MA26864A1 - Antagonistes du facteur de liberation de corticotrophine. - Google Patents
Antagonistes du facteur de liberation de corticotrophine.Info
- Publication number
- MA26864A1 MA26864A1 MA26728A MA26728A MA26864A1 MA 26864 A1 MA26864 A1 MA 26864A1 MA 26728 A MA26728 A MA 26728A MA 26728 A MA26728 A MA 26728A MA 26864 A1 MA26864 A1 MA 26864A1
- Authority
- MA
- Morocco
- Prior art keywords
- corticotrophin
- factor antagonists
- release factor
- antagonists
- disorders
- Prior art date
Links
- 239000000275 Adrenocorticotropic Hormone Substances 0.000 title abstract 3
- 101800000414 Corticotropin Proteins 0.000 title abstract 3
- 239000005557 antagonist Substances 0.000 title abstract 3
- IDLFZVILOHSSID-OVLDLUHVSA-N corticotropin Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=C(O)C=C1 IDLFZVILOHSSID-OVLDLUHVSA-N 0.000 title abstract 3
- 229960000258 corticotropin Drugs 0.000 title abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 208000035475 disorder Diseases 0.000 abstract 3
- 239000003488 releasing hormone Substances 0.000 abstract 2
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
- C07D213/643—2-Phenoxypyridines; Derivatives thereof
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- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
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- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
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- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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Abstract
DEPOSANT Société dite: PFIZERPRODUCTS INC. REVENDICATION DE PRIORITES US 18 Janvier2000 60/176,611 Antagonistes du facteur de libération de corticotrophine Antagonistes du facteur de libération de corticotrophine (CRF) répondant à la formule (I), (II) ou (III) , dans laquelle les lignes en traits interrompus, A, B, Y, Z, G, R3, R4, R5, R6, R16 et R17 répondent aux définitions figurant dans la présente demande, et procédés pour leur préparation. Ces composés et leurs sels pharmaceutiquement acceptables sont utiles dans le traitement de troubles comprenant des troubles du système nerveux central et de troubles en rapport avec un stress.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17661100P | 2000-01-18 | 2000-01-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA26864A1 true MA26864A1 (fr) | 2004-12-20 |
Family
ID=22645084
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA26728A MA26864A1 (fr) | 2000-01-18 | 2002-07-11 | Antagonistes du facteur de liberation de corticotrophine. |
Country Status (36)
| Country | Link |
|---|---|
| US (1) | US6833378B2 (fr) |
| EP (1) | EP1263732A1 (fr) |
| JP (1) | JP2003520272A (fr) |
| KR (1) | KR20020063934A (fr) |
| CN (1) | CN1395566A (fr) |
| AP (1) | AP2002002583A0 (fr) |
| AR (1) | AR027221A1 (fr) |
| AU (1) | AU779995B2 (fr) |
| BG (1) | BG106853A (fr) |
| BR (1) | BR0107662A (fr) |
| CA (1) | CA2397633A1 (fr) |
| CO (1) | CO5271658A1 (fr) |
| CR (1) | CR6698A (fr) |
| CZ (1) | CZ20022390A3 (fr) |
| EA (2) | EA200200688A1 (fr) |
| EE (1) | EE200200400A (fr) |
| GT (1) | GT200100007A (fr) |
| HN (1) | HN2001000006A (fr) |
| HR (1) | HRP20020599A2 (fr) |
| HU (1) | HUP0204272A3 (fr) |
| IL (1) | IL150632A0 (fr) |
| IS (1) | IS6445A (fr) |
| MA (1) | MA26864A1 (fr) |
| MX (1) | MXPA02007047A (fr) |
| NO (1) | NO20023424L (fr) |
| OA (1) | OA12157A (fr) |
| PA (1) | PA8510001A1 (fr) |
| PE (1) | PE20011166A1 (fr) |
| PL (1) | PL357589A1 (fr) |
| SK (1) | SK10062002A3 (fr) |
| SV (1) | SV2002000289A (fr) |
| TN (1) | TNSN01008A1 (fr) |
| UY (1) | UY26544A1 (fr) |
| WO (1) | WO2001053263A1 (fr) |
| YU (1) | YU54402A (fr) |
| ZA (1) | ZA200205660B (fr) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6956047B1 (en) * | 1995-06-06 | 2005-10-18 | Pfizer Inc. | Corticotropin releasing factor antagonists |
| EP1449532A1 (fr) * | 1999-08-27 | 2004-08-25 | Pfizer Products Inc. | Composé [2-(4-chloro-2,6-diméthyl-phénoxy)- 3,6-diméthyl-pyridin-4-yl] -(1-ethyl-propyl)- amine et utilisation comme CRF antagoniste |
| GB0117396D0 (en) | 2001-07-17 | 2001-09-05 | Glaxo Group Ltd | Chemical compounds |
| GB0119249D0 (en) | 2001-08-07 | 2001-10-03 | Novartis Ag | Organic compounds |
| US7323469B2 (en) | 2001-08-07 | 2008-01-29 | Novartis Ag | 7H-pyrrolo[2,3-d]pyrimidine derivatives |
| AR040456A1 (es) | 2002-06-27 | 2005-04-06 | Bristol Myers Squibb Co | Piridina n-oxidos 2,4 -disubstituidos utiles como inhibidores de transcriptasa inversa del virus de inmunodeficiencia humana |
| EP1688408A3 (fr) * | 2002-08-08 | 2007-08-22 | Amgen, Inc | Ligands du récepteur vanilloide et leur utilisation dans des traitements |
| AR041191A1 (es) | 2002-08-08 | 2005-05-04 | Amgen Inc | Ligandos del receptor vanilloide y su uso en tratamientos |
| MXPA05007485A (es) | 2003-01-14 | 2006-01-30 | Arena Pharm Inc | Derivados de arilo y heteroarilo 1,2,3-trisubstituidos como moduladores del metabolismo y la profilaxis y tratamiento de trastornos relacionados con ello tales como diabetes e hiperglicemia. |
| WO2004062665A1 (fr) * | 2003-01-16 | 2004-07-29 | Sb Pharmco Puerto Rico Inc | Derives pyrrolo[2,3-b]pyridine a substitution heteroaryle utilises comme antagonistes des recepteurs du crf |
| GB0308208D0 (en) | 2003-04-09 | 2003-05-14 | Glaxo Group Ltd | Chemical compounds |
| US7112585B2 (en) | 2003-04-18 | 2006-09-26 | Bristol-Myers Squibb Company | Pyrimidine derivatives as corticotropin releasing factor inhibitors |
| US7030145B2 (en) | 2003-04-18 | 2006-04-18 | Bristol-Myers Squibb Company | Pyridinyl derivatives for the treatment of depression |
| AR045047A1 (es) * | 2003-07-11 | 2005-10-12 | Arena Pharm Inc | Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos |
| RS20060018A (sr) | 2003-07-14 | 2007-12-31 | Arena Pharmaceuticals Inc., | Derivati spojenih arila i heteroarila kao modulatori metabolizma u profilaksi i lečenju sa njima povezanih stanja |
| EP1701961A1 (fr) * | 2004-01-06 | 2006-09-20 | Taisho Pharmaceutical Co., Ltd | Derives de thienopyrimidine et de thienopyridine substitues par un groupe amino cyclique |
| US20050171095A1 (en) * | 2004-01-06 | 2005-08-04 | Pfizer Inc | Combination of CRF antagonists and 5-HT1B receptor antagonists |
| MY139645A (en) | 2004-02-11 | 2009-10-30 | Amgen Inc | Vanilloid receptor ligands and their use in treatments |
| AU2005212438A1 (en) | 2004-02-11 | 2005-08-25 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
| JP4185154B2 (ja) | 2004-04-30 | 2008-11-26 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | 中枢神経系障害治療用の置換モルホリン化合物 |
| AU2005245389A1 (en) * | 2004-05-12 | 2005-12-01 | Bristol-Myers Squibb Company | Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions |
| EP1827438B2 (fr) | 2004-09-20 | 2014-12-10 | Xenon Pharmaceuticals Inc. | Derives de la piperazine et leur utilisation comme agents therapeutiques |
| US7301022B2 (en) | 2005-02-15 | 2007-11-27 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
| US8153791B2 (en) | 2005-12-21 | 2012-04-10 | Janssen Pharmaceutica N.V. | Substituted pyrimidinyl oxime kinase inhibitors |
| US8013153B2 (en) * | 2006-03-23 | 2011-09-06 | Janssen Pharmaceutica, N.V. | Substituted pyrimidine kinase inhibitors |
| DE602007011793D1 (de) | 2006-10-18 | 2011-02-17 | Pfizer Prod Inc | Biaryl-ether-harnstoffverbindungen |
| WO2009144632A1 (fr) * | 2008-05-30 | 2009-12-03 | Pfizer Limited | Nouveaux composés |
| GB0913636D0 (en) * | 2009-08-05 | 2009-09-16 | Univ Leuven Kath | Novel viral replication inhibitors |
| EP3323818A1 (fr) | 2010-09-22 | 2018-05-23 | Arena Pharmaceuticals, Inc. | Modulateurs du récepteur gpr119 et traitement de troubles associés |
| DK3013813T3 (da) | 2013-06-27 | 2019-06-03 | Pfizer | Heteroaromatiske forbindelser og anvendelse deraf som dopamin-d1-ligander |
| PL3242666T3 (pl) | 2015-01-06 | 2025-02-17 | Arena Pharmaceuticals, Inc. | Związek do zastosowania w leczeniu dolegliwości związanych z receptorem s1p1 |
| AU2016229268B2 (en) | 2015-03-06 | 2020-09-10 | Pharmakea, Inc. | Fluorinated lysyl oxidase-like 2 inhibitors and uses thereof |
| EP3265445B1 (fr) | 2015-03-06 | 2021-05-05 | Pharmakea, Inc. | Inhibiteurs de la lysyl oxydase-like 2 et utilisations desdits inhibiteurs |
| BR112017027656B1 (pt) | 2015-06-22 | 2023-12-05 | Arena Pharmaceuticals, Inc. | Hábito cristalino de placa livre de sal de l-arginina de ácido (r)-2-(7-(4- ciclopentil-3-(trifluorometil)benzilóxi)- 1,2,3,4-tetra-hidrociclo-penta[b]indol-3- il)acético, composição farmacêutica que o compreende, seus usos e método de preparação do mesmo |
| WO2018007331A1 (fr) * | 2016-07-08 | 2018-01-11 | F. Hoffmann-La Roche Ag | Dérivés fusionnés de pyrimidine |
| CA3036064A1 (fr) | 2016-09-07 | 2018-03-15 | Pharmakea, Inc. | Formes cristallines d'un inhibiteur de lysyl oxydase de type 2 et leurs procedes de fabrication |
| WO2018048942A1 (fr) | 2016-09-07 | 2018-03-15 | Pharmakea, Inc. | Utilisations d'un inhibiteur d'homologue 2 de lysyl-oxydase |
| JP7187037B2 (ja) * | 2016-09-07 | 2022-12-12 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | p-タウを減少させ、認知機能を改善させるアロステリック副腎皮質刺激ホルモン放出因子受容体1(CRFR1)アンタゴニスト |
| MX2019009841A (es) | 2017-02-16 | 2020-01-30 | Arena Pharm Inc | Compuestos y metodos para el tratamiento de la colangitis biliar primaria. |
| ES2963044T3 (es) | 2017-03-13 | 2024-03-25 | Raqualia Pharma Inc | Derivados de tetrahidroquinolina como antagonistas del receptor P2X7 |
| CA3102136A1 (fr) | 2018-06-06 | 2019-12-12 | Arena Pharmaceuticals, Inc. | Methodes de traitement de troubles associes au recepteur s1p1<sb /> |
| WO2020168068A1 (fr) * | 2019-02-13 | 2020-08-20 | The University Of Vermont And State Agricultural College | Antagoniste des récepteurs du pacap de type petite molécule et ses utilisations |
| CA3160447A1 (fr) * | 2019-11-06 | 2021-05-14 | Albert Einstein College Of Medicine | Inhibiteurs de transport de prostaglandines a petites molecules |
| WO2024086061A2 (fr) * | 2022-10-18 | 2024-04-25 | Merck Sharp & Dohme Llc | Nouveaux modulateurs de canaux kv3 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3145287A1 (de) | 1981-11-14 | 1983-05-19 | Troponwerke GmbH & Co KG, 5000 Köln | Pyrrolo (2.3-d)pyrimidine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| US4605642A (en) | 1984-02-23 | 1986-08-12 | The Salk Institute For Biological Studies | CRF antagonists |
| EP0264883A3 (fr) | 1986-10-21 | 1990-04-04 | Banyu Pharmaceutical Co., Ltd. | Dérivés de la pyridine substitués |
| US5063245A (en) | 1990-03-28 | 1991-11-05 | Nova Pharmaceutical Corporation | Corticotropin-releasing factor antagonism compounds |
| CA2051012C (fr) | 1990-09-14 | 2002-04-02 | David R. Borcherding | Analogues carbocycliques de l'adenosine pouvant etre utilises comme immunosuppresseurs |
| EP0582804B1 (fr) | 1992-08-10 | 1996-09-25 | Volkswagen Aktiengesellschaft | Mécanisme de changement de vitesse pour une boîte de vitesses |
| KR19990067704A (ko) * | 1992-12-17 | 1999-08-25 | 디. 제이. 우드, 스피겔 알렌 제이 | 부신피질자극호르몬 유리인자 길항제로서의 피롤로피리미딘을함유하는 약학 조성물 |
| WO1995010506A1 (fr) * | 1993-10-12 | 1995-04-20 | The Du Pont Merck Pharmaceutical Company | 1n-alkyle-n-arylpyrimidinamines et leurs derives |
| TW530047B (en) * | 1994-06-08 | 2003-05-01 | Pfizer | Corticotropin releasing factor antagonists |
| US5691364A (en) | 1995-03-10 | 1997-11-25 | Berlex Laboratories, Inc. | Benzamidine derivatives and their use as anti-coagulants |
| US6403599B1 (en) * | 1995-11-08 | 2002-06-11 | Pfizer Inc | Corticotropin releasing factor antagonists |
| PA8467401A1 (es) * | 1998-02-17 | 2000-09-29 | Pfizer Prod Inc | Procedimiento para tratar la insuficiencia cardiaca |
| US6130188A (en) * | 1998-05-05 | 2000-10-10 | American Cyanamid Company | Herbicidal pyridine compounds |
| EP1040831A3 (fr) * | 1999-04-02 | 2003-05-02 | Pfizer Products Inc. | Utilisation d'antagonistes du facteur de libération de la corticotropine pour la prévention de la mort subite |
| US6387894B1 (en) * | 1999-06-11 | 2002-05-14 | Pfizer Inc. | Use of CRF antagonists and renin-angiotensin system inhibitors |
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- 2001-01-05 KR KR1020027009229A patent/KR20020063934A/ko not_active Ceased
- 2001-01-05 MX MXPA02007047A patent/MXPA02007047A/es unknown
- 2001-01-05 HR HR20020599A patent/HRP20020599A2/hr not_active Application Discontinuation
- 2001-01-05 IL IL15063201A patent/IL150632A0/xx unknown
- 2001-01-05 EE EEP200200400A patent/EE200200400A/xx unknown
- 2001-01-05 CN CN01803846A patent/CN1395566A/zh active Pending
- 2001-01-05 YU YU54402A patent/YU54402A/sh unknown
- 2001-01-05 CA CA002397633A patent/CA2397633A1/fr not_active Abandoned
- 2001-01-05 AU AU23905/01A patent/AU779995B2/en not_active Ceased
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- 2001-01-05 AP APAP/P/2002/002583A patent/AP2002002583A0/en unknown
- 2001-01-05 SK SK1006-2002A patent/SK10062002A3/sk unknown
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- 2001-01-05 OA OA1200200206A patent/OA12157A/en unknown
- 2001-01-05 BR BR0107662-0A patent/BR0107662A/pt not_active IP Right Cessation
- 2001-01-05 WO PCT/IB2001/000004 patent/WO2001053263A1/fr not_active Ceased
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| Publication | Publication Date | Title |
|---|---|---|
| MA26864A1 (fr) | Antagonistes du facteur de liberation de corticotrophine. | |
| MA29772B1 (fr) | Benzimidazoles substitues et procedes de preparation | |
| MA27647A1 (fr) | Antagonistes de ccr5 utiles comme agents therapeutiques | |
| TNSN07021A1 (fr) | Derives de quinazoline -4-yl-piperidine et cinnoline -4-yl-piperidine servant d'inhibiteurs de pde10 pour le traitement de troubles du snc | |
| MA27990A1 (fr) | Derives de piperazine pour le traitement d'infections par le vih | |
| MA28747B1 (fr) | Dérivés de pyridine | |
| MA31766B1 (fr) | Composés organiques | |
| MA31952B1 (fr) | Pyrrolopyrimidines et pyrrolopyridines | |
| TNSN07248A1 (fr) | Derive de pyrrolidyle de composes heteroaromatiques servant d'inhibiteurs de phosphodiesterases | |
| TNSN06360A1 (fr) | 4-phenylamino-quinazoline-6-yl-amides | |
| TNSN97145A1 (fr) | Derives 6,5-heterobicycliques substitues, procede pour leur preparation et compositions pharmaceutiques les contenant | |
| MA27568A1 (fr) | Derives de pyrrolopyrimidine | |
| MA27009A1 (fr) | Derives de pyrazole pour le traitement d'une infection par le vih | |
| MA27774A1 (fr) | Inhibiteurs de phosphatidylinositol 3-kinase | |
| MA27389A1 (fr) | Derives de benzimidazole nouveaux utiles comme agents antiproliferatifs. | |
| TNSN07275A1 (fr) | Derives de triazole substitues, servant d'antagonistes d'ocytocine | |
| MA26875A1 (fr) | Composes azapolycycliques a noyau aryle condensé | |
| MA26718A1 (fr) | Derives de quinoleine-2-one a substituant heteroaryle nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant | |
| MXPA04005209A (es) | Antagonistas del receptor de adenosina a2a. | |
| MA32070B1 (fr) | Dérivés hétérocycliques réunis par fusion et procédés d'utilisation associés | |
| TNSN99169A1 (fr) | Derives de 4,4-biarylpiperidine nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant | |
| MA30089B1 (fr) | (arylsulfonyl)-pyrasolopiperidines | |
| TNSN99155A1 (fr) | 1-aryl-3-arylmethyl-1,8-naphtyridine-4(1h)-ones nouvelles, procede pour leur preparation et compositions pharmaceutiques les contenant | |
| TNSN99031A1 (fr) | Composes heterocycliques nouveaux inhibiteurs de romatases, procede pour leur preparation et compositions pharmaceutiques les contenant | |
| TNSN05073A1 (fr) | Quinazolinones spirocondensees nouvelles et leur utilisation comme inhibiteurs de phosphodiesterase |