MA26703A1 - Macrolides antibiotiques nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant - Google Patents
Macrolides antibiotiques nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenantInfo
- Publication number
- MA26703A1 MA26703A1 MA25832A MA25832A MA26703A1 MA 26703 A1 MA26703 A1 MA 26703A1 MA 25832 A MA25832 A MA 25832A MA 25832 A MA25832 A MA 25832A MA 26703 A1 MA26703 A1 MA 26703A1
- Authority
- MA
- Morocco
- Prior art keywords
- preparation
- pharmaceutical compositions
- compositions containing
- novel antibiotic
- macrolides
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 239000003120 macrolide antibiotic agent Substances 0.000 title abstract 2
- 229940041033 macrolides Drugs 0.000 title abstract 2
- 230000003115 biocidal effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 241000894006 Bacteria Species 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Heart & Thoracic Surgery (AREA)
- Tropical Medicine & Parasitology (AREA)
- Vascular Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
DEPOSANT Société dite : PFIZER PRODUCTS INC REVENDICATION DE PRIORITES US 03/11/1998 60/106,836 Voir en annexe le titre de l'invention et le texte de l'abrégé Macrolides antibiotiques nouveaux, procédé pour leur préparation et compositions pharmaceutiqueS les contenant La présente invention concerne des composés répondant à la formule : dans laquelle a est égal à 0 ou 1, et R1, R2, R3, R4, R5, R6 et X représentent divers radicaux. Elle concerne également un procédé pour leur préparation et des compositions pharmaceutiques les contenant. Application : utilisation de ces composés et compositions pour le traitement d'infections par des bactéries et des protozoaires.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10683698P | 1998-11-03 | 1998-11-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA26703A1 true MA26703A1 (fr) | 2004-12-20 |
Family
ID=22313524
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA25832A MA26703A1 (fr) | 1998-11-03 | 1999-11-02 | Macrolides antibiotiques nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant |
Country Status (34)
| Country | Link |
|---|---|
| US (3) | US20020040007A1 (fr) |
| EP (1) | EP1124837A2 (fr) |
| JP (1) | JP4043191B2 (fr) |
| KR (1) | KR20010083944A (fr) |
| CN (1) | CN1376160A (fr) |
| AP (1) | AP2001002131A0 (fr) |
| AU (1) | AU5995299A (fr) |
| BG (1) | BG105543A (fr) |
| BR (1) | BR9914998A (fr) |
| CA (1) | CA2349338C (fr) |
| CO (1) | CO5140110A1 (fr) |
| CZ (1) | CZ20011512A3 (fr) |
| EA (1) | EA200100396A1 (fr) |
| EE (1) | EE200100245A (fr) |
| GT (1) | GT199900192A (fr) |
| HK (1) | HK1049010A1 (fr) |
| HR (1) | HRP20010306A2 (fr) |
| HU (1) | HUP0104192A3 (fr) |
| ID (1) | ID28286A (fr) |
| IL (1) | IL142628A0 (fr) |
| IS (1) | IS5919A (fr) |
| MA (1) | MA26703A1 (fr) |
| NO (1) | NO20012155L (fr) |
| OA (1) | OA11670A (fr) |
| PA (1) | PA8485101A1 (fr) |
| PE (1) | PE20001289A1 (fr) |
| PL (1) | PL348114A1 (fr) |
| SK (1) | SK5812001A3 (fr) |
| SV (1) | SV1999000188A (fr) |
| TN (1) | TNSN99205A1 (fr) |
| TR (4) | TR200200436T2 (fr) |
| UY (1) | UY25780A1 (fr) |
| WO (1) | WO2000026224A2 (fr) |
| ZA (1) | ZA200103289B (fr) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AP9801420A0 (en) * | 1998-01-02 | 1998-12-31 | Pfizer Prod Inc | Novel macrolides. |
| CZ20011512A3 (cs) | 1998-11-03 | 2001-09-12 | Pfizer Products Inc. | Nová makrolidová antibiotika |
| AP2001002222A0 (en) | 1999-01-27 | 2001-09-30 | Pfizer Prod Inc | Ketolide antibiotics. |
| US6451768B1 (en) | 1999-04-16 | 2002-09-17 | Kosan Biosciences, Inc. | Macrolide antiinfective agents |
| US6514944B2 (en) | 1999-04-16 | 2003-02-04 | Kosan Biosciences, Inc. | Macrolide antiinfective agents |
| US6590083B1 (en) | 1999-04-16 | 2003-07-08 | Ortho-Mcneil Pharmaceutical, Inc. | Ketolide antibacterials |
| US6939861B2 (en) | 1999-04-16 | 2005-09-06 | Kosan Biosciences, Inc. | Amido macrolides |
| AU775637B2 (en) | 1999-04-16 | 2004-08-12 | Kosan Biosciences, Inc. | Macrolide antiinfective agents |
| JP2002542197A (ja) | 1999-04-16 | 2002-12-10 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | ケトライド抗菌剤 |
| TR200103395T2 (tr) | 1999-05-24 | 2002-04-22 | Pfizer Products Inc. | 13-metil eritromisin türevleri. |
| EP1114826A3 (fr) * | 1999-12-29 | 2001-10-31 | Pfizer Products Inc. | Macrolides antibactériennes et prokinétiques |
| EP1146051A3 (fr) * | 2000-04-10 | 2001-10-31 | Pfizer Products Inc. | Dérivées de l' érythromycine A |
| DE60104240T2 (de) * | 2000-06-30 | 2005-08-04 | Pfizer Products Inc., Groton | Makrolid-Antibiotika |
| BRPI0513903A (pt) * | 2004-07-28 | 2008-05-20 | Ranbaxy Lab Ltd | derivados de cetolìdeos úteis como agentes antimicrobianos, seus processos de preparação e composições farmacêuticas compreendendo os mesmos |
| EP1807439A2 (fr) * | 2004-10-25 | 2007-07-18 | Ranbaxy Laboratories Limited | Derives de cetolides utiles comme agents antibacteriens |
| EA011281B1 (ru) * | 2004-12-21 | 2009-02-27 | Пфайзер Продактс Инк. | Макролиды |
| WO2007060618A2 (fr) * | 2005-11-23 | 2007-05-31 | Ranbaxy Laboratories Limited | Dérivés macrolides en tant qu’agents antibactériens |
| WO2007060518A2 (fr) * | 2005-11-23 | 2007-05-31 | Ranbaxy Laboratories Limited | Dérivés de cétolide en tant qu'agents antibactériens |
| US7801502B2 (en) * | 2006-12-18 | 2010-09-21 | Aai Corporation | Method for implementing continuous radio frequency (RF) alignment in advanced electronic warfare (EW) signal stimulation systems |
| US8409628B2 (en) | 2010-02-04 | 2013-04-02 | Penguin IP Holdings, Inc. | Methods and compositions for oxygenation of skin to treat skin disorders |
| WO2011123619A2 (fr) | 2010-03-31 | 2011-10-06 | Penguin Ip Holdings Inc. | Mélanges perméables, procédés et compositions pour la peau |
| AU2014262127B2 (en) * | 2013-05-01 | 2019-05-02 | Neoculi Pty Ltd | Methods for treating bacterial infections |
| RU2537143C1 (ru) * | 2013-11-08 | 2014-12-27 | Государственное научное учреждение Ставропольский научно-исследовательский институт животноводства и кормопроизводства РАСХН | Препарат для лечения и профилактики мастита у коров |
| WO2018080072A2 (fr) * | 2016-10-27 | 2018-05-03 | 한국생명공학연구원 | Nouveau composé à base de macrolide, son procédé de production, et composition pharmaceutique destinée à prévenir ou à traiter le paludisme et le contenant à titre de principe actif |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI8110592A8 (en) * | 1981-03-06 | 1996-06-30 | Pliva Pharm & Chem Works | Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof |
| US4474768A (en) * | 1982-07-19 | 1984-10-02 | Pfizer Inc. | N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor |
| IL99995A (en) * | 1990-11-21 | 1997-11-20 | Roussel Uclaf | Erythromycin derivatives, their preparation and pharmaceutical compositions containing them |
| FR2697524B1 (fr) * | 1992-11-05 | 1994-12-23 | Roussel Uclaf | Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments. |
| US5527780A (en) | 1992-11-05 | 1996-06-18 | Roussel Uclaf | Erythromycin derivatives |
| US5332807A (en) | 1993-04-14 | 1994-07-26 | Merck & Co., Inc. | Process of producing 8A- and 9A-azalide antibiotics |
| FR2702480B1 (fr) * | 1993-03-09 | 1995-04-28 | Roussel Uclaf | Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments. |
| HRP931480B1 (en) * | 1993-12-08 | 1997-08-31 | Sour Pliva | 9a-N-(N'-CARBAMONYL) and 9a-N-(N'-THIOCARBAMONYL) DERIVATES OF 9-DEOXO-9a-HOMOERYTHROMYCIN A |
| HRP950145A2 (en) * | 1995-03-27 | 1997-08-31 | Sour Pliva | New compounds of the secomacrolide and secoazalide class and a process for the preparation thereof |
| HN1996000101A (es) | 1996-02-28 | 1997-06-26 | Inc Pfizer | Terapia combinada para la osteoporosis |
| CA2253338C (fr) * | 1996-05-07 | 2007-05-08 | Abbott Laboratories | Erythromycines 6-o substituees et leur procede de preparation |
| WO1998001546A2 (fr) | 1996-07-05 | 1998-01-15 | Biotica Technology Limited | Polyketides et leur synthese |
| ATE296831T1 (de) * | 1996-09-04 | 2005-06-15 | Abbott Lab | 6-0-substituierte ketoliden mit antibakteriellen wirkung |
| UA51730C2 (uk) * | 1996-09-04 | 2002-12-16 | Ебботт Лабораторіз | 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців |
| HRP960497B1 (en) | 1996-10-28 | 2003-08-31 | Pliva Pharm & Chem Works | 9-n-ethenyl derivatives of 9(s)-erythromycylamine |
| HN1998000074A (es) | 1997-06-11 | 1999-01-08 | Pfizer Prod Inc | Derivados de macrolidos c-4 sustituidos |
| US6407074B1 (en) * | 1997-06-11 | 2002-06-18 | Pfizer Inc | C-4″-substituted macrolide derivatives |
| EP0895999A1 (fr) * | 1997-08-06 | 1999-02-10 | Pfizer Products Inc. | Macrolides antibiotiques substitués C"-4 |
| US6339063B1 (en) | 1997-09-10 | 2002-01-15 | Merck & Co., Inc. | 9a-azalides as veterinary antimicrobial agents |
| NZ503897A (en) | 1997-10-16 | 2002-10-25 | Pliva Pharm & Chem Works | 3,6-hemiketals from the class of 9a-azalides |
| DK0941998T3 (da) | 1998-03-03 | 2004-09-20 | Pfizer Prod Inc | 3,6-ketalmakrolidantibiotika |
| CZ20011512A3 (cs) | 1998-11-03 | 2001-09-12 | Pfizer Products Inc. | Nová makrolidová antibiotika |
| TR200103395T2 (tr) | 1999-05-24 | 2002-04-22 | Pfizer Products Inc. | 13-metil eritromisin türevleri. |
| EP1114826A3 (fr) | 1999-12-29 | 2001-10-31 | Pfizer Products Inc. | Macrolides antibactériennes et prokinétiques |
| EP1122261A3 (fr) | 2000-01-31 | 2001-09-26 | Pfizer Products Inc. | Macrolides antibactériennes à 13 ou 14 chainons |
| DE60104240T2 (de) | 2000-06-30 | 2005-08-04 | Pfizer Products Inc., Groton | Makrolid-Antibiotika |
| JP4509553B2 (ja) | 2001-07-03 | 2010-07-21 | ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド | 抗菌活性を有するｃ１２修飾エリスロマイシンマクロライドおよびケトライド |
-
1999
- 1999-10-18 CZ CZ20011512A patent/CZ20011512A3/cs unknown
- 1999-10-18 CA CA002349338A patent/CA2349338C/fr not_active Expired - Fee Related
- 1999-10-18 TR TR2002/00436T patent/TR200200436T2/xx unknown
- 1999-10-18 HR HR20010306A patent/HRP20010306A2/hr not_active Application Discontinuation
- 1999-10-18 TR TR2001/01241T patent/TR200101241T2/xx unknown
- 1999-10-18 AU AU59952/99A patent/AU5995299A/en not_active Abandoned
- 1999-10-18 OA OA1200100102A patent/OA11670A/en unknown
- 1999-10-18 EA EA200100396A patent/EA200100396A1/ru unknown
- 1999-10-18 BR BR9914998-2A patent/BR9914998A/pt not_active IP Right Cessation
- 1999-10-18 TR TR2002/00435T patent/TR200200435T2/xx unknown
- 1999-10-18 TR TR2002/00434T patent/TR200200434T2/xx unknown
- 1999-10-18 SK SK581-2001A patent/SK5812001A3/sk unknown
- 1999-10-18 HK HK03101144.0A patent/HK1049010A1/zh unknown
- 1999-10-18 HU HU0104192A patent/HUP0104192A3/hu unknown
- 1999-10-18 EE EEP200100245A patent/EE200100245A/xx unknown
- 1999-10-18 ID IDW20010956D patent/ID28286A/id unknown
- 1999-10-18 EP EP99971424A patent/EP1124837A2/fr not_active Withdrawn
- 1999-10-18 CN CN99812941A patent/CN1376160A/zh active Pending
- 1999-10-18 JP JP2000579612A patent/JP4043191B2/ja not_active Expired - Fee Related
- 1999-10-18 WO PCT/IB1999/001701 patent/WO2000026224A2/fr not_active Ceased
- 1999-10-18 PL PL99348114A patent/PL348114A1/xx not_active Application Discontinuation
- 1999-10-18 IL IL14262899A patent/IL142628A0/xx unknown
- 1999-10-18 AP APAP/P/2001/002131A patent/AP2001002131A0/en unknown
- 1999-10-18 KR KR1020017005535A patent/KR20010083944A/ko not_active Ceased
- 1999-10-29 SV SV1999000188A patent/SV1999000188A/es not_active Application Discontinuation
- 1999-10-29 PE PE1999001084A patent/PE20001289A1/es not_active Application Discontinuation
- 1999-10-29 UY UY25780A patent/UY25780A1/es unknown
- 1999-11-02 TN TNTNSN99205A patent/TNSN99205A1/fr unknown
- 1999-11-02 PA PA19998485101A patent/PA8485101A1/es unknown
- 1999-11-02 MA MA25832A patent/MA26703A1/fr unknown
- 1999-11-03 CO CO99069359A patent/CO5140110A1/es unknown
- 1999-11-03 GT GT199900192A patent/GT199900192A/es unknown
-
2001
- 2001-04-17 IS IS5919A patent/IS5919A/is unknown
- 2001-04-23 ZA ZA200103289A patent/ZA200103289B/xx unknown
- 2001-05-02 NO NO20012155A patent/NO20012155L/no not_active Application Discontinuation
- 2001-05-29 BG BG105543A patent/BG105543A/xx unknown
- 2001-10-01 US US09/969,486 patent/US20020040007A1/en not_active Abandoned
-
2002
- 2002-07-24 US US10/206,652 patent/US6835716B2/en not_active Expired - Fee Related
-
2004
- 2004-07-21 US US10/896,293 patent/US7071170B2/en not_active Expired - Fee Related
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| TNSN05073A1 (fr) | Quinazolinones spirocondensees nouvelles et leur utilisation comme inhibiteurs de phosphodiesterase | |
| CA2174033A1 (fr) | Nouveaux composes pyridiniques, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent | |
| TNSN99236A1 (fr) | Derives bicycliques substitues nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant. | |
| MA24936A1 (fr) | Procede d'emulsification | |
| MA26701A1 (fr) | PYRAZOLOPYRIMIDINONES NOUVELLES INHIBITRICES DE PDE-5 GMPc, PROCEDE POUR LEUR PREPARATION ET COMPOSTIONS PHARMACEUTIQUES LES CONTENANT. | |
| TNSN98084A1 (fr) | Derives de macrolides substitues en position c-4 | |
| TNSN01121A1 (fr) | Antibiotiques nouveaux faisant partie des macrolides, et compositions les contenant | |
| MA26690A1 (fr) | COMPOSITIONS PHARMACEUTIQUES CONTENANT DES DERIVES DE PYRIDO [1,2-a ] PYRAZINE ET PROCEDE POUR LEUR PREPARATION | |
| CA2285037A1 (fr) | Nouveaux derives du 2-(iminomethyl)amino-phenyle, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant | |
| MA26711A1 (fr) | Macrolides nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant | |
| TNSN99214A1 (fr) | Azalides nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant. | |
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| CA2167040A1 (fr) | Nouveaux composes (hetero)cycliques alkyles, leur procede de preparationet les compositions pharmaceutiques qui les contiennent | |
| FR2716883B1 (fr) | Nouveaux dérivés tétrasubstitués de l'imidazole, leur préparation, nouveaux intermédiaires obtenus, leur application à titre de médicaments, compositions pharmaceutiques les renfermant. | |
| MA24685A1 (fr) | Derives d'erythromycine tricycliques nouveaux, procede pour leur preparation et composition les contenant | |
| MA26735A1 (fr) | Formes cristallines nouvelles d'un antibiotique macrolide, procede pour leur preparation et compositions pharmaceutiques les contenant |