MA27944A1 - N-[3-(3-substituees-pyrazolo [1,5-a] pyrimidin-7-yl) - phenyl] - sulfonamides et compositions et methodes rapportees. - Google Patents

N-[3-(3-substituees-pyrazolo [1,5-a] pyrimidin-7-yl) - phenyl] - sulfonamides et compositions et methodes rapportees.

Info

Publication number
MA27944A1
MA27944A1 MA28797A MA28797A MA27944A1 MA 27944 A1 MA27944 A1 MA 27944A1 MA 28797 A MA28797 A MA 28797A MA 28797 A MA28797 A MA 28797A MA 27944 A1 MA27944 A1 MA 27944A1
Authority
MA
Morocco
Prior art keywords
pyrazolo
sulfonamides
pyrimidin
phenyl
substituted
Prior art date
Application number
MA28797A
Other languages
English (en)
Inventor
Luis Anglada
Albert Palomer
Marta Princep
Antonio Guglietta
Original Assignee
Ferrer Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferrer Int filed Critical Ferrer Int
Publication of MA27944A1 publication Critical patent/MA27944A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A61P25/10—Antiepileptics; Anticonvulsants for petit-mal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A61P25/12—Antiepileptics; Anticonvulsants for grand-mal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Composés de formule (I) dans laquelle R1, R2 et R3 sont tels que définis dans les revendications. Lesdits composés possèdent une affinité spécifique pour le récepteur GABAA et sont par conséquent utiles pour traiter et prévenir des maladies modulées par les récepteurs GABAA (alpha)1 et (alpha)2.
MA28797A 2003-07-24 2006-02-13 N-[3-(3-substituees-pyrazolo [1,5-a] pyrimidin-7-yl) - phenyl] - sulfonamides et compositions et methodes rapportees. MA27944A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES200301746A ES2222813B1 (es) 2003-07-24 2003-07-24 N-(3-(3-sustituidas-pirazolo(1,5-a)pirimidin-7-il)-fenil)-sulfonamidas y composiciones y metodos relacionados.
ES200401697A ES2245894B1 (es) 2003-07-24 2004-07-12 Mejoras en el objeto de la patente de invencion n.p200301746 que se refiere a "n-(3-(3-sustituidas-pirazolo(1,5-a)pirimidin-7-il)-fenil)-sulfonamidas y composiciones y metodos relacionados".

Publications (1)

Publication Number Publication Date
MA27944A1 true MA27944A1 (fr) 2006-06-01

Family

ID=34137682

Family Applications (1)

Application Number Title Priority Date Filing Date
MA28797A MA27944A1 (fr) 2003-07-24 2006-02-13 N-[3-(3-substituees-pyrazolo [1,5-a] pyrimidin-7-yl) - phenyl] - sulfonamides et compositions et methodes rapportees.

Country Status (29)

Country Link
US (1) US7947688B2 (fr)
EP (1) EP1648897B1 (fr)
JP (1) JP2006528608A (fr)
KR (1) KR100840450B1 (fr)
CN (1) CN100393721C (fr)
AR (1) AR047017A1 (fr)
AT (1) ATE417048T1 (fr)
AU (1) AU2004263278B2 (fr)
BR (1) BRPI0412826A (fr)
CA (1) CA2532437C (fr)
CL (1) CL2004001814A1 (fr)
DE (1) DE602004018320D1 (fr)
DK (1) DK1648897T3 (fr)
EA (1) EA009519B1 (fr)
ES (2) ES2222813B1 (fr)
HR (1) HRP20060009A2 (fr)
IL (1) IL173252A0 (fr)
MA (1) MA27944A1 (fr)
MX (1) MXPA06000754A (fr)
NO (1) NO20060580L (fr)
NZ (1) NZ544349A (fr)
PA (1) PA8607501A1 (fr)
PE (1) PE20050254A1 (fr)
PL (1) PL1648897T3 (fr)
PT (1) PT1648897E (fr)
TW (1) TWI340140B (fr)
UA (1) UA81959C2 (fr)
UY (1) UY28440A1 (fr)
WO (1) WO2005014597A1 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006084835A1 (fr) * 2005-02-10 2006-08-17 Ferrer Internacional, S. A. N-(3-(imidazo[1,5-a]pyrimidin-4-yl)phenyl]sulfonamides et n-[3-(imidazo[1,5-a]pyrimidin-4-yl)phenyl]carboxamides et leur utilisation en tant que modulateurs des recepteurs gabaa
EP1736475A1 (fr) * 2005-06-21 2006-12-27 Ferrer Internacional, S.A. Pyrazolo[1,5-a]pyrimidines halogenées, processus, utilisations, compositions et produits intermédiaires
JP2009530296A (ja) * 2006-03-17 2009-08-27 ワイス ピラゾロ［１，５−ａ］ピリミジン誘導体およびその使用方法
EP1845098A1 (fr) * 2006-03-29 2007-10-17 Ferrer Internacional, S.A. Imidazo[1,2-b]pyridazines, leur procédés de préparation et leur utilisation comme ligands du recepteur GABA
EP1884516A1 (fr) * 2006-08-04 2008-02-06 Ferrer Internacional, S.A. Pyrazolo[1,5-a]pyrimidines, compositions pharmaceutiques les contenant et leur utilisation
EP1956021A1 (fr) 2006-10-11 2008-08-13 Ferrer Internacional, S.A. Procédé de préparation d'un pyrazole[1,5-a]pyrimidine en forme crystalline
EP1921079A1 (fr) 2006-11-08 2008-05-14 Ferrer Internacional, S.A. Forme amorphe de N-{2-Fluoro-5-[3-(thiophen-2-carbonyl)-pyrazolo[1,5-a] pyrimidin-7-yl]-phenyl}-N-methyl-acetamide
CA2747392C (fr) * 2009-01-13 2016-10-18 Interquim, S.A. Procede de preparation de n-[5-(3-dimethylamino-acryloyl)-2-fluoro-phenyl]-n-methyl-acetamide
WO2013039985A2 (fr) * 2011-09-12 2013-03-21 The Johns Hopkins University Inhibiteurs de sérine protéase
CN102807569B (zh) * 2012-08-21 2015-02-25 四川大学 一种镇静催眠的化合物及其制备方法和用途
KR102148681B1 (ko) * 2013-02-21 2020-08-27 칼리토르 사이언시즈, 엘엘씨 Pi3 키나제 모듈레이터로서의 헤테로방향족 화합물

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE792533A (fr) * 1971-12-09 1973-06-08 Int Chem & Nuclear Corp Nouvelles pyrazolo (1,5a) pyrimidines et leur procede de preparation
US4626538A (en) 1983-06-23 1986-12-02 American Cyanamid Company [7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidines
NZ208554A (en) * 1983-06-23 1987-06-30 American Cyanamid Co (aryl and heteroaryl)-(7-(aryl and heteroaryl)-pyrazolo (1,5-a) pyrimidin-3-yl)-methanone derivatives and pharmaceutical compositions
US4654347A (en) * 1983-06-23 1987-03-31 American Cyanamid Company Aryl and heteroaryl[[7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]methanones
DE3689294T2 (de) * 1985-05-13 1994-06-09 American Cyanamid Co [7-(3-Disubstituierte Amino)phenyl]pyrazolo[1,5-a]-pyrimidine.
EP0264773A1 (fr) * 1986-10-16 1988-04-27 American Cyanamid Company 4,5-Dihydro- et 4,5,6,7-tétrahydropyrazolo[1,5-a]pyrimidines
DE4333705C2 (de) * 1993-10-02 2003-10-30 Guenter Ege Arylmethylsubstituierte Pyrazolo-azine, insbesondere 3-Arylmethylpyrazolo[1,5-a]pyrimidine und Verfahren zur Herstellung von 8-Arylmethyl-pyrazolo[5,1-c][1,2,4]triazinen
US5538977A (en) * 1995-03-17 1996-07-23 American Cyanamid Company 3-Substituted-7-[3-(imidazol-1-yl)phenyl]-pyrazolo[1,5-a]pyrimidines
JP2002541151A (ja) * 1999-04-02 2002-12-03 ニューロゲン コーポレイション アリールおよびヘテロアリール縮合アミノアルキル−イミダゾール誘導体：ＧＡＢＡａ受容体の選択的修飾物質
US6399621B1 (en) 1999-08-10 2002-06-04 American Cyanamid Company N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1, 5-α]-pyrimidin-7-yl}phenyl)acetamide and compositions and methods related thereto

Also Published As

Publication number Publication date
JP2006528608A (ja) 2006-12-21
ES2245894A1 (es) 2006-01-16
IL173252A0 (en) 2006-06-11
EA009519B1 (ru) 2008-02-28
TW200510422A (en) 2005-03-16
PE20050254A1 (es) 2005-04-11
US20060270690A1 (en) 2006-11-30
HRP20060009A2 (en) 2006-08-31
ES2222813B1 (es) 2005-12-16
PL1648897T3 (pl) 2009-07-31
KR100840450B1 (ko) 2008-06-20
US7947688B2 (en) 2011-05-24
ES2222813A1 (es) 2005-02-01
CA2532437C (fr) 2010-01-26
NZ544349A (en) 2009-05-31
PT1648897E (pt) 2009-03-17
EP1648897B1 (fr) 2008-12-10
CN100393721C (zh) 2008-06-11
DE602004018320D1 (de) 2009-01-22
AU2004263278B2 (en) 2009-03-12
CN1829719A (zh) 2006-09-06
ATE417048T1 (de) 2008-12-15
UA81959C2 (en) 2008-02-25
EA200600316A1 (ru) 2006-06-30
BRPI0412826A (pt) 2006-09-26
HK1083844A1 (en) 2006-07-14
MXPA06000754A (es) 2006-03-30
TWI340140B (en) 2011-04-11
WO2005014597A1 (fr) 2005-02-17
CL2004001814A1 (es) 2005-06-03
AR047017A1 (es) 2006-01-04
DK1648897T3 (da) 2009-04-06
NO20060580L (no) 2006-02-03
EP1648897A1 (fr) 2006-04-26
PA8607501A1 (es) 2005-09-28
CA2532437A1 (fr) 2005-02-17
AU2004263278A1 (en) 2005-02-17
KR20060030908A (ko) 2006-04-11
ES2245894B1 (es) 2006-12-01
UY28440A1 (es) 2004-11-08

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