MA32449B1 - Agents de liaison de notch et antagonistes de notch ainsi que procedes d'utilisation correspondants - Google Patents

Agents de liaison de notch et antagonistes de notch ainsi que procedes d'utilisation correspondants

Info

Publication number
MA32449B1
MA32449B1 MA33484A MA33484A MA32449B1 MA 32449 B1 MA32449 B1 MA 32449B1 MA 33484 A MA33484 A MA 33484A MA 33484 A MA33484 A MA 33484A MA 32449 B1 MA32449 B1 MA 32449B1
Authority
MA
Morocco
Prior art keywords
notch
antagonists
binding agents
corresponding methods
tumor growth
Prior art date
Application number
MA33484A
Other languages
Arabic (ar)
English (en)
Inventor
Austin L Gurney
Timothy Charles Hoey
Van Der Horst Edward Thein Htun
Aaron Ken Sato
Yuan Ching Liu
Maureen Fitch Bruhns
John A Lewicki
Original Assignee
Oncomed Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncomed Pharm Inc filed Critical Oncomed Pharm Inc
Publication of MA32449B1 publication Critical patent/MA32449B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3046—Stomach, Intestines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/462—Igs containing a variable region (Fv) from one specie and a constant region (Fc) from another
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/464—Igs containing CDR-residues from one specie grafted between FR-residues from another
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/18—Kallidins; Bradykinins; Related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/22—Tachykinins, e.g. Eledoisins, Substance P; Related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0693—Tumour cells; Cancer cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/998—Proteins not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • Mycology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des agents de liaison de Notch et des antagonistes de Notch ainsi que des procédés d'utilisation des agents et/ou des antagonistes pour le traitement de maladies comme le cancer. On décrit des anticorps qui se lient spécifiquement avec une zone de liaison hors ligand du domaine extracellulaire d'un ou plusieurs récepteurs Notch humains, du type Notch2 et/ou Notch3 et inhibent la croissance tumorale. L'invention concerne en outre des procédés de traitement du cancer, qui consistent à administrer une quantité thérapeutiquement efficace d'anticorps se liant spécifiquement à une zone de liaison hors ligand du domaine extracellulaire d'une protéine de récepteur Notch humains et inhibe la croissance tumorale
MA33484A 2008-07-08 2011-01-03 Agents de liaison de notch et antagonistes de notch ainsi que procedes d'utilisation correspondants MA32449B1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US7909508P 2008-07-08 2008-07-08
US11269908P 2008-11-07 2008-11-07
US11270108P 2008-11-07 2008-11-07
PCT/US2009/003994 WO2010005566A2 (fr) 2008-07-08 2009-07-08 Agents de liaison de notch et antagonistes de notch ainsi que procédés d'utilisation correspondants

Publications (1)

Publication Number Publication Date
MA32449B1 true MA32449B1 (fr) 2011-07-03

Family

ID=41507637

Family Applications (2)

Application Number Title Priority Date Filing Date
MA33483A MA32448B1 (fr) 2008-07-08 2011-01-03 Agents de liaison de recepteur notch1 et procedes d'utilisation
MA33484A MA32449B1 (fr) 2008-07-08 2011-01-03 Agents de liaison de notch et antagonistes de notch ainsi que procedes d'utilisation correspondants

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MA33483A MA32448B1 (fr) 2008-07-08 2011-01-03 Agents de liaison de recepteur notch1 et procedes d'utilisation

Country Status (31)

Country Link
US (11) US8435513B2 (fr)
EP (4) EP2307051B1 (fr)
JP (2) JP5560271B2 (fr)
KR (2) KR101640099B1 (fr)
CN (3) CN102316897B (fr)
AU (2) AU2009269095B2 (fr)
BR (2) BRPI0914004A2 (fr)
CA (2) CA2729602A1 (fr)
CO (2) CO6390041A2 (fr)
CR (1) CR20110069A (fr)
CY (2) CY1116195T1 (fr)
DK (2) DK2307459T3 (fr)
DO (2) DOP2011000004A (fr)
EA (2) EA026109B1 (fr)
ES (2) ES2535614T3 (fr)
HR (2) HRP20150443T1 (fr)
IL (2) IL210222A (fr)
MA (2) MA32448B1 (fr)
ME (2) ME02148B (fr)
MX (2) MX2011000236A (fr)
MY (2) MY159815A (fr)
NZ (2) NZ590127A (fr)
PL (2) PL2307459T3 (fr)
PT (2) PT2307051E (fr)
RS (2) RS53750B1 (fr)
SG (2) SG192467A1 (fr)
SI (2) SI2307051T1 (fr)
SM (2) SMT201500047B (fr)
UA (1) UA101672C2 (fr)
WO (2) WO2010005566A2 (fr)
ZA (2) ZA201009280B (fr)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6984522B2 (en) * 2000-08-03 2006-01-10 Regents Of The University Of Michigan Isolation and use of solid tumor stem cells
WO2007136856A2 (fr) * 2006-05-19 2007-11-29 The Johns Hopkins University Heyl utilisé en tant que cible thérapeutique et en tant que marqueur diagnostique d'une néoplasie et utilisations correspondantes
PL2032166T3 (pl) 2006-06-13 2013-09-30 Oncomed Pharm Inc Kompozycje i sposoby diagnozowania i leczenia nowotworów
NZ577274A (en) 2006-12-18 2012-10-26 Genentech Inc Antagonist anti-notch3 antibodies and their use in the prevention and treatment of notch3-related diseases
US8088617B2 (en) 2007-01-24 2012-01-03 Oncomed Pharmaceuticals, Inc. Antibodies that bind the glutamate ligand binding region of Notch1
US9132189B2 (en) 2008-07-08 2015-09-15 Oncomed Pharmaceuticals, Inc. Notch1 binding agents and methods of use thereof
EP2307051B1 (fr) 2008-07-08 2015-02-11 OncoMed Pharmaceuticals, Inc. Agents de liaison de notch et antagonistes de notch ainsi que procédés d'utilisation correspondants
AU2009298569A1 (en) * 2008-10-01 2010-04-08 Genentech, Inc. Anti-Notch2 antibodies and methods of use
PE20121494A1 (es) 2009-06-18 2012-11-01 Pfizer Anticuerpos anti notch-1
CA2775880A1 (fr) * 2009-09-30 2011-04-07 Genentech, Inc. Anticorps antagonistes anti-notch3 servant a traiter des leucemies a lymphocytes t reagissant a un inhibiteur de secretase gamma et ne reagissant pas a un anticorps antagoniste anti-notch1
US8883145B2 (en) 2009-10-16 2014-11-11 Oncomed Pharmaceuticals, Inc. Methods of treatment with DLL4 antagonists and an anti-hypertensive agent
WO2011088215A2 (fr) 2010-01-13 2011-07-21 Oncomed Pharmaceuticals, Inc. Agents de liaison notch1 et leurs procédés d'utilisation
CA2787673A1 (fr) 2010-03-01 2011-09-09 Tau Therapeutics Llc Diagnostic du cancer et imagerie
CN102958941A (zh) * 2010-05-03 2013-03-06 霍夫曼-拉罗奇有限公司 用于肿瘤诊断和治疗的组合物和方法
MX346995B (es) 2010-12-15 2017-04-06 Wyeth Llc Anticuerpos anti-notch1.
US20130058947A1 (en) * 2011-09-02 2013-03-07 Stem Centrx, Inc Novel Modulators and Methods of Use
CA2848311A1 (fr) * 2011-09-12 2013-03-21 Tau Therapeutics Llc Antagonistes des produits du groupe unigene hs.459642 pour inhiber la proliferation, le developpement ou la differenciation des cellules souches comprenant des cellules souches cancereuses
JP6170496B2 (ja) 2011-09-23 2017-07-26 オンコメッド ファーマシューティカルズ インコーポレイテッド Ｖｅｇｆ／ｄｌｌ４結合剤およびその使用
TW201329105A (zh) * 2011-10-04 2013-07-16 Thr Trustees Of Columbia University In The City Of New York 人類ｎｏｔｃｈ１引誘物
US9663573B2 (en) 2011-10-05 2017-05-30 Genentech, Inc. Methods of treating liver conditions using Notch2 antagonists
CA2864197A1 (fr) * 2011-11-16 2013-05-23 Oncomed Pharmaceuticals, Inc. Mutations du recepteur notch humain et leur utilisation
KR101535219B1 (ko) * 2011-11-18 2015-07-09 한국생명공학연구원 Ｎｏｔｃｈ３에 대한 인간 단일클론항체
US9534058B2 (en) 2012-02-08 2017-01-03 Abbvie Stemcentrx Llc Anti-CD324 monoclonal antibodies and uses thereof
WO2013173542A1 (fr) * 2012-05-16 2013-11-21 Oncomed Pharmaceuticals, Inc. Procédés de traitement du cancer avec des anticorps notch2/3
BR112015003032B1 (pt) 2012-08-13 2023-03-28 Genentech, Inc Anticorpos isolados, imunoconjugado, formulação farmacêutica e uso do anticorpo
JP6486272B2 (ja) 2012-09-07 2019-03-20 マサチューセッツ・アイ・アンド・イア・インファーマリー 有毛細胞および／または支持細胞再生のための方法および組成物
CA2885659A1 (fr) * 2012-09-21 2014-03-27 Oncomed Pharmaceuticals, Inc. Methodes de traitement de malignites hematologiques par des anticorps diriges contre notch1
HK1208371A1 (en) * 2012-10-09 2016-03-04 桑比欧公司 Methods and compositions for treatment of retinal degeneration
JP6371294B2 (ja) 2012-10-31 2018-08-08 オンコメッド ファーマシューティカルズ インコーポレイテッド Ｄｌｌ４アンタゴニストによる処置の方法およびモニタリング
KR20150082548A (ko) * 2012-11-07 2015-07-15 화이자 인코포레이티드 항-notch3 항체 및 항체-약물 접합체
WO2014100435A1 (fr) * 2012-12-19 2014-06-26 Aveo Pharmaceuticals, Inc. Anticorps anti-notch3
GB201302447D0 (en) 2013-02-12 2013-03-27 Oxford Biotherapeutics Ltd Therapeutic and diagnostic target
SG11201506520TA (en) * 2013-02-18 2015-09-29 Univ Health Network Methods for generating hepatocytes and cholangiocytes from pluripotent stem cells
WO2014141064A1 (fr) 2013-03-13 2014-09-18 Novartis Ag Molécules de liaison à notch2 pour le traitement de maladies respiratoires
CN105246916A (zh) * 2013-03-14 2016-01-13 诺华股份有限公司 针对notch 3的抗体
CA2900969A1 (fr) * 2013-03-15 2014-09-25 Oncomed Pharmaceuticals, Inc. Procedes de traitement du cancer du pancreas
US9550829B2 (en) 2013-03-15 2017-01-24 Genentech, Inc. Compositions and methods for diagnosis and treatment of hepatic cancers
WO2015123325A1 (fr) 2014-02-12 2015-08-20 Genentech, Inc. Anticorps anti-jagged1 et procédés d'utilisation correspondants
WO2015153997A2 (fr) * 2014-04-04 2015-10-08 Oncomed Pharmaceuticals, Inc. Anticorps anti-notch 3 et leurs utilisations
BR112017000130A2 (pt) 2014-07-11 2018-01-09 Genentech Inc método para atenuar a toxicidade associada à inibição da via de notch e método de tratamento do câncer
GB201416832D0 (en) * 2014-09-24 2014-11-05 Glaxosmithkline Plc Methods of treatment
EP3212773B1 (fr) 2014-10-29 2021-09-15 Massachusetts Eye and Ear Infirmary Administration efficace de molécules thérapeutiques en direction de cellules de l'oreille interne
WO2016070051A2 (fr) * 2014-10-31 2016-05-06 Oncomed Pharmaceuticals, Inc. Thérapie combinée pour le traitement d'une maladie
CN105986001B (zh) * 2015-02-12 2019-12-03 上海交通大学 一种基于膜结合蛋白和荧光互补的高通量猎物拮抗剂筛选方法
IL287914B2 (en) * 2015-02-24 2025-10-01 Univ California Linkage-activated transcription switches and methods of using them
TWI609687B (zh) * 2015-04-14 2018-01-01 美國禮來大藥廠 平滑肌肉瘤之標靶性治療
CN107428834B (zh) * 2015-04-16 2021-08-27 卫材R&D管理有限公司 抗人类Notch4抗体
SG10201913841SA (en) * 2015-07-24 2020-03-30 Oncotracker Inc Gamma secretase modulators for the treatment of immune system dysfunction
EP3353204B1 (fr) 2015-09-23 2023-10-18 Mereo BioPharma 5, Inc. Anticorps anti-vegf/dll4 bi-spécifique pour le traitement du cancer de l'ovaire résistant au platine
CN105585636B (zh) * 2015-11-24 2020-03-03 南方医科大学 一种人NOTCH1 NICD蛋白Ser2162位点磷酸化抗体及其制备方法和应用
AU2017234528B2 (en) * 2016-03-16 2023-09-28 Nathan Bartlett Neutralizing monoclonal antibodies to IL-25 and uses thereof
US11142573B2 (en) 2016-04-29 2021-10-12 Aveo Pharmaceuticals, Inc. Anti-Notch3 antibody
US11400116B2 (en) 2016-05-06 2022-08-02 The Regents Of The University Of California Systems and methods for targeting cancer cells
US11026996B2 (en) * 2016-05-25 2021-06-08 The Trustees Of Columbia University In The City Of New York Human Notch1 based fusion proteins as decoy inhibitors of jagged-notch signaling and DLL-notch signaling
SG10201913583QA (en) 2016-08-23 2020-02-27 Univ California Proteolytically cleavable chimeric polypeptides and methods of use thereof
JP2020500033A (ja) * 2016-11-07 2020-01-09 ザ ウィスター インスティテュート オブ アナトミー アンド バイオロジー ライム病に対する使用のためのｄｎａ抗体構築物
US11453718B2 (en) 2017-03-27 2022-09-27 The Schepens Eye Research Institute, Inc. NOTCH3 agonist compositions and methods for treating small vessel diseases
US20200103419A1 (en) 2017-03-27 2020-04-02 The Schepens Eye Research Institute, Inc. Blood biomarkers and diagnostic methods for small vessel diseases
US11325957B2 (en) * 2017-06-19 2022-05-10 Cell Design Labs, Inc. Methods and compositions for reducing the immunogenicity of chimeric notch receptors
CN107557343B (zh) * 2017-08-09 2020-09-25 苏州大学附属儿童医院 抗人dll4单克隆抗体3f9
US11590152B2 (en) 2018-01-26 2023-02-28 Massachusetts Eye And Ear Infirmary Treatment of hearing loss
AU2019252878B2 (en) * 2018-04-10 2024-02-22 Stichting Sanquin Bloedvoorziening Chimeric Notch receptors
WO2020016855A1 (fr) * 2018-07-20 2020-01-23 The Hong Kong Polytechnic University Peptides pour l'inhibition spécifique de la voie de signalisation jag1-notch1
CA3118692A1 (fr) * 2018-11-06 2020-05-14 Alsatech, Inc. Therapie genique de maladies neurodegeneratives a base de cellules
CN111334575A (zh) * 2020-02-18 2020-06-26 至本医疗科技（上海）有限公司 Notch家族基因变异在预测实体瘤患者对免疫检查点抑制剂疗法敏感性中的应用
MX2023000617A (es) * 2020-07-17 2023-02-13 Genentech Inc Anticuerpos anti-notch2 y metodos de uso.
CN112625125B (zh) * 2021-01-18 2021-12-14 中国人民解放军军事科学院军事医学研究院 一株中和新型冠状病毒感染的单抗
CN116917009A (zh) 2021-02-19 2023-10-20 美国迈胜医疗系统有限公司 用于粒子治疗系统的机架
WO2022272283A1 (fr) * 2021-06-24 2022-12-29 H. Lee Moffitt Cancer Center And Research Institute Inc. Cellules t à double récepteur antigénique chimérique egfr-muc1
WO2023141445A1 (fr) * 2022-01-19 2023-07-27 Genentech, Inc. Anticorps et conjugués anti-notch2, et méthodes d'utilisation
CN118344474B (zh) * 2024-05-28 2024-11-15 中国农业科学院兰州兽医研究所(中国动物卫生与流行病学中心兰州分中心) 口蹄疫病毒O型、A型和Asia1型广谱中和性猪源单克隆抗体及其应用

Family Cites Families (153)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US4485045A (en) 1981-07-06 1984-11-27 Research Corporation Synthetic phosphatidyl cholines useful in forming liposomes
US4588585A (en) 1982-10-19 1986-05-13 Cetus Corporation Human recombinant cysteine depleted interferon-β muteins
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4544545A (en) 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
US4676980A (en) 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5567610A (en) 1986-09-04 1996-10-22 Bioinvent International Ab Method of producing human monoclonal antibodies and kit therefor
US5892019A (en) 1987-07-15 1999-04-06 The United States Of America, As Represented By The Department Of Health And Human Services Production of a single-gene-encoded immunoglobulin
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US5175384A (en) 1988-12-05 1992-12-29 Genpharm International Transgenic mice depleted in mature t-cells and methods for making transgenic mice
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5013556A (en) 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
US5229275A (en) 1990-04-26 1993-07-20 Akzo N.V. In-vitro method for producing antigen-specific human monoclonal antibodies
US5270163A (en) 1990-06-11 1993-12-14 University Research Corporation Methods for identifying nucleic acid ligands
US6344321B1 (en) 1990-06-11 2002-02-05 Gilead Sciences, Inc. Nucleic acid ligands which bind to hepatocyte growth factor/scatter factor (HGF/SF) or its receptor c-met
US5496938A (en) 1990-06-11 1996-03-05 Nexstar Pharmaceuticals, Inc. Nucleic acid ligands to HIV-RT and HIV-1 rev
US5705337A (en) 1990-06-11 1998-01-06 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: chemi-SELEX
US5683867A (en) 1990-06-11 1997-11-04 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: blended SELEX
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
US6172197B1 (en) 1991-07-10 2001-01-09 Medical Research Council Methods for producing members of specific binding pairs
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
ES2108048T3 (es) 1990-08-29 1997-12-16 Genpharm Int Produccion y utilizacion de animales inferiores transgenicos capaces de producir anticuerpos heterologos.
DE69129154T2 (de) 1990-12-03 1998-08-20 Genentech, Inc., South San Francisco, Calif. Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften
US5840867A (en) 1991-02-21 1998-11-24 Gilead Sciences, Inc. Aptamer analogs specific for biomolecules
ES2134212T3 (es) 1991-04-25 1999-10-01 Chugai Pharmaceutical Co Ltd Anticuerpo humano reconstituido contra el receptor de la interleuquina 6 humano.
IE20030749A1 (en) * 1991-05-03 2003-11-12 Indiana University Foundation Human notch and delta binding domains in torporythmic proteins, and methods based thereon
IL101728A (en) 1991-05-03 2007-08-19 Univ Yale Human Abandonment and Delta, Restrictive Areas of Effect in Tophoric Proteins, and Methods Based on Them
US5582981A (en) 1991-08-14 1996-12-10 Gilead Sciences, Inc. Method for identifying an oligonucleotide aptamer specific for a target
ATE463573T1 (de) 1991-12-02 2010-04-15 Medimmune Ltd Herstellung von autoantikörpern auf phagenoberflächen ausgehend von antikörpersegmentbibliotheken
US20050112121A1 (en) 1992-04-30 2005-05-26 Yale University Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids
US5786158A (en) * 1992-04-30 1998-07-28 Yale University Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids
US5756291A (en) 1992-08-21 1998-05-26 Gilead Sciences, Inc. Aptamers specific for biomolecules and methods of making
DE4425115A1 (de) 1994-07-15 1996-01-18 Boehringer Mannheim Gmbh Verfahren zur Modifizierung der Stabilität von Antikörpern
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
US5641870A (en) 1995-04-20 1997-06-24 Genentech, Inc. Low pH hydrophobic interaction chromatography for antibody purification
AU5752696A (en) 1995-05-18 1996-11-29 Regents Of The University Of Michigan, The Dna binding antibodies
US6828422B1 (en) 1995-08-18 2004-12-07 Morphosys Ag Protein/(poly)peptide libraries
WO1997008320A1 (fr) 1995-08-18 1997-03-06 Morphosys Gesellschaft Für Proteinoptimierung Mbh Banques de proteines/(poly)peptides
DE19544393A1 (de) 1995-11-15 1997-05-22 Hoechst Schering Agrevo Gmbh Synergistische herbizide Mischungen
AU2160297A (en) 1996-03-30 1997-10-22 Boehringer Mannheim Gmbh Method for the production of activated marked tumor-specific t cells and use thereof in treatment of tumors
JP2000512134A (ja) 1996-05-31 2000-09-19 ザ ナショナル アメリカン レッド クロス Ｊａｇｇｅｄ／Ｎｏｔｃｈタンパク質および核酸に基づく治療および診断の方法および組成物
FR2751986B1 (fr) 1996-08-01 1998-12-31 Inst Nat Sante Rech Med Gene implique dans le cadasil, methode de diagnostic et application therapeutique
WO1998020142A1 (fr) 1996-11-07 1998-05-14 Lorantis Limited Notch
DK0979281T3 (da) 1997-05-02 2005-11-21 Genentech Inc Fremgangsmåde til fremstilling af multispecifikke antistoffer med heteromultimere og fælles bestanddele
US6379925B1 (en) 1997-06-18 2002-04-30 The Trustees Of Columbia University In The City Of New York Angiogenic modulation by notch signal transduction
AU8162898A (en) 1997-06-18 1999-01-04 Trustees Of Columbia University In The City Of New York, The Angiogenic modulation by notch signal transduction
US6692919B1 (en) 1997-07-23 2004-02-17 Yale University Activated forms of notch and methods based thereon
US7361336B1 (en) 1997-09-18 2008-04-22 Ivan Bergstein Methods of cancer therapy targeted against a cancer stem line
US6004528A (en) 1997-09-18 1999-12-21 Bergstein; Ivan Methods of cancer diagnosis and therapy targeted against the cancer stemline
AU768269B2 (en) 1998-10-02 2003-12-04 Government of The United States of America, as represented by The Secretary Department of Health & Human Services, The National Institutes of Health, The Apoptosis inducing agents and methods
US20030054360A1 (en) 1999-01-19 2003-03-20 Larry Gold Method and apparatus for the automated generation of nucleic acid ligands
US20030003572A1 (en) 1999-03-05 2003-01-02 David J. Anderson Isolation and enrichment of neural stem cells from uncultured tissue based on cell-surface marker expression
US20020010320A1 (en) 1999-04-05 2002-01-24 James W. Fett Chemeric and humanized antibodies to angiogenin
WO2001002588A2 (fr) 1999-07-02 2001-01-11 Morphosys Ag Production de partenaires de liaison specifiques se liant a des (poly)peptides codes par des fragments d'adn genomiques ou est
US7605238B2 (en) * 1999-08-24 2009-10-20 Medarex, Inc. Human CTLA-4 antibodies and their uses
US20030031670A1 (en) 1999-11-08 2003-02-13 Jack R. Wands Diagnosis and treatment of malignant neoplasms
DE10031380A1 (de) 2000-06-28 2002-01-10 Merck Patent Gmbh Verfahren zur Übertragung von Alkyliden-Gruppen auf organischen Verbindungen
US8044259B2 (en) 2000-08-03 2011-10-25 The Regents Of The University Of Michigan Determining the capability of a test compound to affect solid tumor stem cells
US20080194022A1 (en) 2000-08-03 2008-08-14 Clarke Michael F Isolation and use of solid tumor stem cells
US6984522B2 (en) 2000-08-03 2006-01-10 Regents Of The University Of Michigan Isolation and use of solid tumor stem cells
US20050089518A1 (en) 2001-12-07 2005-04-28 Clarke Michael F. Prospective identification and characterization of breast cancer stem cells
AU2001288628A1 (en) 2000-08-31 2002-03-13 Loyola University Chicago Method and reagents for treatment of skin disorders by modulating the notch pathway
US6689744B2 (en) 2000-09-22 2004-02-10 Genentech, Inc. Notch receptor agonists and uses
CA2425208C (fr) 2000-09-26 2013-04-09 Duke University Aptameres d'arn et procede d'identification desdits aptameres
EP1322761A4 (fr) 2000-10-02 2005-03-23 Korea Res Inst Of Bioscience Anticorps humanise dirige contre l'antigene s de surface du virus de l'hepatite b et procede de preparation de ce dernier
DE60237969D1 (de) 2001-04-24 2010-11-25 Bayer Corp Menschliche antikörper gegen timp-1
US7356224B2 (en) 2001-07-03 2008-04-08 Brown University Research Foundation Method and apparatus for detecting multiple optical wave lengths
AU2002339157A1 (en) 2001-11-14 2003-05-26 Lorantis Limited Inhibitors of the notch signalling pathway for use in the treatment of cancer
GB0201674D0 (en) 2002-01-25 2002-03-13 Lorantis Ltd Medical treatment
EP1481090A4 (fr) 2002-02-15 2006-08-09 Somalogic Inc Methodes et reactifs destines a la detection d'une liaison de cibles par des ligands d'acides nucleiques
AU2003278161A1 (en) 2002-06-21 2004-01-06 Johns Hopkins University School Of Medicine Membrane associated tumor endothelium markers
DE10228103A1 (de) 2002-06-24 2004-01-15 Bayer Cropscience Ag Fungizide Wirkstoffkombinationen
US20060263774A1 (en) 2002-11-01 2006-11-23 Genentech, Inc. Compositions and methods for the treatment of immune related diseases
US20050124565A1 (en) 2002-11-21 2005-06-09 Diener John L. Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics
AU2003295089A1 (en) 2002-12-06 2004-06-30 Singapore General Hospital Pte Ltd Nogo, Caspr, F3 NB-3 useful in the treatment of injury and disease to the central nervous system
EP1608255A4 (fr) 2003-04-01 2008-06-25 Univ Johns Hopkins Med Modeles d'expression des cellules endotheliales mammaires
US7425328B2 (en) 2003-04-22 2008-09-16 Purdue Pharma L.P. Tissue factor antibodies and uses thereof
US7563748B2 (en) 2003-06-23 2009-07-21 Cognis Ip Management Gmbh Alcohol alkoxylate carriers for pesticide active ingredients
WO2005024042A2 (fr) 2003-09-04 2005-03-17 The Regents Of The University Of California Aptameres et procedes pour leur selection in vitro, et utilisations correspondantes
GB0321805D0 (en) 2003-09-18 2003-10-15 Univ Wales Medicine Human tumour growth patterns
AU2004294563B2 (en) 2003-11-26 2009-03-26 Health Research, Inc. Use of notch pathway interfering agents for treatment of plasma cell disorders
WO2005074633A2 (fr) 2004-02-03 2005-08-18 The Regents Of The University Of Michigan Compositions et procédés permettant de caractériser, de réguler, de diagnostiquer et de traiter des cancers
FR2867784B1 (fr) 2004-03-17 2006-06-09 Commissariat Energie Atomique Aptameres selectionnes a partir de cellules vivantes tumorales et leurs applications
EP1730531B1 (fr) * 2004-03-24 2014-01-15 Technion Research and Development Foundation, Limited Electrode
US20050239134A1 (en) 2004-04-21 2005-10-27 Board Of Regents, The University Of Texas System Combinatorial selection of phosphorothioate single-stranded DNA aptamers for TGF-beta-1 protein
WO2005111072A2 (fr) 2004-04-29 2005-11-24 The Trustees Of Columbia University In The City Of New York Protéines hybrides de notch et leurs utilisations
RU2346996C2 (ru) 2004-06-29 2009-02-20 ЮРОПИЭН НИКЕЛЬ ПиЭлСи Усовершенствованное выщелачивание основных металлов
US20070077245A1 (en) 2004-08-04 2007-04-05 The Brigham And Women's Hospital, Inc. NOTCH mutations leading to increased receptor signaling
GB0421838D0 (en) 2004-09-30 2004-11-03 Congenia S R L Cancer markers
WO2006053063A2 (fr) 2004-11-05 2006-05-18 The Regents Of The University Of California Dosage de notch-1 utilise dans la detection de maladies neurodegeneratives
RU2392961C2 (ru) 2004-11-10 2010-06-27 Хубрехт Лабораториум Лечение аденомы и/или аденокарциномы кишечника с помощью ингибирования активации пути notch
CA2629330C (fr) 2004-11-12 2018-05-22 Cambridge University Technical Services Ltd. Procedes et moyens lies aux cellules souches cancereuses
WO2006110585A2 (fr) 2005-04-07 2006-10-19 Novartis Vaccines And Diagnostics Inc. Genes lies au cancer (prlr)
KR101280096B1 (ko) 2005-06-29 2013-06-28 컴퓨메딕스 리미티드 전도성 브리지를 포함하는 센서 어셈블리
US7723112B2 (en) 2005-10-31 2010-05-25 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
US20090305310A1 (en) 2005-11-22 2009-12-10 University Of Vermont And State Agricultural College Methods for Determining Notch Signaling and Uses Thereof
JP5489465B2 (ja) 2005-12-16 2014-05-14 リジェネロン・ファーマシューティカルズ・インコーポレイテッド Ｄｌｌ４アンタゴニストによって腫瘍増殖を阻害する治療方法
WO2007075915A2 (fr) 2005-12-22 2007-07-05 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anticorps monoclonaux utilises contre des orthopoxvirus
AR059922A1 (es) 2006-04-01 2008-05-07 Galaxy Biotech Llc Anticuerpos monoclonales humanizados para el factor de crecimiento de hepatocitos
US20080241150A1 (en) 2006-05-15 2008-10-02 The Brigham And Women's Hospital, Inc. Functional negative regulatory domain sequences from human NOTCH1 and 2 and isolated LNR domains from human NOTCH1
KR20090016762A (ko) 2006-06-06 2009-02-17 제넨테크, 인크. 혈관 발달을 조정하기 위한 조성물 및 방법
CA2654000A1 (fr) 2006-06-06 2008-05-22 Genentech, Inc. Anticorps anti-dll4 et leurs procedes d'utilisation
PL2032166T3 (pl) 2006-06-13 2013-09-30 Oncomed Pharm Inc Kompozycje i sposoby diagnozowania i leczenia nowotworów
TW200801513A (en) 2006-06-29 2008-01-01 Fermiscan Australia Pty Ltd Improved process
CA2664738C (fr) 2006-09-29 2017-03-07 Oncomed Pharmaceuticals, Inc. Compositions et procedes permettant de diagnostiquer et de traiter le cancer
WO2008050525A1 (fr) 2006-09-29 2008-05-02 Konica Minolta Opto, Inc. Film retardateur
CL2007002989A1 (es) 2006-10-19 2008-05-16 Genentech Inc Anticuerpos anti-notch3; acido nucleico que los codifica; vector y celula que lo comprende; metodo de produccion; y su uso para el diagnostico de enfermedades relacionadas con notch3.
CL2007002987A1 (es) 2006-10-19 2008-06-06 Genentech Inc Anticuerpos anti-notch3; acido nucleico que los codifica; vector y celula que lo comprende; metodo de produccion; y su uso para tratar enfermedades relacionadas con notch3.
WO2008048680A2 (fr) 2006-10-19 2008-04-24 Maine Medical Center Research Institute Voie de transmission du signal notch 2 utile comme mécanisme suppresseur du cancer du sein
US20100068688A1 (en) 2006-11-06 2010-03-18 Howard Shapiro Management of teaching processes for individualized instruction in a multistudent environment
NO347649B1 (no) 2006-12-14 2024-02-12 Regeneron Pharma Humant antistoff eller antistoff fragment som spesifikt binder human deltaliknende ligand 4 (hDII4), nukleinsyremolekyl som koder for slike og vektor og vert-vektorsystemer, samt fremgangsmåte for fremstilling, sammensetning og anvendelse.
NZ577274A (en) 2006-12-18 2012-10-26 Genentech Inc Antagonist anti-notch3 antibodies and their use in the prevention and treatment of notch3-related diseases
WO2008079326A2 (fr) 2006-12-20 2008-07-03 Vasgene Therapeutics, Inc. Procédés d'utilisation et d'identification de modulateurs de dll4
US8088617B2 (en) 2007-01-24 2012-01-03 Oncomed Pharmaceuticals, Inc. Antibodies that bind the glutamate ligand binding region of Notch1
US20100119526A1 (en) 2007-01-26 2010-05-13 Bioinvent International Ab DLL4 Signaling Inhibitors and Uses Thereof
WO2008100563A2 (fr) 2007-02-14 2008-08-21 Oncomed Pharmaceuticals, Inc. Compositions et méthodes pour diagnostiquer et traiter le cancer
WO2008109075A2 (fr) * 2007-03-05 2008-09-12 Bristol-Myers Squibb Company Biomarqueurs et procédés pour déterminer une sensibilité à des antagonistes de ctla-4
EP2134356A2 (fr) 2007-03-05 2009-12-23 Board of Regents, The University of Texas System Régulation génétique négative de la regénération des cellules cancéreuses en synergie avec une immunothérapie notch ou numb spécifique
PE20090321A1 (es) * 2007-06-04 2009-04-20 Genentech Inc Anticuerpos anti-notch1 nrr, metodo de preparacion y composicion farmaceutica
NZ583367A (en) 2007-07-16 2012-10-26 Genentech Inc Anti-cd79b antibodies and immunoconjugates and methods of use
KR20100076947A (ko) 2007-08-23 2010-07-06 더 트러스티스 오브 컬럼비아 유니버시티 인 더 시티 오브 뉴욕 인간화 노치 융합 단백질 조성물 및 치료방법
US20110166028A1 (en) 2007-08-28 2011-07-07 Donald Bergstrom Methods for predicting treatment response based on the expression profiles of biomarker genes in notch mediated cancers
US8377886B2 (en) 2007-09-14 2013-02-19 Albert Einstein College Of Medicine Of Yeshiva University Use of gamma secretase inhibitors and notch pathway inhibitors for treatment and prevention of renal disease
WO2009036167A1 (fr) 2007-09-14 2009-03-19 Vanderbilt University Ciblage d'une fonction de récepteurs notch3 pour une thérapie du cancer
US20120082659A1 (en) 2007-10-02 2012-04-05 Hartmut Land Methods And Compositions Related To Synergistic Responses To Oncogenic Mutations
US8119366B2 (en) 2007-10-05 2012-02-21 Trojan Technologies, Ltd. Antennapedia-dominant negative mastermind-like construct
WO2009124931A2 (fr) 2008-04-07 2009-10-15 Ablynx Nv Séquences d'acides aminés dirigées contre les voies notch et leurs utilisations
WO2010000020A1 (fr) 2008-06-30 2010-01-07 Cathrx Ltd Cathéter
EP2307051B1 (fr) 2008-07-08 2015-02-11 OncoMed Pharmaceuticals, Inc. Agents de liaison de notch et antagonistes de notch ainsi que procédés d'utilisation correspondants
US9132189B2 (en) 2008-07-08 2015-09-15 Oncomed Pharmaceuticals, Inc. Notch1 binding agents and methods of use thereof
AU2009298569A1 (en) 2008-10-01 2010-04-08 Genentech, Inc. Anti-Notch2 antibodies and methods of use
US8425930B2 (en) 2009-03-13 2013-04-23 The Regents Of The University Of California Prebiotic oligosaccharides
CA2775880A1 (fr) 2009-09-30 2011-04-07 Genentech, Inc. Anticorps antagonistes anti-notch3 servant a traiter des leucemies a lymphocytes t reagissant a un inhibiteur de secretase gamma et ne reagissant pas a un anticorps antagoniste anti-notch1
DE102009047243A1 (de) 2009-11-27 2011-06-01 Orgentec Diagnostika Gmbh Monospezifische Polypeptidreagenzien
WO2011088215A2 (fr) 2010-01-13 2011-07-21 Oncomed Pharmaceuticals, Inc. Agents de liaison notch1 et leurs procédés d'utilisation
NZ601743A (en) 2010-02-12 2014-11-28 Oncomed Pharm Inc Methods for identifying and isolating cells expressing a polypeptide
JP5450221B2 (ja) 2010-04-14 2014-03-26 株式会社神戸製鋼所 高電流密度ガスシールドアーク溶接方法
MX355418B (es) 2010-05-04 2018-04-18 Five Prime Therapeutics Inc Anticuerpos que se unen a factor estimulante de colonias 1 (csf1r).
WO2012003472A1 (fr) 2010-07-02 2012-01-05 Aveo Pharmaceuticals, Inc. Anticorps anti-notch1
EP3556774B1 (fr) 2011-03-11 2024-01-03 Beth Israel Deaconess Medical Center Inc. Anticorps anti-cd40 et leurs utilisations
CA2864197A1 (fr) 2011-11-16 2013-05-23 Oncomed Pharmaceuticals, Inc. Mutations du recepteur notch humain et leur utilisation
WO2013173542A1 (fr) 2012-05-16 2013-11-21 Oncomed Pharmaceuticals, Inc. Procédés de traitement du cancer avec des anticorps notch2/3
CA2883703C (fr) 2012-09-04 2021-10-19 Eleison Pharmaceuticals, Llc Prevention de la rechute du cancer pulmonaire avec un complexe lipide/cisplatine
CA2885659A1 (fr) 2012-09-21 2014-03-27 Oncomed Pharmaceuticals, Inc. Methodes de traitement de malignites hematologiques par des anticorps diriges contre notch1
KR20150082548A (ko) 2012-11-07 2015-07-15 화이자 인코포레이티드 항-notch3 항체 및 항체-약물 접합체
CA2900969A1 (fr) 2013-03-15 2014-09-25 Oncomed Pharmaceuticals, Inc. Procedes de traitement du cancer du pancreas
CA2941733A1 (fr) 2014-03-07 2015-09-11 Oncomed Pharmaceuticals, Inc. Procedes de traitement du cancer au moyen d'anticorps anti-notch1
WO2015153997A2 (fr) 2014-04-04 2015-10-08 Oncomed Pharmaceuticals, Inc. Anticorps anti-notch 3 et leurs utilisations

Also Published As

Publication number Publication date
CY1116230T1 (el) 2017-02-08
EP2307051A4 (fr) 2012-07-18
EP2899211A1 (fr) 2015-07-29
US20170183405A1 (en) 2017-06-29
MX2011000233A (es) 2011-05-19
CN104402998A (zh) 2015-03-11
SMT201500120B (it) 2015-07-09
EP2307459B1 (fr) 2015-01-07
RS53924B1 (sr) 2015-08-31
CO6390041A2 (es) 2012-02-29
MA32448B1 (fr) 2011-07-03
CR20110069A (es) 2011-07-11
ES2535614T3 (es) 2015-05-13
BRPI0914007A2 (pt) 2015-11-17
US20140011271A1 (en) 2014-01-09
CA2729602A1 (fr) 2010-01-14
EP2307051B1 (fr) 2015-02-11
US20150197563A1 (en) 2015-07-16
EP2307459A4 (fr) 2012-07-18
DOP2011000002A (es) 2011-04-15
CN102112490B (zh) 2014-10-22
SI2307051T1 (sl) 2015-04-30
SG192468A1 (en) 2013-08-30
HK1151296A1 (en) 2012-01-27
KR101640099B1 (ko) 2016-07-15
US9505832B2 (en) 2016-11-29
MX2011000236A (es) 2011-02-24
US20120288496A1 (en) 2012-11-15
WO2010005566A3 (fr) 2010-09-16
MY159815A (en) 2017-02-15
JP2012501625A (ja) 2012-01-26
ES2531541T3 (es) 2015-03-17
CY1116195T1 (el) 2017-02-08
HK1151218A1 (en) 2012-01-27
CA2729306C (fr) 2015-08-18
PL2307459T3 (pl) 2015-05-29
CN102316897B (zh) 2014-11-05
AU2016216568A1 (en) 2016-09-01
IL210221A (en) 2014-02-27
DOP2011000004A (es) 2011-04-15
AU2009269096A1 (en) 2010-01-14
JP5560271B2 (ja) 2014-07-23
KR20110028621A (ko) 2011-03-21
EP2307459A2 (fr) 2011-04-13
UA101672C2 (uk) 2013-04-25
SI2307459T1 (sl) 2015-04-30
US8226943B2 (en) 2012-07-24
US8980260B2 (en) 2015-03-17
US20130260455A1 (en) 2013-10-03
DK2307459T3 (da) 2015-02-09
NZ590127A (en) 2012-11-30
US20100111958A1 (en) 2010-05-06
US20170198031A1 (en) 2017-07-13
PT2307459E (pt) 2015-03-11
JP5560270B2 (ja) 2014-07-23
HRP20150256T1 (hr) 2015-04-10
KR20110031315A (ko) 2011-03-25
CN102112490A (zh) 2011-06-29
US20130296536A1 (en) 2013-11-07
CO6612253A2 (es) 2013-02-01
US20110311552A1 (en) 2011-12-22
PT2307051E (pt) 2015-05-21
US8945874B2 (en) 2015-02-03
JP2012501626A (ja) 2012-01-26
US20130280277A1 (en) 2013-10-24
SG192467A1 (en) 2013-08-30
WO2010005567A3 (fr) 2010-05-27
IL210222A0 (en) 2011-03-31
NZ590131A (en) 2012-10-26
US8945547B2 (en) 2015-02-03
ME02148B (me) 2015-10-20
US9499613B2 (en) 2016-11-22
CA2729306A1 (fr) 2010-01-14
US8435513B2 (en) 2013-05-07
DK2307051T3 (en) 2015-04-20
AU2009269095A1 (en) 2010-01-14
CN102316897A (zh) 2012-01-11
KR101682490B1 (ko) 2016-12-05
ZA201100029B (en) 2012-03-28
US8425903B2 (en) 2013-04-23
AU2009269096B2 (en) 2016-05-12
RS53750B1 (sr) 2015-06-30
PL2307051T3 (pl) 2015-07-31
IL210222A (en) 2016-05-31
BRPI0914004A2 (pt) 2015-11-17
US8945873B2 (en) 2015-02-03
EA201170157A1 (ru) 2011-08-30
EP2924051A1 (fr) 2015-09-30
AU2009269095B2 (en) 2016-05-19
ME02069B (me) 2015-05-20
US20150166963A1 (en) 2015-06-18
HRP20150443T1 (hr) 2015-05-22
EP2307051A2 (fr) 2011-04-13
SMT201500047B (it) 2015-05-05
WO2010005567A2 (fr) 2010-01-14
ZA201009280B (en) 2012-04-25
EA026109B1 (ru) 2017-03-31
EA201170158A1 (ru) 2011-08-30
IL210221A0 (en) 2011-03-31
MY155603A (en) 2015-11-13
WO2010005566A2 (fr) 2010-01-14

Similar Documents

Publication Publication Date Title
MA32449B1 (fr) Agents de liaison de notch et antagonistes de notch ainsi que procedes d'utilisation correspondants
UA109633C2 (uk) Антитіло людини проти тканинного фактора
NZ599628A (en) Axl antibodies
EA201100239A1 (ru) Композиции, одновалетные в отношении связывания cd28, и способы их применения
CY1111714T1 (el) Δεσμευτικες πρωτεϊνες αυξητικου παραγοντα ηπατοκυτταρων (hgf).
NO20092470L (no) Substituerte diazepanforbindelser som orexinreseptorantagonister
SG10201407388XA (en) Humanized anti-cxcr5 antibodies, derivatives thereof and their uses
BR112015013127A2 (pt) imunoterapia com agentes de ligação
PH12012500881A1 (en) Antibodies binding preferentially human csf1r extracellular domain 4 and their use
EA201291180A1 (ru) Композиции и способы применения терапевтических антител против белка, родственного рецептору липопротеинов низкой плотности 6 (lrp6)
MX2009008104A (es) Hepcidina, antagonistas de hepcidina y metodos de uso.
MX2009006500A (es) Anticuerpos antagonistas anti-notch3 y su uso en la prevencion y el tratamiento de enfermedades relacionadas con el receptor notch3.
SG10201407281UA (en) Specific binding proteins and uses thereof
CY1110882T1 (el) Ανταγωνιστες υποδοχεων ορεξινης υποκατεστημενης διαζεπανης
ATE496051T1 (de) Pyrazolotetrahydropyridinderivate als orexinrezeptorantagonisten
EA201070730A1 (ru) Гуманизированные антитела, специфичные к фактору фон виллебранда
EA201190280A1 (ru) Производные l-(пиперидин-4-ил)пиразола в качестве модуляторов gpr 119
EA201490822A1 (ru) Модифицированные полипептиды рецептора активина и их применение
EA200900202A1 (ru) Селективные модуляторы андрогенного рецептора, их аналоги и производные и их использование
EA201070822A1 (ru) Доставка антител посредством модульного домена распознавания
NO20083895L (no) Anti-IGF-1R human monoklonalantibody formulering
MXPA05011922A (es) Ligandos del receptor de cannabinoides y sus usos.
EA200970251A1 (ru) Антитела к миостатину
ATE469658T1 (de) Kombinationstherapien gegen multiple toll-like- rezeptoren und ihre verwendung
NZ704269A (en) Rspo3 binding agents and uses thereof