MA24340A1 - Procede de production de derives nouveaux d'aminophosphates, et de compositions pharmaceutiques les contenant - Google Patents

Procede de production de derives nouveaux d'aminophosphates, et de compositions pharmaceutiques les contenant

Info

Publication number: MA24340A1
Authority: MA; Morocco
Prior art keywords: aminophosphates; pharmaceutical compositions; compositions containing; novel derivatives; producing novel
Prior art date: 1995-06-30

Application number

MA24297A

Other languages

English (en)

Inventor

Azoulay Raymond

Floret Simon

Van Diep Vinh

Leigh Bentzen Craig

Niesor Eric

John Ife Robert

Bulla Alexandre

Guyon-Gellin Yves

Trung Phan Hieu

Mong Nguyen Lang

Original Assignee

Symphar Sa

Smithkline Beecham Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-06-30

Filing date

1996-06-28

Publication date

1998-07-01

1996-06-28 Application filed by Symphar Sa, Smithkline Beecham Plc filed Critical Symphar Sa

1998-07-01 Publication of MA24340A1 publication Critical patent/MA24340A1/fr

Links

239000008194 pharmaceutical composition Substances 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4056—Esters of arylalkanephosphonic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/58—Pyridine rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/59—Hydrogenated pyridine rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Hematology (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Obesity (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

MA24297A 1995-06-30 1996-06-28 Procede de production de derives nouveaux d'aminophosphates, et de compositions pharmaceutiques les contenant MA24340A1 (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CH01920/95A CH690264A5 (fr)	1995-06-30	1995-06-30	Dérivés aminophosphonates substitués, leur procédé de préparation et leur utilisation pour la préparation de compositions pharmaceutiques.

Publications (1)

Publication Number	Publication Date
MA24340A1 true MA24340A1 (fr)	1998-07-01

Family

ID=4221681

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MA24297A MA24340A1 (fr)	1995-06-30	1996-06-28	Procede de production de derives nouveaux d'aminophosphates, et de compositions pharmaceutiques les contenant

Country Status (27)

Country	Link
US (2)	US6060464A (fr)
EP (1)	EP0835116A1 (fr)
JP (1)	JPH11508576A (fr)
KR (1)	KR19990028542A (fr)
CN (1)	CN1113654C (fr)
AP (1)	AP778A (fr)
AR (1)	AR004498A1 (fr)
AU (1)	AU705206B2 (fr)
BG (1)	BG102215A (fr)
BR (1)	BR9609653A (fr)
CA (1)	CA2225391A1 (fr)
CH (1)	CH690264A5 (fr)
CZ (1)	CZ422097A3 (fr)
EA (1)	EA199800106A1 (fr)
HU (1)	HUP9901684A3 (fr)
IL (1)	IL122717A0 (fr)
MA (1)	MA24340A1 (fr)
MX (1)	MX9800189A (fr)
NO (1)	NO976128L (fr)
NZ (1)	NZ312696A (fr)
OA (1)	OA10554A (fr)
PL (1)	PL187024B1 (fr)
SK (1)	SK178397A3 (fr)
TR (1)	TR199701700T1 (fr)
TW (1)	TW413681B (fr)
WO (1)	WO1997002037A1 (fr)
ZA (1)	ZA965505B (fr)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6548084B2 (en)	1995-07-20	2003-04-15	Smithkline Beecham Plc	Controlled release compositions
GB9626616D0 (en) *	1996-12-20	1997-02-05	Symphar Sa	Novel compounds
GB9626615D0 (en)	1996-12-20	1997-02-05	Symphar Sa	Novel compounds
GB9626536D0 (en) *	1996-12-20	1997-02-05	Symphar Sa	Novel compounds
DE19748659A1 (de) *	1997-11-04	1999-05-06	Hoechst Ag	Aminophosphoniumgruppen enthaltende vernetzte Copolymere für medizinische Verwendungen
US6017918A (en) *	1998-08-06	2000-01-25	Warner-Lambert Company	Phenyl glycine compounds and methods of treating atherosclerosis and restenosis
US6284795B1 (en)	1998-09-04	2001-09-04	Warner-Lambert Company	Sulfonamide compounds and methods of treating atherosclerosis and restenosis
IL149308A0 (en)	1999-10-27	2002-11-10	Teva Pharma	Use of 1-aminoindan derivatives for treatment of manic disorders
DK1263740T3 (da)	2000-02-16	2006-11-13	Smithkline Beecham Plc	Pyrimidin-4-on-derivat som LDL-PLA2-inhibitor
AU9479201A (en)	2000-09-27	2002-04-08	Ilex Oncology Res S A	Alpha-substituted beta-aminoethyl phosphonates
US20030114421A1 (en) *	2000-09-27	2003-06-19	Phan Hieu Trung	Alpha-substituted beta-aminoethyl phosphonate derivatives
GB0024808D0 (en)	2000-10-10	2000-11-22	Smithkline Beecham Plc	Novel compounds
GB0025849D0 (en) *	2000-10-23	2000-12-06	Smithkline Beecham Plc	Novel compounds
EP1482953A4 (fr) *	2002-02-11	2006-12-13	Ilex Products Inc	Derives alpha-substitues d'heteroarylalkyl phosphonate
US20060128667A1 (en) *	2002-05-11	2006-06-15	Montes Imber F	Hydroxyphosphonates and phosphonophosphates as apolipoprotein e modulators
AU2003268292A1 (en) *	2002-08-30	2004-03-19	Biostratum, Inc.	Inhibitors of post-amadori advanced glycation end products
KR101861883B1 (ko)	2010-12-06	2018-05-28	글락소 그룹 리미티드	Lp-PLA₂에 의해 매개되는 질환 또는 상태의 치료에 사용하기 위한 피리미디논 화합물
AR087309A1 (es)	2011-07-27	2014-03-12	Glaxo Group Ltd	Compuesto heterociclico de anillos condensados sustituido, composicion farmaceutica que lo comprende y su uso para la fabricacion de un medicamento para el tratamiento de enfermedades neurogenerativas y aterosclerosis
CA2842965A1 (fr)	2011-07-27	2013-01-31	Glaxo Group Limited	Composes 2,3-dihydroimidazo[1,2-c]pyrimidin-5(1h)-one et utilisation en tant qu'inhibiteurs de lp-pla2
LT2751094T (lt)	2011-09-01	2018-11-12	Glaxo Group Limited	Naujoji kristalinė forma
US9296755B2 (en)	2013-01-25	2016-03-29	Glaxosmithkline Intellectual Property Development Limited	3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one compounds and their therapeutic applications
MX2015009633A (es)	2013-01-25	2015-11-30	Glaxosmithkline Ip Dev Ltd	Inhibidores de fosfolipasa a2 asociada con lipoproteinas basados en 2,3-dihidroimidazol[1,2-c] pirimidin-5(1h)-ona.
EP2948456A4 (fr)	2013-01-25	2016-09-14	Glaxosmithkline Ip Dev Ltd	Composés de pyrimidone bicycliques utilisés en tant qu'inhibiteurs de lp-pla2
WO2016012917A1 (fr)	2014-07-22	2016-01-28	Glaxosmithkline Intellectual Property Development Limited	Dérivés 1,2,3,5-tétrahydro-imidazo [1,2-c]pyrimidine utiles pour le traitement de maladies et de troubles médiés par la lp-pla2
WO2016012916A1 (fr)	2014-07-22	2016-01-28	Glaxosmithkline Intellectual Property Development Limited	Dérivés 1,2,3,5-tétrahydro-imidazo [1,2-c]pyrimidine utiles pour le traitement de maladies et de troubles médiés par la lp-pla2
EP4056571A4 (fr)	2019-11-09	2024-01-24	Shanghai Simr Biotechnology Co., Ltd.	Dérivé de dihydroimidazopyrimidone tricyclique, son procédé de préparation, composition pharmaceutique et son utilisation
CN115304620A (zh)	2021-05-07	2022-11-08	上海赛默罗生物科技有限公司	嘧啶酮衍生物、其制备方法、药物组合物和用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH683996A5 (fr) *	1992-03-05	1994-06-30	Symphar Sa	Dérivés aminophosphonates substitués, leur procédé de préparation et compositions pharmaceutiques les contenant.
DE4433244A1 (de) *	1994-09-19	1996-03-28	Hoechst Ag	Aminomethylphosphon- und Aminomethylphosphinsäure-Derivate und deren Verwendung zur Behandlung von degenerativen Gelenkserkrankungen

1995
- 1995-06-30 CH CH01920/95A patent/CH690264A5/fr not_active IP Right Cessation
1996
- 1996-06-26 CZ CZ974220A patent/CZ422097A3/cs unknown
- 1996-06-26 JP JP9504801A patent/JPH11508576A/ja not_active Withdrawn
- 1996-06-26 BR BR9609653-5A patent/BR9609653A/pt not_active Application Discontinuation
- 1996-06-26 NZ NZ312696A patent/NZ312696A/en unknown
- 1996-06-26 MX MX9800189A patent/MX9800189A/es unknown
- 1996-06-26 SK SK1783-97A patent/SK178397A3/sk unknown
- 1996-06-26 AP APAP/P/1997/001160A patent/AP778A/en active
- 1996-06-26 PL PL96324341A patent/PL187024B1/pl unknown
- 1996-06-26 WO PCT/EP1996/002842 patent/WO1997002037A1/fr not_active Ceased
- 1996-06-26 CN CN96196395A patent/CN1113654C/zh not_active Expired - Fee Related
- 1996-06-26 HU HU9901684A patent/HUP9901684A3/hu unknown
- 1996-06-26 TR TR97/01700T patent/TR199701700T1/xx unknown
- 1996-06-26 IL IL12271796A patent/IL122717A0/xx unknown
- 1996-06-26 AU AU64185/96A patent/AU705206B2/en not_active Ceased
- 1996-06-26 EA EA199800106A patent/EA199800106A1/ru unknown
- 1996-06-26 CA CA002225391A patent/CA2225391A1/fr not_active Abandoned
- 1996-06-26 EP EP96923971A patent/EP0835116A1/fr not_active Withdrawn
- 1996-06-26 US US08/973,669 patent/US6060464A/en not_active Expired - Fee Related
- 1996-06-26 KR KR1019970709860A patent/KR19990028542A/ko not_active Withdrawn
- 1996-06-28 MA MA24297A patent/MA24340A1/fr unknown
- 1996-06-28 AR ARP960103399A patent/AR004498A1/es unknown
- 1996-06-28 ZA ZA9605505A patent/ZA965505B/xx unknown
- 1996-07-01 TW TW085107922A patent/TW413681B/zh not_active IP Right Cessation
1997
- 1997-12-29 NO NO976128A patent/NO976128L/no not_active Application Discontinuation
- 1997-12-30 OA OA70171A patent/OA10554A/en unknown
1998
- 1998-01-28 BG BG102215A patent/BG102215A/xx unknown
2000
- 2000-04-03 US US09/541,217 patent/US6660724B1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
PL187024B1 (pl)	2004-04-30
AP778A (en)	1999-10-29
US6060464A (en)	2000-05-09
TR199701700T1 (xx)	1998-03-21
NZ312696A (en)	1999-10-28
US6660724B1 (en)	2003-12-09
JPH11508576A (ja)	1999-07-27
HUP9901684A3 (en)	2000-04-28
WO1997002037A1 (fr)	1997-01-23
CH690264A5 (fr)	2000-06-30
SK178397A3 (en)	1998-06-03
BG102215A (en)	1998-09-30
AU705206B2 (en)	1999-05-20
KR19990028542A (ko)	1999-04-15
TW413681B (en)	2000-12-01
MX9800189A (es)	1998-04-30
CA2225391A1 (fr)	1997-01-23
CN1193913A (zh)	1998-09-23
ZA965505B (en)	1998-03-30
BR9609653A (pt)	1999-12-21
IL122717A0 (en)	1998-08-16
HUP9901684A2 (hu)	1999-09-28
AR004498A1 (es)	1998-12-16
CZ422097A3 (cs)	1998-10-14
NO976128L (no)	1998-02-10
NO976128D0 (no)	1997-12-29
PL324341A1 (en)	1998-05-25
AP9701160A0 (en)	1998-01-31
EP0835116A1 (fr)	1998-04-15
EA199800106A1 (ru)	1998-08-27
AU6418596A (en)	1997-02-05
CN1113654C (zh)	2003-07-09
OA10554A (en)	2002-05-29

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