
|
1998-01-09 |
2001-07-24 |
Geltex Pharmaceuticals, Inc. |
Fat-binding polymers
|
|
US7048917B1
(en)
|
1998-01-09 |
2006-05-23 |
Genzyme Corporation |
Fat-binding polymers
|
|
BR9912980B1
(pt)
|
1998-08-14 |
2013-10-22 |
|
Composição farmacêutica administrável oralmente, tablete de mascar contendo a mesma e utilização da mesma
|
|
DE69916288T2
(de)
*
|
1998-08-14 |
2005-03-24 |
F. Hoffmann-La Roche Ag |
Lipasehemmer und chitosan enthaltende arzneimittel
|
|
DK1140185T3
(da)
|
1998-12-23 |
2003-09-29 |
Searle Llc |
Kombinationer af cholesterylestertransferhæmmere og galdesyre kompleksdannende forbindelser til hjertekar indikationer
|
|
EP1140186B1
(en)
|
1998-12-23 |
2003-06-04 |
G.D. Searle LLC. |
Combinations of cholesteryl ester transfer protein inhibitors and fibric acid derivatives for cardiovascular indications
|
|
AU2157400A
(en)
|
1998-12-23 |
2000-07-31 |
G.D. Searle & Co. |
Combinations of cholesteryl ester transfer protein inhibitors and hmg coa reductase inhibitors for cardiovascular indications
|
|
PT1140190E
(pt)
|
1998-12-23 |
2003-02-28 |
Searle Llc |
Combinacoes de inibidores do transporte ileal dos acidos biliares e agentes sequestrantes dos acidos biliares usadas para problemas cardiovasculares
|
|
MXPA01006472A
(es)
|
1998-12-23 |
2004-03-10 |
Searle Llc |
Combinaciones de inhibidores de transporte de acido biliar ileal y derivados de acido fibrico para indicaciones cardiovasculares.
|
|
DK1140184T3
(da)
|
1998-12-23 |
2003-09-29 |
Searle Llc |
Kombinationer af cholesterylestertransferproteinhæmmere og nikotinsyrederivater til hjertekar indikationer
|
|
EP1342475A1
(en)
|
1998-12-23 |
2003-09-10 |
G.D. Searle LLC. |
Combinations of ileal bile acid transport inhibitors and cholesteryl ester transfer protein inhibitors for cardiovascular indications
|
|
EP1028115B1
(en)
*
|
1999-01-29 |
2002-11-20 |
F. Hoffmann-La Roche Ag |
Purification of lipstatin
|
|
EP1196181A1
(en)
*
|
1999-07-14 |
2002-04-17 |
Geltex Pharmaceuticals, Inc. |
Fat-binding polymers, optionally combined with lipase inhibitors
|
|
AR025609A1
(es)
|
1999-09-13 |
2002-12-04 |
Hoffmann La Roche |
Formulaciones lipidas solidas
|
|
AR025587A1
(es)
*
|
1999-09-13 |
2002-12-04 |
Hoffmann La Roche |
Formulaciones en dispersion que contienen inhibidores de lipasa
|
|
EP1132389A1
(en)
|
2000-03-06 |
2001-09-12 |
Vernalis Research Limited |
New aza-indolyl derivatives for the treatment of obesity
|
|
EP1286984A2
(en)
|
2000-03-10 |
2003-03-05 |
Pharmacia Corporation |
Method for the preparation of tetrahydrobenzothiepines
|
|
DE10021618A1
(de)
*
|
2000-05-04 |
2001-11-15 |
Volker Helmstaedter |
Präparat für Darmerkrankungen und dessen Verwendung
|
|
EP1142572A1
(de)
*
|
2000-04-04 |
2001-10-10 |
Volker Dr. Helmstädter |
Oxetanon-enthaltende Präparate zur Behandlung von Darmerkrankungen
|
|
AU2001281846B2
(en)
*
|
2000-06-27 |
2006-04-27 |
Cheplapharm Arzneimittel Gmbh |
Method for preparing a composition
|
|
CN100423715C
(zh)
*
|
2000-07-28 |
2008-10-08 |
霍夫曼-拉罗奇有限公司 |
新型药物组合物
|
|
BR0112800A
(pt)
|
2000-07-28 |
2003-07-01 |
Hoffmann La Roche |
Utilização de um inibidor de lìpases e de um sequestrante de ácido de bìlis farmaceuticamente aceitáveis e processo para a prevenção e tratamento de enfermidades associadas com altos nìveis de colesterol de plasma
|
|
CA2417607C
(en)
*
|
2000-08-09 |
2008-01-29 |
Christine Feinle |
Lipase inhibitors for the treatment of dyspepsia
|
|
US6900226B2
(en)
*
|
2000-09-06 |
2005-05-31 |
Hoffman-La Roche Inc. |
Neuropeptide Y antagonists
|
|
JP4047723B2
(ja)
|
2000-10-16 |
2008-02-13 |
エフ.ホフマン−ラ ロシュ アーゲー |
インドリン誘導体、および5−ht2受容体リガンドとしてのその使用
|
|
GB0030710D0
(en)
*
|
2000-12-15 |
2001-01-31 |
Hoffmann La Roche |
Piperazine derivatives
|
|
EP1347979B1
(en)
|
2000-12-27 |
2007-08-08 |
F. Hoffmann-La Roche Ag |
Indole derivatives and their use as 5-ht2b and 5-ht2c receptor ligands
|
|
GB0106177D0
(en)
*
|
2001-03-13 |
2001-05-02 |
Hoffmann La Roche |
Piperazine derivatives
|
|
US20030072804A1
(en)
*
|
2001-03-19 |
2003-04-17 |
The Procter & Gamble Company |
Use of non-digestible polymeric foams to sequester ingested materials thereby inhibiting their absorption by the body
|
|
US20030091610A1
(en)
*
|
2001-03-19 |
2003-05-15 |
The Procter & Gamble Company |
Use of non-digestible polymeric foams to sequester ingested materials thereby inhibiting their absorption by the body
|
|
KR100621287B1
(ko)
|
2001-05-21 |
2006-09-13 |
에프. 호프만-라 로슈 아게 |
신경 펩타이드 y 수용체에 대한 리간드로서의 퀴놀린유도체
|
|
US20030027786A1
(en)
*
|
2001-06-06 |
2003-02-06 |
Karsten Maeder |
Lipase inhibiting composition
|
|
US6730319B2
(en)
|
2001-06-06 |
2004-05-04 |
Hoffmann-La Roche Inc. |
Pharmaceutical compositions having depressed melting points
|
|
US7041280B2
(en)
*
|
2001-06-29 |
2006-05-09 |
Genzyme Corporation |
Aryl boronate functionalized polymers for treating obesity
|
|
US7049345B2
(en)
*
|
2001-06-29 |
2006-05-23 |
Genzyme Corporation |
Fat-binding polymers
|
|
CN1556706B
(zh)
|
2001-08-30 |
2011-04-27 |
罗吉尼有限责任公司 |
具有脂肪酶抑制活性的噻吩并-(1,3)-噁嗪-4-酮
|
|
US6787558B2
(en)
*
|
2001-09-28 |
2004-09-07 |
Hoffmann-La Roche Inc. |
Quinoline derivatives
|
|
US10285910B2
(en)
|
2001-10-12 |
2019-05-14 |
Aquestive Therapeutics, Inc. |
Sublingual and buccal film compositions
|
|
US8765167B2
(en)
|
2001-10-12 |
2014-07-01 |
Monosol Rx, Llc |
Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
|
|
US20110033542A1
(en)
|
2009-08-07 |
2011-02-10 |
Monosol Rx, Llc |
Sublingual and buccal film compositions
|
|
US20190328679A1
(en)
|
2001-10-12 |
2019-10-31 |
Aquestive Therapeutics, Inc. |
Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
|
|
US8603514B2
(en)
|
2002-04-11 |
2013-12-10 |
Monosol Rx, Llc |
Uniform films for rapid dissolve dosage form incorporating taste-masking compositions
|
|
US11207805B2
(en)
|
2001-10-12 |
2021-12-28 |
Aquestive Therapeutics, Inc. |
Process for manufacturing a resulting pharmaceutical film
|
|
US7357891B2
(en)
|
2001-10-12 |
2008-04-15 |
Monosol Rx, Llc |
Process for making an ingestible film
|
|
US8900498B2
(en)
|
2001-10-12 |
2014-12-02 |
Monosol Rx, Llc |
Process for manufacturing a resulting multi-layer pharmaceutical film
|
|
US20070281003A1
(en)
|
2001-10-12 |
2007-12-06 |
Fuisz Richard C |
Polymer-Based Films and Drug Delivery Systems Made Therefrom
|
|
US8900497B2
(en)
|
2001-10-12 |
2014-12-02 |
Monosol Rx, Llc |
Process for making a film having a substantially uniform distribution of components
|
|
GB0125659D0
(en)
*
|
2001-10-25 |
2001-12-19 |
Ssl Int Plc |
Spermicides
|
|
US6740663B2
(en)
|
2001-11-02 |
2004-05-25 |
G.D. Searle, Llc |
Mono- and di-fluorinated benzothiepine compounds as inhibitors of apical sodium co-dependent bile acid transport (ASBT) and taurocholate uptake
|
|
IL162323A0
(en)
|
2001-12-04 |
2005-11-20 |
Biogal Pharmaceutical Co |
Preparation of orlistat and orlistat crystalline forms
|
|
US6844174B2
(en)
|
2001-12-04 |
2005-01-18 |
Biogal Gyogyszergyar Rt. |
Fermentation process for lipstatin and method of extracting lipstatin from a fermentation broth
|
|
AU2002366810B2
(en)
|
2001-12-20 |
2009-06-11 |
Osi Pharmaceuticals, Inc. |
Pancreatic lipase inhibitor compounds, their synthesis and use
|
|
AU2003207431A1
(en)
|
2002-01-17 |
2003-09-02 |
Pharmacia Corporation |
Novel alkyl/aryl hydroxy or keto thiepines.
|
|
GB0202015D0
(en)
*
|
2002-01-29 |
2002-03-13 |
Hoffmann La Roche |
Piperazine Derivatives
|
|
JP4216196B2
(ja)
*
|
2002-02-04 |
2009-01-28 |
エフ.ホフマン−ラ ロシュ アーゲー |
Npyアンタゴニストとしてのキノリン誘導体
|
|
RU2004129285A
(ru)
*
|
2002-02-28 |
2005-10-27 |
Ф.Хоффманн-Ля Рош Аг (Ch) |
Производные тиазола в качестве антагонистов рецептора npy
|
|
US7728153B2
(en)
|
2002-04-17 |
2010-06-01 |
The Burnham Institute For Medical Research |
Method for the asymmetric synthesis of beta-lactone compounds
|
|
AU2003226370A1
(en)
*
|
2002-04-17 |
2003-11-03 |
The Burnham Institute |
Inhibition of fatty acid synthase by beta-lactones and other compounds for inhibition of cellular proliferation
|
|
EP1501498B1
(en)
*
|
2002-04-26 |
2009-12-30 |
F. Hoffmann-La Roche Ag |
Pharmaceutical composition comprising a lipase inhibitor and glucomannan
|
|
US7105526B2
(en)
|
2002-06-28 |
2006-09-12 |
Banyu Pharmaceuticals Co., Ltd. |
Benzimidazole derivatives
|
|
EP1560816A1
(en)
*
|
2002-07-05 |
2005-08-10 |
F. Hoffmann-La Roche Ag |
Quinazoline derivatives
|
|
AU2003253364B2
(en)
*
|
2002-08-07 |
2007-06-07 |
F. Hoffmann-La Roche Ag |
Thiazole derivatives
|
|
NZ537979A
(en)
*
|
2002-09-12 |
2007-08-31 |
Hoffmann La Roche |
N-substituted-1H-indol-5-propionic acid compounds as PPAR agonists useful for the treatment of diabetes
|
|
MXPA05005445A
(es)
*
|
2002-11-25 |
2005-08-26 |
Hoffmann La Roche |
Derivados de indolilo.
|
|
US8372430B2
(en)
*
|
2002-12-17 |
2013-02-12 |
The Procter & Gamble Company |
Compositions, methods, and kits useful for the alleviation of gastrointestinal effects
|
|
US7772188B2
(en)
|
2003-01-28 |
2010-08-10 |
Ironwood Pharmaceuticals, Inc. |
Methods and compositions for the treatment of gastrointestinal disorders
|
|
US20040178058A1
(en)
*
|
2003-03-10 |
2004-09-16 |
Hsueh-Chung Chen |
Electro-chemical deposition apparatus and method of preventing cavities in an ECD copper film
|
|
EP1457206A1
(en)
*
|
2003-03-13 |
2004-09-15 |
Fournier Laboratories Ireland Limited |
Combined use of a fibrate and orlistat for the treatment of obesity
|
|
CN1812983A
(zh)
*
|
2003-05-30 |
2006-08-02 |
兰贝克赛实验室有限公司 |
取代的吡咯衍生物及其作为hmg-co抑制剂的用途
|
|
WO2004113314A1
(en)
*
|
2003-06-23 |
2004-12-29 |
Biocon Limited |
Novel boronate esters
|
|
GB0314967D0
(en)
*
|
2003-06-26 |
2003-07-30 |
Hoffmann La Roche |
Piperazine derivatives
|
|
US20060025337A1
(en)
*
|
2003-07-01 |
2006-02-02 |
President And Fellows Of Harvard College |
Sirtuin related therapeutics and diagnostics for neurodegenerative diseases
|
|
WO2005007639A1
(en)
*
|
2003-07-17 |
2005-01-27 |
Biocon Limited |
Preparation of tetrahydrolipstatin by hydrogenation of lipstatin, solvent extraction and purification
|
|
RU2006107444A
(ru)
*
|
2003-08-12 |
2007-09-20 |
Ф.Хоффманн-Ля Рош Аг (Ch) |
2-амино-5-бензоилтиазолы в качестве антагонистов npy
|
|
CA2533464A1
(en)
*
|
2003-08-12 |
2005-02-17 |
F. Hoffmann-La Roche Ag |
Thiazole derivatives as npy antagonists
|
|
US20050239859A2
(en)
*
|
2003-09-03 |
2005-10-27 |
Solvay Pharmaceuticals Gmbh |
Novel medical uses of 4,5-dihydro-1h-pyrazole derivatives having cb1- antagonistic activity
|
|
JP4765627B2
(ja)
|
2003-09-22 |
2011-09-07 |
Msd株式会社 |
新規ピペリジン誘導体
|
|
US20050124660A1
(en)
*
|
2003-10-27 |
2005-06-09 |
Jochen Antel |
Novel medical uses of compounds showing CB1-antagonistic activity and combination treatment involving said compounds
|
|
US20050143441A1
(en)
*
|
2003-10-27 |
2005-06-30 |
Jochen Antel |
Novel medical combination treatment of obesity involving 4,5-dihydro-1H-pyrazole derivatives having CB1-antagonistic activity
|
|
EP1689383B1
(en)
|
2003-11-19 |
2012-10-31 |
Metabasis Therapeutics, Inc. |
Novel phosphorus-containing thyromimetics
|
|
CN101247793B
(zh)
*
|
2003-12-29 |
2013-04-10 |
哈佛大学校长及研究员协会 |
治疗或预防肥胖和胰岛素抗性病症的组合物
|
|
US8017634B2
(en)
|
2003-12-29 |
2011-09-13 |
President And Fellows Of Harvard College |
Compositions for treating obesity and insulin resistance disorders
|
|
PL209905B1
(pl)
|
2004-01-15 |
2011-11-30 |
Bringwell Internat Ab |
Preparat do leczenia otyłości i związanego z nią syndromu metabolicznego
|
|
KR20060124679A
(ko)
|
2004-01-16 |
2006-12-05 |
후지 세이유 가부시키가이샤 |
리파아제 저해제
|
|
US7074822B2
(en)
|
2004-02-23 |
2006-07-11 |
Solvay Pharmaceuticals Gmbh |
Alkyl carbamate-substituted β-lactones, process for their preparation, and pharmaceutical compositions containing them
|
|
US20080125403A1
(en)
|
2004-04-02 |
2008-05-29 |
Merck & Co., Inc. |
Method of Treating Men with Metabolic and Anthropometric Disorders
|
|
AU2005239788A1
(en)
|
2004-05-10 |
2005-11-17 |
University Of Copenhagen |
Flaxseeds for body weight management
|
|
JP2008508190A
(ja)
*
|
2004-07-19 |
2008-03-21 |
ノボ ノルディスク アクティーゼルスカブ |
肥満または肥満に関連する疾患および障害の治療におけるカプサイシン受容体の活性の阻害
|
|
MX2007004889A
(es)
|
2004-10-25 |
2007-09-11 |
Solvay Pharm Gmbh |
Composiciones farmaceuticas que comprenden antagonistas del receptor cannabinoide cb1 y activadores de canales de potasio para el tratamiento de la diabetes mellitus tipo i, la obesidad y trastornos relacionados.
|
|
AU2005308575A1
(en)
*
|
2004-11-23 |
2006-06-01 |
Warner-Lambert Company Llc |
7-(2h-pyrazol-3-yl)-3, 5-dihyroxy-heptanoic acid derivatives as HMG Co-A reductase inhibitors for the treatment of lipidemia
|
|
US20060246141A1
(en)
*
|
2005-04-12 |
2006-11-02 |
Elan Pharma International, Limited |
Nanoparticulate lipase inhibitor formulations
|
|
AU2006243243B2
(en)
*
|
2005-05-03 |
2009-05-14 |
F. Hoffmann-La Roche Ag |
Tetracyclic azapyrazinoindolines as 5-HT2 ligands
|
|
US8138206B2
(en)
|
2005-05-30 |
2012-03-20 |
Msd. K.K. |
Piperidine derivative
|
|
WO2006138418A2
(en)
*
|
2005-06-14 |
2006-12-28 |
President And Fellows Of Harvard College |
Improvement of cognitive performance with sirtuin activators
|
|
US20070149466A1
(en)
*
|
2005-07-07 |
2007-06-28 |
Michael Milburn |
Methods and related compositions for treating or preventing obesity, insulin resistance disorders, and mitochondrial-associated disorders
|
|
CA2618112A1
(en)
|
2005-08-10 |
2007-02-15 |
Banyu Pharmaceutical Co., Ltd. |
Pyridone compound
|
|
EP1945635B1
(en)
*
|
2005-08-18 |
2009-05-06 |
F.Hoffmann-La Roche Ag |
Thiazolyl piperidine derivatives useful as h3 receptor modulators
|
|
WO2007024004A1
(ja)
|
2005-08-24 |
2007-03-01 |
Banyu Pharmaceutical Co., Ltd. |
フェニルピリドン誘導体
|
|
AU2006288153A1
(en)
|
2005-09-07 |
2007-03-15 |
Msd K.K. |
Bicyclic aromatic substituted pyridone derivative
|
|
US7355055B2
(en)
*
|
2005-09-08 |
2008-04-08 |
Reliance Life Sciences Pvt. Ltd. |
Compounds for treatment of lipase-mediated diseases
|
|
US7741317B2
(en)
|
2005-10-21 |
2010-06-22 |
Bristol-Myers Squibb Company |
LXR modulators
|
|
RU2008119687A
(ru)
|
2005-10-21 |
2009-11-27 |
Новартис АГ (CH) |
Комбинации органических соединений
|
|
CA2627139A1
(en)
|
2005-10-27 |
2007-05-03 |
Banyu Pharmaceutical Co., Ltd. |
Novel benzoxathiin derivative
|
|
SG166829A1
(en)
*
|
2005-11-08 |
2010-12-29 |
Ranbaxy Lab Ltd |
Process for (3r, 5r)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- [(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3, 5-dihydroxy-heptanoic acid hemi calcium salt
|
|
ES2381205T3
(es)
|
2005-11-10 |
2012-05-24 |
Msd K.K. |
Derivado espiro aza-sustituido
|
|
US7888376B2
(en)
|
2005-11-23 |
2011-02-15 |
Bristol-Myers Squibb Company |
Heterocyclic CETP inhibitors
|
|
WO2007063000A1
(en)
*
|
2005-11-30 |
2007-06-07 |
F. Hoffmann-La Roche Ag |
5-substituted indole-2-carboxamide derivatives
|
|
WO2007062999A2
(en)
*
|
2005-11-30 |
2007-06-07 |
F. Hoffmann-La Roche Ag |
1,5-substituted indol-2-yl amide derivatives
|
|
EP1968967B1
(en)
*
|
2005-11-30 |
2011-04-27 |
F. Hoffmann-La Roche AG |
1,1-dioxo-thiomorpholinyl indolyl methanone derivatives for use as h3 modulators
|
|
WO2007065820A1
(en)
*
|
2005-12-09 |
2007-06-14 |
F. Hoffmann-La Roche Ag |
Tricyclic amide derivatives useful for treating obesity
|
|
WO2007068620A1
(en)
*
|
2005-12-15 |
2007-06-21 |
F. Hoffmann-La Roche Ag |
Pyrrolo[2,3-c]pyridine derivatives
|
|
JP2009519293A
(ja)
*
|
2005-12-16 |
2009-05-14 |
エフ.ホフマン−ラ ロシュ アーゲー |
H3レセプター調節剤としてのピロロ[2,3−b]ピリジン誘導体
|
|
SK22006A3
(sk)
*
|
2006-01-03 |
2007-08-02 |
Biotika, A. S. |
Kmeň Streptomyces toxytricini produkujúci lipstatín a príprava lipstatínu s uvedeným kmeňom
|
|
US20080021092A1
(en)
*
|
2006-01-06 |
2008-01-24 |
Deepak Murpani |
Stable pharmaceutical compositions of orlistat
|
|
CA2635719A1
(en)
*
|
2006-01-13 |
2007-07-19 |
F. Hoffmann-La Roche Ag |
Cyclohexyl piperazinyl methanone derivatives and their use as histamine h3 receptor modulators
|
|
DE602007008831D1
(de)
*
|
2006-01-23 |
2010-10-14 |
Hoffmann La Roche |
Cyclohexyl-sulfonamid-derivate mit h3-rezeptoraktivität
|
|
WO2008020314A2
(en)
*
|
2006-03-14 |
2008-02-21 |
Ranbaxy Laboratories Limited |
Statin stabilizing dosage formulations
|
|
KR101252635B1
(ko)
|
2006-04-20 |
2013-04-10 |
(주)아모레퍼시픽 |
리파아제 저해제 및 친유성 오일흡수제를 포함하는 약학조성물 및 이로부터 제조된 경구 투여용 제제
|
|
US7432255B2
(en)
*
|
2006-05-16 |
2008-10-07 |
Hoffmann-La Roche Inc. |
1H-indol-5-yl-piperazin-1-yl-methanone derivatives
|
|
US7902184B2
(en)
*
|
2006-05-30 |
2011-03-08 |
Hoffmann-La Roche Inc. |
Piperazinyl pyrimidine derivatives
|
|
WO2008010087A2
(en)
*
|
2006-07-14 |
2008-01-24 |
Ranbaxy Laboratories Limited |
Polymorphic forms of an hmg-coa reductase inhibitor and uses thereof
|
|
US7514433B2
(en)
|
2006-08-03 |
2009-04-07 |
Hoffmann-La Roche Inc. |
1H-indole-6-yl-piperazin-1-yl-methanone derivatives
|
|
WO2008047544A1
(en)
|
2006-09-28 |
2008-04-24 |
Banyu Pharmaceutical Co., Ltd. |
Diaryl ketimine derivative
|
|
CL2007002958A1
(es)
*
|
2006-10-12 |
2008-05-09 |
Epix Delaware Inc |
Compuestos derivados de heteroaril-carboxamida, antagonistas del receptor de quimioquina; composicion farmaceutica; y uso para el tratamiento o prevencion de enfermedades tales como rechazo de transplante de organos, artritis reumatoidea, lupus, entr
|
|
JP5498168B2
(ja)
|
2006-12-01 |
2014-05-21 |
ブリストル−マイヤーズ スクイブ カンパニー |
アテローム性動脈硬化および循環器疾患の治療のためのcetp阻害剤としてのn−((3−ベンジル)−2,2−(ビス−フェニル)−プロパン−1−アミン誘導体
|
|
US20080146559A1
(en)
|
2006-12-08 |
2008-06-19 |
Li Chen |
4,5,6,7-Tetrahydro-Thieno [2,3-C] Pyridine Derivatives
|
|
US20080200422A1
(en)
*
|
2007-01-09 |
2008-08-21 |
Cavener Douglas R |
Methods for reduction of adipose tissue mass
|
|
JP5319518B2
(ja)
|
2007-04-02 |
2013-10-16 |
Msd株式会社 |
インドールジオン誘導体
|
|
US20080249156A1
(en)
*
|
2007-04-09 |
2008-10-09 |
Palepu Nageswara R |
Combinations of statins and anti-obesity agent and glitazones
|
|
CA2681449A1
(en)
*
|
2007-04-09 |
2008-10-16 |
Scidose, Llc |
Combinations of statins and anti-obesity agent
|
|
KR20100031528A
(ko)
|
2007-06-01 |
2010-03-22 |
더 트러스티즈 오브 프린스턴 유니버시티 |
숙주세포 대사경로의 조절을 통한 바이러스 감염 치료
|
|
MX2009013293A
(es)
|
2007-06-04 |
2010-02-15 |
Synergy Pharmaceuticals Inc |
Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos.
|
|
US8969514B2
(en)
|
2007-06-04 |
2015-03-03 |
Synergy Pharmaceuticals, Inc. |
Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
|
|
SG182171A1
(en)
*
|
2007-06-06 |
2012-07-30 |
Ranbaxy Lab Ltd |
Process for the preparation of orlistat
|
|
EP2190303A1
(en)
|
2007-09-12 |
2010-06-02 |
Københavns Universitet |
Compositions and methods for increasing the suppression of hunger and reducing the digestibility of non-fat energy satiety
|
|
EA201070378A1
(ru)
*
|
2007-09-17 |
2010-08-30 |
Др. Редди`С Лабораторис Лтд. |
Фармацевтические составы орлистата
|
|
WO2009044380A2
(en)
|
2007-10-05 |
2009-04-09 |
Ranbaxy Laboratories Limited |
Formulations containing orlistat particles having controlled particle size
|
|
MX2010004072A
(es)
*
|
2007-10-15 |
2010-09-14 |
Inventis Dds Pvt Ltd |
Composicion farmaceutica de orlistat.
|
|
US8298583B2
(en)
*
|
2007-10-19 |
2012-10-30 |
Monosol Rx, Llc |
Film delivery system for tetrahydrolipstatin
|
|
KR20100102646A
(ko)
|
2007-12-11 |
2010-09-24 |
가부시키가이샤 사이토파스파인더 |
카르복스아미드 화합물 및 케모카인 수용체 길항제로서의 이의 용도
|
|
US20090214682A1
(en)
*
|
2008-02-22 |
2009-08-27 |
Heuer Marvin A |
Composition and methods for weight loss in a subject
|
|
JPWO2009110510A1
(ja)
|
2008-03-06 |
2011-07-14 |
Msd株式会社 |
アルキルアミノピリジン誘導体
|
|
CA2719581C
(en)
*
|
2008-03-26 |
2013-11-12 |
Biocon Limited |
Improved fermentation process for higher yield coefficient of lipase-inhibitor with respect to consumed fatty acid
|
|
US20110015198A1
(en)
|
2008-03-28 |
2011-01-20 |
Banyu Pharmaceutical Co., Inc. |
Diarylmethylamide derivative having melanin-concentrating hormone receptor antagonism
|
|
EP2810951B1
(en)
|
2008-06-04 |
2017-03-15 |
Synergy Pharmaceuticals Inc. |
Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
|
|
JPWO2009154132A1
(ja)
|
2008-06-19 |
2011-12-01 |
Msd株式会社 |
スピロジアミン−ジアリールケトオキシム誘導体
|
|
EP2141236A1
(en)
*
|
2008-07-03 |
2010-01-06 |
KRKA, D.D., Novo Mesto |
Process for production of lipstatin and microorganisms therefore
|
|
CA2730603C
(en)
|
2008-07-16 |
2019-09-24 |
Synergy Pharmaceuticals Inc. |
Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
|
|
JPWO2010013595A1
(ja)
|
2008-07-30 |
2012-01-12 |
Msd株式会社 |
5員−5員又は5員−6員縮環シクロアルキルアミン誘導体
|
|
JP2012504600A
(ja)
|
2008-10-03 |
2012-02-23 |
シグマ・アリメントス・ソシエダ・アノニマ・デ・カピタル・バリアブレ |
総コレステロールおよびldlコレステロールの制御ならびに/または体重減少ならびに/または熱産生を促進するための組成物
|
|
WO2010042499A1
(en)
*
|
2008-10-06 |
2010-04-15 |
Banner Pharmacaps, Inc. |
Stable solutions of orlistat for pharmaceutical dosage forms
|
|
WO2010043592A1
(en)
*
|
2008-10-15 |
2010-04-22 |
Revotar Biopharmaceuticals Ag |
Lipase inhibitors for use for the treatment of obesity
|
|
EP2348857B1
(en)
|
2008-10-22 |
2016-02-24 |
Merck Sharp & Dohme Corp. |
Novel cyclic benzimidazole derivatives useful anti-diabetic agents
|
|
JP5557845B2
(ja)
|
2008-10-31 |
2014-07-23 |
メルク・シャープ・アンド・ドーム・コーポレーション |
糖尿病用剤として有用な新規環状ベンゾイミダゾール誘導体
|
|
US20120046364A1
(en)
|
2009-02-10 |
2012-02-23 |
Metabasis Therapeutics, Inc. |
Novel Sulfonic Acid-Containing Thyromimetics, and Methods for Their Use
|
|
US20120053172A1
(en)
|
2009-02-12 |
2012-03-01 |
Cooperatieve Mirzorg U.A. |
Use of a combination of diazoxide and metformin for treating obesity or obesity related disorders
|
|
US20100215635A1
(en)
*
|
2009-02-23 |
2010-08-26 |
Zoltan Kiss |
Small molecules to induce weight loss or to reduce weight gain
|
|
US8993509B2
(en)
|
2009-03-31 |
2015-03-31 |
Robert Zimmerman |
Method for treatment of cachexia by administering inhibitors of adipose triglyceride lipase expression or activity
|
|
WO2010112569A1
(en)
|
2009-03-31 |
2010-10-07 |
Robert Zimmermann |
Modulation of adipose triglyceride lipase for prevention and treatment of cachexia, loss of weight and muscle atrophy and methods of screening therefor
|
|
BRPI0901602B8
(pt)
|
2009-04-03 |
2021-05-25 |
Ems S/A |
formulação farmacêuticas
|
|
RU2412713C2
(ru)
*
|
2009-05-14 |
2011-02-27 |
Открытое Акционерное Общество Завод Экологической Техники И Экопитания "Диод" |
Фармацевтическая композиция, биологически активная добавка и способ уменьшения поглощения жира из пищи
|
|
US9334266B2
(en)
|
2009-09-04 |
2016-05-10 |
The University Of Toledo |
Catalysts and related processes for producing optically pure beta-lactones from aldehydes and compositions produced thereby
|
|
NZ599945A
(en)
|
2009-11-02 |
2014-05-30 |
Pfizer |
Dioxa-bicyclo[3.2.1]octane-2,3,4-triol derivatives
|
|
UA107369C2
(en)
|
2010-02-01 |
2014-12-25 |
Lab Bago S A |
Pharmaceutical composition with anti-obesity activity comprising a premixture of pure orlistat and preparation process
|
|
US8524909B2
(en)
|
2010-02-02 |
2013-09-03 |
Hoffmann-La Roche Inc. |
Tetrahydro-pyran derivatives
|
|
RU2441654C2
(ru)
*
|
2010-02-17 |
2012-02-10 |
Лабораториос Баго С.А. |
Фармацевтическая композиция с активностью против ожирения, включающая премикс чистого орлистата, и способ ее изготовления
|
|
AU2011218830B2
(en)
|
2010-02-25 |
2014-07-24 |
Merck Sharp & Dohme Corp. |
Novel cyclic benzimidazole derivatives useful anti-diabetic agents
|
|
WO2011140190A1
(en)
|
2010-05-05 |
2011-11-10 |
Infinity Pharmaceuticals |
Tetrazolones as inhibitors of fatty acid synthase
|
|
US8450350B2
(en)
|
2010-05-05 |
2013-05-28 |
Infinity Pharmaceuticals, Inc. |
Triazoles as inhibitors of fatty acid synthase
|
|
CA2799708A1
(en)
|
2010-05-21 |
2011-11-24 |
Pfizer Inc. |
2-phenyl benzoylamides
|
|
DK2575768T3
(da)
|
2010-05-24 |
2018-03-12 |
Swedish Oat Fiber Ab |
Vandig dispergering omfattende galactolipider og fremgangsmåde til fremstilling deraf
|
|
EP2392327A1
(en)
|
2010-06-04 |
2011-12-07 |
Universitätsmedizin der Johannes Gutenberg-Universität Mainz |
Use of orlistat for the anti-parasitic treatment of a parasitic disease
|
|
MX2012015102A
(es)
|
2010-07-06 |
2013-05-01 |
Astrazeneca Ab |
Agentes terapeuticos 976.
|
|
CN101885713B
(zh)
*
|
2010-07-19 |
2011-11-30 |
大邦(湖南)生物制药有限公司 |
一种毒三素链霉菌发酵液中分离提取利普司他汀的工艺
|
|
US9616097B2
(en)
|
2010-09-15 |
2017-04-11 |
Synergy Pharmaceuticals, Inc. |
Formulations of guanylate cyclase C agonists and methods of use
|
|
CN101948450B
(zh)
*
|
2010-10-13 |
2013-04-24 |
鲁南制药集团股份有限公司 |
一种生产制备奥利司他的方法
|
|
US9149959B2
(en)
|
2010-10-22 |
2015-10-06 |
Monosol Rx, Llc |
Manufacturing of small film strips
|
|
ES2586931T3
(es)
|
2010-11-04 |
2016-10-19 |
Albireo Ab |
Inhibidores de IBAT para el tratamiento de enfermedades hepáticas
|
|
RU2619215C2
(ru)
|
2010-11-08 |
2017-05-12 |
Альбирео Аб |
Фармацевтическая комбинация, включающая ibat-ингибитор и связующее желчной кислоты
|
|
MX348131B
(es)
|
2011-02-25 |
2017-05-26 |
Merck Sharp & Dohme |
Novedosos derivados de azabencimidazol ciclico utiles como agentes antidiabeticos.
|
|
CA2828343A1
(en)
|
2011-03-04 |
2012-09-13 |
The Scripps Research Institute |
Edn3-like peptides and uses thereof
|
|
UY34194A
(es)
|
2011-07-15 |
2013-02-28 |
Astrazeneca Ab |
?(3-(4-(espiroheterocíclico)metil)fenoxi)azetidin-1-il)(5-(fenil)-1,3,4-oxadiazol-2-il)metanona en el tratamiento de la obesidad?
|
|
CN102304105B
(zh)
*
|
2011-07-15 |
2013-07-10 |
鲁南新时代生物技术有限公司 |
一种制备高纯度奥利司他的方法
|
|
CN103030613B
(zh)
*
|
2011-09-29 |
2014-11-12 |
北大方正集团有限公司 |
一种利普司他汀的提纯方法
|
|
JP2013249293A
(ja)
*
|
2012-06-04 |
2013-12-12 |
Kao Corp |
リパーゼ活性阻害剤、抗真菌剤、及びフケ抑制剤
|
|
WO2014022528A1
(en)
|
2012-08-02 |
2014-02-06 |
Merck Sharp & Dohme Corp. |
Antidiabetic tricyclic compounds
|
|
WO2014060445A1
(en)
|
2012-10-19 |
2014-04-24 |
Akzo Nobel Chemicals International B.V. |
Method for preparing high purity orlistat
|
|
CN102936234B
(zh)
*
|
2012-11-15 |
2015-04-01 |
江苏阿尔法药业有限公司 |
一种制备脂肪酶抑制剂奥利司他的方法
|
|
CN102993134B
(zh)
*
|
2012-12-31 |
2015-08-05 |
鲁南新时代生物技术有限公司 |
一种利普司他汀的提纯方法
|
|
WO2014130608A1
(en)
|
2013-02-22 |
2014-08-28 |
Merck Sharp & Dohme Corp. |
Antidiabetic bicyclic compounds
|
|
WO2014139388A1
(en)
|
2013-03-14 |
2014-09-18 |
Merck Sharp & Dohme Corp. |
Novel indole derivatives useful as anti-diabetic agents
|
|
JP2016514670A
(ja)
|
2013-03-15 |
2016-05-23 |
シナジー ファーマシューティカルズ インコーポレイテッド |
他の薬物と組み合わせたグアニル酸シクラーゼ受容体アゴニスト
|
|
JP2016514671A
(ja)
|
2013-03-15 |
2016-05-23 |
シナジー ファーマシューティカルズ インコーポレイテッド |
グアニル酸シクラーゼのアゴニストおよびその使用
|
|
SG11201507496UA
(en)
|
2013-04-17 |
2015-11-27 |
Pfizer |
N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
|
|
EA201592263A1
(ru)
|
2013-06-05 |
2016-05-31 |
Синерджи Фармасьютикалз, Инк. |
Ультрачистые агонисты гуанилатциклазы c, способ их получения и использования
|
|
WO2015051496A1
(en)
|
2013-10-08 |
2015-04-16 |
Merck Sharp & Dohme Corp. |
Antidiabetic tricyclic compounds
|
|
EP3186242B1
(en)
|
2014-08-29 |
2021-10-06 |
Tes Pharma S.r.l. |
Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase
|
|
US10743813B2
(en)
|
2014-09-11 |
2020-08-18 |
Rattan Nath |
Diabetes control using postprandial feedback
|
|
WO2016055901A1
(en)
|
2014-10-08 |
2016-04-14 |
Pfizer Inc. |
Substituted amide compounds
|
|
US12427121B2
(en)
|
2016-05-05 |
2025-09-30 |
Aquestive Therapeutics, Inc. |
Enhanced delivery epinephrine compositions
|
|
US12433850B2
(en)
|
2016-05-05 |
2025-10-07 |
Aquestive Therapeutics, Inc. |
Enhanced delivery epinephrine and prodrug compositions
|
|
US11273131B2
(en)
|
2016-05-05 |
2022-03-15 |
Aquestive Therapeutics, Inc. |
Pharmaceutical compositions with enhanced permeation
|
|
JP7653218B2
(ja)
|
2016-05-05 |
2025-03-28 |
アクエスティブ セラピューティクス インコーポレイテッド |
送達増強エピネフリン組成物
|
|
AU2017342083A1
(en)
|
2016-10-14 |
2019-04-11 |
Tes Pharma S.R.L. |
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(es)
|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
WO2021157619A1
(ja)
|
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2021-08-12 |
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|
|
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(en)
|
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|