MA31183B1 - Inhibiteurs de mek - Google Patents

Inhibiteurs de mek

Info

Publication number
MA31183B1
MA31183B1 MA32166A MA32166A MA31183B1 MA 31183 B1 MA31183 B1 MA 31183B1 MA 32166 A MA32166 A MA 32166A MA 32166 A MA32166 A MA 32166A MA 31183 B1 MA31183 B1 MA 31183B1
Authority
MA
Morocco
Prior art keywords
mek inhibitors
compounds
mek
inhibitors
arylamino
Prior art date
Application number
MA32166A
Other languages
Arabic (ar)
English (en)
Inventor
Jean-Michel Vernier
Andreas Maderna
Yung-Hyo Koh
Zhi Hong
Original Assignee
Ardea Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ardea Biosciences Inc filed Critical Ardea Biosciences Inc
Publication of MA31183B1 publication Critical patent/MA31183B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Quinoline Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La présente invention concerne des n-(2-arylamino) aryle sulfonamides, qui sont des inhibiteurs de mek, des procédés d'utilisation de tels composés dans le traitement de maladies hyperprolifératives, et des compositions pharmaceutiques contenant de tels composés.
MA32166A 2007-01-19 2009-08-12 Inhibiteurs de mek MA31183B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US88584907P 2007-01-19 2007-01-19
PCT/US2008/051518 WO2008089459A1 (fr) 2007-01-19 2008-01-18 Inhibiteurs de mek

Publications (1)

Publication Number Publication Date
MA31183B1 true MA31183B1 (fr) 2010-02-01

Family

ID=39333043

Family Applications (1)

Application Number Title Priority Date Filing Date
MA32166A MA31183B1 (fr) 2007-01-19 2009-08-12 Inhibiteurs de mek

Country Status (19)

Country Link
US (2) US7820664B2 (fr)
EP (1) EP2121620B1 (fr)
JP (1) JP5491199B2 (fr)
KR (1) KR20090111847A (fr)
CN (1) CN101663279A (fr)
AU (1) AU2008206045A1 (fr)
BR (1) BRPI0806898A2 (fr)
CA (1) CA2675358C (fr)
CO (1) CO6210813A2 (fr)
CR (1) CR10939A (fr)
DO (1) DOP2009000181A (fr)
EA (1) EA200900959A1 (fr)
EC (1) ECSP099525A (fr)
ES (1) ES2547303T3 (fr)
IL (1) IL199727A0 (fr)
MA (1) MA31183B1 (fr)
MX (1) MX2009007661A (fr)
TN (1) TN2009000291A1 (fr)
WO (1) WO2008089459A1 (fr)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE428421T1 (de) 2004-09-17 2009-05-15 Eisai R&D Man Co Ltd Medizinische zusammensetzung mit verbesserter stabilität und reduzierten gelierungseigenschaften
US7429667B2 (en) 2005-01-20 2008-09-30 Ardea Biosciences, Inc. Phenylamino isothiazole carboxamidines as MEK inhibitors
US9095581B2 (en) 2005-07-21 2015-08-04 Ardea Biosciences, Inc. Combinations of MEK inhibitors and Raf kinase inhibitors and uses thereof
JP4989476B2 (ja) 2005-08-02 2012-08-01 エーザイ・アール・アンド・ディー・マネジメント株式会社 血管新生阻害物質の効果を検定する方法
CN104706637A (zh) 2006-05-18 2015-06-17 卫材R&D管理有限公司 针对甲状腺癌的抗肿瘤剂
US8227603B2 (en) 2006-08-01 2012-07-24 Cytokinetics, Inc. Modulating skeletal muscle
PL2069352T3 (pl) 2006-08-02 2014-03-31 Cytokinetics Inc Określone cząstki chemiczne, kompozycje i sposoby
US8299248B2 (en) 2006-08-02 2012-10-30 Cytokinetics, Incorporated Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols and methods for their use
EP2139478A4 (fr) * 2007-03-30 2010-05-05 Cytokinetics Inc Entités chimiques, compositions et procédés
CA2924436A1 (fr) * 2007-07-30 2009-02-05 Ardea Biosciences, Inc. Combinaisons pharmaceutiques de n-3(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide comme inhibiteurs de mek et methodes d'utilisation
US8044240B2 (en) 2008-03-06 2011-10-25 Ardea Biosciences Inc. Polymorphic form of N-(S)-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide and uses thereof
AR071587A1 (es) * 2008-04-21 2010-06-30 Novartis Ag Compuestos heterociclicos como inhibidores de mek
US10253020B2 (en) 2009-06-12 2019-04-09 Abivax Compounds for preventing, inhibiting, or treating cancer, AIDS and/or premature aging
SI2440547T1 (sl) 2009-06-12 2023-05-31 Abivax Nove kemične molekule, ki zavirajo mehanizem spajanja za zdravljenje bolezni, ki so posledica napak pri spajanju
MY162940A (en) 2009-08-19 2017-07-31 Eisai R&D Man Co Ltd Quinoline derivative-containing pharmaceutical composition
CN102666512B (zh) 2009-10-13 2014-11-26 奥斯特姆医疗公司 对疾病治疗有用的mek抑制剂
PH12012500775A1 (en) 2009-10-21 2012-11-26 Boehringer Ingelheim Int Indazole and pyrazolopyridine compounds as ccr1 receptor antagonists
US8927550B2 (en) 2009-10-27 2015-01-06 Boehringer Ingelheim International Gmbh Heterocyclic compounds as CCR1 receptor antagonists
AU2010317167B2 (en) * 2009-11-04 2012-11-29 Novartis Ag Heterocyclic sulfonamide derivatives useful as MEK inhibitors
EA201200823A1 (ru) * 2009-12-08 2013-02-28 Новартис Аг Гетероциклические производные сульфонамидов
US8871786B2 (en) 2010-04-30 2014-10-28 Boehringer Ingelheim International Gmbh Azaindazole amide compounds as CCR1 receptor antagonists
CN103402519B (zh) 2011-04-18 2015-11-25 卫材R&D管理有限公司 肿瘤治疗剂
JP6038128B2 (ja) 2011-06-03 2016-12-07 エーザイ・アール・アンド・ディー・マネジメント株式会社 レンバチニブ化合物に対する甲状腺癌対象及び腎臓癌対象の反応性を予測及び評価するためのバイオマーカー
CN103748085A (zh) * 2011-06-09 2014-04-23 诺华股份有限公司 杂环磺酰胺衍生物
EA201391820A1 (ru) * 2011-06-09 2014-12-30 Новартис Аг Гетероциклические сульфонамидные производные
BR112014000742A2 (pt) 2011-07-13 2016-08-23 Andrew A Wolff terapia de combinação de als
CN103204825B (zh) 2012-01-17 2015-03-04 上海科州药物研发有限公司 作为蛋白激酶抑制剂的苯并噻唑化合物及其制备方法和用途
US20150265679A1 (en) 2012-11-02 2015-09-24 The United States Of America, As Represented By Secretary, Department Of Health And Human Services Method of reducing adverse effects in a cancer patient undregoing treatment with a mek inhibitor
KR20150098605A (ko) 2012-12-21 2015-08-28 에자이 알앤드디 매니지먼트 가부시키가이샤 퀴놀린 유도체의 비정질 형태 및 그의 제조방법
EP2757161A1 (fr) 2013-01-17 2014-07-23 Splicos miRNA-124 comme biomarqueur de l'infection virale
NZ714049A (en) 2013-05-14 2020-05-29 Eisai R&D Man Co Ltd Biomarkers for predicting and assessing responsiveness of endometrial cancer subjects to lenvatinib compounds
CN105530938B (zh) 2013-07-05 2019-10-22 Abivax公司 用于治疗由逆转录病毒引起的疾病的化合物
CN103739550B (zh) * 2014-01-02 2016-06-01 中国药科大学 2,3-二甲基-6-脲-2h-吲唑类化合物及其制备方法与应用
AU2015206603B9 (en) 2014-01-14 2019-07-18 Dana-Farber Cancer Institute, Inc. Compositions and methods for identification, assessment, prevention, and treatment of melanoma using PD-L1 isoforms
US20170114323A1 (en) 2014-06-19 2017-04-27 Whitehead Institute For Biomedical Research Uses of kinase inhibitors for inducing and maintaining pluripotency
EP2974729A1 (fr) 2014-07-17 2016-01-20 Abivax Dérivés de quinoléine utilisés dans le traitement de maladies inflammatoires
PT3524595T (pt) 2014-08-28 2022-09-19 Eisai R&D Man Co Ltd Derivado de quinolina altamente puro e método para produção do mesmo
CN105384754B (zh) * 2014-09-02 2018-04-20 上海科州药物研发有限公司 作为蛋白激酶抑制剂的杂环类化合物及其制备方法和用途
CA2963091A1 (fr) 2014-10-06 2016-04-14 Dana-Farber Cancer Institute, Inc. Biomarqueurs a base d'angiopoietine -2 utilises pour la prediction de la reponse de point de controle anti-immunitaire
LT3263106T (lt) 2015-02-25 2024-01-10 Eisai R&D Management Co., Ltd. Chinolino darinių kartumo sumažinimo būdas
KR102662228B1 (ko) 2015-03-04 2024-05-02 머크 샤프 앤드 돔 코포레이션 암을 치료하기 위한 pd-1 길항제 및 vegfr/fgfr/ret 티로신 키나제 억제제의 조합
MA41866A (fr) 2015-03-31 2018-02-06 Massachusetts Gen Hospital Molécules à auto-assemblage pour l'administration ciblée de médicaments
MX373231B (es) 2015-06-16 2020-05-08 Eisai R&D Man Co Ltd Agente anticancerigeno.
US12220398B2 (en) 2015-08-20 2025-02-11 Eisai R&D Management Co., Ltd. Tumor therapeutic agent
CN105085427B (zh) * 2015-08-21 2018-06-05 中国科学院广州生物医药与健康研究院 一类苯并[d]异恶唑类化合物及其应用
WO2017033113A1 (fr) 2015-08-21 2017-03-02 Acerta Pharma B.V. Associations thérapeutiques d'un inhibiteur de mek et d'un inhibiteur de btk
US12303505B2 (en) 2017-02-08 2025-05-20 Eisai R&D Management Co., Ltd. Tumor-treating pharmaceutical composition
JP7113023B2 (ja) 2017-03-30 2022-08-04 ブリストル－マイヤーズ スクイブ カンパニー ６－（シクロプロパンアミド）－４－（（２－メトキシ－３－（１－メチル－１ｈ－１，２，４－トリアゾール－３－イル）フェニル）アミノ）－ｎ－（メチル－ｄ３）ピリダジン－３－カルボキシアミドの製造方法
RU2019134940A (ru) 2017-05-16 2021-06-16 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Лечение гепатоцеллюлярной карциномы
MX2021003904A (es) 2018-10-05 2021-10-26 Annapurna Bio Inc Compuestos y composiciones para el tratamiento de afecciones asociadas con la actividad del receptor apj.
EP3669873A1 (fr) 2018-12-20 2020-06-24 Abivax Dérivés de quinoline destinés à être utilisés dans le traitement de maladies inflammatoires
EA202192575A1 (ru) 2019-03-21 2022-01-14 Онксео Соединения dbait в сочетании с ингибиторами киназ для лечения рака
CN110229173A (zh) * 2019-07-17 2019-09-13 泰州职业技术学院 一种5-6-5氮杂三环化合物及其制备方法
CN114761006A (zh) 2019-11-08 2022-07-15 Inserm(法国国家健康医学研究院) 对激酶抑制剂产生耐药性的癌症的治疗方法
WO2021148581A1 (fr) 2020-01-22 2021-07-29 Onxeo Nouvelle molécule dbait et son utilisation
CN112759552A (zh) * 2020-12-31 2021-05-07 武汉九州钰民医药科技有限公司 司美替尼的合成方法
US12371667B2 (en) 2021-05-13 2025-07-29 Washington University Enhanced methods for inducing and maintaining naive human pluripotent stem cells
US12280055B2 (en) 2021-05-27 2025-04-22 Mirati Therapeutics, Inc. Combination therapies
WO2025073765A1 (fr) 2023-10-03 2025-04-10 Institut National de la Santé et de la Recherche Médicale Méthodes de pronostic et de traitement de patients souffrant de mélanome
CN119019338B (zh) * 2024-10-28 2025-02-18 合肥欧创基因生物科技有限公司 一种5-氯哒嗪-3-羧酸的制备方法

Family Cites Families (122)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US622068A (en) * 1899-03-28 payne
US1468428A (en) * 1921-07-18 1923-09-18 Amos S Wells Dental molding apparatus
US1896123A (en) * 1925-07-29 1933-02-07 Schweitzer Heinrich Wax dental form and method of making same
US1864365A (en) * 1929-09-06 1932-06-21 Ac Spark Plug Co Process and apparatus for forming ceramic bodies
US2271454A (en) * 1938-06-25 1942-01-27 Dental Res Corp Method of forming a reproducting of an article
US2310448A (en) * 1940-03-11 1943-02-09 Henry H Leib Dental apparatus
US2480048A (en) * 1944-07-10 1949-08-23 William S Rice Casting process
US2474676A (en) * 1946-02-27 1949-06-28 Myerson Tooth Corp Method of forming artificial teeth
US2551812A (en) * 1947-07-14 1951-05-08 Alex A Nelson Process of preparing an artificial denture
US2678470A (en) * 1949-11-25 1954-05-18 H D Justi & Son Inc Polymerizing method
US3390458A (en) * 1965-05-10 1968-07-02 Joseph M. Lytton Method of preparing for dental impressions
US3565387A (en) * 1968-09-17 1971-02-23 Dental Innovations Inc Prefabricated dental pattern having adjusting slot means
US3585723A (en) * 1969-06-20 1971-06-22 Ion Co The Dental crown and method of installation thereof
GB1408265A (en) * 1971-10-18 1975-10-01 Ici Ltd Photopolymerisable composition
US3949476A (en) * 1974-03-25 1976-04-13 Henry Kahn Device useful in dental crown procedures and method of using the same
US4024637A (en) * 1975-07-11 1977-05-24 Polythetics, Inc. Dentures and process for making the same
US4024636A (en) * 1975-07-11 1977-05-24 Polythetics, Inc. Dentures
US4113499A (en) * 1976-03-18 1978-09-12 Valentin Nikolaevich Ivanov Suspension for making molds in disposable pattern casting
DE2759214A1 (de) * 1977-12-31 1979-07-05 Scheicher Hans Verfahren zur herstellung von implantaten
ATE15588T1 (de) * 1979-07-13 1985-10-15 Corning Glass Works Kuenstliche zaehne und zahnaerztliche werkzeuge sowie deren herstellung.
US4585417A (en) * 1979-12-14 1986-04-29 Coors Porcelain Company Dental appliance and method of manufacture
US4347888A (en) * 1980-03-20 1982-09-07 Butler Melvyn P Method of making forms for investment casting and products produced therefrom
DE3110009A1 (de) * 1981-03-11 1982-09-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue benzofuran-derivate, ihre herstellung und verwendung
DE3135469C1 (de) * 1981-09-08 1983-04-21 Peter 6272 Niedernhausen Bayer Verfahren zur Anfertigung von Zahnersatz,Zahnersatzteilen oder verlorenen Giessmodellen hierfuer und Formen zur Durchfuehrung dieses Verfahrens
US4514174A (en) * 1982-11-19 1985-04-30 Dentsply Research & Development Corp. Methods for posterior dental restoration employing light curable packable compositions
US4737550A (en) * 1983-01-07 1988-04-12 The Dow Chemical Company Bridged dense star polymers
US4568737A (en) * 1983-01-07 1986-02-04 The Dow Chemical Company Dense star polymers and dendrimers
CH662266A5 (de) * 1983-10-04 1987-09-30 Weissenfluh Hans Dr Von Folienfoermige dentalmatrize.
US4503169A (en) * 1984-04-19 1985-03-05 Minnesota Mining And Manufacturing Company Radiopaque, low visual opacity dental composites containing non-vitreous microparticles
JPS60252083A (ja) * 1984-05-28 1985-12-12 本田技研工業株式会社 車両における空気取入装置
US4571188A (en) * 1984-07-05 1986-02-18 Sybron Corporation Occlusal matrix for light cured composites
US4587329A (en) * 1984-08-17 1986-05-06 The Dow Chemical Company Dense star polymers having two dimensional molecular diameter
US4642126A (en) * 1985-02-11 1987-02-10 Norton Company Coated abrasives with rapidly curable adhesives and controllable curvature
US4648843A (en) * 1985-07-19 1987-03-10 Minnesota Mining And Manufacturing Company Method of dental treatment using poly(ethylenically unsaturated) carbamoyl isocyanurates and dental materials made therewith
US4652274A (en) * 1985-08-07 1987-03-24 Minnesota Mining And Manufacturing Company Coated abrasive product having radiation curable binder
US4694064A (en) * 1986-02-28 1987-09-15 The Dow Chemical Company Rod-shaped dendrimer
CA1323949C (fr) * 1987-04-02 1993-11-02 Michael C. Palazzotto Systeme ternaire de photoinitiateur pour la polymerisation additive
US4767331A (en) * 1987-05-28 1988-08-30 Hoe Khin A Dental crown manufacturing apparatus
US4857599A (en) * 1988-02-08 1989-08-15 The Dow Chemical Company Modified dense star polymers
GB8827305D0 (en) 1988-11-23 1988-12-29 British Bio Technology Compounds
US5348154A (en) * 1989-05-10 1994-09-20 Minnesota Mining And Manufacturing Company Packaging curable materials
DE69004245T2 (de) * 1990-02-23 1994-05-11 Minnesota Mining & Mfg Semi-thermoplastische Formmasse mit thermostabilem Formerinnerungsvermögen.
US5066231A (en) * 1990-02-23 1991-11-19 Minnesota Mining And Manufacturing Company Dental impression process using polycaprolactone molding composition
US5102332A (en) * 1991-02-25 1992-04-07 Ticore Dental Systems Braided fiber dental retainer and container therefor
US5135545A (en) * 1991-03-22 1992-08-04 The Dow Chemical Company Method for making machinable abrasive greenware
US5192207A (en) * 1991-09-17 1993-03-09 Rosellini Davey G Composite resin crown, replacement tooth and method
SE9200564L (sv) * 1992-02-26 1993-03-15 Perstorp Ab Dendritisk makromolekyl av polyestertyp, foerfarande foer framstaellning daerav samt anvaendning daerav
US5455258A (en) 1993-01-06 1995-10-03 Ciba-Geigy Corporation Arylsulfonamido-substituted hydroxamic acids
US5914185A (en) * 1993-01-19 1999-06-22 Shoher; Itzhak Moldable dental material composition
US5401169A (en) * 1993-06-10 1995-03-28 Minnesota Mining And Manufacturing Multiple-part dental material delivery system
JP3690825B2 (ja) * 1993-07-26 2005-08-31 エーザイ株式会社 三環式ヘテロ環含有スルホンアミドおよびスルホン酸エステル誘導体
ATE225334T1 (de) * 1993-07-26 2002-10-15 Eisai Co Ltd Sulfonamide und sulfonsäure-ester mit je einem trizyclischen heteroring
US5487663A (en) * 1993-08-16 1996-01-30 Wilson; George M. Oral appliances and method
US5863949A (en) 1995-03-08 1999-01-26 Pfizer Inc Arylsulfonylamino hydroxamic acid derivatives
US5538129A (en) * 1995-03-21 1996-07-23 Minnesota Mining And Manufacturing Company Package for adhesive precoated dental appliance
ES2153031T4 (es) 1995-04-20 2001-05-16 Pfizer Derivados del acido arilsulfonil hidroxamico como inhibidores de mmp y tnf.
CN1196679A (zh) * 1995-07-19 1998-10-21 麦克公司 结肠腺瘤治疗方法
US5919870A (en) * 1995-07-31 1999-07-06 Fmc Corporation Functional telechelic star polymers
ATE225343T1 (de) 1995-12-20 2002-10-15 Hoffmann La Roche Matrix-metalloprotease inhibitoren
US6057383A (en) * 1996-06-18 2000-05-02 Ivoclar Ag Dental material based on polymerizable waxes
EP0818442A3 (fr) 1996-07-12 1998-12-30 Pfizer Inc. Dérivés cycliques de sulfones comme inhibiteurs de métalloprotéinase et de la production du facteur de nécrose des tumeurs
KR20000067904A (ko) 1996-07-18 2000-11-25 디. 제이. 우드, 스피겔 알렌 제이 매트릭스 메탈로프로테아제의 포스피네이트계 억제제
KR20000068248A (ko) 1996-08-23 2000-11-25 디. 제이. 우드, 스피겔 알렌 제이 아릴설포닐아미노 하이드록삼산 유도체
US5797236A (en) * 1996-09-09 1998-08-25 Posey, Jr.; John T. Auxiliary bottom insert apparatus for a container
US5785178A (en) * 1996-11-04 1998-07-28 Minnesota Mining And Manufacturing Co. Packaged photocurable composition
JP3338064B2 (ja) 1997-01-06 2002-10-28 ファイザー・インク 環状スルホン誘導体
NZ336840A (en) 1997-02-03 2001-01-26 Pfizer Prod Inc Arylsulfonylamino hydroxamic acid derivatives useful in the treatment of tumor necrosis factor and matrix metalloproteinase mediated diseases
JP2000507975A (ja) 1997-02-07 2000-06-27 ファイザー・インク Ｎ−ヒドロキシ−β−スルホニルプロピオンアミド誘導体類及びそれらのマトリックスメタロプロテイナーゼ阻害薬としての使用
EP0960098A1 (fr) 1997-02-11 1999-12-01 Pfizer Inc. Derives de l'acide arylsulfonylhydroxamique
US6353040B1 (en) * 1997-04-02 2002-03-05 Dentsply Research & Development Corp. Dental composite restorative material and method of restoring a tooth
JPH10277061A (ja) * 1997-04-04 1998-10-20 Injietsukusu:Kk 支台歯模型および歯冠修復物の製造方法
USD403768S (en) * 1997-05-09 1999-01-05 Minnesota Mining And Manufacturing Company Fiber tip applicator
US5775913A (en) * 1997-05-27 1998-07-07 Updyke; John R. Process for minimal time tooth capping
US6506816B1 (en) * 1997-07-17 2003-01-14 3M Innovative Properties Company Dental resin cements having improved handling properties
CA2299355C (fr) 1997-08-08 2005-09-27 Pfizer Products Inc. Derives de l'acide aryloxyarylsulfonylamino hydroxamique
DE19736471A1 (de) * 1997-08-21 1999-02-25 Espe Dental Ag Lichtinduziert kationisch härtende Zusammensetzungen und deren Verwendung
US6002336A (en) 1997-12-02 1999-12-14 Lynx System Developers, Inc. Reaction time measurement system
GB9725782D0 (en) 1997-12-05 1998-02-04 Pfizer Ltd Therapeutic agents
US6186790B1 (en) * 1998-04-13 2001-02-13 Jeneric/Pentron Incorporated Prefabricated components for dental appliances
US6345984B2 (en) * 1998-04-13 2002-02-12 Jeneric/Pentron, Inc. Prefabricated components for dental appliances
GB9801690D0 (en) 1998-01-27 1998-03-25 Pfizer Ltd Therapeutic agents
US5876209A (en) * 1998-02-27 1999-03-02 Letcher; William F. Method of manufacturing a dental crown
JP4462654B2 (ja) 1998-03-26 2010-05-12 ソニー株式会社 映像素材選択装置及び映像素材選択方法
PA8469501A1 (es) 1998-04-10 2000-09-29 Pfizer Prod Inc Hidroxamidas del acido (4-arilsulfonilamino)-tetrahidropiran-4-carboxilico
PA8469401A1 (es) 1998-04-10 2000-05-24 Pfizer Prod Inc Derivados biciclicos del acido hidroxamico
US6187836B1 (en) * 1998-06-05 2001-02-13 3M Innovative Properties Company Compositions featuring cationically active and free radically active functional groups, and methods for polymerizing such compositions
US6127450A (en) * 1998-06-09 2000-10-03 Kerr Corporation Dental restorative composite
US6359090B1 (en) * 1998-06-09 2002-03-19 Kerr Corporation Polymerizable dispersant
IT245694Y1 (it) * 1998-07-27 2002-03-22 Rini Guido Confezione per denti artificiali ad uso protesico
US6252014B1 (en) * 1998-08-04 2001-06-26 Colorado School Of Mines Star polymers and polymeric particles in the nanometer-sized range by step growth reactions
US6196840B1 (en) * 1998-08-14 2001-03-06 Dentsply Research & Development Corp. Custom fitting variable dimension dental impression tray, product and method
EP1004578B1 (fr) 1998-11-05 2004-02-25 Pfizer Products Inc. Dérivés d'hydroxamide de l'acide 5-oxo-pyrrolidine-2-carboxylique
CA2349832A1 (fr) * 1999-01-13 2000-07-20 Warner-Lambert Company Derives de benzenesulfonamide et leur utilisation comme inhibiteurs de mek
US6318994B1 (en) * 1999-05-13 2001-11-20 Align Technology, Inc Tooth path treatment plan
GB9912961D0 (en) 1999-06-03 1999-08-04 Pfizer Ltd Metalloprotease inhibitors
HUP0202381A3 (en) * 1999-07-16 2004-12-28 Warner Lambert Co Method for treating chronic pain using mek inhibitors
US6183249B1 (en) * 1999-07-29 2001-02-06 3M Innovative Properties Company Release substrate for adhesive precoated orthodontic appliances
US6572693B1 (en) * 1999-10-28 2003-06-03 3M Innovative Properties Company Aesthetic dental materials
US20020117393A1 (en) * 2000-10-13 2002-08-29 Sun Benjamin J. Licht curing system and method
US6592369B2 (en) * 2000-09-26 2003-07-15 Dentsply Research & Development Corp. Wax-like polymerizable dental material, method and shaped product
US7566412B2 (en) * 1999-11-10 2009-07-28 Dentsply International Inc. Dental method and device
US7175433B2 (en) * 1999-11-10 2007-02-13 Dentsply International Inc. Dental material and method
US6382980B1 (en) * 2000-03-21 2002-05-07 Itzhak Shoher Compact dental multi-layered material for crown and bridge prosthodontics and method
WO2001074301A1 (fr) * 2000-04-03 2001-10-11 3M Innovative Properties Company Produits dentaires dotes de temps de travail extensible, kits et procedes
US6448301B1 (en) * 2000-09-08 2002-09-10 3M Innovative Properties Company Crosslinkable polymeric compositions and use thereof
US20070018346A1 (en) * 2000-09-26 2007-01-25 Sun Benjamin J Light curing system and method
US20020102519A1 (en) * 2001-01-26 2002-08-01 Lloyd Baum Dental prostheses fabrication method using pre-contoured impressionable pattern
US6635690B2 (en) * 2001-06-19 2003-10-21 3M Innovative Properties Company Reactive oligomers
JP5329734B2 (ja) * 2001-08-15 2013-10-30 スリーエム イノベイティブ プロパティズ カンパニー 硬化性自己支持形構造および方法
US7134875B2 (en) * 2002-06-28 2006-11-14 3M Innovative Properties Company Processes for forming dental materials and device
US8956160B2 (en) * 2002-07-02 2015-02-17 Ranir, Llc Device and method for delivering an oral care agent
CN100579579C (zh) 2002-10-01 2010-01-13 诺华疫苗和诊断公司 抗癌及抗感染性疾病组合物及其使用方法
US6989124B2 (en) * 2003-01-24 2006-01-24 Husky Injection Molding Systems Ltd. Apparatus and method for removing a molded article from a mold
TW200505834A (en) * 2003-03-18 2005-02-16 Sankyo Co Sulfamide derivative and the pharmaceutical composition thereof
US20050042576A1 (en) * 2003-08-19 2005-02-24 Oxman Joel D. Dental article forms and methods
US20050040551A1 (en) * 2003-08-19 2005-02-24 Biegler Robert M. Hardenable dental article and method of manufacturing the same
US20050042577A1 (en) * 2003-08-19 2005-02-24 Kvitrud James R. Dental crown forms and methods
CN1905873A (zh) * 2003-11-19 2007-01-31 阵列生物制药公司 Mek的杂环抑制剂及其使用方法
US20050147944A1 (en) * 2003-12-31 2005-07-07 Naimul Karim Curable dental mill blanks and related methods
EP1828184B1 (fr) * 2004-12-01 2009-09-16 Merck Serono SA Dérivés de [1,2,4]triazolo[4,3-a]pyridine pour le traitement de maladies hyperprolifératives
CA2618218C (fr) * 2005-07-21 2015-06-30 Ardea Biosciences, Inc. Inhibiteurs n-(arylamino)-sulfonamide de mek
US7960567B2 (en) * 2007-05-02 2011-06-14 Amgen Inc. Compounds and methods useful for treating asthma and allergic inflammation

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MX2009007661A (es) 2009-12-14
EP2121620A1 (fr) 2009-11-25
US20080255133A1 (en) 2008-10-16
KR20090111847A (ko) 2009-10-27
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BRPI0806898A2 (pt) 2015-07-14
CA2675358A1 (fr) 2008-07-24
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US8063049B2 (en) 2011-11-22
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JP5491199B2 (ja) 2014-05-14
IL199727A0 (en) 2010-04-15
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WO2008089459A1 (fr) 2008-07-24

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