MA25007A1 - Procede pour la preparation de pyrazolo [4,3-d] pyrimidine-7-ones, et intermediaires pour ce procede - Google Patents

Procede pour la preparation de pyrazolo [4,3-d] pyrimidine-7-ones, et intermediaires pour ce procede

Info

Publication number
MA25007A1
MA25007A1 MA25812A MA25812A MA25007A1 MA 25007 A1 MA25007 A1 MA 25007A1 MA 25812 A MA25812 A MA 25812A MA 25812 A MA25812 A MA 25812A MA 25007 A1 MA25007 A1 MA 25007A1
Authority
MA
Morocco
Prior art keywords
preparation
intermediates
pyrazolo
pyrimidine
ones
Prior art date
Application number
MA25812A
Other languages
English (en)
Inventor
James Dunn Peter
Charles Levett Philip
Original Assignee
Pfizer Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10840421&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA25007(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Res & Dev filed Critical Pfizer Res & Dev
Publication of MA25007A1 publication Critical patent/MA25007A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Reproductive Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'INVENTION CONCERNE UN PROCÉDÉ POUR LA PRÉPARATION D'UN COMPOSÉ DE FORMULE (IA) ET UN COMPOSÉ DE FORMULE (IB) ELLE CONCERNE ÉGALEMENT LES INTERMÉDIAIRES UTILISÉS POUR CETTE PRÉPARTATION.APPLICATION : UTILISATION DE CES COMPOSÉS DANS LA PRÉPARATION DE MÉDICAMENTS POUR LE TRAITEMENT DE DIVERSES MALADIES, NOTAMMENT D'UN DYSFONCTIONNEMENT DE L'ÉRECTION MASCULINE.
MA25812A 1998-10-12 1999-10-11 Procede pour la preparation de pyrazolo [4,3-d] pyrimidine-7-ones, et intermediaires pour ce procede MA25007A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9822238.3A GB9822238D0 (en) 1998-10-12 1998-10-12 Process for preparation of pyrazolo[4,3-D]pyrimidin-7-ones and intermediates thereof

Publications (1)

Publication Number Publication Date
MA25007A1 true MA25007A1 (fr) 2000-07-01

Family

ID=10840421

Family Applications (1)

Application Number Title Priority Date Filing Date
MA25812A MA25007A1 (fr) 1998-10-12 1999-10-11 Procede pour la preparation de pyrazolo [4,3-d] pyrimidine-7-ones, et intermediaires pour ce procede

Country Status (48)

Country Link
US (3) US6207829B1 (fr)
EP (1) EP0994115B1 (fr)
JP (1) JP3721021B2 (fr)
KR (1) KR100380954B1 (fr)
CN (2) CN1207295C (fr)
AP (1) AP1233A (fr)
AR (1) AR019244A1 (fr)
AT (1) ATE290003T1 (fr)
AU (1) AU756463B2 (fr)
BG (1) BG63205B1 (fr)
BR (1) BR9905092A (fr)
CA (1) CA2285733C (fr)
CO (1) CO5150214A1 (fr)
CR (1) CR6118A (fr)
CU (1) CU22928A3 (fr)
CZ (1) CZ296816B6 (fr)
DE (1) DE69923906T2 (fr)
DK (1) DK0994115T3 (fr)
DZ (1) DZ2912A1 (fr)
EA (1) EA003774B1 (fr)
EE (1) EE04192B1 (fr)
EG (1) EG22630A (fr)
ES (1) ES2237049T3 (fr)
GB (1) GB9822238D0 (fr)
GE (1) GEP20022700B (fr)
GT (1) GT199900172A (fr)
HR (1) HRP990318B1 (fr)
HU (1) HU226162B1 (fr)
ID (1) ID23351A (fr)
IL (11) IL152923A (fr)
IS (1) IS1951B (fr)
MA (1) MA25007A1 (fr)
MY (1) MY124620A (fr)
NO (1) NO313700B1 (fr)
OA (1) OA11165A (fr)
PE (1) PE20001086A1 (fr)
PL (1) PL198150B1 (fr)
PT (1) PT994115E (fr)
RS (1) RS49762B (fr)
SG (1) SG118060A1 (fr)
SI (1) SI0994115T1 (fr)
SK (1) SK285215B6 (fr)
TN (1) TNSN99189A1 (fr)
TR (1) TR199902541A2 (fr)
TW (1) TW589314B (fr)
UA (1) UA66787C2 (fr)
UY (1) UY25750A1 (fr)
ZA (1) ZA996412B (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5204800A (en) * 1999-06-21 2001-01-09 Biochemical Pharmaceutical Factory of Zhuhai Sez, The Process for preparing sildenafil, and troche which comprises sildenafil and apomorphine
US6667398B2 (en) 2000-06-22 2003-12-23 Pfizer Inc Process for the preparation of pyrazolopyrimidinones
EP1292586B1 (fr) * 2000-06-22 2004-08-04 Pfizer Limited Procede de preparation de pyrazolopyrimidinones
YU51701A (sh) * 2000-07-28 2003-12-31 Pfizer Inc. Postupak za dobijanje jedinjenja pirazola/4,3-d/ pirimidin-7-ona i njihovih derivata
EP1176142A1 (fr) * 2000-07-28 2002-01-30 Pfizer Inc. Procédé pour la préparation de pyrazoles
US6407259B1 (en) 2000-07-28 2002-06-18 Pfizer Inc. Process for the preparation of pyrazoles
PE20020394A1 (es) 2000-08-18 2002-06-21 Agouron Pharma Compuestos de pirazol y composiciones farmaceuticas que los contienen, que modulan y/o inhiben la actividad de erab/hadh2
DE60235198D1 (de) * 2001-12-20 2010-03-11 Merck Serono Sa Coinsins Pyrrolidin-derivatie als prostaglandin-modulatoren
US6908923B2 (en) 2001-12-21 2005-06-21 Cytokinetics, Inc. Compositions and methods for treating heart failure
SI1509525T1 (sl) 2002-05-31 2006-12-31 Schering Corp Postopek priprave inhibitorjev ksantinske fosfodiesteraze V in njihovih prekurzorjev
WO2004072079A1 (fr) * 2003-02-11 2004-08-26 Pfizer Limited Compose d'hemi-citrate de sildenafil hydrate et anhydre
EP1605752B1 (fr) * 2003-03-27 2011-09-14 Cytokinetics, Inc. Sulfonamides pour le traitment de l' insuffisance cardiaque congestive, leur compositions et utilisations.
CN100360531C (zh) * 2003-12-18 2008-01-09 中国人民解放军军事医学科学院放射与辐射医学研究所 用于预防或治疗阳萎和性冷淡的新吡唑并嘧啶类化合物
US20070010525A1 (en) * 2005-06-27 2007-01-11 Meyer Jackson Method and compositions for modulating neuropeptide hormone secretion
NL2000291C2 (nl) * 2005-11-10 2009-02-17 Pfizer Prod Inc 1-(1-(2-ethoxyethyl)-3-ethyl-7-(4-methylpyridin-2-ylamino)-1H- pyrazool(4,3-d)pyrimidine-5-yl)piperidine-4-carbonzuur en zouten daarvan.
WO2007141805A2 (fr) * 2006-06-05 2007-12-13 Matrix Laboratories Limited Nouveau procédé de préparation du citrate de sildénafil
CZ308056B6 (cs) * 2015-07-20 2019-11-27 Ustav Experimentalni Botaniky Av Cr V V I 5-Substituované-7-[4-(substituované)benzyl]amino-3-isopropylpyrazolo[4,3-d]pyrimidiny, jejich použití jako antirevmatika, a farmaceutické přípravky
WO2017168174A1 (fr) 2016-04-02 2017-10-05 N4 Pharma Uk Limited Nouvelles formes pharmaceutiques du sildénafil
CN107759603B (zh) * 2016-08-18 2020-09-01 四川科伦药物研究院有限公司 一种杂环化合物的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3992441A (en) * 1972-12-26 1976-11-16 Pfizer Inc. Sulfamylbenzoic acids
GB9013750D0 (en) * 1990-06-20 1990-08-08 Pfizer Ltd Therapeutic agents
GB9612514D0 (en) * 1996-06-14 1996-08-14 Pfizer Ltd Novel process
US6723719B1 (en) * 1997-04-25 2004-04-20 Pfizer Inc Pyrazolopyrimidinones which inhibit type 5 cyclic guanosine 3′,5′—monophosphate phosphodiesterase (cGMP PDE5) for the treatment of sexual dysfunction

Also Published As

Publication number Publication date
JP3721021B2 (ja) 2005-11-30
JP2000119273A (ja) 2000-04-25
IS1951B (is) 2004-10-13
PE20001086A1 (es) 2000-10-18
KR100380954B1 (ko) 2003-04-21
PT994115E (pt) 2005-06-30
NO994943L (no) 2000-04-13
US6207829B1 (en) 2001-03-27
EG22630A (en) 2003-05-31
HUP9903469A3 (en) 2000-10-30
DE69923906D1 (de) 2005-04-07
HK1027559A1 (en) 2001-01-19
IL152927A (en) 2004-06-01
IL152928A (en) 2007-07-04
IL152924A (en) 2004-02-19
GB9822238D0 (en) 1998-12-09
AP9901672A0 (en) 1999-12-31
EE04192B1 (et) 2003-12-15
NO313700B1 (no) 2002-11-18
HU9903469D0 (en) 1999-12-28
GEP20022700B (en) 2002-05-27
AU5358199A (en) 2000-04-13
IL132273A0 (en) 2001-03-19
ES2237049T3 (es) 2005-07-16
HRP990318B1 (en) 2004-06-30
ZA996412B (en) 2001-04-11
HUP9903469A2 (hu) 2000-08-28
CZ296816B6 (cs) 2006-06-14
DZ2912A1 (fr) 2004-03-01
CN1255497A (zh) 2000-06-07
HRP990318A2 (en) 2000-06-30
NO994943D0 (no) 1999-10-11
CO5150214A1 (es) 2002-04-29
EP0994115A2 (fr) 2000-04-19
RS49762B (sr) 2008-04-04
IS5209A (is) 2000-04-13
TW589314B (en) 2004-06-01
AP1233A (en) 2003-12-18
HU226162B1 (en) 2008-05-28
MY124620A (en) 2006-06-30
CU22928A3 (es) 2004-02-20
EA003774B1 (ru) 2003-08-28
SI0994115T1 (fr) 2005-08-31
CN1207295C (zh) 2005-06-22
SK285215B6 (sk) 2006-09-07
EE9900507A (et) 2000-06-15
CA2285733A1 (fr) 2000-04-12
CR6118A (es) 2005-09-16
UY25750A1 (es) 2001-08-27
IL152926A0 (en) 2003-06-24
ATE290003T1 (de) 2005-03-15
IL152924A0 (en) 2003-06-24
IL152923A0 (en) 2003-06-24
US20030069422A1 (en) 2003-04-10
CN1473831A (zh) 2004-02-11
PL335959A1 (en) 2000-04-25
IL152927A0 (en) 2003-06-24
DE69923906T2 (de) 2006-04-06
YU48999A (sh) 2002-06-19
KR20000028987A (ko) 2000-05-25
UA66787C2 (en) 2004-06-15
TNSN99189A1 (fr) 2005-11-10
CA2285733C (fr) 2004-08-24
IL152923A (en) 2004-02-08
ID23351A (id) 2000-04-13
GT199900172A (es) 2001-03-28
SG118060A1 (en) 2006-01-27
PL198150B1 (pl) 2008-05-30
BG103794A (en) 2000-09-29
EP0994115A3 (fr) 2000-05-24
EP0994115B1 (fr) 2005-03-02
IL152928A0 (en) 2003-06-24
EA199900822A3 (ru) 2000-08-28
BR9905092A (pt) 2000-08-08
CZ353299A3 (cs) 2000-05-17
AR019244A1 (es) 2001-12-26
OA11165A (en) 2003-04-22
AU756463B2 (en) 2003-01-16
IL152926A (en) 2004-02-19
EA199900822A2 (ru) 2000-04-24
IL132273A (en) 2004-06-20
BG63205B1 (bg) 2001-06-29
US20010009962A1 (en) 2001-07-26
DK0994115T3 (da) 2005-06-20
SK138599A3 (en) 2000-05-16
TR199902541A2 (xx) 2000-07-21

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