PL2252609T3 - Pochodne pirydyn-2-ylu jako środki immunomodulujące - Google Patents

Pochodne pirydyn-2-ylu jako środki immunomodulujące

Info

Publication number
PL2252609T3
PL2252609T3 PL09716943T PL09716943T PL2252609T3 PL 2252609 T3 PL2252609 T3 PL 2252609T3 PL 09716943 T PL09716943 T PL 09716943T PL 09716943 T PL09716943 T PL 09716943T PL 2252609 T3 PL2252609 T3 PL 2252609T3
Authority
PL
Poland
Prior art keywords
pyridin
derivatives
immunomodulating agents
immunomodulating
agents
Prior art date
Application number
PL09716943T
Other languages
English (en)
Inventor
Martin Bolli
Cyrille Lescop
Boris Mathys
Claus Mueller
Oliver Nayler
Beat Steiner
Original Assignee
Idorsia Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40584746&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2252609(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Idorsia Pharmaceuticals Ltd filed Critical Idorsia Pharmaceuticals Ltd
Publication of PL2252609T3 publication Critical patent/PL2252609T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
PL09716943T 2008-03-07 2009-02-25 Pochodne pirydyn-2-ylu jako środki immunomodulujące PL2252609T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IB2008050848 2008-03-07
PCT/IB2009/050749 WO2009109872A1 (en) 2008-03-07 2009-02-25 Pyridin-2-yl derivatives as immunomodulating agents
EP09716943.7A EP2252609B1 (en) 2008-03-07 2009-02-25 Pyridin-2-yl derivatives as immunomodulating agents

Publications (1)

Publication Number Publication Date
PL2252609T3 true PL2252609T3 (pl) 2013-09-30

Family

ID=40584746

Family Applications (1)

Application Number Title Priority Date Filing Date
PL09716943T PL2252609T3 (pl) 2008-03-07 2009-02-25 Pochodne pirydyn-2-ylu jako środki immunomodulujące

Country Status (26)

Country Link
US (1) US8575200B2 (pl)
EP (1) EP2252609B1 (pl)
JP (1) JP5435745B2 (pl)
KR (1) KR101615779B1 (pl)
CN (1) CN102015695B (pl)
AR (1) AR070858A1 (pl)
AU (1) AU2009220861B2 (pl)
BR (1) BRPI0909055A2 (pl)
CA (1) CA2715437C (pl)
CL (1) CL2009000532A1 (pl)
CY (1) CY1114096T1 (pl)
DK (1) DK2252609T3 (pl)
ES (1) ES2414533T3 (pl)
HR (1) HRP20130641T1 (pl)
IL (1) IL207972A (pl)
MA (1) MA32173B1 (pl)
MX (1) MX2010009644A (pl)
MY (1) MY183039A (pl)
NZ (1) NZ588438A (pl)
PL (1) PL2252609T3 (pl)
PT (1) PT2252609E (pl)
RU (1) RU2494099C2 (pl)
SI (1) SI2252609T1 (pl)
TW (1) TWI444377B (pl)
WO (1) WO2009109872A1 (pl)
ZA (1) ZA201007136B (pl)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5253401B2 (ja) * 2006-09-07 2013-07-31 アクテリオン ファーマシューティカルズ リミテッド 免疫調節薬としてのピリジン−４−イル誘導体
CL2007002594A1 (es) * 2006-09-08 2008-06-06 Actelion Pharmaceuticals Ltd Compuestos derivados de piridin-3-il, agentes inmunomoduladores; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto en el tratamiento de enfermedades asociadas con un sistema inmunologico activado. .
CA2662673A1 (en) * 2006-09-21 2008-03-27 Martin Bolli Phenyl derivatives and their use as immunomodulators
DK2125797T3 (da) * 2007-03-16 2014-02-10 Actelion Pharmaceuticals Ltd Aminopyridinderivater som s1p1/edg1-receptoragonister
EP2195311B1 (en) * 2007-08-17 2011-03-23 Actelion Pharmaceuticals Ltd. Pyridine derivatives as s1p1/edg1 receptor modulators
BRPI0818804A2 (pt) * 2007-11-01 2015-04-22 Actelion Pharmaceuticals Ltd Composto derivado de pirimidina, composição farmacêutica que o compreende e uso desse composto.
TWI410421B (zh) 2009-07-16 2013-10-01 Actelion Pharmaceuticals Ltd 吡啶－４－基衍生物
JP5778755B2 (ja) * 2010-04-15 2015-09-16 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ ヒドロキノンの製造方法
CA2818470C (en) 2011-01-19 2019-03-05 Actelion Pharmaceuticals Ltd 2-methoxy-pyridin-4-yl derivatives
HRP20171763T1 (hr) * 2013-03-15 2017-12-29 Idorsia Pharmaceuticals Ltd Derivati piridin-4-ila
ES2770348T3 (es) 2015-05-20 2020-07-01 Idorsia Pharmaceuticals Ltd Forma cristalina del compuesto (s)-3-{4-[5-(2-ciclopentil-6-metoxi-piridin-4-il)-[1,2,4]oxadiazol-3-il]-2-etil-6-metil-fenoxi}-propano-1,2-diol

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL31990A (en) * 1968-04-26 1974-05-16 Chinoin Gyogyszer Es Vegyeszet Pyridyl 1,2,4-oxadiazole derivatives,process for the preparation thereof and pharmaceutical compositions containing same
AU653957B2 (en) 1990-09-20 1994-10-20 Merrell Dow Pharmaceuticals Inc. 1-aryl-3-pyridinyl-2-propene-1-ones
DE4429465A1 (de) 1994-08-19 1996-02-22 Bayer Ag Verfahren zur Herstellung von 2-Halogenpyridinaldehyden und neue 2-Halogenpyridinaldehyde
JP2003034684A (ja) * 2001-06-29 2003-02-07 Biofor Inc 新規な種類の抗真菌剤
EP1549640A4 (en) * 2002-06-17 2008-08-06 Merck & Co Inc 1 - ((5-ARYL-1,2,4-OXADIAZOL-3-YL) BENZYL) AZETIDINE-3-CARBOXYLATE AND 1 - ((5-ARYL-1,2,4-OXADIAZOL-3-YL) BENZYL) PYRROLIDIN-3-CARBOXYLATE AS EDG RECEPTOR AGONISTS
DE10237883A1 (de) 2002-08-19 2004-03-04 Merckle Gmbh Chem.-Pharm. Fabrik Substituierte Isoxazolderivate und ihre Verwendung in der Pharmazie
AU2003279915A1 (en) * 2002-10-15 2004-05-04 Merck And Co., Inc. Process for making azetidine-3-carboxylic acid
WO2005032465A2 (en) * 2003-10-01 2005-04-14 Merck & Co., Inc. 3,5-aryl, heteroaryl or cycloalkyl substituted-1,2,4-oxadiazoles as s1p receptor agonists
US7605171B2 (en) * 2003-12-17 2009-10-20 Merck & Co., Inc. (3,4-disubstituted)propanoic carboxylates as S1P (Edg) receptor agonists
WO2006001463A1 (ja) * 2004-06-23 2006-01-05 Ono Pharmaceutical Co., Ltd. Ｓ１ｐ受容体結合能を有する化合物およびその用途
WO2006010379A1 (en) * 2004-07-29 2006-02-02 Actelion Pharmaceuticals Ltd. Novel thiophene derivatives as immunosuppressive agents
CA2591399C (en) * 2004-12-13 2014-05-20 Ono Pharmaceutical Co., Ltd. Aminocarboxylic acid derivative and medicinal use thereof
ES2370791T3 (es) * 2005-03-23 2011-12-22 Actelion Pharmaceuticals Ltd. Nuevos derivados de tiofeno como agonistas del receptor de esfingosina-1-fosfato-1.
WO2006100633A1 (en) * 2005-03-23 2006-09-28 Actelion Pharmaceuticals Ltd NOVEL THIOPHENE DERIVATIVES AS SPHINGOSINE-l-PHOSPHATE-1 RECEPTOR AGONISTS
JP5047941B2 (ja) * 2005-03-23 2012-10-10 アクテリオン ファーマシューティカルズ リミテッド 免疫調節物質としての水素付加されたベンゾ（ｃ）チオフェン誘導体
BRPI0610514A2 (pt) * 2005-04-05 2016-11-16 Pharmacopeia Inc composto, composição farmacêutica, e, método de tratamento de um distúrbio
WO2006115188A1 (ja) 2005-04-22 2006-11-02 Daiichi Sankyo Company, Limited ヘテロ環化合物
RU2007147940A (ru) * 2005-06-08 2009-07-20 Новартис АГ (CH) Полициклические оксадиазолы или изоксазолы и их применение в качестве лигандов s1p рецептора
US20080306124A1 (en) * 2005-06-08 2008-12-11 Rainer Albert Polycyclic Oxadiazoles or I Soxazoles and Their Use as Sip Receptor Ligands
WO2006135694A2 (en) * 2005-06-10 2006-12-21 Acadia Pharmaceuticals Inc. Uii-modulating compounds and their use
CA2612661A1 (en) * 2005-06-24 2006-12-28 Actelion Pharmaceuticals Ltd. Novel thiophene derivatives
AR057894A1 (es) * 2005-11-23 2007-12-26 Actelion Pharmaceuticals Ltd Derivados de tiofeno
TWI404706B (zh) * 2006-01-11 2013-08-11 Actelion Pharmaceuticals Ltd 新穎噻吩衍生物
CN101370805B (zh) * 2006-01-24 2011-04-27 埃科特莱茵药品有限公司 吡啶衍生物
EA200802058A1 (ru) * 2006-05-09 2009-06-30 Пфайзер Продактс Инк. Производные циклоалкиламинокислот и их фармацевтические композиции
AR061841A1 (es) * 2006-09-07 2008-09-24 Actelion Pharmaceuticals Ltd Derivados de tiofen-oxadiazoles, agonistas del receptor s1p1/edg1, composiciones farmaceuticas que los contienen y usos como agentes inmunomoduladores.
JP5253401B2 (ja) * 2006-09-07 2013-07-31 アクテリオン ファーマシューティカルズ リミテッド 免疫調節薬としてのピリジン−４−イル誘導体
CL2007002594A1 (es) * 2006-09-08 2008-06-06 Actelion Pharmaceuticals Ltd Compuestos derivados de piridin-3-il, agentes inmunomoduladores; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto en el tratamiento de enfermedades asociadas con un sistema inmunologico activado. .
CA2662673A1 (en) * 2006-09-21 2008-03-27 Martin Bolli Phenyl derivatives and their use as immunomodulators
CN101522646A (zh) * 2006-09-29 2009-09-02 诺瓦提斯公司 具有抗炎和免疫抑制特性的二唑衍生物
JP2008120794A (ja) 2006-10-16 2008-05-29 Daiichi Sankyo Co Ltd ヘテロ環化合物を含有する医薬組成物
RU2009127095A (ru) * 2006-12-15 2011-01-20 Эбботт Лэборетриз (Us) Новые оксадиазольные соединения
DK2125797T3 (da) * 2007-03-16 2014-02-10 Actelion Pharmaceuticals Ltd Aminopyridinderivater som s1p1/edg1-receptoragonister
EP2195311B1 (en) * 2007-08-17 2011-03-23 Actelion Pharmaceuticals Ltd. Pyridine derivatives as s1p1/edg1 receptor modulators
BRPI0818804A2 (pt) * 2007-11-01 2015-04-22 Actelion Pharmaceuticals Ltd Composto derivado de pirimidina, composição farmacêutica que o compreende e uso desse composto.
BRPI0820868A2 (pt) * 2007-12-10 2019-09-24 Actelion Pharmaceuticals Ltd composto de tiofeno fórmula(i), composição farmacêutica contendo o mesmo e uso deste para a prevenção ou tratamento de doenças ou disturbíos associados a um sistema imune ativado
CN101965345B (zh) * 2008-03-06 2014-05-28 埃科特莱茵药品有限公司 吡啶化合物
EP2262800A1 (en) * 2008-03-06 2010-12-22 Actelion Pharmaceuticals Ltd. Novel pyrimidine-pyridine derivatives
MX2010009645A (es) * 2008-03-07 2010-09-28 Actelion Pharmaceuticals Ltd Derivados novedosos de aminometil benceno.
TWI410421B (zh) * 2009-07-16 2013-10-01 Actelion Pharmaceuticals Ltd 吡啶－４－基衍生物

Also Published As

Publication number Publication date
AU2009220861B2 (en) 2014-05-29
ES2414533T3 (es) 2013-07-19
CN102015695B (zh) 2014-08-27
CA2715437A1 (en) 2009-09-11
CN102015695A (zh) 2011-04-13
TWI444377B (zh) 2014-07-11
MX2010009644A (es) 2010-09-22
BRPI0909055A2 (pt) 2019-02-26
JP5435745B2 (ja) 2014-03-05
KR20100137493A (ko) 2010-12-30
AR070858A1 (es) 2010-05-12
RU2494099C2 (ru) 2013-09-27
CY1114096T1 (el) 2016-07-27
SI2252609T1 (sl) 2013-07-31
NZ588438A (en) 2012-05-25
JP2011513381A (ja) 2011-04-28
EP2252609B1 (en) 2013-04-17
DK2252609T3 (da) 2013-06-24
WO2009109872A1 (en) 2009-09-11
CL2009000532A1 (es) 2010-04-09
RU2010140854A (ru) 2012-04-20
CA2715437C (en) 2016-05-24
IL207972A (en) 2016-03-31
KR101615779B1 (ko) 2016-04-26
PT2252609E (pt) 2013-06-24
TW200940532A (en) 2009-10-01
ZA201007136B (en) 2014-03-26
US8575200B2 (en) 2013-11-05
AU2009220861A1 (en) 2009-09-11
IL207972A0 (en) 2010-12-30
MA32173B1 (fr) 2011-03-01
MY183039A (en) 2021-02-08
HRP20130641T1 (en) 2013-08-31
HK1150601A1 (en) 2012-01-06
US20100331372A1 (en) 2010-12-30
EP2252609A1 (en) 2010-11-24

Similar Documents

Publication Publication Date Title
PT2069335E (pt) Derivados de piridin-3-ilo como agentes imunomoduladores
IL197393A0 (en) Pyridin-4-yl derivatives as immunomodulating agents
IL235745A (en) Annotated 2-Aminopyridine
IL210548A0 (en) Spiroaminodihydrothiazine derivatives
IL212285A0 (en) Azaindole derivatives
ZA201100799B (en) Imidazopyridin-2-one derivatives
IL207972A0 (en) Pyridin-2-yl derivatives as immunomodulating agents
SG10201506608RA (en) 3-deazaneplanocin derivatives
IL206276A0 (en) Pyridine derivatives
IL210406A0 (en) Pyrrolopyridinylpyrimidin - 2 - ylamine derivatives
ZA201102449B (en) Morpholinopurine derivatives
IL211241A0 (en) 7-azaindole derivatives
IL208336A0 (en) Pyrisazinone derivatives
IL210869A0 (en) Imidazothiadiazoles derivatives
IL213424A0 (en) Quinazolinamide derivatives
ZA201100948B (en) Acylaminobenzamide derivatives
IL210164A0 (en) Thiazolylpiperidine derivatives
IL207231A0 (en) Substituted arylamide oxazepinopyrimidone derivatives
IL207192A0 (en) Substituted heteroarylamide diazepinopyrimidone derivatives
IL207191A0 (en) Substituted heteroaylamide oxazepyrimidone derivatives
ZA201008052B (en) 2-phenyl-4-cyclopropyl-pyrimidine derivatives
EP2448934A4 (en) DERIVATIVES OF 2-CARBOXAMIDE-7-PIPERAZINYL-BENZOFURAN
ZA201007615B (en) Aminopyridine derivatives
IL218500A0 (en) Apogossypolone derivatives as anticaner agents
EP2301922A4 (en) pyridone