MA30023B1 - Nouvelle composition - Google Patents
Nouvelle compositionInfo
- Publication number
- MA30023B1 MA30023B1 MA30995A MA30995A MA30023B1 MA 30023 B1 MA30023 B1 MA 30023B1 MA 30995 A MA30995 A MA 30995A MA 30995 A MA30995 A MA 30995A MA 30023 B1 MA30023 B1 MA 30023B1
- Authority
- MA
- Morocco
- Prior art keywords
- lipopolysaccharide
- present
- saponin
- human dose
- adjuvant
- Prior art date
Links
- 239000002671 adjuvant Substances 0.000 abstract 3
- 239000002158 endotoxin Substances 0.000 abstract 3
- 229920006008 lipopolysaccharide Polymers 0.000 abstract 3
- 239000001397 quillaja saponaria molina bark Substances 0.000 abstract 3
- 229930182490 saponin Natural products 0.000 abstract 3
- 150000007949 saponins Chemical class 0.000 abstract 3
- 239000002502 liposome Substances 0.000 abstract 2
- 241001092142 Molina Species 0.000 abstract 1
- 241001454523 Quillaja saponaria Species 0.000 abstract 1
- 235000009001 Quillaja saponaria Nutrition 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 230000000890 antigenic effect Effects 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/002—Protozoa antigens
- A61K39/015—Hemosporidia antigens, e.g. Plasmodium antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/104—Pseudomonadales, e.g. Pseudomonas
- A61K39/1045—Moraxella
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6068—Other bacterial proteins, e.g. OMP
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10111—Atadenovirus, e.g. ovine adenovirus D
- C12N2710/10134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16111—Cytomegalovirus, e.g. human herpesvirus 5
- C12N2710/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16111—Cytomegalovirus, e.g. human herpesvirus 5
- C12N2710/16171—Demonstrated in vivo effect
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
- C12N2710/16734—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
- C12N2710/16771—Demonstrated in vivo effect
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20071—Demonstrated in vivo effect
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16171—Demonstrated in vivo effect
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16211—Influenzavirus B, i.e. influenza B virus
- C12N2760/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16211—Influenzavirus B, i.e. influenza B virus
- C12N2760/16271—Demonstrated in vivo effect
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/20011—Rhabdoviridae
- C12N2760/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Biotechnology (AREA)
- AIDS & HIV (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
La présente invention concerne une dose humaine d'une composition immunogène comprenant un antigène ou une préparation antigénique, en association avec un adjuvant, lequel adjuvant comprend une fraction immunologiquement active de saponine dérivée de l'écorce de Quillaja saponaria Molina présentée sous la forme d'un liposome et un lipopolysaccharide, ladite fraction de saponine et ledit lipopolysaccharide étant tous deux présents dans ladite dose humaine à un niveau inférieur à 30 µg. La présente invention concerne en plus une composition d'adjuvant dans un volume convenant pour une dose humaine comprenant entre 1 et 30 µg d'un lipopolysaccharide et entre 1 et 30 µg d'une fraction immunologiquement active de saponine présentée sous la forme d'un liposome.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0525321.6A GB0525321D0 (en) | 2005-12-13 | 2005-12-13 | Novel compositions |
| GB0609902A GB0609902D0 (en) | 2006-05-18 | 2006-05-18 | Novel composition |
| GB0620337A GB0620337D0 (en) | 2006-10-12 | 2006-10-12 | Vaccine |
| GBGB0620336.8A GB0620336D0 (en) | 2006-10-12 | 2006-10-12 | Vaccine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA30023B1 true MA30023B1 (fr) | 2008-12-01 |
Family
ID=37876836
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA30995A MA30023B1 (fr) | 2005-12-13 | 2008-06-03 | Nouvelle composition |
Country Status (28)
| Country | Link |
|---|---|
| US (3) | US20080279926A1 (fr) |
| EP (6) | EP2364721B1 (fr) |
| JP (2) | JP5461015B2 (fr) |
| KR (1) | KR101363879B1 (fr) |
| CN (3) | CN102631670A (fr) |
| AR (1) | AR058543A1 (fr) |
| AT (1) | ATE542543T1 (fr) |
| AU (1) | AU2006325377B2 (fr) |
| BR (1) | BRPI0619795B8 (fr) |
| CA (1) | CA2633008C (fr) |
| CR (2) | CR10101A (fr) |
| CY (3) | CY1112589T1 (fr) |
| DK (3) | DK1959992T3 (fr) |
| EA (2) | EA014353B1 (fr) |
| ES (6) | ES2436645T3 (fr) |
| HR (3) | HRP20120136T1 (fr) |
| IL (2) | IL191703A (fr) |
| MA (1) | MA30023B1 (fr) |
| MY (1) | MY145943A (fr) |
| NO (1) | NO20082472L (fr) |
| NZ (2) | NZ568825A (fr) |
| PE (1) | PE20071098A1 (fr) |
| PL (3) | PL2364724T3 (fr) |
| PT (3) | PT1959992E (fr) |
| SG (2) | SG10201405533TA (fr) |
| SI (3) | SI2364720T1 (fr) |
| TW (1) | TWI457133B (fr) |
| WO (1) | WO2007068907A2 (fr) |
Families Citing this family (102)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101515078B1 (ko) | 2005-12-22 | 2015-04-24 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 백신 |
| WO2007144772A2 (fr) * | 2006-06-15 | 2007-12-21 | Novartis Ag | Régime de vaccination multidose à adjuvant limité contre la grippe |
| CA2690708A1 (fr) | 2007-06-26 | 2008-12-31 | Glaxosmithkline Biologicals S.A. | Vaccin |
| EP2034022A1 (fr) | 2007-09-10 | 2009-03-11 | Universite Libre De Bruxelles | Récepteur de la lipocaline soluble liant le leukotriène B4 issu de Ixodes ricinus |
| EP2045263A1 (fr) | 2007-10-02 | 2009-04-08 | Universite Libre De Bruxelles | Identification et caractérisation moléculaire de métalloprotéases salivaires exprimées dans les glandes salivaires de la tique |
| JP5711972B2 (ja) * | 2007-12-24 | 2015-05-07 | アイディー バイオメディカル コーポレイション オブ ケベック | 組換えrsv抗原 |
| PE20110992A1 (es) | 2009-02-17 | 2012-02-12 | Glaxosmithkline Biolog Sa | Composicion inmunogenica que comprende un antigeno del virus del dengue |
| GB0910046D0 (en) * | 2009-06-10 | 2009-07-22 | Glaxosmithkline Biolog Sa | Novel compositions |
| CN104288763B (zh) * | 2009-06-19 | 2018-03-06 | 艾金株式会社 | 宫颈癌疫苗 |
| HUE028085T2 (en) | 2009-06-24 | 2016-11-28 | Glaxosmithkline Biologicals Sa | Recombinant RSV antigens |
| EP2445527A2 (fr) | 2009-06-24 | 2012-05-02 | ID Biomedical Corporation of Quebec | Vaccin |
| CA2768186A1 (fr) | 2009-07-15 | 2011-01-20 | Novartis Ag | Compositions a base de proteine f du vrs et procedes de fabrication associes |
| AU2010335970B2 (en) * | 2009-12-22 | 2016-11-03 | Sanofi Pasteur Limited | Immunogenic compositions |
| CN101791401B (zh) * | 2009-12-31 | 2012-04-18 | 中国水产科学研究院黄海水产研究所 | 鱼用浸泡疫苗多组合佐剂及其应用和使用方法 |
| BR112012018669A2 (pt) | 2010-01-27 | 2017-09-05 | Glaxosmithkline Biologicals Sa | Proteína rv3616c modificada, uso de uma proteína rv3616c modificada, polinucleotídeo, uso de um polinucleotídeo, composição farmacêutica, composição imunogênica, proteína de fusão, e, polipeptídeo. |
| GB201101331D0 (en) * | 2011-01-26 | 2011-03-09 | Glaxosmithkline Biolog Sa | Compositions and uses |
| JP2017071615A (ja) * | 2010-10-27 | 2017-04-13 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 神経障害を治療するための免疫原性組成物及び方法 |
| CA2835644C (fr) | 2011-05-13 | 2021-06-15 | Novartis Ag | Antigenes de pre-fusion f du vrs |
| CN103533953A (zh) | 2011-05-17 | 2014-01-22 | 葛兰素史密丝克莱恩生物有限公司 | 针对肺炎链球菌的疫苗 |
| GB201116248D0 (en) * | 2011-09-20 | 2011-11-02 | Glaxosmithkline Biolog Sa | Liposome production using isopropanol |
| CN113876945A (zh) * | 2011-10-06 | 2022-01-04 | 免疫疫苗技术有限公司 | 包括激活或增加tlr2活性的佐剂的脂质体组合物及其应用 |
| GB201213364D0 (en) | 2012-07-27 | 2012-09-12 | Glaxosmithkline Biolog Sa | Purification process |
| DK2885007T3 (en) * | 2012-08-16 | 2018-12-03 | Pfizer | Methods for glycoconjugation and compositions |
| WO2014086787A1 (fr) * | 2012-12-05 | 2014-06-12 | Glaxosmithkline Biologicals S.A. | Composition immunogène |
| MX2016001695A (es) * | 2013-08-05 | 2016-05-02 | Glaxosmithkline Biolog Sa | Composiciones inmunogenas de combinacion. |
| RU2016109150A (ru) * | 2013-10-03 | 2017-11-10 | Нитто Денко Корпорейшн | Мукозальная вакцинная композиция |
| CN105530958A (zh) | 2013-10-03 | 2016-04-27 | 日东电工株式会社 | 粘膜疫苗组合物 |
| US10071155B2 (en) | 2013-10-03 | 2018-09-11 | Nitto Denko Corporation | Nasal mucosal vaccine composition |
| WO2015050181A1 (fr) * | 2013-10-03 | 2015-04-09 | 日東電工株式会社 | Composition de vaccin injectable |
| GB201318862D0 (en) * | 2013-10-25 | 2013-12-11 | Glaxosmithkline Biolog Sa | Calcium fluoride compositions |
| AU2015236106A1 (en) * | 2014-03-25 | 2016-10-20 | The Government Of The United States Of America As Represented By The Secretary Of The Army | Non-toxic adjuvant formulation comprising a monophosphoryl lipid a (MPLA)-containing liposome composition and a saponin |
| GB201405921D0 (en) * | 2014-04-02 | 2014-05-14 | Glaxosmithkline Biolog Sa | Novel methods for inducing an immune response |
| US9107906B1 (en) | 2014-10-28 | 2015-08-18 | Adma Biologics, Inc. | Compositions and methods for the treatment of immunodeficiency |
| EP3233118A1 (fr) * | 2014-12-18 | 2017-10-25 | GlaxoSmithKline Biologicals S.A. | Vaccination |
| EP3242883A4 (fr) | 2015-01-06 | 2018-10-17 | ImmunoVaccine Technologies Inc. | Mimétiques de lipide a, procédés de préparation, et leurs utilisations |
| KR20200038339A (ko) * | 2015-09-10 | 2020-04-10 | 인벤트프라이즈 엘엘씨 | 다가 vlp 접합체 |
| GB201518684D0 (en) | 2015-10-21 | 2015-12-02 | Glaxosmithkline Biolog Sa | Vaccine |
| CN108778289B (zh) | 2015-11-06 | 2020-11-17 | 佐剂技术公司 | 三萜皂苷类似物 |
| GB201522068D0 (en) * | 2015-12-15 | 2016-01-27 | Glaxosmithkline Biolog Sa | Dried composition |
| BE1024160B9 (fr) | 2015-12-22 | 2017-12-06 | Glaxosmithkline Biologicals Sa | Formulation immunogène |
| CN105770887A (zh) * | 2016-03-04 | 2016-07-20 | 邓招红 | 一种用于hbv疫苗的佐剂及其制备方法 |
| US10611800B2 (en) | 2016-03-11 | 2020-04-07 | Pfizer Inc. | Human cytomegalovirus gB polypeptide |
| US10695424B2 (en) | 2016-12-07 | 2020-06-30 | Glaxosmithkline Biologicals S.A. | Method of making a liposome composition |
| CN110225757A (zh) | 2017-01-31 | 2019-09-10 | 默沙东公司 | 由肺炎链球菌血清型19f生产荚膜多糖蛋白缀合物的方法 |
| US10259865B2 (en) | 2017-03-15 | 2019-04-16 | Adma Biologics, Inc. | Anti-pneumococcal hyperimmune globulin for the treatment and prevention of pneumococcal infection |
| CA3061205A1 (fr) | 2017-04-25 | 2018-11-01 | Memorial Sloan Kettering Cancer Center | Analogues de saponine triterpenique |
| EP3615005B1 (fr) | 2017-04-28 | 2025-07-30 | The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. | Compositions et méthodes d'administration de vaccins |
| BR112019025104A2 (pt) | 2017-05-30 | 2020-06-23 | Glaxosmithkline Biologicals S.A. | Método de fabricar um sistema de entrega não viral, sistema de entrega não viral, e, composição |
| MX2020002558A (es) | 2017-09-07 | 2020-07-13 | Merck Sharp & Dohme | Procesos para la formulacion de polisacaridos neumococicos para la conjugacion a una proteina transportadora. |
| WO2019051149A1 (fr) | 2017-09-08 | 2019-03-14 | Infectious Disease Research Institute | Formulations liposomales comprenant de la saponine et procédés d'utilisation |
| SG11202001826YA (en) | 2017-10-16 | 2020-03-30 | Adjuvance Technologies Inc | Triterpene saponin analogues |
| ES2991988T3 (es) | 2017-10-30 | 2024-12-05 | Takeda Pharmaceuticals Co | Detergentes compatibles con el medio ambiente para la inactivación de virus con envoltura lipídica |
| WO2019106191A1 (fr) | 2017-12-01 | 2019-06-06 | Glaxosmithkline Biologicals Sa | Extraction de saponine |
| BR112020010790A2 (pt) | 2017-12-01 | 2020-11-10 | Glaxosmithkline Biologicals S.A. | purificação da saponina |
| WO2019175147A1 (fr) | 2018-03-12 | 2019-09-19 | Janssen Vaccines & Prevention B.V. | Vaccins contre des infections intra-abdominales |
| TWI820099B (zh) | 2018-03-28 | 2023-11-01 | 台灣浩鼎生技股份有限公司 | 新穎皂素佐劑及其評估方法 |
| US11389519B2 (en) * | 2018-06-11 | 2022-07-19 | Inventprise, Llc | Virus-like particle conjugates |
| CN112969474A (zh) | 2018-09-12 | 2021-06-15 | 艾芬尼维克斯公司 | 多价肺炎球菌疫苗 |
| WO2020055503A1 (fr) | 2018-09-14 | 2020-03-19 | Massachusetts Institute Of Technology | Adjuvant vaccinal à base de nanoparticules, et méthodes d'utilisation associées |
| EP3886901A1 (fr) | 2018-11-29 | 2021-10-06 | GlaxoSmithKline Biologicals S.A. | Procédés de fabrication d'un adjuvant |
| US11629172B2 (en) | 2018-12-21 | 2023-04-18 | Pfizer Inc. | Human cytomegalovirus gB polypeptide |
| WO2020154595A1 (fr) | 2019-01-24 | 2020-07-30 | Massachusetts Institute Of Technology | Plateforme de nanostructure d'acide nucléique pour présentation d'antigène et formulations de vaccin formées grâce à son utilisation |
| IL286467B2 (en) | 2019-03-18 | 2026-02-01 | Janssen Pharmaceuticals Inc | Methods for producing bioconjugates of polysaccharides E. coli o-antigen, preparations thereof and methods for using them |
| CA3134216A1 (fr) | 2019-03-18 | 2020-09-24 | Janssen Pharmaceuticals, Inc. | Bioconjugues d'antigenes polysaccharidiques o d'e. coli, procedes de production de ces derniers, et methodes d'utilisation de ces derniers |
| WO2020245207A1 (fr) | 2019-06-05 | 2020-12-10 | Glaxosmithkline Biologicals Sa | Purification de saponine |
| US20220273789A1 (en) | 2019-07-21 | 2022-09-01 | Glaxosmithkline Biologicals Sa | Therapeutic viral vaccine |
| EP3777884A1 (fr) | 2019-08-15 | 2021-02-17 | GlaxoSmithKline Biologicals S.A. | Composition immunogène |
| EP4021407A1 (fr) | 2019-08-30 | 2022-07-06 | GlaxoSmithKline Biologicals S.A. | Procédé de fabrication de nanoparticules lipidiques mélangées par jet |
| JP2022550884A (ja) | 2019-10-02 | 2022-12-05 | ヤンセン ファッシンズ アンド プリベンション ベーフェー | スタフィロコッカス(Staphylococcus)ペプチドおよび使用方法 |
| CN112972671B (zh) | 2019-12-13 | 2024-04-19 | 远大赛威信生命科学(南京)有限公司 | 药物组合物及其用途 |
| WO2021122551A1 (fr) | 2019-12-19 | 2021-06-24 | Glaxosmithkline Biologicals Sa | Antigènes de s. aureus et compositions associées |
| EP4461744A3 (fr) | 2020-01-16 | 2025-01-08 | Janssen Pharmaceuticals, Inc. | Mutant fimh, compositions le contenant et leur utilisation |
| JP2023516904A (ja) * | 2020-02-14 | 2023-04-21 | メルク・シャープ・アンド・ドーム・エルエルシー | Hpvワクチン |
| BR112022017852A2 (pt) | 2020-03-09 | 2022-11-01 | Dynavax Tech Corp | Vacinas para herpes zoster compreendendo um agonista de tlr9 |
| WO2021195024A1 (fr) * | 2020-03-23 | 2021-09-30 | Adjuvance Technologies, Inc. | Composés adjuvants, formes salines et formulations |
| EP4146378A1 (fr) * | 2020-05-05 | 2023-03-15 | GlaxoSmithKline Biologicals S.A. | Dispositif de mélange microfluidique et procédés d'utilisation |
| WO2021245611A1 (fr) | 2020-06-05 | 2021-12-09 | Glaxosmithkline Biologicals Sa | Protéines modifiées de spicule de coronavirus bêta |
| TWI810589B (zh) | 2020-06-21 | 2023-08-01 | 美商輝瑞股份有限公司 | 人巨細胞病毒糖蛋白B(gB)多肽 |
| WO2022056195A1 (fr) * | 2020-09-10 | 2022-03-17 | The Rochester General Hospital | Vaccin contre haemophilus inenzae et méthodes d'utilisation |
| AU2021342797B2 (en) | 2020-09-17 | 2024-02-08 | Janssen Pharmaceuticals, Inc. | Multivalent vaccine compositions and uses thereof |
| AU2021367917A1 (en) * | 2020-10-28 | 2023-06-22 | Sanofi Pasteur | Liposomes containing tlr4 agonist, preparation and uses thereof |
| GB2600468A (en) | 2020-10-30 | 2022-05-04 | Excivion Ltd | Adjuvant composition |
| KR20250007029A (ko) | 2021-01-12 | 2025-01-13 | 얀센 파마슈티칼즈, 인코포레이티드 | FimH 돌연변이체, 이를 포함하는 조성물 및 이의 용도 |
| EP4032547A1 (fr) | 2021-01-20 | 2022-07-27 | GlaxoSmithKline Biologicals S.A. | Fragments dérivés du hsv 1 fce pour le traitement du hsv |
| IL307247A (en) | 2021-04-01 | 2023-11-01 | Janssen Pharmaceuticals Inc | Production of E. Coli O18 bioconjugates |
| WO2023020994A1 (fr) * | 2021-08-16 | 2023-02-23 | Glaxosmithkline Biologicals Sa | Nouveaux procédés |
| JP2024532127A (ja) * | 2021-08-19 | 2024-09-05 | メルク・シャープ・アンド・ドーム・エルエルシー | 熱安定性脂質ナノ粒子およびその使用方法 |
| CN116199727B (zh) * | 2021-12-01 | 2025-04-08 | 上海安奕康生物科技有限公司 | 一种mpl三乙胺盐、其制备工艺及应用 |
| WO2023114570A1 (fr) | 2021-12-19 | 2023-06-22 | Massachusetts Institute Of Technology | Compositions et méthodes pour obtenir des réponses durables des centres germinatifs à une sensibilisation active |
| US20250161429A1 (en) | 2022-02-14 | 2025-05-22 | University Of Georgia Research Foundation, Inc. | Pan-pneumovirus vaccine compositions and methods of use thereof |
| JP2025509460A (ja) | 2022-03-14 | 2025-04-11 | ファイザー・インク | アジュバントを生産するための方法 |
| CN114767844B (zh) * | 2022-04-28 | 2025-12-23 | 泰州拜奥生物技术有限公司 | 一种水痘-带状疱疹病毒疫苗及其应用 |
| CN116162173B (zh) * | 2022-10-28 | 2024-06-04 | 安徽农业大学 | 一种GnRH6-CRM197重组蛋白去势疫苗及制备方法 |
| AU2023403045A1 (en) | 2022-12-01 | 2025-06-12 | Pfizer Inc. | Pneumococcal conjugate vaccine formulations |
| CN120813371A (zh) | 2023-03-02 | 2025-10-17 | 赛诺菲巴斯德有限公司 | 用于在衣原体病的治疗中使用的组合物 |
| US12502424B2 (en) | 2023-05-05 | 2025-12-23 | Sanofi Pasteur Inc. | Compositions for use in treatment of acne |
| WO2025015042A1 (fr) | 2023-07-10 | 2025-01-16 | Dynavax Technologies Corporation | Vaccins contre la maladie de lyme contenant un adjuvant et un antigène de protéine a de surface externe de borrélia |
| WO2025015077A1 (fr) | 2023-07-10 | 2025-01-16 | Dynavax Technologies Corporation | Vaccins contre la maladie de lyme contenant un adjuvant et des antigènes des protéines de surface externe a et c de borrelia |
| TWI909678B (zh) | 2023-09-13 | 2025-12-21 | 美商輝瑞股份有限公司 | 產製佐劑之方法 |
| TW202527906A (zh) * | 2023-09-14 | 2025-07-16 | 美商輝瑞股份有限公司 | 包含經結合之肺炎鏈球菌莢膜醣抗原之佐劑化致免疫性組成物及其用途 |
| WO2025163460A2 (fr) | 2024-01-30 | 2025-08-07 | Pfizer Inc. | Vaccins contre des maladies respiratoires |
| WO2025191415A1 (fr) | 2024-03-11 | 2025-09-18 | Pfizer Inc. | Compositions immunogènes comprenant des saccharides conjugués d'escherichia coli et leurs utilisations |
Family Cites Families (191)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US666843A (en) * | 1900-07-02 | 1901-01-29 | Eastman Kodak Co | Spirit-level. |
| US3238190A (en) | 1963-10-23 | 1966-03-01 | Madaus & Co K G Fa Dr | Aescin recovery |
| DE2921961C2 (de) | 1979-05-30 | 1986-02-06 | Santrade Ltd., Luzern/Lucerne | Bohreinheit |
| US4372945A (en) | 1979-11-13 | 1983-02-08 | Likhite Vilas V | Antigen compounds |
| US4270537A (en) | 1979-11-19 | 1981-06-02 | Romaine Richard A | Automatic hypodermic syringe |
| DD155875A1 (de) | 1980-12-31 | 1982-07-14 | Willy Nordheim | Verfahren zur herstellung eines ballaststoffarmen inaktivierten influenzaimpfstoffes |
| IL61904A (en) | 1981-01-13 | 1985-07-31 | Yeda Res & Dev | Synthetic vaccine against influenza virus infections comprising a synthetic peptide and process for producing same |
| US4436727A (en) | 1982-05-26 | 1984-03-13 | Ribi Immunochem Research, Inc. | Refined detoxified endotoxin product |
| US4866034A (en) | 1982-05-26 | 1989-09-12 | Ribi Immunochem Research Inc. | Refined detoxified endotoxin |
| DD211444A3 (de) | 1982-08-19 | 1984-07-11 | Saechsisches Serumwerk | Verfahren zur herstellung von influenza-impfstoffen |
| US4596556A (en) | 1985-03-25 | 1986-06-24 | Bioject, Inc. | Hypodermic injection apparatus |
| FI861417A0 (fi) | 1985-04-15 | 1986-04-01 | Endotronics Inc | Hepatitis b ytantigen framstaelld med rekombinant-dna-teknik, vaccin, diagnostiskt medel och cellinjer samt foerfaranden foer framstaellning daerav. |
| DD300833A7 (de) | 1985-10-28 | 1992-08-13 | Saechsische Landesgewerbefoerd | Verfahren zur herstellung von inaktivierten influenza-vollvirusimpfstoffen |
| US4877611A (en) | 1986-04-15 | 1989-10-31 | Ribi Immunochem Research Inc. | Vaccine containing tumor antigens and adjuvants |
| US5173294A (en) | 1986-11-18 | 1992-12-22 | Research Foundation Of State University Of New York | Dna probe for the identification of haemophilus influenzae |
| CA1283827C (fr) | 1986-12-18 | 1991-05-07 | Giorgio Cirelli | Dispositif pour l'injection de formules liquides |
| US6054438A (en) | 1987-01-07 | 2000-04-25 | Imperial Cancer Research Technology Limited | Nucleic acid fragments encoding portions of the core protein of the human mammary epithelial mucin |
| CA1339204C (fr) | 1987-01-07 | 1997-08-05 | Joyce Taylor-Papadimitriou | Polypeptides, anticorps et sondes a noyau de mucine |
| GB8704027D0 (en) | 1987-02-20 | 1987-03-25 | Owen Mumford Ltd | Syringe needle combination |
| US5057540A (en) | 1987-05-29 | 1991-10-15 | Cambridge Biotech Corporation | Saponin adjuvant |
| EP0362278A4 (fr) | 1987-06-05 | 1990-05-14 | Us Health | Facteurs de motilite de l'autocrine dans le diagnostic et le traitement du cancer. |
| US4941880A (en) | 1987-06-19 | 1990-07-17 | Bioject, Inc. | Pre-filled ampule and non-invasive hypodermic injection device assembly |
| US4790824A (en) | 1987-06-19 | 1988-12-13 | Bioject, Inc. | Non-invasive hypodermic injection device |
| US4940460A (en) | 1987-06-19 | 1990-07-10 | Bioject, Inc. | Patient-fillable and non-invasive hypodermic injection device assembly |
| EP1088830A3 (fr) | 1987-06-22 | 2004-04-07 | Medeva Holdings B.V. | Particules de l'antigène de surface de l'hépatitie B |
| DE3734306A1 (de) * | 1987-10-10 | 1989-04-27 | Pfeiffer Erich Gmbh & Co Kg | Austragvorrichtung fuer fliessfaehige medien |
| US4963484A (en) | 1988-01-29 | 1990-10-16 | Dana-Farber Cancer Institute, Inc. | Genetically engineered polypeptides with determinants of the human DF3 breast carcinoma-associated antigen |
| US5339163A (en) | 1988-03-16 | 1994-08-16 | Canon Kabushiki Kaisha | Automatic exposure control device using plural image plane detection areas |
| US4912094B1 (en) | 1988-06-29 | 1994-02-15 | Ribi Immunochem Research Inc. | Modified lipopolysaccharides and process of preparation |
| GB8819209D0 (en) | 1988-08-12 | 1988-09-14 | Research Corp Ltd | Polypeptide & dna encoding same |
| FR2638359A1 (fr) | 1988-11-03 | 1990-05-04 | Tino Dalto | Guide de seringue avec reglage de la profondeur de penetration de l'aiguille dans la peau |
| WO1990006951A1 (fr) | 1988-12-16 | 1990-06-28 | De Staat Der Nederlanden Vertegenwoordigd Door De Minister Van Welzijn, Volksgezondheid En Cultuur | Mutants de pneumolysine et vaccins contre le pneumocoque obtenus a partir de tels mutants |
| GB8913737D0 (en) | 1989-06-15 | 1989-08-02 | Univ Birmingham | A novel anti-allergy treatment |
| EP0414374B1 (fr) | 1989-07-25 | 1997-10-08 | Smithkline Biologicals S.A. | Antigènes ainsi que les méthodes pour leur préparation |
| US5312335A (en) | 1989-11-09 | 1994-05-17 | Bioject Inc. | Needleless hypodermic injection device |
| US5064413A (en) | 1989-11-09 | 1991-11-12 | Bioject, Inc. | Needleless hypodermic injection device |
| DE4005528C2 (de) * | 1990-02-22 | 1998-01-15 | Pfeiffer Erich Gmbh & Co Kg | Austragvorrichtung für Medien |
| US5256643A (en) | 1990-05-29 | 1993-10-26 | The Government Of The United States | Human cripto protein |
| SE466259B (sv) | 1990-05-31 | 1992-01-20 | Arne Forsgren | Protein d - ett igd-bindande protein fraan haemophilus influenzae, samt anvaendning av detta foer analys, vacciner och uppreningsaendamaal |
| US5190521A (en) | 1990-08-22 | 1993-03-02 | Tecnol Medical Products, Inc. | Apparatus and method for raising a skin wheal and anesthetizing skin |
| US5527288A (en) | 1990-12-13 | 1996-06-18 | Elan Medical Technologies Limited | Intradermal drug delivery device and method for intradermal delivery of drugs |
| CA2059693C (fr) | 1991-01-28 | 2003-08-19 | Peter J. Kniskern | Antigenes polysaccharides de streptococcus pneumoniae |
| CA2059692C (fr) | 1991-01-28 | 2004-11-16 | Peter J. Kniskern | Vaccin conjugue de polysaccharide contre les pneumocoques |
| US5476929A (en) | 1991-02-15 | 1995-12-19 | Uab Research Foundation | Structural gene of pneumococcal protein |
| US6592876B1 (en) | 1993-04-20 | 2003-07-15 | Uab Research Foundation | Pneumococcal genes, portions thereof, expression products therefrom, and uses of such genes, portions and products |
| FI933580A7 (fi) | 1991-02-15 | 1993-10-13 | Uab Research Foundation | Pneumokokkiproteiinin rakennegeeni |
| GB9113809D0 (en) | 1991-06-26 | 1991-08-14 | Cancer Res Campaign Tech | Papillomavirus l2 protein |
| ES2194839T3 (es) | 1991-07-19 | 2003-12-01 | Univ Queensland | Vacuna de papilomavirus. |
| US5552146A (en) | 1991-08-15 | 1996-09-03 | Board Of Regents, The University Of Texas System | Methods and compositions relating to useful antigens of Moraxella catarrhalis |
| GB9118204D0 (en) | 1991-08-23 | 1991-10-09 | Weston Terence E | Needle-less injector |
| SE9102652D0 (sv) | 1991-09-13 | 1991-09-13 | Kabi Pharmacia Ab | Injection needle arrangement |
| AU2927892A (en) | 1991-11-16 | 1993-06-15 | Smithkline Beecham Biologicals (Sa) | Hybrid protein between cs from plasmodium and hbsag |
| US5328483A (en) | 1992-02-27 | 1994-07-12 | Jacoby Richard M | Intradermal injection device with medication and needle guard |
| CA2138997C (fr) * | 1992-06-25 | 2003-06-03 | Jean-Paul Prieels | Composition vaccinale qui contient des adjuvants |
| EP1835029A1 (fr) | 1992-06-25 | 2007-09-19 | Georgetown University | Vaccins de papillomavirus |
| JPH06510799A (ja) | 1992-06-25 | 1994-12-01 | シティ・オブ・ホープ | サイトメガロウイルスのポリペプチドによる細胞溶解性t−リンパ球の誘導 |
| US5786148A (en) | 1996-11-05 | 1998-07-28 | Incyte Pharmaceuticals, Inc. | Polynucleotides encoding a novel prostate-specific kallikrein |
| US5383851A (en) | 1992-07-24 | 1995-01-24 | Bioject Inc. | Needleless hypodermic injection device |
| US5437951A (en) | 1992-09-03 | 1995-08-01 | The United States Of America As Represented By The Department Of Health And Human Services | Self-assembling recombinant papillomavirus capsid proteins |
| US5569189A (en) | 1992-09-28 | 1996-10-29 | Equidyne Systems, Inc. | hypodermic jet injector |
| US5334144A (en) | 1992-10-30 | 1994-08-02 | Becton, Dickinson And Company | Single use disposable needleless injector |
| GB9224584D0 (en) | 1992-11-23 | 1993-01-13 | Connaught Lab | Use of outer membrane protein d15 and its peptides as vaccine against haempohilus influenzae diseases |
| ATE492289T1 (de) | 1993-03-09 | 2011-01-15 | Univ Rochester | Herstellung von menschlichen papillomavirus hbv- 11 kapsidprotein l1 und virus-ähnliche partikeln |
| US5801005A (en) | 1993-03-17 | 1998-09-01 | University Of Washington | Immune reactivity to HER-2/neu protein for diagnosis of malignancies in which the HER-2/neu oncogene is associated |
| US5776468A (en) | 1993-03-23 | 1998-07-07 | Smithkline Beecham Biologicals (S.A.) | Vaccine compositions containing 3-0 deacylated monophosphoryl lipid A |
| JP3429313B2 (ja) | 1993-05-18 | 2003-07-22 | オハイオ・ステイト・リサーチ・ファウンデーション | 中耳炎ワクチン |
| US5744144A (en) | 1993-07-30 | 1998-04-28 | University Of Pittsburgh University Patent Committee Policy And Procedures | Synthetic multiple tandem repeat mucin and mucin-like peptides, and uses thereof |
| WO1995008348A1 (fr) | 1993-09-22 | 1995-03-30 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Procede permettant d'activer un glucide soluble a l'aide de nouveaux reactifs cyanylants pour produire des structures immunogenes |
| BE1007535A3 (nl) | 1993-09-24 | 1995-07-25 | Innovative Sputtering Tech | Gelaagde metaalstructuur. |
| GB9326253D0 (en) | 1993-12-23 | 1994-02-23 | Smithkline Beecham Biolog | Vaccines |
| US5688506A (en) | 1994-01-27 | 1997-11-18 | Aphton Corp. | Immunogens against gonadotropin releasing hormone |
| WO1995024176A1 (fr) | 1994-03-07 | 1995-09-14 | Bioject, Inc. | Dispositif de remplissage d'ampoule |
| US5466220A (en) | 1994-03-08 | 1995-11-14 | Bioject, Inc. | Drug vial mixing and transfer device |
| GB9409962D0 (en) | 1994-05-18 | 1994-07-06 | Smithkline Beecham Biolog | Novel compounds |
| US5565204A (en) | 1994-08-24 | 1996-10-15 | American Cyanamid Company | Pneumococcal polysaccharide-recombinant pneumolysin conjugate vaccines for immunization against pneumococcal infections |
| DE122007000092I1 (de) | 1994-10-07 | 2008-03-27 | Univ Loyola Chicago | Papillomavirusähnliche partikel, fusionsproteine sowie verfahren zu deren herstellung |
| US5599302A (en) | 1995-01-09 | 1997-02-04 | Medi-Ject Corporation | Medical injection system and method, gas spring thereof and launching device using gas spring |
| JP3958360B2 (ja) | 1995-02-24 | 2007-08-15 | キャンタブ ファーマシューティカルズ リサーチ リミティド | 免疫治療剤として役立つポリペプチド及びポリペプチド調製の方法 |
| IL117459A (en) | 1995-03-22 | 2005-11-20 | Merck & Co Inc | Dna encoding human papillomavirus type 18 |
| US20030219453A1 (en) * | 1998-03-19 | 2003-11-27 | Smithkline Beecham Biologicals, Sa | Vaccines |
| UA56132C2 (uk) * | 1995-04-25 | 2003-05-15 | Смітклайн Бічем Байолоджікалс С.А. | Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини |
| US20010053365A1 (en) * | 1995-04-25 | 2001-12-20 | Smithkline Beecham Biologicals S.A. | Vaccines |
| GB9620795D0 (en) * | 1996-10-05 | 1996-11-20 | Smithkline Beecham Plc | Vaccines |
| US5688267A (en) * | 1995-05-01 | 1997-11-18 | Ep Technologies, Inc. | Systems and methods for sensing multiple temperature conditions during tissue ablation |
| US6440425B1 (en) | 1995-05-01 | 2002-08-27 | Aventis Pasteur Limited | High molecular weight major outer membrane protein of moraxella |
| US5730723A (en) | 1995-10-10 | 1998-03-24 | Visionary Medical Products Corporation, Inc. | Gas pressured needle-less injection device and method |
| US5668267A (en) | 1995-05-31 | 1997-09-16 | Washington University | Polynucleotides encoding mammaglobin, a mammary-specific breast cancer protein |
| US5843464A (en) | 1995-06-02 | 1998-12-01 | The Ohio State University | Synthetic chimeric fimbrin peptides |
| US5981215A (en) | 1995-06-06 | 1999-11-09 | Human Genome Sciences, Inc. | Human criptin growth factor |
| EA199800046A1 (ru) | 1995-06-07 | 1998-06-25 | Байокем Вэксинс Инк. | Полипептид, последовательность днк, вакцинная композиция (варианты), антитело или его фрагмент, вакцина, применения указанных полипептида, последовательности днк и антитела или его фрагмента |
| GB9513074D0 (en) | 1995-06-27 | 1995-08-30 | Cortecs Ltd | Novel anigen |
| US6290970B1 (en) | 1995-10-11 | 2001-09-18 | Aventis Pasteur Limited | Transferrin receptor protein of Moraxella |
| US5997881A (en) | 1995-11-22 | 1999-12-07 | University Of Maryland, Baltimore | Method of making non-pyrogenic lipopolysaccharide or A |
| US5893397A (en) | 1996-01-12 | 1999-04-13 | Bioject Inc. | Medication vial/syringe liquid-transfer apparatus |
| US6090576A (en) | 1996-03-08 | 2000-07-18 | Connaught Laboratories Limited | DNA encoding a transferrin receptor of Moraxella |
| GB9607549D0 (en) | 1996-04-11 | 1996-06-12 | Weston Medical Ltd | Spring-powered dispensing device |
| ES2262177T3 (es) | 1996-05-01 | 2006-11-16 | The Rockefeller University | Proteinas de union a colina para vacunas frente a neumococos. |
| US7341727B1 (en) | 1996-05-03 | 2008-03-11 | Emergent Product Development Gaithersburg Inc. | M. catarrhalis outer membrane protein-106 polypeptide, methods of eliciting an immune response comprising same |
| WO1998006734A1 (fr) | 1996-08-16 | 1998-02-19 | Smithkline Beecham Corporation | Nouveaux polynucleotides et polypeptides procaryotes et leurs utilisations |
| US5955306A (en) | 1996-09-17 | 1999-09-21 | Millenium Pharmaceuticals, Inc. | Genes encoding proteins that interact with the tub protein |
| US5882896A (en) | 1996-09-24 | 1999-03-16 | Smithkline Beecham Corporation | M protein |
| US5882871A (en) | 1996-09-24 | 1999-03-16 | Smithkline Beecham Corporation | Saliva binding protein |
| JP4469026B2 (ja) | 1996-10-31 | 2010-05-26 | ヒューマン ジノーム サイエンシーズ,インコーポレイテッド | Streptococcus pneumoniaeの抗原およびワクチン |
| JP2002503087A (ja) | 1996-11-12 | 2002-01-29 | リージェンツ オブ ザ ユニバーシティ オブ ミネソタ | ストレプトコッカス・ニューモニアのc3結合タンパク質 |
| US5840871A (en) | 1997-01-29 | 1998-11-24 | Incyte Pharmaceuticals, Inc. | Prostate-associated kallikrein |
| WO1998033923A1 (fr) | 1997-01-30 | 1998-08-06 | Imperial College Of Science, Technology & Medicine | GENES MUTANTS msbB ou $i(htrB) |
| CA2281954A1 (fr) | 1997-02-25 | 1998-08-27 | Corixa Corporation | Composes servant au diagnostic immunologique de cancer de la prostate et leurs procedes d'utilisation |
| JP3036686B2 (ja) | 1997-02-27 | 2000-04-24 | 政夫 高橋 | 冠状動脈のバイパス手術に用いる血管吻合部の止血保持装置 |
| DE19708537A1 (de) | 1997-03-03 | 1998-09-10 | Biotechnolog Forschung Gmbh | Neues Oberflächenprotein (SpsA-Protein) von Streptococcus pneumoniae etc. |
| CN1326564C (zh) * | 1997-04-01 | 2007-07-18 | 科里克萨有限公司 | 单磷酰基脂质a的水性免疫佐剂组合物 |
| ZA982968B (en) | 1997-04-09 | 1998-10-27 | Corixa Corp | Compositions and methods for the treatment and diagnosis of breast cancer |
| WO1998050567A1 (fr) | 1997-05-02 | 1998-11-12 | Abbott Laboratories | Reactifs et procedes pour detecter les maladies de la prostate |
| US5993412A (en) | 1997-05-19 | 1999-11-30 | Bioject, Inc. | Injection apparatus |
| AU739129B2 (en) | 1997-06-03 | 2001-10-04 | Connaught Laboratories Limited | Lactoferrin receptor genes of moraxella |
| GB9712347D0 (en) | 1997-06-14 | 1997-08-13 | Smithkline Beecham Biolog | Vaccine |
| EP0998557A2 (fr) | 1997-07-21 | 2000-05-10 | North American Vaccine, Inc. | Compositions de pneumolysine immunogene modifiee utiles en tant que vaccins |
| US5928215A (en) * | 1997-08-14 | 1999-07-27 | Becton, Dickinson And Acompany | Syringe filling and delivery device |
| GB9717953D0 (en) | 1997-08-22 | 1997-10-29 | Smithkline Beecham Biolog | Vaccine |
| AU1145699A (en) * | 1997-09-05 | 1999-03-22 | Smithkline Beecham Biologicals (Sa) | Oil in water emulsions containing saponins |
| EP1015561B1 (fr) | 1997-09-05 | 2006-07-19 | Medimmune, Inc. | Methode de desassemblage-reassemblage in vitro de particules viroides (vlp) du papillomavirus |
| AU9510598A (en) | 1997-09-24 | 1999-04-12 | American Cyanamid Company | Human complement c3-degrading proteinase from (streptococcus pneumoniae) |
| AU2447999A (en) | 1997-09-26 | 1999-05-03 | Corixa Corporation | Murine model for human carcinoma |
| WO1999033869A2 (fr) | 1997-12-24 | 1999-07-08 | Corixa Corporation | Composes destines a l'immunotherapie et au diagnostic du cancer du sein, et leur mode d'utilisation |
| IT1298087B1 (it) | 1998-01-08 | 1999-12-20 | Fiderm S R L | Dispositivo per il controllo della profondita' di penetrazione di un ago, in particolare applicabile ad una siringa per iniezioni |
| CZ298364B6 (cs) | 1998-02-05 | 2007-09-05 | Smithkline Beecham Biologicals S. A. | Deriváty antigenu asociovaných s nádory z MAGE rodiny a sekvence nukleových kyselin kodující tyto deriváty, jejich použití pro prípravu fúzních proteinu a prostredku pro vakcinaci |
| US20020039584A1 (en) | 1998-02-20 | 2002-04-04 | Medigene Ag | Papilloma virus capsomere vaccine formulations and methods of use |
| DE69942176D1 (de) | 1998-04-07 | 2010-05-06 | Medimmune Llc | Choline-bindende proteine derivate aus pneumokoken als impfstoff |
| PL202844B1 (pl) | 1998-04-07 | 2009-07-31 | Corixa Corp | Immunogeniczny polipeptyd, polinukleotyd, polipeptyd, kompozycja farmaceutyczna, wektor ekspresji, kompozycja szczepionki, polipeptyd do stosowania w leczeniu lub zapobieganiu infekcjom Mycobacterium tuberculosis, polinukleotyd do stosowania w leczeniu lub zapobieganiu infekcjom Mycobacterium tuberculosis i sposób wytwarzania polipeptydu |
| IL138939A0 (en) | 1998-04-07 | 2001-11-25 | St Jude Childrens Res Hospital | A polypeptide comprising the amino acid of an n-terminal choline binding protein a truncate, vaccine derived therefrom and uses thereof |
| AU3560399A (en) | 1998-04-15 | 1999-11-01 | Ludwig Institute For Cancer Research | Tumor associated nucleic acids and uses therefor |
| WO1999053940A1 (fr) | 1998-04-23 | 1999-10-28 | Uab Research Foundation | Proteine de surface pneumococcique c(pspc), regions epitopes et selection de souches d'une telle proteine, et utilisations correspondantes |
| GB9809683D0 (en) | 1998-05-06 | 1998-07-01 | Smithkline Beecham Biolog | Novel compounds |
| GB9810285D0 (en) | 1998-05-13 | 1998-07-15 | Smithkline Beecham Biolog | Novel compounds |
| TR200003608T2 (tr) | 1998-06-03 | 2001-04-20 | Smithkline Beecham Biologicals S.A. | Moraxella Catarrhalis'e ait BASB027 proteinleri ve genleri. |
| GB9812163D0 (en) | 1998-06-05 | 1998-08-05 | Smithkline Beecham Biolog | Novel compounds |
| GB9812440D0 (en) | 1998-06-09 | 1998-08-05 | Smithkline Beecham Biolog | Novel compounds |
| GB9812613D0 (en) | 1998-06-11 | 1998-08-12 | Smithkline Beecham Biolog | Vaccine |
| HUP0203035A3 (en) | 1998-07-14 | 2007-12-28 | Corixa Corp | Compositions and methods for therapy and diagnosis of prostate cancer |
| GB9820002D0 (en) | 1998-09-14 | 1998-11-04 | Smithkline Beecham Biolog | Novel compounds |
| EP1115875A1 (fr) | 1998-09-24 | 2001-07-18 | Regents Of The University Of Minnesota | Polypeptide de degradation du complement humain c3 de streptococcus pneumoniae |
| WO2000030299A1 (fr) | 1998-11-17 | 2000-05-25 | Schlumberger Technology Corporation | Transmission de donnees dans une liaison de communications |
| WO2000029434A2 (fr) | 1998-11-19 | 2000-05-25 | St. Jude Children's Research Hospital | IDENTIFICATION ET CARACTERISATION DE NOUVELLES PROTEINES PNEUMOCOCCIQUES SE LIANT A LA CHOLINE, CbpG AND CbpD, ET UTILISATIONS DIAGNOSTIQUES ET THERAPEUTIQUES CORRESPONDANTES |
| EP1140157B1 (fr) | 1998-12-21 | 2009-02-18 | MedImmune, Inc. | Proteines de streptococcus pneumoniae et fragments immunogenes pour vaccins |
| CZ20012587A3 (cs) | 1999-01-29 | 2002-05-15 | Corixa Corporation | Izolovaný protein, nukleová kyselina, virový vektor, farmaceutický prostředek, izolovaná populace T buněk, způsob posílení imunitní odpovědi, způsob odstranění nádorových buněk, způsob stimulace a/nebo namnoľení T buněk a způsob přípravy fúzního proteinu |
| GB9904559D0 (en) | 1999-02-26 | 1999-04-21 | Smithkline Beecham Biolog | Novel compounds |
| AU3391200A (en) | 1999-03-04 | 2000-09-21 | Corixa Corporation | Compositions and methods for breast cancer therapy and diagnosis |
| ATE459373T1 (de) | 1999-03-19 | 2010-03-15 | Glaxosmithkline Biolog Sa | Impfstoff gegen kapsulare polysaccharide von streptococcus pneumoniae |
| US6245568B1 (en) | 1999-03-26 | 2001-06-12 | Merck & Co., Inc. | Human papilloma virus vaccine with disassembled and reassembled virus-like particles |
| PT1187629E (pt) | 1999-04-19 | 2005-02-28 | Glaxosmithkline Biolog Sa | Composicao adjuvante que compreende saponina e um oligonucleotido imunoestimulador |
| JP2003501110A (ja) | 1999-06-10 | 2003-01-14 | メディミューン,インコーポレーテッド | 肺炎連鎖球菌タンパク質とワクチン |
| FR2796289B1 (fr) * | 1999-07-16 | 2001-08-10 | Cross Site Technologies | Seringue sans aiguille avec injecteur a elements superposes |
| FR2796290B1 (fr) * | 1999-07-16 | 2001-09-14 | Cross Site Technologies | Seringue sans aiguille fonctionnant avec un generateur d'onde de choc a travers une paroi |
| FR2796291B1 (fr) | 1999-07-16 | 2001-09-21 | Cross Site Technologies | Seringue sans aiguille munie d'un systeme de declenchement piezo-electrique |
| GB9917977D0 (en) | 1999-07-30 | 1999-09-29 | Smithkline Beecham Biolog | Novel compounds |
| GB9918038D0 (en) | 1999-07-30 | 1999-09-29 | Smithkline Beecham Biolog | Novel compounds |
| GB9918302D0 (en) | 1999-08-03 | 1999-10-06 | Smithkline Beecham Biolog | Novel compounds |
| GB9918208D0 (en) | 1999-08-03 | 1999-10-06 | Smithkline Beecham Biolog | Novel compounds |
| US6139179A (en) | 1999-09-03 | 2000-10-31 | Davis-Standard Corporation | Extruder screw having multi-channeled barrier section |
| GB9921146D0 (en) | 1999-09-07 | 1999-11-10 | Smithkline Beecham Biolog | Novel composition |
| GB9921147D0 (en) | 1999-09-07 | 1999-11-10 | Smithkline Beecham Biolog | Novel composition |
| US6494865B1 (en) | 1999-10-14 | 2002-12-17 | Becton Dickinson And Company | Intradermal delivery device including a needle assembly |
| FR2800619B1 (fr) | 1999-11-05 | 2002-02-08 | Cross Site Technologies | Seringue sans aiguille avec un moyen de poussee temporairement retenu |
| FR2802102B1 (fr) | 1999-12-08 | 2002-07-12 | Poudres & Explosifs Ste Nale | Seringue sans aiguille munie d'un tube d'ejection a section constante |
| FR2802103B1 (fr) | 1999-12-08 | 2003-10-03 | Poudres & Explosifs Ste Nale | Seringue sans aiguille fonctionnant avec entrainement du principe actif par effet tube a choc |
| FR2802820B1 (fr) * | 1999-12-27 | 2002-10-18 | Poudres & Explosifs Ste Nale | Seringue sans aiguille fonctionnant par effet tube a choc, avec maintien prealable du principe actif sur le cote |
| FR2804329B1 (fr) | 2000-02-02 | 2002-12-13 | Poudres & Explosifs Ste Nale | Seringue sans aiguille munie d'un opercule contenant le principe actif |
| FR2804869B1 (fr) | 2000-02-11 | 2002-05-17 | Poudres & Explosifs Ste Nale | Seringue sans aiguille pour l'injection d'un liquide contenu dans une ampoule pre-remplie |
| FR2805749B1 (fr) * | 2000-03-01 | 2002-05-17 | Poudres & Explosifs Ste Nale | Seringue sans aiguille a deux niveaux de vitesse d'injection |
| FR2807946B1 (fr) * | 2000-04-19 | 2002-06-07 | Poudres & Explosifs Ste Nale | Seringue sans aiguille fonctionnant avec un chargement pyrotechnique bicomposition |
| FR2809626B1 (fr) | 2000-05-30 | 2003-03-07 | Poudres & Explosifs Ste Nale | Seringue sans aiguille avec membrane d'isolation d'un ejecteur multiconduit |
| CA2413450C (fr) | 2000-06-20 | 2014-02-18 | Shire Biochem Inc. | Antigenes de streptocoque |
| FR2810554B1 (fr) | 2000-06-22 | 2003-05-16 | Poudres & Explosifs Ste Nale | Seringue sans aiguille munie d'un reservoir modulable |
| FR2812202B1 (fr) | 2000-07-28 | 2002-09-13 | Poudres & Explosifs Ste Nale | Seringue sans aiguille fonctionnant par mise en compression du reservoir contenant le principe actif liquide |
| GB0019375D0 (en) | 2000-08-07 | 2000-09-27 | Int Centre Genetic Eng & Bio | Method of polypeptide renaturation |
| GB0022742D0 (en) | 2000-09-15 | 2000-11-01 | Smithkline Beecham Biolog | Vaccine |
| GB0025577D0 (en) * | 2000-10-18 | 2000-12-06 | Smithkline Beecham Biolog | Vaccine |
| FR2815544B1 (fr) | 2000-10-23 | 2003-02-14 | Poudres & Explosifs Ste Nale | Seringue sans aiguille securisee a architecture compacte |
| CA2438960A1 (fr) * | 2001-02-23 | 2002-09-06 | Glaxosmithkline Biologicals S.A. | Nouveau vaccin |
| US20030031684A1 (en) | 2001-03-30 | 2003-02-13 | Corixa Corporation | Methods for the production of 3-O-deactivated-4'-monophosphoryl lipid a (3D-MLA) |
| MY134424A (en) | 2001-05-30 | 2007-12-31 | Saechsisches Serumwerk | Stable influenza virus preparations with low or no amount of thiomersal |
| GB0123580D0 (en) * | 2001-10-01 | 2001-11-21 | Glaxosmithkline Biolog Sa | Vaccine |
| US20030139364A1 (en) * | 2001-10-12 | 2003-07-24 | University Of Iowa Research Foundation | Methods and products for enhancing immune responses using imidazoquinoline compounds |
| EP1456231A2 (fr) | 2001-12-20 | 2004-09-15 | Shire Biochem Inc. | Antigenes de streptococcus |
| US7026465B2 (en) | 2002-02-15 | 2006-04-11 | Corixa Corporation | Fusion proteins of Mycobacterium tuberculosis |
| WO2004005476A2 (fr) * | 2002-07-03 | 2004-01-15 | Coley Pharmaceutical Group, Inc. | Compositions d'acide nucleique destinees a stimuler les reponses immunitaires |
| EP2269638A3 (fr) * | 2004-05-28 | 2012-06-13 | GlaxoSmithKline Biologicals S.A. | Compositions de vaccin comprenant des virosomes et un adjuvant à base de saponine |
| GB0504436D0 (en) * | 2005-03-03 | 2005-04-06 | Glaxosmithkline Biolog Sa | Vaccine |
| WO2006104890A2 (fr) | 2005-03-31 | 2006-10-05 | Glaxosmithkline Biologicals Sa | Vaccins destines a lutter contre une infection a chlamydia |
| WO2006114312A2 (fr) | 2005-04-26 | 2006-11-02 | Glaxosmithkline Biologicals S.A. | Vaccin |
| DK2457926T3 (da) | 2005-04-29 | 2015-01-05 | Glaxosmithkline Biolog Sa | Ny fremgangsmåde til forebyggelse eller behandling af M. tuberkulose-infektion |
| JP2008540625A (ja) * | 2005-05-19 | 2008-11-20 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | E.coli易熱性毒素のB−サブユニット、抗原およびアジュバントを含むワクチン組成物 |
-
2006
- 2006-12-11 TW TW095146300A patent/TWI457133B/zh not_active IP Right Cessation
- 2006-12-12 EP EP11168821.4A patent/EP2364721B1/fr active Active
- 2006-12-12 MY MYPI20082050A patent/MY145943A/en unknown
- 2006-12-12 NZ NZ568825A patent/NZ568825A/en not_active IP Right Cessation
- 2006-12-12 CN CN2012101089032A patent/CN102631670A/zh active Pending
- 2006-12-12 SI SI200631793T patent/SI2364720T1/sl unknown
- 2006-12-12 ES ES11168827.1T patent/ES2436645T3/es active Active
- 2006-12-12 PT PT06831376T patent/PT1959992E/pt unknown
- 2006-12-12 PT PT111688206T patent/PT2364720E/pt unknown
- 2006-12-12 AU AU2006325377A patent/AU2006325377B2/en not_active Ceased
- 2006-12-12 IL IL191703A patent/IL191703A/en active IP Right Grant
- 2006-12-12 SI SI200631300T patent/SI1959992T1/sl unknown
- 2006-12-12 WO PCT/GB2006/004634 patent/WO2007068907A2/fr not_active Ceased
- 2006-12-12 PL PL11168827T patent/PL2364724T3/pl unknown
- 2006-12-12 EP EP11168820.6A patent/EP2364720B1/fr active Active
- 2006-12-12 SG SG10201405533TA patent/SG10201405533TA/en unknown
- 2006-12-12 DK DK06831376.6T patent/DK1959992T3/da active
- 2006-12-12 ES ES11168822.2T patent/ES2444623T3/es active Active
- 2006-12-12 CN CN201410035418.6A patent/CN103861100A/zh active Pending
- 2006-12-12 ES ES11168821.4T patent/ES2445170T3/es active Active
- 2006-12-12 EA EA200801307A patent/EA014353B1/ru not_active IP Right Cessation
- 2006-12-12 PL PL06831376T patent/PL1959992T3/pl unknown
- 2006-12-12 EP EP06831376A patent/EP1959992B1/fr active Active
- 2006-12-12 EP EP11168826.3A patent/EP2364723B1/fr active Active
- 2006-12-12 EP EP11168822.2A patent/EP2364722B1/fr active Active
- 2006-12-12 CN CN2013103564887A patent/CN103405764A/zh active Pending
- 2006-12-12 JP JP2008545078A patent/JP5461015B2/ja not_active Expired - Fee Related
- 2006-12-12 DK DK11168820.6T patent/DK2364720T3/da active
- 2006-12-12 BR BRPI0619795A patent/BRPI0619795B8/pt not_active IP Right Cessation
- 2006-12-12 NZ NZ596870A patent/NZ596870A/xx not_active IP Right Cessation
- 2006-12-12 SG SG201101856-1A patent/SG170127A1/en unknown
- 2006-12-12 PT PT111688271T patent/PT2364724E/pt unknown
- 2006-12-12 US US12/096,838 patent/US20080279926A1/en not_active Abandoned
- 2006-12-12 ES ES11168826.3T patent/ES2451573T3/es active Active
- 2006-12-12 EA EA201001189A patent/EA018860B1/ru not_active IP Right Cessation
- 2006-12-12 CA CA2633008A patent/CA2633008C/fr active Active
- 2006-12-12 ES ES06831376T patent/ES2378471T3/es active Active
- 2006-12-12 DK DK11168827.1T patent/DK2364724T3/da active
- 2006-12-12 HR HR20120136T patent/HRP20120136T1/hr unknown
- 2006-12-12 PL PL11168820T patent/PL2364720T3/pl unknown
- 2006-12-12 ES ES11168820.6T patent/ES2479165T3/es active Active
- 2006-12-12 SI SI200631697T patent/SI2364724T1/sl unknown
- 2006-12-12 AT AT06831376T patent/ATE542543T1/de active
- 2006-12-12 KR KR1020087016980A patent/KR101363879B1/ko not_active Expired - Fee Related
- 2006-12-12 EP EP11168827.1A patent/EP2364724B1/fr active Active
- 2006-12-13 PE PE2006001600A patent/PE20071098A1/es not_active Application Discontinuation
- 2006-12-13 AR ARP060105496A patent/AR058543A1/es not_active Application Discontinuation
-
2008
- 2008-05-29 NO NO20082472A patent/NO20082472L/no not_active Application Discontinuation
- 2008-06-03 MA MA30995A patent/MA30023B1/fr unknown
- 2008-06-20 CR CR10101A patent/CR10101A/es not_active Application Discontinuation
- 2008-06-26 CR CR10118A patent/CR10118A/xx unknown
-
2011
- 2011-02-03 US US13/020,045 patent/US10039823B2/en active Active
-
2012
- 2012-03-30 CY CY20121100324T patent/CY1112589T1/el unknown
- 2012-11-22 JP JP2012256348A patent/JP2013056927A/ja active Pending
-
2013
- 2013-11-06 HR HRP20131057TT patent/HRP20131057T1/hr unknown
- 2013-11-20 IL IL229521A patent/IL229521A0/en unknown
- 2013-11-22 CY CY20131101050T patent/CY1114864T1/el unknown
-
2014
- 2014-05-28 HR HRP20140484TT patent/HRP20140484T1/hr unknown
- 2014-06-25 CY CY20141100461T patent/CY1115308T1/el unknown
-
2016
- 2016-11-17 US US15/354,233 patent/US10143745B2/en active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MA30023B1 (fr) | Nouvelle composition | |
| MA31381B1 (fr) | Vaccin contre la grippe a emulsion huile dans l'eau | |
| MA30866B1 (fr) | Vaccin | |
| BRPI0407101A (pt) | Vacinas meningocócicas mucosais | |
| MA27729A1 (fr) | Compositions pharmaceutiques solides contenant un agoniste des recepteurs de la s1p et un alcool de sucre | |
| MA30298B1 (fr) | Composition | |
| MA29321B1 (fr) | Vaccin a base de rotavirus vivant attenue pour administration orale | |
| TR200002930T2 (tr) | Kolaylaştırıcı kompozisyonlar | |
| BR0110779A (pt) | Composições e métodos para adquirir supressão imunológica | |
| EP1790340A3 (fr) | Chimotherapie combinée | |
| MA29601B1 (fr) | Vaccin antipaludeen | |
| FR11C0001I2 (fr) | Vaccins combines contre neisseria meningitidis | |
| AR108718A2 (es) | Composición | |
| PE20020968A1 (es) | Preparados de insulina exentos de zinc y pobres en zinc, con estabilidad mejorada | |
| MA30624B1 (fr) | Vaccin anti-grippal | |
| DE602005020608D1 (de) | NEISSERIA MENINGITIDIS IgtB LOS ALS ADJUVANS | |
| WO2006081363A3 (fr) | Formulations orales pour l'administration de butanes catecholiques comprenant des composes ndga | |
| BRPI0518091A2 (pt) | mycobacterium, mÉtodo para permitir com que uma mycobacterium escape a partir de endossomos e preparaÇço para uma vacina | |
| MA30691B1 (fr) | Compositions pharmaceutiques contenant un anticorps monoclonal anti-idiotypique anti-ca-125 et de l'aluminium. | |
| BRPI0414073A (pt) | método para induzir uma resposta imune contra infecção por rotavìrus a partir de um sorotipo de rotavìrus, e, uso de uma cepa de rotavìrus atenuado de um sorotipo | |
| MA32003B1 (fr) | Vaccin | |
| EP2433648A3 (fr) | Vaccin comprenant une émulsion adjuvante huile en l'eau | |
| FR3092754B1 (fr) | Composition adjuvante pour vaccin | |
| MX2009010963A (es) | Vacuna de influenza de emulsion de aceite en agua. | |
| TH94291A (th) | สารผสมวัคซีนที่ได้เสริมฤทธิ์โดยที่สารเสริม คือ สูตรผสมไลโปโซมที่ประกอบรวมด้วยซาโปนิน และไลโปพอลิแซ็กคาไรด์ |