MA32223B1 - Combinaisons de conjugues anticorps anti-her2-medicament et d'agents chimiotherapiques, et procedes d'utilisation - Google Patents

Combinaisons de conjugues anticorps anti-her2-medicament et d'agents chimiotherapiques, et procedes d'utilisation

Info

Publication number
MA32223B1
MA32223B1 MA33240A MA33240A MA32223B1 MA 32223 B1 MA32223 B1 MA 32223B1 MA 33240 A MA33240 A MA 33240A MA 33240 A MA33240 A MA 33240A MA 32223 B1 MA32223 B1 MA 32223B1
Authority
MA
Morocco
Prior art keywords
combinations
her2
methods
chemotherapeutic agents
antibody conjugates
Prior art date
Application number
MA33240A
Other languages
Arabic (ar)
English (en)
Inventor
Leanne Berry
Gail Lewis Phillips
Mark X Sliwkowski
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40858064&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA32223(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of MA32223B1 publication Critical patent/MA32223B1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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  • General Chemical & Material Sciences (AREA)
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Abstract

L'invention concerne des combinaisons du conjugué anticorps-médicament trastuzumab-mcc-dm1 et d'agents chimiothérapiques, y compris des stéréoisomères, des isomères géométriques, des tautomères, des solvates, des métabolites et des sels de qualité pharmaceutique de ceux-ci, qui s'utilisent pour inhiber la croissance de cellules de tumeur, et pour traiter des troubles tels qu'un cancer à médiation par her2 et kdr (récepteur 1 de vegfr). Des procédés d'utilisation de telles combinaisons pour un diagnostic, une prévention ou un traitement in vitro, in situ et in vivo de tels troubles dans des cellules de mammifère, ou d'affections pathologiques associées, sont divulgués.
MA33240A 2008-03-18 2010-10-11 Combinaisons de conjugues anticorps anti-her2-medicament et d'agents chimiotherapiques, et procedes d'utilisation MA32223B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3741008P 2008-03-18 2008-03-18
PCT/US2009/036608 WO2009117277A2 (fr) 2008-03-18 2009-03-10 Combinaisons de conjugués anticorps anti-her2-médicament et d’agents chimiothérapiques, et procédés d’utilisation

Publications (1)

Publication Number Publication Date
MA32223B1 true MA32223B1 (fr) 2011-04-01

Family

ID=40858064

Family Applications (1)

Application Number Title Priority Date Filing Date
MA33240A MA32223B1 (fr) 2008-03-18 2010-10-11 Combinaisons de conjugues anticorps anti-her2-medicament et d'agents chimiotherapiques, et procedes d'utilisation

Country Status (28)

Country Link
US (6) US8663643B2 (fr)
EP (6) EP2644204B1 (fr)
JP (5) JP5656823B2 (fr)
KR (9) KR102449659B1 (fr)
CN (5) CN104888232B (fr)
AR (1) AR070865A1 (fr)
AU (1) AU2009225877B2 (fr)
BR (1) BRPI0906181A2 (fr)
CA (3) CA3146422C (fr)
CL (1) CL2009000559A1 (fr)
CR (2) CR20180483A (fr)
DK (3) DK2644194T3 (fr)
ES (4) ES2545977T3 (fr)
HU (3) HUE035182T2 (fr)
IL (8) IL274393B (fr)
MA (1) MA32223B1 (fr)
MX (3) MX2010010168A (fr)
MY (5) MY201555A (fr)
NZ (4) NZ621433A (fr)
PH (4) PH12014502134B1 (fr)
PL (4) PL2644204T3 (fr)
RU (2) RU2510272C2 (fr)
SG (3) SG10201401941RA (fr)
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