MA27385A1 - Therapie combinee de maladies hyperproliferatives. - Google Patents
Therapie combinee de maladies hyperproliferatives.Info
- Publication number
- MA27385A1 MA27385A1 MA28110A MA28110A MA27385A1 MA 27385 A1 MA27385 A1 MA 27385A1 MA 28110 A MA28110 A MA 28110A MA 28110 A MA28110 A MA 28110A MA 27385 A1 MA27385 A1 MA 27385A1
- Authority
- MA
- Morocco
- Prior art keywords
- hyperproliferative diseases
- present
- treatment
- relates
- group
- Prior art date
Links
- 201000010099 disease Diseases 0.000 title abstract 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 5
- 230000003463 hyperproliferative effect Effects 0.000 title abstract 5
- 238000002648 combination therapy Methods 0.000 title abstract 2
- 241000124008 Mammalia Species 0.000 abstract 2
- 229940045799 anthracyclines and related substance Drugs 0.000 abstract 2
- 229940030600 antihypertensive agent Drugs 0.000 abstract 2
- 239000002220 antihypertensive agent Substances 0.000 abstract 2
- 239000003534 dna topoisomerase inhibitor Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000002777 nucleoside Substances 0.000 abstract 2
- 150000003833 nucleoside derivatives Chemical class 0.000 abstract 2
- 229910052697 platinum Inorganic materials 0.000 abstract 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Substances [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 abstract 2
- -1 platinum coordination complex Chemical class 0.000 abstract 2
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 abstract 2
- 229940044693 topoisomerase inhibitor Drugs 0.000 abstract 2
- 229960000303 topotecan Drugs 0.000 abstract 2
- UCFGDBYHRUNTLO-QHCPKHFHSA-N topotecan Chemical compound C1=C(O)C(CN(C)C)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 UCFGDBYHRUNTLO-QHCPKHFHSA-N 0.000 abstract 2
- 102000014654 Aromatase Human genes 0.000 abstract 1
- 108010078554 Aromatase Proteins 0.000 abstract 1
- 229940122815 Aromatase inhibitor Drugs 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- XCPGHVQEEXUHNC-UHFFFAOYSA-N amsacrine Chemical compound COC1=CC(NS(C)(=O)=O)=CC=C1NC1=C(C=CC=C2)C2=NC2=CC=CC=C12 XCPGHVQEEXUHNC-UHFFFAOYSA-N 0.000 abstract 1
- 229960001220 amsacrine Drugs 0.000 abstract 1
- 239000003886 aromatase inhibitor Substances 0.000 abstract 1
- 229940088954 camptosar Drugs 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 190000008236 carboplatin Chemical compound 0.000 abstract 1
- 229960004562 carboplatin Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 abstract 1
- 229960005420 etoposide Drugs 0.000 abstract 1
- SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 abstract 1
- 229960005144 gemcitabine hydrochloride Drugs 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 abstract 1
- 150000003854 isothiazoles Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- NRUKOCRGYNPUPR-QBPJDGROSA-N teniposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@@H](OC[C@H]4O3)C=3SC=CC=3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 NRUKOCRGYNPUPR-QBPJDGROSA-N 0.000 abstract 1
- 229960001278 teniposide Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/282—Platinum compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
DEPOSANT Société dite : PFIZER PRODUCTS INC. REVENDICATION DE PRIORITES US 19 Août 2002 60/404,461 Thérapie combinée de maladies hyperprolifératives La présente invention concerne une méthode pour le traitement de maladies hyperprolifératives. Plus particulièrement, la présente invention concerne une méthode pour le traitement de maladies hyperprolifératives, telles que le cancer, comprenant l'étape consistant à administrer à un mammifère, nécessitant un tel traitement, simultanément ou séquentiellement, (i) une quantité thérapeutiquement efficace d'un dérivé de taxane, d'un complexe de coordination de platine choisi dans le groupe consistant en carboplatine, tétraplatine et topotécan, d'un analogue de nucléoside choisi dans le groupe consistant en chlorhydrate de gemcitabine et 5-FU, d'une anthracycline, d'un inhibiteur de topoisomérase choisi dans le groupe consistant en l'étoposide, le téniposide, l'amsacrine, le topotécan et le Camptosar??, un inhibiteur d'aromatase ; et (ii) une quantité thérapeutiquement efficace d'un dérivé d'isothiazole. Les associations de la présente invention peuvent comprendre éventuellement un agent antihypertensif. La présente invention concerne également des compositions pharmaceutiques utiles dans le traitement de maladies hyperprolifératives chez un mammifère, contenant ces associations. La présente invention concerne également des kits comprenant un premier compartiment avec un composé de formule 1 et un deuxième compartiment contenant un dérivé de taxane, un complexe de coordination de platine, un analogue de nucléoside, une anthracycline, un inhibiteur de topoisomérase ou un inhibiteur d'aromatase, et un troisième compartiment contenant un agent antihypertensif.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40446102P | 2002-08-19 | 2002-08-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA27385A1 true MA27385A1 (fr) | 2005-06-01 |
Family
ID=31946725
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA28110A MA27385A1 (fr) | 2002-08-19 | 2005-02-18 | Therapie combinee de maladies hyperproliferatives. |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US20070197517A1 (fr) |
| EP (1) | EP1545519B1 (fr) |
| JP (1) | JP3835763B2 (fr) |
| KR (1) | KR100668539B1 (fr) |
| CN (1) | CN1681495B (fr) |
| AP (1) | AP2005003232A0 (fr) |
| AR (1) | AR040995A1 (fr) |
| AT (1) | ATE502635T1 (fr) |
| AU (1) | AU2003250483A1 (fr) |
| BR (1) | BR0313593A (fr) |
| CA (1) | CA2495962A1 (fr) |
| CR (1) | CR7693A (fr) |
| DE (1) | DE60336485D1 (fr) |
| EA (1) | EA200500234A1 (fr) |
| EC (1) | ECSP055618A (fr) |
| ES (1) | ES2362998T3 (fr) |
| GE (1) | GEP20074134B (fr) |
| GT (1) | GT200300177A (fr) |
| HR (1) | HRP20050163A2 (fr) |
| IL (1) | IL166545A0 (fr) |
| IS (1) | IS7670A (fr) |
| MA (1) | MA27385A1 (fr) |
| MX (1) | MXPA05001958A (fr) |
| NO (1) | NO20050621L (fr) |
| OA (1) | OA12905A (fr) |
| PA (1) | PA8580201A1 (fr) |
| PE (1) | PE20040993A1 (fr) |
| PL (1) | PL375713A1 (fr) |
| RS (1) | RS20050106A (fr) |
| TN (1) | TNSN05051A1 (fr) |
| TW (1) | TW200403057A (fr) |
| WO (1) | WO2004017964A1 (fr) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8641644B2 (en) | 2000-11-21 | 2014-02-04 | Sanofi-Aventis Deutschland Gmbh | Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means |
| US9795747B2 (en) | 2010-06-02 | 2017-10-24 | Sanofi-Aventis Deutschland Gmbh | Methods and apparatus for lancet actuation |
| US9427532B2 (en) | 2001-06-12 | 2016-08-30 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
| US7041068B2 (en) | 2001-06-12 | 2006-05-09 | Pelikan Technologies, Inc. | Sampling module device and method |
| US9226699B2 (en) | 2002-04-19 | 2016-01-05 | Sanofi-Aventis Deutschland Gmbh | Body fluid sampling module with a continuous compression tissue interface surface |
| US8579831B2 (en) | 2002-04-19 | 2013-11-12 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
| US9248267B2 (en) | 2002-04-19 | 2016-02-02 | Sanofi-Aventis Deustchland Gmbh | Tissue penetration device |
| US8702624B2 (en) | 2006-09-29 | 2014-04-22 | Sanofi-Aventis Deutschland Gmbh | Analyte measurement device with a single shot actuator |
| US9314194B2 (en) | 2002-04-19 | 2016-04-19 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
| US8784335B2 (en) | 2002-04-19 | 2014-07-22 | Sanofi-Aventis Deutschland Gmbh | Body fluid sampling device with a capacitive sensor |
| US7226461B2 (en) | 2002-04-19 | 2007-06-05 | Pelikan Technologies, Inc. | Method and apparatus for a multi-use body fluid sampling device with sterility barrier release |
| US9795334B2 (en) | 2002-04-19 | 2017-10-24 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
| US7462181B2 (en) | 2002-06-04 | 2008-12-09 | Stanford Office Of Technology Licensing | Device and method for rapid aspiration and collection of body tissue from within an enclosed body space |
| US8574895B2 (en) | 2002-12-30 | 2013-11-05 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus using optical techniques to measure analyte levels |
| WO2006001797A1 (fr) | 2004-06-14 | 2006-01-05 | Pelikan Technologies, Inc. | Element penetrant peu douloureux |
| EP1671096A4 (fr) | 2003-09-29 | 2009-09-16 | Pelikan Technologies Inc | Procede et appareil permettant d'obtenir un dispositif de capture d'echantillons ameliore |
| US9351680B2 (en) | 2003-10-14 | 2016-05-31 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for a variable user interface |
| EP1706026B1 (fr) | 2003-12-31 | 2017-03-01 | Sanofi-Aventis Deutschland GmbH | Procédé et appareil permettant d'améliorer le flux fluidique et le prélèvement d'échantillons |
| WO2005102327A1 (fr) * | 2004-04-20 | 2005-11-03 | Pfizer Products Inc. | Formes posologiques et procedes de traitement utilisant des inhibiteurs vegfr |
| WO2006011062A2 (fr) | 2004-05-20 | 2006-02-02 | Albatros Technologies Gmbh & Co. Kg | Hydrogel imprimable pour biocapteurs |
| US9775553B2 (en) | 2004-06-03 | 2017-10-03 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for a fluid sampling device |
| KR20070114753A (ko) | 2005-02-18 | 2007-12-04 | 아브락시스 바이오사이언스 인크. | 치료제의 조합 및 투여 방식, 및 조합 요법 |
| US8735394B2 (en) | 2005-02-18 | 2014-05-27 | Abraxis Bioscience, Llc | Combinations and modes of administration of therapeutic agents and combination therapy |
| JP2008543750A (ja) * | 2005-06-13 | 2008-12-04 | アストラゼネカ アクチボラグ | 心不整脈の処置用の新規オキサビスピジン化合物 |
| US8080534B2 (en) * | 2005-10-14 | 2011-12-20 | Phigenix, Inc | Targeting PAX2 for the treatment of breast cancer |
| WO2009117769A1 (fr) * | 2008-03-25 | 2009-10-01 | Newcastle Innovation Limited | Inhibition de cancers à c-kit |
| US9375169B2 (en) | 2009-01-30 | 2016-06-28 | Sanofi-Aventis Deutschland Gmbh | Cam drive for managing disposable penetrating member actions with a single motor and motor and control system |
| MX2012011155A (es) | 2010-03-29 | 2012-12-05 | Abraxis Bioscience Llc | Metodos para mejorar suministros de farmacos y efectividad de agentes terapeuticos. |
| EP3141245A1 (fr) | 2010-03-29 | 2017-03-15 | Abraxis BioScience, LLC | Méthodes de traitement du cancer |
| US8965476B2 (en) | 2010-04-16 | 2015-02-24 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
| MX347225B (es) | 2010-06-04 | 2017-04-19 | Abraxis Bioscience Llc * | Metodos de tratamiento contra el cancer pancreatico. |
| RS54648B1 (sr) * | 2010-11-12 | 2016-08-31 | Pharma Mar S.A. | Kombinovana terapija sa antitumorskim alkaloidom |
| CN105473147A (zh) | 2013-04-24 | 2016-04-06 | 萨克生物研究学院 | 维生素d受体/smad基因组回路门纤维化反应 |
| EP3473299A1 (fr) | 2013-06-05 | 2019-04-24 | Salk Institute for Biological Studies | Agonistes du récepteur de la vitamine d pour traiter des maladies impliquant l'activité cxcl12 |
| US20180085377A1 (en) * | 2015-04-22 | 2018-03-29 | Syn-Nat Products Enterprise LLC | Co-crystal composition and its pharmaceutical use |
| AU2016265922B2 (en) | 2015-05-18 | 2021-05-20 | Syn-Nat Products Enterprise LLC | A pharmaceutical co-crystal and use thereof |
| BR112017027285A2 (pt) | 2015-06-19 | 2018-09-11 | Syn Nat Products Entpr Llc | ?cocristal, composição farmacêutica e método para o tratamento de uma doença? |
| BR112017027277A2 (pt) | 2015-06-19 | 2018-09-04 | Syn Nat Products Entpr Llc | ?método para o tratamento ou prevenção de uma doença e métodos para matar uma célula? |
| US10428099B2 (en) | 2015-06-25 | 2019-10-01 | Syn-Nat Products Enterprise LLC | Pharmaceutical co-crystal composition and use thereof |
| EP4628116A3 (fr) | 2016-02-01 | 2025-12-10 | Regenmed Systems, Inc. | Systèmes et procédés d'estimation de l'authenticité d'un réseau local d'un dispositif initiant une transaction à distance |
| WO2019023149A1 (fr) | 2017-07-24 | 2019-01-31 | Salk Institute For Biological Studies | Utilisation d'antagonistes de la protéine 9 contenant un bromodomaine en association avec des agonistes du récepteur de la vitamine d dans le traitement du diabète |
| PE20252386A1 (es) | 2019-11-21 | 2025-10-10 | Pharma Mar Sa | Metodo de tratamiento del cancer de pulmon de celulas pequenas con formulaciones de lurbinectedina |
| US20230098628A1 (en) * | 2021-08-23 | 2023-03-30 | Ckp Therapeutics, Inc. | Composition for preventing, alleviating or treating cancer |
| US11738021B2 (en) | 2021-08-23 | 2023-08-29 | Ckp Therapeutics, Inc. | Composition and method for preventing, alleviating or treating cancer |
| WO2026002137A1 (fr) * | 2024-06-27 | 2026-01-02 | 苏州必扬医药科技有限公司 | Forme cristalline de base libre d'inhibiteur de protéine tyrosine kinase |
| WO2026002126A1 (fr) * | 2024-06-27 | 2026-01-02 | 苏州必扬医药科技有限公司 | Inhibiteur de protéine tyrosine kinase et préparation ophtalmique associée |
Family Cites Families (219)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2882271A (en) | 1959-04-14 | Xcixcxh | ||
| US2783241A (en) | 1957-02-26 | S-acylimino-x-substituted-az-i | ||
| US3108097A (en) | 1963-10-22 | Ehnojs | ||
| US2802005A (en) | 1957-08-06 | S-eluorourace | ||
| US2809194A (en) | 1957-10-08 | Thiadiazine type natriuretic agents | ||
| US3262852A (en) | 1966-07-26 | Vasodilator and anti-anginose com- pounds containing methoxy benzyl piperazines and method of using the same | ||
| US437201A (en) | 1890-09-30 | Mechanism for testing reed-organs | ||
| SE168308C1 (fr) | ||||
| US338899A (en) | 1886-03-30 | Sun-shield for horses | ||
| US3254076A (en) | 1966-05-31 | Sulfamyl hydro | ||
| US3009911A (en) | 1961-11-21 | Derivatives of j | ||
| US2661372A (en) | 1953-12-01 | Pharmacologically valuable stereo | ||
| US3164588A (en) | 1965-01-05 | Hjnsoj | ||
| DE55956C (de) | CH. GROOMBRIDGE und W. A. SOUTH in London, 40 New Bond Street | Bremskurbel für Pferdebahn- und andere Wagen | ||
| US2937169A (en) | 1960-05-17 | Toiutf alrtqn of h | ||
| US2976289A (en) | 1961-03-21 | X-tetrahydro - | ||
| US2161938A (en) | 1934-07-31 | 1939-06-13 | Soc Of Chemical Ind | Imidazolines |
| DE905738C (de) | 1943-06-11 | 1954-11-02 | Diwag Chemische Fabriken Ag | Verfahren zur Herstellung basischer Thymoldimethylaminoaethylaether |
| US2500444A (en) | 1944-10-10 | 1950-03-14 | Polaroid Corp | Uramidohomomeroquinene |
| AT168063B (de) | 1948-11-23 | 1951-04-10 | Richter Gedeon Vegyeszet | Verfahren zur Herstellung von neuen asymmetrischen Substitutionsprodukten des 2,4-Diamino-1,3,5-Triazins |
| US2554816A (en) | 1950-04-04 | 1951-05-29 | American Cyanamid Co | Heterocyclic sulfonamides and methods of preparation thereof |
| DE860217C (de) | 1950-10-28 | 1952-12-18 | Albert Ag Chem Werke | Verfahren zur Herstellung von 1-Hexyl-3, 7-dimethylxanthin |
| GB740932A (en) | 1952-08-01 | 1955-11-23 | Rhone Poulenc Sa | Improvements in or relating to phenthiazine derivatives |
| US2661373A (en) | 1953-03-02 | 1953-12-01 | Kulz Ida | Certain amino alcohols and ketones |
| US2816118A (en) | 1953-11-12 | 1957-12-10 | S B Penick & Company Inc | Isolation of crystalline components from visnagan |
| US2909194A (en) | 1954-02-15 | 1959-10-20 | Goodyear Tire & Rubber | Relay valve |
| FR1103113A (fr) | 1954-04-15 | 1955-10-31 | Triméthylol-alcanes et leur procédé de préparation | |
| GB769757A (en) | 1954-05-13 | 1957-03-13 | American Cyanamid Co | Improvements in or relating to the manufacture of sulfonamides |
| US2769015A (en) | 1954-10-06 | 1956-10-30 | Lab Laroche Navarron | Process of preparing 3-methyl-chromone |
| GB795174A (en) | 1954-10-13 | 1958-05-21 | Upjohn Co | Heterocyclic sulphonamides |
| GB807826A (en) | 1955-03-14 | 1959-01-21 | Thomae Gmbh Dr K | Derivatives of pyrimido[5,4-d] pyrimidine and production thereof |
| FR1165845A (fr) | 1955-05-28 | 1958-10-29 | Philips Nv | Amines secondaires portant des substituants et leur préparation |
| GB803372A (en) | 1955-11-02 | 1958-10-22 | Recordati Lab Farmacologico S | Hydroxychromone derivatives and methods of preparing the same |
| US3012042A (en) | 1956-12-21 | 1961-12-05 | Belge Produits Chimiques Sa | Benzofurans |
| NL224562A (fr) | 1957-02-05 | |||
| GB824547A (en) | 1957-05-07 | 1959-12-02 | Recordati Lab Farmacologico S | Process for preparing flavone-7-ethyl oxyacetate |
| US3055904A (en) | 1957-11-04 | 1962-09-25 | Geigy Chem Corp | New isoindoline derivatives |
| US2965656A (en) | 1957-11-07 | 1960-12-20 | Merck & Co Inc | Process for preparing substituted 1-amino-2, 4-benzene-disulfonamides |
| US2965655A (en) | 1957-11-07 | 1960-12-20 | Merck & Co Inc | Process for preparing substituted 1-amino 2, 4-benzene-disulfonamides |
| US2980699A (en) | 1957-12-20 | 1961-04-18 | S B Penick And Company | Dihydropyranocoumarin derivatives and process for their production |
| US3440244A (en) | 1958-02-17 | 1969-04-22 | Pfizer & Co C | 3,6-disubstituted-7-sulfamyl-1,2,4-benzthiazide-1,1-dioxides |
| FR1217929A (fr) | 1958-03-03 | 1960-05-06 | Ciba Geigy | Procédé de préparation du 1,1-dioxyde de la 6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine et de ses sels |
| CH366523A (de) | 1958-04-14 | 1963-01-15 | Eprova Ag | Verfahren zur Herstellung der neuen 1,3,4,6- und 1,3,4,5-Tetranicotinoyl-fructose |
| SU115905A1 (ru) | 1958-04-19 | 1958-11-30 | Н.Е. Акопян | Препарат ганглерон |
| NL238796A (fr) | 1958-05-07 | |||
| GB851287A (en) | 1958-07-10 | 1960-10-12 | British Drug Houses Ltd | 5-chlorotoluene-2:4-disulphonamide and alkali metal salts thereof |
| DE1102750B (de) | 1958-07-17 | 1961-03-23 | Wuelfing J A Fa | Verfahren zur Herstellung eines Salzes von Theophyllinbasen |
| GB856409A (en) | 1958-07-26 | 1960-12-14 | Chime Et Atomistique | Improvements in and relating to a new pyridazine derivative and its process of preparation |
| GB862248A (en) | 1958-08-04 | 1961-03-08 | Italseber S P A | Di-isopropylammonium salts of chloroacetic and chloropropionic acids |
| GB863474A (en) | 1958-08-13 | 1961-03-22 | Knud Abildgaard | Benzothiadiazine derivatives and their preparation |
| US2970082A (en) | 1958-10-07 | 1961-01-31 | Walker Lab Inc | Aluminum nicotinate compositions for hypercholesteremia |
| GB885078A (en) | 1959-01-12 | 1961-12-20 | Ciba Ltd | 3:4-dihydro-1:2:4-benzothiadiazine-1:1-dioxides and process for their manufacture |
| ES255386A1 (es) | 1959-02-04 | 1960-09-16 | Ciba Geigy | Procedimiento para preparar derivados del 3,4-dihidro-1,2,4-benzotiadiazina-1,1,-diëxido |
| US3058882A (en) | 1959-12-28 | 1962-10-16 | Hoechst Ag | N'-substituted-3-carboxy-6-halo-sulfanilamide and derivatives thereof |
| DE1102973B (de) | 1960-03-25 | 1961-03-23 | Bayer Ag | Verfahren zur Herstellung von hoch gereinigten Kallikrein-Praeparaten |
| NL291944A (fr) | 1960-05-04 | |||
| DE1265758B (de) | 1960-05-25 | 1968-04-11 | Guidotti & C Spa Labor | Verfahren zur Herstellung von o-(beta-Dialkylaminoaethoxy)-phenylketonen und deren Saeureadditionssalzen und quartaeren Salzen |
| US3081230A (en) | 1960-09-08 | 1963-03-12 | Smith Kline French Lab | Diuretic and antihypertensive triaminoarylpteridines |
| DE1302648B (fr) | 1960-09-27 | |||
| SE300218B (fr) | 1960-11-08 | 1968-04-22 | Recip Ab | |
| NL270803A (fr) | 1960-11-09 | |||
| US3255241A (en) | 1961-01-19 | 1966-06-07 | Merck & Co Inc | (2-alkylidene acyl)phenoxy-and (2-alkylidene acyl)phenylmercaptocarboxylic acids |
| US3072653A (en) | 1961-03-06 | 1963-01-08 | Warner Lamber Pharmaceutical C | 5-amino derivatives of 4-thiazolidinones and process therefor |
| DE1154810B (de) | 1961-04-01 | 1963-09-26 | Knoll Ag | Verfahren zur Herstellung basisch substituierter Phenylacetonitrile |
| FR1312427A (fr) | 1961-04-12 | 1962-12-21 | Science Union Et Compagnie Soc | Nouveaux dérivés de la pipérazine et leurs préparations |
| GB979994A (en) | 1961-07-28 | 1965-01-06 | May & Baker Ltd | Isoindolinone derivatives |
| US3160641A (en) | 1961-08-07 | 1964-12-08 | Atlas Chem Ind | Purification of isosorbide |
| NL281975A (fr) | 1961-08-12 | |||
| GB984810A (en) | 1961-10-05 | 1965-03-03 | Farmaceutici Italia | Polypeptides |
| DE1236523C2 (de) | 1962-02-15 | 1975-06-12 | Sanol-Arzneimittel Dr. Schwarz Gmbh, 4019 Monheim | Verfahren zur herstellung von basischen phenylaethern und deren salzen |
| US3262977A (en) | 1962-03-10 | 1966-07-26 | Chinoin Gyogyszer Es Vegyeszet | N-aralkyl-1, 1-diphenyl-propylamine derivatives |
| BE629910A (fr) | 1962-03-22 | |||
| US3188329A (en) | 1962-04-10 | 1965-06-08 | Colgate Palmolive Co | Diuretic anils |
| US3228943A (en) | 1962-06-11 | 1966-01-11 | Lumilysergol derivatives | |
| BE639386A (fr) | 1962-10-30 | |||
| NL300886A (fr) | 1962-11-23 | |||
| NL301580A (fr) | 1962-12-11 | |||
| NL142872C (fr) | 1963-03-28 | |||
| FR2790M (fr) | 1963-05-24 | 1964-10-16 | Soc Ind Fab Antibiotiques Sifa | Nouveaux dérivés des thiachromanes. |
| GB1069343A (en) | 1963-09-10 | 1967-05-17 | Ici Ltd | Propanolamine derivatives |
| US3238215A (en) | 1963-10-17 | 1966-03-01 | Sterling Drug Inc | 1-[(3-, 2-, and 1-indolyl)-lower-alkyl-, lower-alkenyl-, and lower-alkynyl]piperidines |
| NL127996C (fr) | 1963-11-19 | |||
| BR6464291D0 (pt) | 1963-11-26 | 1973-07-26 | Merrell Inc Richardson | Processo para preparar o novo composto quimico 1-1-di cloro-hexil-2-(2-piperidil)-etina |
| DE1278443C2 (de) | 1963-11-30 | 1975-07-24 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von 2,4-disulfonamid-1-chlorbenzolen |
| NL128190C (fr) | 1964-02-07 | |||
| FR1390056A (fr) | 1964-04-21 | 1965-02-19 | Holding Ceresia S A | Procédé de préparation de nouveaux dérivés du tétrahydronaphtalène et produits conformes à ceux obtenus par le présent procédé ou procédé similaire |
| NL127065C (fr) | 1964-04-22 | |||
| NL137318C (fr) | 1964-06-09 | |||
| US3422107A (en) | 1964-09-05 | 1969-01-14 | Albert Ag Chem Werke | Certain oxoalkyldimethylxanthines and a process for the preparation thereof |
| NL130749C (fr) | 1964-09-10 | |||
| GB1078852A (en) | 1964-09-30 | 1967-08-09 | Ici Ltd | Alkanolamine derivatives |
| NL6514807A (fr) | 1964-11-18 | 1966-05-20 | ||
| NL128191C (fr) | 1965-01-12 | |||
| US3466325A (en) | 1965-04-30 | 1969-09-09 | Haessle Ab | 1-(ortho-alkenyl phenoxy) - 2-hydroxy-3-isopropylaminopropanes and the salts thereof |
| US3929836A (en) | 1965-05-11 | 1975-12-30 | Hoffmann La Roche | 2-(2-Lower alkylamino-1-hydroxy-ethyl)-substituted benzofurans |
| FR1460571A (fr) | 1965-06-10 | 1966-03-04 | Innothera Lab Sa | Composés thiényl acétiques et leur préparation |
| DE1270544B (de) | 1965-06-19 | 1968-06-20 | Beiersdorf Ag | 4-Chlor-5-sulfamylsalicylsaeure-(2', 6'-dimethyl)-anilid und dessen Alkali- oder Ammonium-Salze sowie Verfahren zu deren Herstellung |
| DE1545575C2 (de) | 1965-12-16 | 1970-09-10 | Asta-Werke Ag, Chemische Fabrik, 4812 Brackwede | N, N'-Bis- eckige Klammer auf 3"(3', 4', 5'-trimethoxybenzoyloxy)-propyl eckige Klammer zu -homopiperazin |
| US3360518A (en) | 1966-01-03 | 1967-12-26 | Wallace & Tiernan Inc | Tetrahydro-halo-sulfamyl quinazolinones |
| CH472404A (de) | 1966-03-04 | 1969-05-15 | Sandoz Ag | Verfahren zur Herstellung neuer Indolderivate |
| CH469002A (de) | 1966-06-21 | 1969-02-28 | Sandoz Ag | Verfahren zur Herstellung neuer Indolderivate |
| FR5733M (fr) | 1966-09-27 | 1968-01-22 | ||
| FR6087M (fr) | 1967-01-10 | 1968-06-04 | ||
| US3541130A (en) | 1967-02-06 | 1970-11-17 | Boehringer Sohn Ingelheim | 1-(cyanophenoxy)-2-hydroxy-3-tert.-butylamine propanes |
| GB1160925A (en) | 1967-02-08 | 1969-08-06 | Menarini Sas | 2-Substituted Benzofuran Derivatives |
| DE1668055B2 (de) | 1967-03-10 | 1973-09-06 | Farbwerke Hoechst AG, vormals Mei ster Lucius & Bruning, 6000 Frankfurt | Basisch substituierte cyclopentylphenolaether, deren salze mit physiologisch vertraeglichen saeuren und verfahren zu deren herstellung |
| DE1670827C3 (de) | 1967-03-20 | 1974-10-24 | Bayer Ag, 5090 Leverkusen | 4-(2'-Nitrophenyl)-2,6-dimethyl-3,5-dicarbmethoxy-1,4-dihydropyridin |
| US3562257A (en) | 1967-10-28 | 1971-02-09 | Tanabe Seiyaku Co | Benzothiazepine derivatives |
| US3511836A (en) | 1967-12-13 | 1970-05-12 | Pfizer & Co C | 2,4,6,7-tetra substituted quinazolines |
| US3857952A (en) | 1967-12-22 | 1974-12-31 | May & Baker Ltd | Certain benzene derivatives useful in treating cardiac disorders |
| NL6903138A (fr) | 1968-03-02 | 1969-09-04 | ||
| GB1203691A (en) | 1968-03-06 | 1970-09-03 | Science Union & Cie | New disubstituted n-amino indoline derivatives and process for preparing them |
| GB1218591A (en) | 1968-04-03 | 1971-01-06 | Delalande Sa | Derivatives of n-(3,4,5-trimethoxy cennamoyl) piperazine and their process of preparation |
| US4045482A (en) | 1968-11-12 | 1977-08-30 | Yamanouchi Pharmaceutical Co. Ltd. | 4-(3-Isopropylamino-2-hydroxypropoxy indene |
| DE1815922C3 (de) | 1968-12-20 | 1979-04-26 | Boehringer Mannheim Gmbh, 6800 Mannheim | 5-Phenyltetrazol-Derivate |
| GB1249490A (en) | 1968-12-24 | 1971-10-13 | Leo Pharm Prod Ltd | New sulphamyl-benzoic acid derivatives |
| FR8120M (fr) | 1968-12-26 | 1970-08-03 | ||
| GB1285038A (en) | 1969-02-21 | 1972-08-09 | Ici Ltd | Alkanolamine derivatives |
| US3836671A (en) | 1969-02-21 | 1974-09-17 | Ici Ltd | Alkanolamine derivatives for producing beta-adrenergic blockade |
| US3655663A (en) | 1969-04-21 | 1972-04-11 | Burton K Wasson | 4-(3-secondary amino-2-hydroxy-proxy) 1 2 5-thiadiazoles |
| US3663570A (en) | 1969-04-28 | 1972-05-16 | Sankyo Co | Coumarin derivatives |
| GB1262785A (en) | 1969-04-29 | 1972-02-09 | Orsymonde | Improvements in or relating to phloroglucinol derivatives |
| CA956632A (en) | 1969-05-16 | 1974-10-22 | Yoshitomi Pharmaceutical Industries | Phenoxy-aminopropanol derivatives |
| US4012444A (en) | 1969-07-08 | 1977-03-15 | Allen & Hanburys Limited | 5-[1-Hydroxy-2-(1-methyl-3-phenylpropyl)aminoethyl] salicylamide and physiologically acceptable acid addition salts thereof |
| BE757001A (fr) | 1969-10-10 | 1971-03-16 | Cerpha | Derives heterocycliques d'acides phenoxy acetique et leur preparation |
| US4018824A (en) | 1969-11-28 | 1977-04-19 | Teikoku Hormone Mfg. Co., Ltd. | 1-Aryloxy-3-aminopropane derivatives |
| US3935259A (en) | 1970-01-08 | 1976-01-27 | Ciba-Geigy Corporation | New amines and processes for their manufacture |
| US4038313A (en) | 1970-01-08 | 1977-07-26 | Ciba-Geigy Corporation | Cycloalkylureido phenoxy propanolamines |
| SE354851B (fr) | 1970-02-18 | 1973-03-26 | Haessle Ab | |
| US3770724A (en) | 1970-03-31 | 1973-11-06 | Roussel Uclaf | Process for preparing pentacyclic alkaloids |
| GB1308191A (en) | 1970-04-06 | 1973-02-21 | Science Union & Cie | Thiochroman derivatives and a process for preparing them |
| US3663597A (en) | 1970-05-05 | 1972-05-16 | American Home Prod | Process for the purification of cyclandelate |
| FR2092133B1 (fr) | 1970-05-06 | 1974-03-22 | Orsymonde | |
| US3669968A (en) | 1970-05-21 | 1972-06-13 | Pfizer | Trialkoxy quinazolines |
| US4059622A (en) | 1970-05-27 | 1977-11-22 | Imperial Chemical Industries Limited | Alkanolamine derivatives |
| DE2130393C3 (de) | 1970-06-22 | 1981-02-26 | E.R. Squibb & Sons Inc., New York, N.Y. (V.St.A.) | 6,7-Dihydroxy -5,6,7,8-tetrahydronaphthyloxyaminopropanole und ihre Salze mit Säuren sowie ihre Verwendung bei der Bekämpfung von Herzerkrankungen |
| FR2092895B1 (fr) | 1970-06-29 | 1973-07-13 | Lafon Victor | |
| AT308089B (de) | 1970-10-14 | 1973-06-25 | Degussa | Verfahren zur Herstellung von neuen Thienylalkanderivaten und ihren Salzen |
| DE2117571C3 (de) | 1971-04-10 | 1979-10-11 | Bayer Ag, 5090 Leverkusen | Unsymmetrische 1,4-Dihydropyridin-33-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel |
| CA989411A (en) | 1971-05-13 | 1976-05-18 | Kakenyaku Kako Co. | Benzofuran derivatives and preparation thereof |
| DE2815926A1 (de) | 1978-04-13 | 1979-10-18 | Boehringer Mannheim Gmbh | Neue carbazolyl-(4)-oxy-propanolamin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| US3773939A (en) | 1971-11-24 | 1973-11-20 | Janssen Pharmaceutica Nv | N-arallyl-n'-aralkyl piperazine pharmaceutical compositions |
| BE790165A (fr) | 1971-12-14 | 1973-02-15 | Parke Davis & Co | Nouveaux aminoalcanols et procede pour les preparer |
| BE795735A (fr) | 1972-03-06 | 1973-06-18 | Cerm Cent Europ Rech Mauvernay | Nouvelles ethylenediamines substituees a activite cardiovasculaire |
| JPS5229318B2 (fr) | 1972-03-30 | 1977-08-01 | ||
| US3910924A (en) | 1972-04-13 | 1975-10-07 | Otsuka Pharma Co Ltd | 3,4-Dihydrocarbostyril derivatives and a process for preparing the same |
| ZA732937B (en) | 1972-05-05 | 1974-03-27 | Maggioni & C Spa | Non mercurial diuretics |
| GB1435139A (en) | 1972-08-17 | 1976-05-12 | Sumitomo Chemical Co | Thiazole derivatives |
| US4167581A (en) | 1972-12-15 | 1979-09-11 | Imperial Chemical Industries Limited | Alkanolamine derivatives and pharmaceutical compositions and uses thereof |
| US3985758A (en) | 1973-02-20 | 1976-10-12 | Yamanouchi Pharmaceutical Co., Ltd. | 1,4-Dihydropyridine derivatives |
| GB1390748A (en) | 1973-04-09 | 1975-04-16 | Continental Pharma | Alkyl and cycloalkylthiophenylalkylaminoalkanols their salts and the preparation thereof |
| DE2319278C2 (de) | 1973-04-17 | 1986-02-20 | Bayer Ag, 5090 Leverkusen | Pharmazeutisches Mittel |
| US4146643A (en) | 1973-12-18 | 1979-03-27 | Sandoz Ltd. | Increasing vigilance or treating cerebral insufficiency with substituted vincamines |
| AT334385B (de) | 1973-12-20 | 1976-01-10 | Chemie Linz Ag | Verfahren zur herstellung von neuen phenoxypropylaminderivaten und deren salzen |
| NL175059C (nl) | 1974-02-23 | Boehringer Mannheim Gmbh | Bereiding van bloeddrukverlagende stoffen en van preparaten die ze bevatten. | |
| GB1501632A (en) | 1974-06-28 | 1978-02-22 | Cm Ind | Aromatic ketones having cardiovascular activity |
| GB1477664A (en) | 1974-04-17 | 1977-06-22 | Christiaens Sa A | Pyridine derivatives |
| DE2419970C3 (de) | 1974-04-25 | 1980-06-12 | Hoechst Ag, 6000 Frankfurt | 3-<l-Pyrrolidinyl)-4-phenoxy-5sulfamoylbenzoesäure und Verfahren zu ihrer Herstellung |
| DE2521113A1 (de) | 1974-05-15 | 1976-03-18 | Maggioni & C Spa | Cycloaliphatische derivate von 3.3-diphenylpropylamin |
| US4338322A (en) | 1975-07-02 | 1982-07-06 | Fujisawa Pharmaceutical Co., Ltd. | 1,4-Dihydropyridine derivatives, pharmaceutical compositions containing same and methods of effecting vasodilation using same |
| US4129565A (en) | 1975-07-11 | 1978-12-12 | Nisshin Flour Milling Co., Ltd. | Isocarbostyril derivatives |
| US4340541A (en) | 1975-08-15 | 1982-07-20 | Sandoz Ltd. | 4-(2-Benzoyloxy-3-tert.-butylaminopropoxy-2-methyl indole |
| US4035750A (en) | 1975-10-14 | 1977-07-12 | Eastman Kodak Company | Electrophotographic apparatus having improved photoconductor regenerative structure and procedure |
| US4105776A (en) | 1976-06-21 | 1978-08-08 | E. R. Squibb & Sons, Inc. | Proline derivatives and related compounds |
| US4154839A (en) | 1975-11-05 | 1979-05-15 | Bayer Aktiengesellschaft | 2,6-Dimethyl-3-carboxymethoxy-4-(2-nitrophenyl)-5-carbisobutoxy-1,4-dihydropyridine |
| FR2330383A1 (fr) | 1975-11-06 | 1977-06-03 | Synthelabo | Nouveaux ethers de phenols substitues, leurs sels, leur preparation et les medicaments qui les renferment |
| US4046889A (en) | 1976-02-13 | 1977-09-06 | E. R. Squibb & Sons, Inc. | Azetidine-2-carboxylic acid derivatives |
| GB1544872A (en) | 1976-06-25 | 1979-04-25 | Sterling Drug Inc | 4-hydroxyphenylalkanolamine derivatives and preparation thereof |
| DE2645710C2 (de) | 1976-10-09 | 1985-06-27 | Merck Patent Gmbh, 6100 Darmstadt | Phenoxy-amino-propanole, Verfahren zu ihrer Herstellung und pharmazeutische Zubereitung |
| US4466972A (en) | 1977-06-20 | 1984-08-21 | Sandoz Ltd. | Benzoxadiazoles and benzothiadiazoles, their preparation and pharmaceutical compositions containing them |
| CA1147342A (fr) | 1977-10-12 | 1983-05-31 | Kazuo Imai | Procede de preparation de nouveaux derives de la phenylethanolamine |
| US4188390A (en) | 1977-11-05 | 1980-02-12 | Pfizer Inc. | Antihypertensive 4-amino-2-[4-(1,4-benzodioxan-2-carbonyl) piperazin-1-yl or homopiperazin-1-yl]quinazolines |
| IT1088554B (it) | 1977-11-17 | 1985-06-10 | F I D I A Spa | Procedimento sellettivo per la preparazione di derivati della 7-indrossi cumarina |
| JPS55301A (en) | 1978-02-14 | 1980-01-05 | Yamanouchi Pharmaceut Co Ltd | 1,4-dihydropyridine-3,5-dicarboxylic ester derivative and its preparation |
| IT1094076B (it) | 1978-04-18 | 1985-07-26 | Acraf | Cicloalchiltriazoli |
| SE429652B (sv) | 1978-06-30 | 1983-09-19 | Haessle Ab | 2.6-dimetyl-4-(2.3-diklorfenyl)-1.4-dihydropyridin-3.5-dikarboxylsyra-3-metylester-5-etylester |
| JPS559058A (en) | 1978-07-06 | 1980-01-22 | Dainippon Pharmaceut Co Ltd | 1-(3-mercapto-2-methylpropanoyl)prolyl amino acid derivative |
| DE2845770A1 (de) | 1978-10-19 | 1980-04-30 | Schering Ag | Neue prostacyclin-derivate und verfahren zu ihrer herstellung |
| IL58849A (en) | 1978-12-11 | 1983-03-31 | Merck & Co Inc | Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them |
| US4508729A (en) | 1979-12-07 | 1985-04-02 | Adir | Substituted iminodiacids, their preparation and pharmaceutical compositions containing them |
| JPS56110665A (en) | 1980-02-08 | 1981-09-01 | Yamanouchi Pharmaceut Co Ltd | Sulfamoyl-substituted phenetylamine derivative and its preparation |
| US4394382A (en) | 1980-06-17 | 1983-07-19 | Kowa Company, Ltd. | Dihydrobenzopyran compounds and pharmaceutical composition comprising said compounds |
| US4344949A (en) | 1980-10-03 | 1982-08-17 | Warner-Lambert Company | Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids |
| US4470972A (en) | 1981-04-28 | 1984-09-11 | Schering Corporation | 7-Carboxyalkylaminoacyl-1,4-dithia-7-azaspiro[4.4]-nonane-8-carboxylic acids |
| ZA817261B (en) | 1980-10-23 | 1982-09-29 | Schering Corp | Carboxyalkyl dipeptides,processes for their production and pharmaceutical compositions containing them |
| JPS57209270A (en) | 1981-06-19 | 1982-12-22 | Chugai Pharmaceut Co Ltd | Proline derivative |
| GB2111978B (en) | 1981-10-19 | 1985-05-01 | Maruko Pharmaceutical Co | 1 4-dihydropyridine compounds |
| US4410520A (en) | 1981-11-09 | 1983-10-18 | Ciba-Geigy Corporation | 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids |
| IE55867B1 (en) | 1981-12-29 | 1991-02-14 | Hoechst Ag | New derivatives of bicyclic aminoacids,processes for their preparation,agents containing these compounds and their use,and new bicyclic aminoacids as intermediates and processes for their preparation |
| US4555502A (en) | 1982-09-30 | 1985-11-26 | Merck & Co., Inc. | Aminoacyl-containing dipeptide derivatives useful as antihypertensives |
| DK161312C (da) | 1982-03-11 | 1991-12-09 | Pfizer | Analogifremgangsmaade til fremstilling af 2-aminoalkoxymethyl-4-phenyl-6-methyl-1,4-dihydropyridin-3,5-dicarboxylsyreestere eller syreadditionssalte deraf samt phthalimidoderivater til anvendelse som udgangsmateriale ved fremgangsmaaden |
| ATE50987T1 (de) | 1982-05-10 | 1990-03-15 | Takeda Chemical Industries Ltd | Dihydropyridinderivate, deren herstellung und verwendung. |
| JPS6058233B2 (ja) | 1982-05-24 | 1985-12-19 | 田辺製薬株式会社 | ２−オキソイミダゾリジン誘導体及びその製法 |
| US4452790A (en) | 1982-06-23 | 1984-06-05 | E. R. Squibb & Sons, Inc. | Phosphonyl hydroxyacyl amino acid derivatives as antihypertensives |
| US4463176A (en) | 1982-09-13 | 1984-07-31 | Mead Johnson & Company | Process for resolution of optical isomers |
| AU557175B2 (en) | 1982-10-15 | 1986-12-11 | Kyowa Hakko Kogyo Co. Ltd. | 2,6-dimethyl-4-(3-nitro phenyl)-1,4-dihydro pyridine-3,5- dicarboxylic acid esters |
| US4567175A (en) | 1983-06-03 | 1986-01-28 | Tanabe Seiyaku Co., Ltd. | 8-Chloro-1,5-benzothiazepine derivatives |
| US4678783B1 (en) | 1983-11-04 | 1995-04-04 | Asahi Chemical Ind | Substituted isoquinolinesulfonyl compounds |
| US4654362A (en) | 1983-12-05 | 1987-03-31 | Janssen Pharmaceutica, N.V. | Derivatives of 2,2'-iminobisethanol |
| GB8403866D0 (en) | 1984-02-14 | 1984-03-21 | Recordati Chem Pharm | Diphenylalkylaminoalkyl esters |
| JPS60222472A (ja) | 1984-03-30 | 1985-11-07 | Kanebo Ltd | 新規なピペラジン誘導体および該化合物を有効成分とする医薬組成物 |
| US4699905A (en) | 1984-04-10 | 1987-10-13 | Sankyo Company, Limited | Perhydrothiazepine derivatives, their preparation and their therapeutic use |
| US4672068A (en) | 1984-05-04 | 1987-06-09 | Fujirebio Kabushiki Kaisha | Antihypertensive 1,4-dihydropyridines having a conjugated ester |
| NZ212895A (en) | 1984-08-22 | 1988-07-28 | Glaxo Spa | 1,4-dihydropyridine derivatives and pharmaceutical compositions |
| KR890004196B1 (ko) | 1985-07-29 | 1989-10-27 | 산텐세이야꾸가부시끼가이샤 | 신규 벤조티아진 유도체의 제조방법 |
| US4885284A (en) | 1986-01-22 | 1989-12-05 | Nissan Chemical Industries Ltd. | Dihydropyridine-5-phosphonic acid cyclic propylene ester |
| US5138069A (en) | 1986-07-11 | 1992-08-11 | E. I. Du Pont De Nemours And Company | Angiotensin II receptor blocking imidazoles |
| CA1319144C (fr) | 1986-11-14 | 1993-06-15 | Quirico Branca | Derives tetrahydronaphtalene |
| ATE61588T1 (de) | 1987-08-03 | 1991-03-15 | Delagrange Lab | 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel. |
| US5185351A (en) | 1989-06-14 | 1993-02-09 | Smithkline Beecham Corporation | Imidazolyl-alkenoic acids useful as angiotensin II receptor antagonists |
| DE122007000050I1 (de) | 1990-02-19 | 2007-11-08 | Novartis Ag | Acylverbindungen |
| US5270317A (en) | 1990-03-20 | 1993-12-14 | Elf Sanofi | N-substituted heterocyclic derivatives, their preparation and the pharmaceutical compositions in which they are present |
| US5196444A (en) | 1990-04-27 | 1993-03-23 | Takeda Chemical Industries, Ltd. | 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof |
| US5440056A (en) | 1992-04-17 | 1995-08-08 | Abbott Laboratories | 9-deoxotaxane compounds |
| US6177401B1 (en) | 1992-11-13 | 2001-01-23 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften | Use of organic compounds for the inhibition of Flk-1 mediated vasculogenesis and angiogenesis |
| UA60365C2 (uk) * | 1998-06-04 | 2003-10-15 | Пфайзер Продактс Інк. | Похідні ізотіазолу, спосіб їх одержання, фармацевтична композиція та спосіб лікування гіперпроліферативного захворювання у ссавця |
| AU2592600A (en) * | 1998-12-23 | 2000-07-31 | G.D. Searle & Co. | Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
| AU2001278322B2 (en) * | 2000-07-27 | 2005-12-22 | Smith & Nephew (Overseas) Limited | Treatment of hyperproliferative skin disorders and diseases |
| IL155371A0 (en) * | 2000-11-28 | 2003-11-23 | Pfizer Prod Inc | Salts of a isothiazole-4-carboxamide and their use as anti-hyperproliferation agents |
-
2003
- 2003-08-07 AU AU2003250483A patent/AU2003250483A1/en not_active Abandoned
- 2003-08-07 WO PCT/IB2003/003550 patent/WO2004017964A1/fr not_active Ceased
- 2003-08-07 CA CA002495962A patent/CA2495962A1/fr not_active Abandoned
- 2003-08-07 BR BR0313593-4A patent/BR0313593A/pt not_active IP Right Cessation
- 2003-08-07 ES ES03792573T patent/ES2362998T3/es not_active Expired - Lifetime
- 2003-08-07 GE GEAP8641A patent/GEP20074134B/en unknown
- 2003-08-07 AP AP2005003232A patent/AP2005003232A0/xx unknown
- 2003-08-07 MX MXPA05001958A patent/MXPA05001958A/es active IP Right Grant
- 2003-08-07 AT AT03792573T patent/ATE502635T1/de active
- 2003-08-07 KR KR1020057002757A patent/KR100668539B1/ko not_active Expired - Fee Related
- 2003-08-07 JP JP2004530452A patent/JP3835763B2/ja not_active Expired - Fee Related
- 2003-08-07 HR HR20050163A patent/HRP20050163A2/xx not_active Application Discontinuation
- 2003-08-07 EP EP03792573A patent/EP1545519B1/fr not_active Expired - Lifetime
- 2003-08-07 OA OA1200500044A patent/OA12905A/en unknown
- 2003-08-07 DE DE60336485T patent/DE60336485D1/de not_active Expired - Lifetime
- 2003-08-07 RS YUP-2005/0106A patent/RS20050106A/sr unknown
- 2003-08-07 EA EA200500234A patent/EA200500234A1/ru unknown
- 2003-08-07 CN CN038221616A patent/CN1681495B/zh not_active Expired - Fee Related
- 2003-08-07 PL PL03375713A patent/PL375713A1/xx not_active Application Discontinuation
- 2003-08-12 PA PA20038580201A patent/PA8580201A1/es unknown
- 2003-08-15 PE PE2003000830A patent/PE20040993A1/es not_active Application Discontinuation
- 2003-08-15 AR ARP030102971A patent/AR040995A1/es not_active Application Discontinuation
- 2003-08-18 TW TW092122639A patent/TW200403057A/zh unknown
- 2003-08-19 GT GT200300177A patent/GT200300177A/es unknown
- 2003-08-19 US US10/643,546 patent/US20070197517A1/en not_active Abandoned
-
2005
- 2005-01-27 IS IS7670A patent/IS7670A/is unknown
- 2005-01-27 IL IL16654505A patent/IL166545A0/xx unknown
- 2005-02-03 NO NO20050621A patent/NO20050621L/no not_active Application Discontinuation
- 2005-02-15 CR CR7693A patent/CR7693A/es not_active Application Discontinuation
- 2005-02-18 TN TNP2005000051A patent/TNSN05051A1/fr unknown
- 2005-02-18 MA MA28110A patent/MA27385A1/fr unknown
- 2005-02-18 EC EC2005005618A patent/ECSP055618A/es unknown
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