MA32596B1 - Inhibiteurs cycliques de la 11 bêta-hydroxystéroïde deshydrogénase 1 - Google Patents

Inhibiteurs cycliques de la 11 bêta-hydroxystéroïde deshydrogénase 1

Info

Publication number
MA32596B1
MA32596B1 MA33610A MA33610A MA32596B1 MA 32596 B1 MA32596 B1 MA 32596B1 MA 33610 A MA33610 A MA 33610A MA 33610 A MA33610 A MA 33610A MA 32596 B1 MA32596 B1 MA 32596B1
Authority
MA
Morocco
Prior art keywords
inhibitors
annular
beta hydroxy
steroid dehydrogenase
hydroxy steroid
Prior art date
Application number
MA33610A
Other languages
Arabic (ar)
English (en)
Inventor
Frank Himmelsbach
David A Claremon
Linghang Zhuang
Katerina Leftheris
Zhenrong Xu
Colin M Tice
Original Assignee
Boehringer Ingelheim Int
Vitae Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41090311&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA32596(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from PCT/US2008/009017 external-priority patent/WO2009017664A1/fr
Priority claimed from PCT/US2009/002653 external-priority patent/WO2009134400A1/fr
Application filed by Boehringer Ingelheim Int, Vitae Pharmaceuticals Inc filed Critical Boehringer Ingelheim Int
Publication of MA32596B1 publication Critical patent/MA32596B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/08—Antibacterial agents for leprosy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/46—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of glucocorticosteroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Reproductive Health (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Oncology (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)

Abstract

Cette invention concerne de nouveaux composés de formule ik, im1, im2, im5, in1, in2, in5, io1, io2, io5, ip1, ip3, leurs sels pharmaceutiquement acceptables et leurs compositions pharmaceutiques, qui sont utilisés en traitement thérapeutique des maladies associées avec la modulation ou l'inhibition de la 11ß-hsd1 chez le mammifère. L'invention concerne par ailleurs des compositions pharmaceutiques des nouveaux composés et leurs procédés d'utilisation dans la réduction ou le contrôle de la production du cortisol dans une cellule ou l'inhibition de la conversion de la cortisone en cortisol dans une cellule.
MA33610A 2008-07-25 2011-02-11 Inhibiteurs cycliques de la 11 bêta-hydroxystéroïde deshydrogénase 1 MA32596B1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US13714808P 2008-07-25 2008-07-25
PCT/US2008/009017 WO2009017664A1 (fr) 2007-07-26 2008-07-25 Inhibiteurs cycliques de la 11β-hydroxystéroïde déshydrogénase 1
US20678509P 2009-02-04 2009-02-04
PCT/US2009/002653 WO2009134400A1 (fr) 2008-05-01 2009-04-30 Inhibiteurs cycliques de la 11-bêta-hydroxystéroïde déhydrogénase 1
PCT/US2009/004261 WO2010011314A1 (fr) 2008-07-25 2009-07-23 Inhibiteurs cycliques de la 11 bêta-hydroxystéroïde déshydrogénase 1

Publications (1)

Publication Number Publication Date
MA32596B1 true MA32596B1 (fr) 2011-09-01

Family

ID=41090311

Family Applications (1)

Application Number Title Priority Date Filing Date
MA33610A MA32596B1 (fr) 2008-07-25 2011-02-11 Inhibiteurs cycliques de la 11 bêta-hydroxystéroïde deshydrogénase 1

Country Status (24)

Country Link
US (3) US8114868B2 (fr)
EP (2) EP2324018B1 (fr)
JP (2) JP5379160B2 (fr)
KR (1) KR20110050459A (fr)
CN (3) CN104327062A (fr)
AR (1) AR073348A1 (fr)
AU (1) AU2009274567B2 (fr)
CA (1) CA2730499A1 (fr)
CL (2) CL2011000159A1 (fr)
CO (1) CO6351743A2 (fr)
DK (1) DK2324018T3 (fr)
EA (2) EA201490304A1 (fr)
EC (1) ECSP10010633A (fr)
ES (1) ES2432150T3 (fr)
IL (1) IL210452A (fr)
MA (1) MA32596B1 (fr)
NZ (1) NZ590495A (fr)
PE (1) PE20110566A1 (fr)
PH (1) PH12014501532A1 (fr)
PL (1) PL2324018T3 (fr)
RU (1) RU2539979C2 (fr)
TW (1) TW201004946A (fr)
UY (1) UY32591A (fr)
WO (1) WO2010011314A1 (fr)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2678577A1 (fr) 2007-02-26 2008-09-04 Vitae Pharmaceuticals, Inc. Inhibiteurs d'uree et de carbamate de 11b-hydroxysteroide deshydrogenase 1 cycliques
JP5470557B2 (ja) 2007-07-26 2014-04-16 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１型の阻害剤の合成
AR069207A1 (es) 2007-11-07 2010-01-06 Vitae Pharmaceuticals Inc Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1
TW200927115A (en) 2007-11-16 2009-07-01 Boehringer Ingelheim Int Aryl-and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use
US8440658B2 (en) 2007-12-11 2013-05-14 Vitae Pharmaceuticals, Inc. Cyclic urea inhibitors of 11β-hydroxysteroid dehydrogenase 1
TW200934490A (en) 2008-01-07 2009-08-16 Vitae Pharmaceuticals Inc Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
WO2009094169A1 (fr) * 2008-01-24 2009-07-30 Vitae Pharmaceuticals, Inc. Carbazate cyclique et inhibiteurs du type semi-carbazide de la 11β-hydroxystéroïde déshydrogénase 1
CA2714532A1 (fr) * 2008-02-11 2009-08-20 Vitae Pharmaceuticals, Inc. INHIBITEURS 1,3-OXAZEPAN-2-ONE ET 1,3-DIAZEPAN-2-ONE DE LA 11ß-HYDROXYSTEROIDE DESHYDROGENASE (TYPE1)
US8598160B2 (en) 2008-02-15 2013-12-03 Vitae Pharmaceuticals, Inc. Cycloalkyl lactame derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
WO2009117109A1 (fr) * 2008-03-18 2009-09-24 Vitae Pharmaceuticals, Inc. Inhibiteurs de la 11-bêta-hydroxystéroïde déshydrogénase de type 1
EP2291370B1 (fr) 2008-05-01 2013-11-27 Vitae Pharmaceuticals, Inc. Inhibiteurs cycliques de la 11-bêta-hydroxystéroïde déhydrogénase 1
RU2531272C2 (ru) 2008-05-01 2014-10-20 Вайтаи Фармасьютиклз, Инк. Циклические ингибиторы 11бета-гидроксистероид-дегидрогеназы 1
US8242111B2 (en) * 2008-05-01 2012-08-14 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1
JP5696037B2 (ja) 2008-05-01 2015-04-08 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状インヒビター
AR071719A1 (es) 2008-05-13 2010-07-07 Boehringer Ingelheim Int Derivados aliciclicos de acido carboxilico de benzomorfanos y estructuras relacionadas, medicamentos que contienen dichos compuestos y su uso.procesos de obtencion
WO2009147189A1 (fr) 2008-06-05 2009-12-10 Glaxo Group Limited Nouveaux composés
WO2009147188A1 (fr) * 2008-06-05 2009-12-10 Glaxo Group Limited Dérivés de benzpyrazole en tant qu'inhibiteurs de p13 kinases
ES2383246T3 (es) 2008-06-05 2012-06-19 Glaxo Group Limited 4-amino-indazoles
EP2323994A1 (fr) 2008-07-25 2011-05-25 Boehringer Ingelheim International GmbH Synthèse d'inhibiteurs de la 11 -hydroxystéroïde déhydrogénase de type 1
NZ590495A (en) 2008-07-25 2012-10-26 Vitae Pharmaceuticals Inc Dihydropyridin-phenyl-3-oxazinan-2-ones as inhibitors of 11beta-hydroxysteroid dehydrogenase 1
WO2010010157A2 (fr) 2008-07-25 2010-01-28 Boehringer Ingelheim International Gmbh Inhibiteurs de la 11 bêta-hydroxystéroïde déshydrogénase 1
JP5679997B2 (ja) 2009-02-04 2015-03-04 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状阻害剤
JP5656880B2 (ja) 2009-03-09 2015-01-21 グラクソ グループ リミテッドＧｌａｘｏ Ｇｒｏｕｐ Ｌｉｍｉｔｅｄ Ｐｉ３キナーゼの阻害剤としての４−オキサジアゾール−２−イル−インダゾール
MX2011011156A (es) 2009-04-23 2011-11-04 Theravance Inc COMPUESTOS DIAMIDA QUE TIENE ACTIVIDAD COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS Y COMO AGONISTAS DE LOS RECEPTORES ANDRENERGICOS ß2.
US8680093B2 (en) 2009-04-30 2014-03-25 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
LT2899191T (lt) 2009-04-30 2017-10-25 Glaxo Group Limited Oksazolo pakeistieji indazolai kaip pi3-kinazės inhibitoriai
US8927539B2 (en) 2009-06-11 2015-01-06 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1 based on the 1,3-oxazinan-2-one structure
EP2448928B1 (fr) 2009-07-01 2014-08-13 Vitae Pharmaceuticals, Inc. Inhibiteurs cycliques de la 11-bêta-hydroxystéroïde déshydrogénase 1
WO2011056737A1 (fr) 2009-11-05 2011-05-12 Boehringer Ingelheim International Gmbh Nouveaux ligands de phosphore chiraux
AR078887A1 (es) 2009-11-06 2011-12-07 Boehringer Ingelheim Int Derivados arilo y heteroarilcarbonilo de hexahidroindenopiridina y octahidrobenzoquinolina y composiciones farmaceuticas que los contienen.
EP2576570A1 (fr) 2010-05-26 2013-04-10 Boehringer Ingelheim International GmbH Dérivés d'acide 2-oxo-1,2-dihydropyridin-4-yle boronique
WO2011159760A1 (fr) 2010-06-16 2011-12-22 Vitae Pharmaceuticals, Inc. Hétérocycles à 5, 6 et 7 chaînons substitués, médicaments contenant ces composés et leur utilisation
WO2011161128A1 (fr) 2010-06-25 2011-12-29 Boehringer Ingelheim International Gmbh Azaspirohexanones comme inhibiteurs de 11-β-hsd1 pour le traitement de troubles métaboliques
GB201018124D0 (en) 2010-10-27 2010-12-08 Glaxo Group Ltd Polymorphs and salts
WO2012059416A1 (fr) * 2010-11-02 2012-05-10 Boehringer Ingelheim International Gmbh Combinaisons pharmaceutiques destinées au traitement de troubles du métabolisme
TWI537258B (zh) 2010-11-05 2016-06-11 百靈佳殷格翰國際股份有限公司 六氫茚并吡啶及八氫苯并喹啉之芳基－及雜環芳基羰基衍生物
WO2012122152A1 (fr) 2011-03-07 2012-09-13 Boehringer Ingelheim International Gmbh Procédé pour méthylallylation asymétrique en présence d'un catalyseur naphtol-2-bi-1,1' substitué 2, 2'
WO2013025664A1 (fr) 2011-08-17 2013-02-21 Boehringer Ingelheim International Gmbh Dérivés d'indénopyridine
WO2013097052A1 (fr) 2011-12-30 2013-07-04 Abbott Laboratories Inhibiteurs de bromodomaine
CN103342700B (zh) * 2012-01-19 2016-04-20 通化济达医药有限公司 11β-羟基类固醇脱氢酶1型抑制剂
CN103398708B (zh) * 2013-07-15 2015-10-21 哈尔滨工程大学 一种双敏感模态的微机械陀螺
PT3442972T (pt) 2016-04-15 2020-05-29 Abbvie Inc Inibidores de bromodomínio

Family Cites Families (229)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3378587A (en) 1963-03-14 1968-04-16 Du Pont 3, 3'-diaminomethyl-1, 1'-biadamantane
NL127995C (fr) 1963-12-20 Geigy Ag J R
US3341538A (en) 1965-06-18 1967-09-12 Geigy Chem Corp Certain 2, 6-methano-3-benzazocines
DE2108954A1 (en) 1971-02-25 1972-09-07 Boehringer Sohn Ingelheim 2-(furylmethyl)-6,7-benzomorphans - useful as cns active agents
DE1801556A1 (de) 1968-10-05 1970-05-21 Huels Chemische Werke Ag Verfahren zur Herstellung von substituierten Hexahydropyrimidinonen-(2)
GB1304175A (fr) 1969-03-31 1973-01-24
DE2105743C3 (de) 1971-02-08 1979-11-29 Boehringer Sohn Ingelheim 2-(Furylmethyl)- a -5,9-dialkyl -6,7benzomorphane, Verfahren zu ihrer Herstellung und deren Verwendung
US3681349A (en) * 1970-03-05 1972-08-01 Morton Norwich Products Inc 1-(substituted benzyl) tetrahydro-2-(1h) pyrimidones
US4043927A (en) 1972-03-07 1977-08-23 Sun Ventures, Inc. Friction or tractive drive containing ethers of adamantanes
DE2229695A1 (de) 1972-06-19 1974-01-31 Boehringer Sohn Ingelheim 2-(heteroaryl-methyl)-5,9 beta-dialkyl6,7-benzomorphane, deren saeureadditionssalze sowie verfahren zu deren herstellung
DE2338369A1 (de) 1973-07-26 1975-02-13 Schering Ag Mikrobiologische hydroxylierung von 2,6-methano-3-benzazocinen
SU511005A3 (ru) 1973-10-27 1976-04-15 К.Х.Берингер Зон., (Фирма) Способ получени (метоксиметилфурилметил)6,7-бензоморфанов или морфинанов
US4009171A (en) 1974-02-21 1977-02-22 Sterling Drug Inc. N-acylated-11-oxygenated-2,6-methano-3-benzazocine intermediates
DE2411382C3 (de) 1974-03-09 1979-09-06 C.H. Boehringer Sohn, 6507 Ingelheim 2-Tetrahydrofurfuryl-6,7-benzomorphane, Verfahren zur Herstellung und deren Verwendung
US4136162A (en) 1974-07-05 1979-01-23 Schering Aktiengesellschaft Medicament carriers in the form of film having active substance incorporated therein
US4136145A (en) 1974-07-05 1979-01-23 Schering Aktiengesellschaft Medicament carriers in the form of film having active substance incorporated therein
DE2437610A1 (de) 1974-08-05 1976-02-26 Boehringer Sohn Ingelheim Neue 5,9-beta-disubstituierte 2-tetrahydrofurfuryl-6,7-benzomorphane, deren saeureadditionssalze, ihre verwendung als arzneimittel und verfahren zu deren herstellung
GB1513961A (en) 1975-02-25 1978-06-14 Acf Chemiefarma Nv 6,7-benzomorphans method for their preparation and intermediates
US4108857A (en) 1975-08-18 1978-08-22 Sterling Drug Inc. Imidazolylmethyl methanobenzazocines
DE2828039A1 (de) 1978-06-26 1980-01-10 Boehringer Sohn Ingelheim 2-(2-alkoxyethyl)-2'-hydroxy-6,7-benzomorphane deren saeureadditionssalze diese enthaltende arzneimittel und verfahren zu deren herstellung
CA2023492A1 (fr) 1989-08-31 1991-03-01 Barry Clifford Lange Glutarimides synthetiques
US5393735A (en) 1990-08-09 1995-02-28 Rohm And Haas Company Herbicidal glutarimides
US5098916A (en) 1990-03-29 1992-03-24 G. D. Searle & Co. Propanobicyclic amine derivatives for cns disorders
EP0454444A1 (fr) 1990-04-24 1991-10-30 Nissan Chemical Industries Ltd. Dérivés du glutarimide et herbicides
US5215992A (en) 1990-04-30 1993-06-01 G. D. Searle & Co. Ethanobicyclic amine derivatives for CNS disorders
US5089506A (en) 1990-04-30 1992-02-18 G. D. Searle & Co. Ethanobicyclic amine derivatives for cns disorders
DK204291D0 (da) 1991-12-20 1991-12-20 Novo Nordisk As Heterocykliske forbindelser deres fremstilling og anvendelse
CA2049244A1 (fr) 1990-08-16 1992-02-17 Steven H. Christiansen Methode d'absorption de composes sulfures a partir de fluides grace a des composes heterocycliques renfermant au moins un atome d'azote cyclique
KR970005927B1 (ko) 1990-10-10 1997-04-22 쉐링 코포레이션 디아릴메틸피페리딘 또는 피페라진의 피리딘 및 피리딘 n-옥사이드 유도체, 이를 함유하는 약제학적 조성물 및 이의 제조방법
GB9023583D0 (en) 1990-10-30 1990-12-12 Beecham Group Plc Novel compounds
DE69221309T2 (de) 1991-10-11 1997-12-11 The Du Pont Merck Pharmaceutical Co., Wilmington, Del. Cyclische harnstoffe und analoga verwendbar als retrovirale proteasehemmer
US5610294A (en) 1991-10-11 1997-03-11 The Du Pont Merck Pharmaceutical Company Substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors
KR0146931B1 (ko) 1992-04-30 1998-08-17 고바야시 유끼오 옥사졸리딘 유도체 및 그의 약학적으로 허용가능한 염
GB9225377D0 (en) 1992-12-04 1993-01-27 Ici Plc Herbicides
AU668818B2 (en) 1993-04-07 1996-05-16 Taiho Pharmaceutical Co., Ltd. Thiazolidine derivative and pharmaceutical composition containing the same
TW280812B (fr) 1993-07-02 1996-07-11 Bayer Ag
EP0640594A1 (fr) 1993-08-23 1995-03-01 Fujirebio Inc. Dérivé de hydantoine comme inhibiteur de métalloprotease
DE19500118A1 (de) 1994-05-18 1995-11-23 Bayer Ag Substituierte Diazacyclohexandi(thi)one
WO1996014297A1 (fr) 1994-11-04 1996-05-17 Sumitomo Pharmaceuticals Company, Limited Nouveaux derives de lactame
US5780466A (en) 1995-01-30 1998-07-14 Sanofi Substituted heterocyclic compounds method of preparing them and pharmaceutical compositions in which they are present
FR2729954B1 (fr) 1995-01-30 1997-08-01 Sanofi Sa Composes heterocycliques substitues, procede pour leur preparation et compositions pharmaceutiques les contenant
GB9510459D0 (en) 1995-05-24 1995-07-19 Zeneca Ltd Bicyclic amines
US5776959A (en) 1995-06-05 1998-07-07 Washington University Anticonvulsant and anxiolytic lactam and thiolactam derivatives
GB9517622D0 (en) 1995-08-29 1995-11-01 Univ Edinburgh Regulation of intracellular glucocorticoid concentrations
CA2249641A1 (fr) 1996-04-03 1997-10-09 Merck & Co., Inc. Inhibiteurs de farnesyl-proteine transferase
DE69730980T2 (de) 1996-07-31 2006-02-23 Nikken Chemicals Co., Ltd. 6-phenyltetrahydro-1,3-oxazin-2-on derivate und medizinische zusammensetzungen, die sie enthalten
US5866702A (en) 1996-08-02 1999-02-02 Cv Therapeutics, Incorporation Purine inhibitors of cyclin dependent kinase 2
US6794390B2 (en) 1996-08-02 2004-09-21 Cv Therapeutics, Inc. Purine inhibitors of cyclin dependent kinase 2 & ikappabalpha
GB9623944D0 (en) 1996-11-15 1997-01-08 Zeneca Ltd Bicyclic amine derivatives
AU740064B2 (en) 1997-06-18 2001-10-25 H. Lundbeck A/S Heterocyclic substituted piperidines and uses thereof
US6159990A (en) 1997-06-18 2000-12-12 Synaptic Pharmaceutical Corporation Oxazolidinones as α1A receptor antagonists
DE19731784A1 (de) 1997-07-24 1999-02-04 Bayer Ag Substituierte N-Aryl-N-thioxocarbonyl-sulfonamide
GB9715892D0 (en) 1997-07-29 1997-10-01 Zeneca Ltd Heterocyclic compounds
US5912114A (en) 1997-09-12 1999-06-15 Johnson & Johnson Medical, Inc. Wound diagnosis by quantitating cortisol in wound fluids
US5936124A (en) 1998-06-22 1999-08-10 Sepacor Inc. Fluoxetine process from benzoylpropionic acid
US7410995B1 (en) 1998-08-14 2008-08-12 Gpi Nil Holdings Inc. N-linked sulfonamide of heterocyclic thioesters for vision and memory disorders
DE19918725A1 (de) 1999-04-24 2000-10-26 Bayer Ag Substituierte N-Cyano-sulfonsäureanilide
DE19929348A1 (de) 1999-06-26 2000-12-28 Bayer Ag Verfahren zur Herstellung von 2-Heterocyclylmethyl-benzoesäurederivaten
US7256005B2 (en) 1999-08-10 2007-08-14 The Chancellor, Masters And Scholars Of The University Of Oxford Methods for identifying iminosugar derivatives that inhibit HCV p7 ion channel activity
CA2381111A1 (fr) 1999-08-26 2001-03-01 Leah M. Giupponi Antagonistes des neuropeptides y: derives de spiroisoquinolinone
US6436928B1 (en) 1999-12-17 2002-08-20 Schering Corporation Selective neurokinin antagonists
ES2258485T3 (es) 1999-12-17 2006-09-01 Schering Corporation Antagonistas selectivos de neuroquinina.
WO2001055063A1 (fr) 2000-01-25 2001-08-02 Idemitsu Petrochemical Co., Ltd. Nouveaux composes a base de bisadamantane, procedes de production et nouveaux derives de bisadamantane
GB0003397D0 (en) 2000-02-14 2000-04-05 Merck Sharp & Dohme Therapeutic agents
IL152701A0 (en) * 2000-05-25 2003-06-24 Hoffmann La Roche Substituted 1-aminoalkyl-lactams and their use as muscarinic receptor antagonists
DE10034623A1 (de) 2000-07-17 2002-01-31 Bayer Ag Heterocyclisch substituierte Pyridine als Cytokin-Inhibitoren
DE10034803A1 (de) 2000-07-18 2002-01-31 Bayer Ag Substituierte Sulfonsäureanilide
DE10034800A1 (de) 2000-07-18 2002-01-31 Bayer Ag Substituierte Benzostickstoffheterocyclen
DE10035928A1 (de) 2000-07-21 2002-03-07 Asta Medica Ag Neue Heteroaryl-Derivate und deren Verwendung als Arzneimittel
DE10035927A1 (de) 2000-07-21 2002-03-07 Asta Medica Ag Neue Heteroaryl-Derivate und deren Verwendung als Arzneimittel
DE10035908A1 (de) 2000-07-21 2002-03-07 Asta Medica Ag Neue Heteroaryl-Derivate und deren Verwendung als Arzneimittel
MXPA03001344A (es) 2000-08-16 2004-04-05 Neurogen Corp Derivados de piridina 2,4-substituidos.
US7294637B2 (en) 2000-09-11 2007-11-13 Sepracor, Inc. Method of treating addiction or dependence using a ligand for a monamine receptor or transporter
EP1318988A2 (fr) 2000-09-11 2003-06-18 Sepracor, Inc. Ligands pour les recepteurs de monoamine et transporteurs, et procedes d'utilisation de ces derniers (neurotransmission)
JP2002179572A (ja) 2000-10-06 2002-06-26 Nikken Chem Co Ltd アレルギー性眼疾患治療剤
US6841671B2 (en) 2000-10-26 2005-01-11 Pfizer Inc. Spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors
US20030143668A1 (en) 2001-06-18 2003-07-31 National Institute Of Advanced Industrial Guanosine triphosphate-binding protein coupled receptors
JP3873115B2 (ja) 2001-09-25 2007-01-24 独立行政法人産業技術総合研究所 環状ウレタン製造方法
KR100687954B1 (ko) 2001-10-15 2007-02-27 쉐링 코포레이션 아데노신 Ａ2ａ 수용체 길항제로서의이미다조（4,3-ｅ）-1,2,4-트리아졸로（1,5-ｃ） 피리미딘
MXPA04004830A (es) 2001-11-22 2004-07-30 Ono Pharmaceutical Co Compuestos derivados de piperidin-2-ona, y composiciones farmaceuticas que los contienen como ingredientes activos.
JP2005516964A (ja) 2001-12-28 2005-06-09 バイエル・フアーマシユーチカルズ・コーポレーシヨン ５−ｈｔ２ｃレセプターと関連する疾患における使用のための１ｈ−ピラゾリル誘導体化合物
JP2003300884A (ja) 2002-04-08 2003-10-21 Nikken Chem Co Ltd ＴＮＦ−α産生阻害剤
AU2003219410A1 (en) 2002-04-26 2003-11-10 Pfizer Products Inc. Triaryl-oxy-aryl-spiro-pyrimidine-2, 4, 6-trione metalloproteinase inhibitors
AU2003216660A1 (en) 2002-04-26 2003-11-10 Pfizer Products Inc. N-substituted-heteroaryloxy-aryl-spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors
DE60335359D1 (de) 2002-04-30 2011-01-27 Kudos Pharm Ltd Phthalazinonderivate
CA2486157C (fr) 2002-05-17 2013-04-16 Jenken Biosciences, Inc. Composes opioides et de type opioide et leurs utilisations
CN1678317B (zh) 2002-07-03 2010-10-27 先灵公司 用作治疗呕吐、抑郁症、焦虑症和咳嗽的神经激肽-1(nk-1)拮抗剂的1-酰氨基-4-苯基-4-苄氧基甲基-哌啶衍生物和相关化合物
WO2004009559A2 (fr) 2002-07-18 2004-01-29 Queen's University At Kingston Composes de dihydro-uracile utilises comme agents anti-ictogenes ou anti-epileptogenes
GB0218630D0 (en) 2002-08-10 2002-09-18 Tanabe Seiyaku Co Novel compounds
AR041198A1 (es) 2002-10-11 2005-05-04 Otsuka Pharma Co Ltd Compuesto 2,3-dihidro-6-nitroimidazo[2,1-b] oxaxol, y composiciones farmaceuticas que lo contienen
AU2003302027A1 (en) 2002-11-21 2004-06-15 Vicore Pharma Ab New tricyclic angiotensin ii agonists
GB0228410D0 (en) 2002-12-05 2003-01-08 Glaxo Group Ltd Novel Compounds
WO2004055008A1 (fr) 2002-12-13 2004-07-01 Smithkline Beecham Corporation Composes, compositions et methodes
WO2004056744A1 (fr) 2002-12-23 2004-07-08 Janssen Pharmaceutica N.V. Adamantyl acetamides utilises comme inhibiteurs de la hydroxysteroide deshydrogenase
CN1764458A (zh) 2003-03-26 2006-04-26 麦克公司 作为黑皮质素－4受体激动剂的双环哌啶衍生物
US7700583B2 (en) 2003-04-11 2010-04-20 High Point Pharmaceuticals, Llc 11β-hydroxysteroid dehydrogenase type 1 active compounds
ATE482747T1 (de) 2003-04-11 2010-10-15 High Point Pharmaceuticals Llc Neue amide derivate und deren pharmazeutische verwendungen
SG169900A1 (en) 2003-04-16 2011-04-29 Memory Pharm Corp 4 - (3,4 - disubstituted phenyl) - pyrrolidin-2-one compounds as phosphodiesterase 4 inhibitors
ITMI20031292A1 (it) 2003-06-25 2004-12-26 Nikem Research Srl Derivati biciclici nk-2 antagonisti selettivi.
DE10358004A1 (de) 2003-12-11 2005-07-14 Abbott Gmbh & Co. Kg Ketolactam-Verbindungen und ihre Verwendung
US7186844B2 (en) 2004-01-13 2007-03-06 Mitsubishi Gas Chemical Co., Inc. Method for producing cyclic carbamate ester
JP4324669B2 (ja) 2004-01-21 2009-09-02 独立行政法人産業技術総合研究所 環状ウレタンの製造方法
JP2005239670A (ja) 2004-02-27 2005-09-08 Ono Pharmaceut Co Ltd 含窒素複素環化合物およびその医薬用途
CN101014574A (zh) 2004-03-09 2007-08-08 默克公司 Hiv整合酶抑制剂
US8519158B2 (en) 2004-03-12 2013-08-27 Ligand Pharmaceuticals Incorporated Androgen receptor modulator compounds and methods
JP2005272321A (ja) 2004-03-23 2005-10-06 Ono Pharmaceut Co Ltd 含窒素複素環化合物およびその医薬用途
AU2005240785B2 (en) 2004-05-07 2011-02-03 Janssen Pharmaceutica N.V. Adamantyl pyrrolidin-2-one derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors
AU2005240784C1 (en) * 2004-05-07 2011-12-22 Janssen Pharmaceutica N.V. Pyrrolidin-2-one and piperidin-2-one derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors
GB0411404D0 (en) 2004-05-21 2004-06-23 Glaxo Group Ltd Novel compounds
BRPI0510394A (pt) 2004-05-24 2007-11-13 Amgen Inc inibidores de 11-beta-hidroxiesteróide desidrogenase tipo 1
CA2571258A1 (fr) 2004-06-24 2006-01-05 Incyte Corporation Composes amido et leur utilisation comme produits pharmaceutiques
GB0414438D0 (en) 2004-06-28 2004-07-28 Syngenta Participations Ag Chemical compounds
DOP2005000123A (es) 2004-07-02 2011-07-15 Merck Sharp & Dohme Inhibidores de cetp
EP1621539A1 (fr) 2004-07-27 2006-02-01 Aventis Pharma S.A. Dérivées d'urée cyclique substitués par un heterocycle, leur prépration et leur utilisation pharmaceutique comee inhibiteurs de kinases
EP1621535A1 (fr) 2004-07-27 2006-02-01 Aventis Pharma S.A. Dérivés substitués d'urée cyclique, leur préparation et leur utilisation pharmaceutique comme inhibiteurs de kinases
EP1621536A1 (fr) 2004-07-27 2006-02-01 Aventis Pharma S.A. Dérivés d'urées cycliques aminés, leur préparation et utilisation pharmaceutique en tant qu'inhibiteurs de Kinase
JP2008508358A (ja) 2004-08-02 2008-03-21 オーエスアイ・ファーマスーティカルズ・インコーポレーテッド アリール−アミノ置換ピロロピリミジンマルチキナーゼ阻害化合物
AU2005273986A1 (en) * 2004-08-10 2006-02-23 Incyte Corporation Amido compounds and their use as pharmaceuticals
EP1784175A4 (fr) 2004-08-23 2009-07-22 Merck & Co Inc Inhibiteurs de l'activite de akt
CA2576850C (fr) 2004-08-30 2013-06-25 Janssen Pharmaceutica N.V. Derives de lactame tricyclique utilises en tant qu'inhibiteurs de 11-beta-hydroxysteroide deshydrogenase
CN101300005B (zh) 2004-08-30 2013-05-01 詹森药业有限公司 作为11-β羟类固醇脱氢酶抑制剂的N-2金刚烷基-2-苯氧基-乙酰胺衍生物
CA2579514A1 (fr) 2004-09-10 2006-03-23 Janssen Pharmaceutica N.V. Derives d'imidazolidine-2-one en tant que modulateurs selectifs du recepteur androgenique
EP1799647A1 (fr) * 2004-10-04 2007-06-27 F.Hoffmann-La Roche Ag Alkyl-pyridines utilisees en tant qu'inhibiteurs de 11 beta pour le traitement du diabete
EP1802623A1 (fr) 2004-10-12 2007-07-04 Novo Nordisk A/S Composes spiro actifs du type a- hydroxysteroide deshydrogenase de type 1
CA2581745A1 (fr) 2004-10-13 2006-04-27 Neurogen Corporation Composes de 8-azabicyclo[3.2.1]octane a substitution aryle comme ligands du recepteur de l'hormone de concentration de la melanine
US7713979B2 (en) 2004-10-29 2010-05-11 Eli Lilly And Company Cycloalkyl lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
ES2547724T3 (es) 2004-11-10 2015-10-08 Incyte Corporation Compuestos de lactama y su uso como productos farmacéuticos
GT200500375A (es) 2004-12-20 2006-11-28 Derivados de piperidina y su uso como agentes antiinflamatorios
JP2008525357A (ja) 2004-12-23 2008-07-17 キエシ・フアルマチエウテイチ・ソチエタ・ペル・アチオニ 抗ムスカリン活性を有するアゾール誘導体
JP5274842B2 (ja) 2004-12-28 2013-08-28 エグゼリクシス， インコーポレイテッド 免疫疾患、炎症疾患および増殖疾患の処置のためのセリン−スレオニンキナーゼモジュレーター（ｐ７０Ｓ６Ｋ、Ａｋｔ−１およびＡｋｔ−２）としての［１Ｈ−ピペラゾ［３，４−ｄ］ピリミジン−４−イル］−ピペラジンまたは［１Ｈ−ピペラゾ［３，４−ｄ］ピリミジン−４−イル］−ピペラジン化合物
WO2006078992A2 (fr) 2005-01-19 2006-07-27 Neurogen Corporation Analogues de piperazinyl-pyridine à substitution hétéroaryle
JP2008530218A (ja) 2005-02-16 2008-08-07 シェーリング コーポレイション Ｃｘｃｒ３アンタゴニスト活性を有する、ピリジルおよびフェニルで置換されたピペラジン−ピペリジン
JP4873352B2 (ja) 2005-02-16 2012-02-08 シェーリング コーポレイション Ｃｘｃｒ３アンタゴニスト活性を有する、複素環で置換されたピペラジン
MX2007010067A (es) 2005-02-16 2007-12-07 Schering Corp Compuestos heterociclicos novedosos sustituidos con piridina o fenilo con actividad antagonista de cxcr3.
PE20061164A1 (es) 2005-02-16 2006-10-27 Schering Corp Piperazin-piperidinas sustituidas con pirazinilo con actividad antagonista de cxcr3
MX2007010068A (es) 2005-02-16 2007-10-10 Schering Corp Piperazino-piperidinas con actividad antagonista de cxcr3.
EP1853583B1 (fr) 2005-02-16 2011-09-07 Schering Corporation Pyridyle a liaison amine et piperazine-piperidines substituees a activite agoniste cxcr3
ZA200707119B (en) 2005-02-24 2009-09-30 Nihon Nohyaku Co Ltd Novel haloalkylsulfonanilide derivative, herbicide, and method of use thereof
JPWO2006104280A1 (ja) 2005-03-31 2008-09-11 武田薬品工業株式会社 糖尿病の予防・治療剤
WO2006109056A1 (fr) 2005-04-12 2006-10-19 Vicore Pharma Ab Nouveaux agonistes de l’angiotensine ii tricyclique
WO2007008529A2 (fr) 2005-07-08 2007-01-18 Kalypsys, Inc Agents modificateurs de l'absorption du cholesterol cellulaire
CA2619881A1 (fr) 2005-08-16 2007-02-22 Genzyme Corporation Composes se liant aux recepteurs de chimiokine
CA2625762A1 (fr) 2005-10-11 2007-04-26 Schering Corporation Composes heterocycliques substitues ayant une activite antagoniste vis-a-vis du cxcr3
CA2627234A1 (fr) 2005-10-27 2007-05-03 Ucb Pharma, S.A. Composes comprenant un lactame ou un groupement derive de lactame, procedes de fabrication de ceux-ci, et leurs utilisations
EA200801243A1 (ru) 2005-11-01 2008-10-30 Транстек Фарма Фармацевтическое применение замещенных амидов
JP2007140188A (ja) 2005-11-18 2007-06-07 Fujifilm Corp ポジ型感光性組成物及びそれを用いたパターン形成方法
JP5204662B2 (ja) 2005-11-22 2013-06-05 アムジエン・インコーポレーテツド １１−β−ヒドロキシステロイドデヒドロゲナーゼ１型の阻害剤
CA2630492C (fr) 2005-12-05 2015-04-14 Incyte Corporation Composes spiro-lactames
EP1801098A1 (fr) 2005-12-16 2007-06-27 Merck Sante Dérivés de 2-Adamantylurea comme inhibiteurs de 11B-HSD1
WO2007076055A2 (fr) 2005-12-22 2007-07-05 Entremed, Inc. Compositions et methodes comprenant l'utilisation d'antagonistes du recepteur active par des proteases
DE102005062990A1 (de) 2005-12-28 2007-07-05 Grünenthal GmbH Substituierte Thiazole und ihre Verwendung zur Herstellung von Arzneimitteln
WO2007081570A2 (fr) 2005-12-30 2007-07-19 Merck & Co., Inc. Inhibiteurs de proteine de transfert des esters de cholesterol
EP1973889B1 (fr) 2005-12-30 2016-08-24 Merck Sharp & Dohme Corp. Inhibiteurs de cetp
EP1971595B1 (fr) 2005-12-30 2013-10-16 Merck Sharp & Dohme Corp. Inhibiteurs de cetp
NZ568904A (en) 2005-12-30 2011-05-27 Merck Sharp & Dohme 1,3-oxazolidin-2-one derivatives useful as CETP inhibitors
WO2007084314A2 (fr) 2006-01-12 2007-07-26 Incyte Corporation MODULATEURS de la 11-ß HYDROXYSTEROIDE DESHYDROGENASE DE TYPE 1, LEURS COMPOSITIONS PHARMACEUTIQUES ET LEURS PROCEDES D'UTILISATION
CA2643163C (fr) 2006-02-27 2020-01-28 Bayer Healthcare Llc Determination d'analyte ajustee a une temperature pour des systemes biocapteurs
US20070213311A1 (en) 2006-03-02 2007-09-13 Yun-Long Li Modulators of 11-beta hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same
WO2007103719A2 (fr) 2006-03-03 2007-09-13 Incyte Corporation MODULATEURS DE LA 11-β-HYDROXYSTÉROÏDE DÉSHYDROGÉNASE DE TYPE 1, LEURS COMPOSITIONS PHARMACEUTIQUES ET LEURS PROCÉDÉS D'UTILISATION
WO2007109456A2 (fr) 2006-03-16 2007-09-27 Pharmacopeia, Inc. Biphényle isoxazole sulfonamides substituées en tant que double antagonistes des récepteurs angiotensine et endothéline
JP2007254409A (ja) 2006-03-24 2007-10-04 Taisho Pharmaceut Co Ltd イミダゾリジノン誘導体
US7435833B2 (en) 2006-04-07 2008-10-14 Abbott Laboratories Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme
WO2007123853A2 (fr) 2006-04-20 2007-11-01 E. I. Du Pont De Nemours And Company Agents hétérocycliques à cinq chaînons utiles dans la lutte contre les parasites invertébrés
JP5161869B2 (ja) 2006-04-21 2013-03-13 イーライ リリー アンド カンパニー １１−β−ヒドロキシステロイドデヒドロゲナーゼ１の阻害剤としての、シクロヘキシルピラゾール−ラクタム誘導体
EA014718B1 (ru) 2006-04-21 2011-02-28 Эли Лилли Энд Компани Производные бифениламидлактама в качестве ингибиторов 11-бета-гидроксистероиддегидрогеназы 1
AU2007240450B2 (en) 2006-04-21 2011-12-22 Eli Lilly And Company Cyclohexylimidazole lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
CN101432263B (zh) * 2006-04-24 2012-03-07 伊莱利利公司 作为11-β-羟类固醇脱氢酶1抑制剂的取代的吡咯烷酮类
CN101432265B (zh) 2006-04-25 2011-12-14 伊莱利利公司 11-β-羟类固醇脱氢酶1的抑制剂
US8178005B2 (en) 2006-06-20 2012-05-15 Chemtura Corporation Liquid phosphite compositions having different alkyl groups
TW200811170A (en) 2006-06-27 2008-03-01 Sanofi Aventis Urea derivatives of tropane, their preparation and their therapeutic application
WO2008012622A2 (fr) 2006-07-25 2008-01-31 Pfizer Products Inc. Composés d'azabenzimidazolyle
WO2008012623A1 (fr) 2006-07-25 2008-01-31 Pfizer Products Inc. Composés de benzimidazolyle constituant des potentialisateurs du sous-type de récepteur de glutamate mglur2
US7538107B2 (en) 2006-08-15 2009-05-26 Wyeth Oxazinan-2-one derivatives useful as PR modulators
WO2008021338A2 (fr) 2006-08-15 2008-02-21 Wyeth Dérivés d'oxazolidone tricycliques utiles en tant que modulateurs du récepteur de la progestérone
US7649007B2 (en) 2006-08-15 2010-01-19 Wyeth Llc Oxazolidine derivatives as PR modulators
US8927715B2 (en) 2006-08-25 2015-01-06 Vitae Pharmaceuticals, Inc. Inhibitors of 11β-hydroxysteroid dehydrogenase type 1
CA2663280A1 (fr) 2006-09-14 2008-03-20 Neuromed Pharmaceuticals Ltd. Composes de diaryle piperidine utilises en tant que bloqueurs de canaux calciques
CA2662574A1 (fr) 2006-09-22 2008-03-27 Novartis Ag Composes organiques
DE102007005799B4 (de) 2006-10-18 2018-01-25 Heinz-Jürgen Mühlen Verfahren zur Erzeugung eines wasserstoffreichen Produktgases
CN101553474B (zh) * 2006-10-19 2013-02-27 霍夫曼-拉罗奇有限公司 作为糖尿病用11b-HSD1抑制剂的咪唑啉酮和咪唑烷酮衍生物
TW200829171A (en) 2006-11-17 2008-07-16 Nihon Nohyaku Co Ltd Haloalkyl sulfonanilide derivatives or salts thereof, herbicide using it as effective constituent and use-method thereof
EP1935420A1 (fr) 2006-12-21 2008-06-25 Merck Sante Dérivés du 2-adamantyl-butyramide en tant qu'inhibiteurs selectifs de la 11beta-HSD1
CA2678577A1 (fr) 2007-02-26 2008-09-04 Vitae Pharmaceuticals, Inc. Inhibiteurs d'uree et de carbamate de 11b-hydroxysteroide deshydrogenase 1 cycliques
MX2009010207A (es) 2007-03-23 2009-10-19 Schering Corp Peptidos de hidrazido como inhibidores de proteasa ns3 de virus de hepatitis c.
WO2008119663A1 (fr) 2007-03-29 2008-10-09 F. Hoffmann-La Roche Ag Composés hétérocycliques antiviraux
JP5470557B2 (ja) 2007-07-26 2014-04-16 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１型の阻害剤の合成
WO2009020140A1 (fr) 2007-08-06 2009-02-12 Dainippon Sumitomo Pharma Co., Ltd. Dérivé d'adamantylurée
JP2009110842A (ja) 2007-10-31 2009-05-21 Sumitomo Chemical Co Ltd ボタンスイッチ被覆用積層樹脂体
AR069207A1 (es) 2007-11-07 2010-01-06 Vitae Pharmaceuticals Inc Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1
TW200927115A (en) 2007-11-16 2009-07-01 Boehringer Ingelheim Int Aryl-and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use
US8440658B2 (en) 2007-12-11 2013-05-14 Vitae Pharmaceuticals, Inc. Cyclic urea inhibitors of 11β-hydroxysteroid dehydrogenase 1
KR101460359B1 (ko) 2007-12-13 2014-11-10 삼성전자주식회사 이동통신 시스템에서의 핸드오버 방법 및 장치
TW200934490A (en) 2008-01-07 2009-08-16 Vitae Pharmaceuticals Inc Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
WO2009094169A1 (fr) 2008-01-24 2009-07-30 Vitae Pharmaceuticals, Inc. Carbazate cyclique et inhibiteurs du type semi-carbazide de la 11β-hydroxystéroïde déshydrogénase 1
CA2714532A1 (fr) 2008-02-11 2009-08-20 Vitae Pharmaceuticals, Inc. INHIBITEURS 1,3-OXAZEPAN-2-ONE ET 1,3-DIAZEPAN-2-ONE DE LA 11ß-HYDROXYSTEROIDE DESHYDROGENASE (TYPE1)
JP5538239B2 (ja) 2008-02-12 2014-07-02 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ベンゾモルファン及び関連骨格の尿素誘導体、そのような化合物を含む医薬ならびにそれらの使用
US8598160B2 (en) 2008-02-15 2013-12-03 Vitae Pharmaceuticals, Inc. Cycloalkyl lactame derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
JP5451646B2 (ja) 2008-02-27 2014-03-26 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１型の阻害剤
JP5108557B2 (ja) 2008-02-27 2012-12-26 東京エレクトロン株式会社 ロードロック装置および基板冷却方法
WO2009117109A1 (fr) 2008-03-18 2009-09-24 Vitae Pharmaceuticals, Inc. Inhibiteurs de la 11-bêta-hydroxystéroïde déshydrogénase de type 1
TW200944526A (en) 2008-04-22 2009-11-01 Vitae Pharmaceuticals Inc Carbamate and urea inhibitors of 11β-hydroxysteroid dehydrogenase 1
JP5696037B2 (ja) 2008-05-01 2015-04-08 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状インヒビター
US8242111B2 (en) 2008-05-01 2012-08-14 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1
RU2531272C2 (ru) 2008-05-01 2014-10-20 Вайтаи Фармасьютиклз, Инк. Циклические ингибиторы 11бета-гидроксистероид-дегидрогеназы 1
EP2291370B1 (fr) 2008-05-01 2013-11-27 Vitae Pharmaceuticals, Inc. Inhibiteurs cycliques de la 11-bêta-hydroxystéroïde déhydrogénase 1
AR071719A1 (es) 2008-05-13 2010-07-07 Boehringer Ingelheim Int Derivados aliciclicos de acido carboxilico de benzomorfanos y estructuras relacionadas, medicamentos que contienen dichos compuestos y su uso.procesos de obtencion
US20110224242A1 (en) 2008-07-23 2011-09-15 Bioalliance Pharma Styrlyquinolines, their process of preparation and their therapeutic uses
EP2303844A1 (fr) 2008-07-23 2011-04-06 BioAlliance Pharma Styrylquinolines, leur procédé de préparation et leurs utilisations thérapeutiques
CA2730208C (fr) 2008-07-25 2016-10-25 Boehringer Ingelheim International Gmbh Acides 1,1'-diadamantyl carboxyliques, medicaments contenant de tels composes et application associee
NZ590495A (en) 2008-07-25 2012-10-26 Vitae Pharmaceuticals Inc Dihydropyridin-phenyl-3-oxazinan-2-ones as inhibitors of 11beta-hydroxysteroid dehydrogenase 1
WO2010010157A2 (fr) * 2008-07-25 2010-01-28 Boehringer Ingelheim International Gmbh Inhibiteurs de la 11 bêta-hydroxystéroïde déshydrogénase 1
EP2323994A1 (fr) 2008-07-25 2011-05-25 Boehringer Ingelheim International GmbH Synthèse d'inhibiteurs de la 11 -hydroxystéroïde déhydrogénase de type 1
CA2735204C (fr) 2008-08-25 2017-06-20 Boehringer Ingelheim International Gmbh Derives aryle et heteroarylcarbonyle de nortropanes substitues, medicaments contenant de tels composes et leurs applications
AR073920A1 (es) 2008-10-23 2010-12-09 Boehringer Ingelheim Int Derivados urea de nortropanos sustituidos, medicamentos que contienen dichos compuestos , su uso en el tratamiento de enfermedades mediadas por la inhibicion de la enzima 11beta-hidroxiesteroide deshidrogenasa y proceso para su preparacion.
JP5679997B2 (ja) 2009-02-04 2015-03-04 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状阻害剤
CA2750517A1 (fr) 2009-02-04 2010-08-12 Vitae Pharmaceuticals, Inc. Inhibiteurs cycliques de 11 beta-hydroxysteroide deshydrogenase 1
US8563583B2 (en) 2009-03-09 2013-10-22 Bristol-Myers Squibb Company Pyridone analogs useful as melanin concentrating hormone receptor-1 antagonists
US8680093B2 (en) 2009-04-30 2014-03-25 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
GEP20156309B (en) 2009-04-30 2015-07-10 Vitae Pharmaceuticals Inc Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
AR076936A1 (es) 2009-06-02 2011-07-20 Vitae Pharmaceuticals Inc Inhibidores de carbamato y urea de la 11 beta hidroxiesteroide deshidrogenasa 1
US8703765B2 (en) 2009-06-02 2014-04-22 Boehringer Ingelheim International Gmbh Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1
US8927539B2 (en) 2009-06-11 2015-01-06 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1 based on the 1,3-oxazinan-2-one structure
EP2448928B1 (fr) 2009-07-01 2014-08-13 Vitae Pharmaceuticals, Inc. Inhibiteurs cycliques de la 11-bêta-hydroxystéroïde déshydrogénase 1
SG179083A1 (en) 2009-09-11 2012-04-27 Cylene Pharmaceuticals Inc Pharmaceutically useful heterocycle-substituted lactams
WO2011056737A1 (fr) 2009-11-05 2011-05-12 Boehringer Ingelheim International Gmbh Nouveaux ligands de phosphore chiraux
AR078887A1 (es) 2009-11-06 2011-12-07 Boehringer Ingelheim Int Derivados arilo y heteroarilcarbonilo de hexahidroindenopiridina y octahidrobenzoquinolina y composiciones farmaceuticas que los contienen.
WO2011159760A1 (fr) 2010-06-16 2011-12-22 Vitae Pharmaceuticals, Inc. Hétérocycles à 5, 6 et 7 chaînons substitués, médicaments contenant ces composés et leur utilisation
WO2011161128A1 (fr) 2010-06-25 2011-12-29 Boehringer Ingelheim International Gmbh Azaspirohexanones comme inhibiteurs de 11-β-hsd1 pour le traitement de troubles métaboliques
WO2012059416A1 (fr) 2010-11-02 2012-05-10 Boehringer Ingelheim International Gmbh Combinaisons pharmaceutiques destinées au traitement de troubles du métabolisme

Also Published As

Publication number Publication date
CL2011002697A1 (es) 2012-06-01
EA201101270A1 (ru) 2012-03-30
US20110009402A1 (en) 2011-01-13
AU2009274567A1 (en) 2010-01-28
US8754076B2 (en) 2014-06-17
JP2011507911A (ja) 2011-03-10
CO6351743A2 (es) 2011-12-20
IL210452A (en) 2016-02-29
PE20110566A1 (es) 2011-09-02
RU2539979C2 (ru) 2015-01-27
CN102421773A (zh) 2012-04-18
PH12014501532A1 (en) 2015-12-14
JP5379160B2 (ja) 2013-12-25
ES2432150T3 (es) 2013-12-02
CN102421773B (zh) 2014-09-03
EP2687525B1 (fr) 2015-09-23
PL2324018T3 (pl) 2014-02-28
EP2324018B1 (fr) 2013-09-04
NZ590495A (en) 2012-10-26
JP5870073B2 (ja) 2016-02-24
DK2324018T3 (da) 2013-10-14
AR073348A1 (es) 2010-11-03
TW201004946A (en) 2010-02-01
UY32591A (es) 2010-11-30
US20130096108A1 (en) 2013-04-18
WO2010011314A1 (fr) 2010-01-28
EP2324018A1 (fr) 2011-05-25
EP2687525A1 (fr) 2014-01-22
CL2011000159A1 (es) 2011-06-17
CA2730499A1 (fr) 2010-01-28
CN104327062A (zh) 2015-02-04
IL210452A0 (en) 2011-03-31
ECSP10010633A (es) 2011-05-31
EA020665B1 (ru) 2014-12-30
RU2011106374A (ru) 2012-08-27
JP2014015475A (ja) 2014-01-30
CN102119160B (zh) 2014-11-05
US8114868B2 (en) 2012-02-14
AU2009274567B2 (en) 2013-04-04
KR20110050459A (ko) 2011-05-13
CN102119160A (zh) 2011-07-06
EA201490304A1 (ru) 2014-05-30
US20120184549A1 (en) 2012-07-19

Similar Documents

Publication Publication Date Title
MA32596B1 (fr) Inhibiteurs cycliques de la 11 bêta-hydroxystéroïde deshydrogénase 1
MA33216B1 (fr) Inhibiteurs cycliques de la 11béta-hydroxysteroïde déshydrogénase 1
MA31117B1 (fr) Composes tricycliques et leur utilisation comme modulateurs du recepteur de glucocorticoïdes
SA521422625B1 (ar) مركبات بنزوثيادايازيبين واستخدامها كمعدلات لحمض الصفراء
MA34909B1 (fr) Triterpénoïdes modifi2s en c-17 et c-3 presentant une activité inhibitrice de la maturation du vih
MA47102B1 (fr) Dérivés de pyrane en tant qu'inhibiteurs de cyp11a1 (cytochrome p450 monooxygénase 11a1)
TN2010000230A1 (fr) Agonistes nouveaux des recepteurs de glucocorticoides
EA200602191A1 (ru) 5,5-дизамещённые-2-амино-4-тиазолидиноны и способ их получения, фармацевтическая композиция и способ лечения
CL2008001839A1 (es) Compuestos derivados de 2,7-diazaespirociclos, inhibidores de 11-beta hidroxil esteroide deshidrogenasa tipo 1; composicion farmaceutica que comprende a dichos compuestos; utiles para tratar la obesidad, diabetes, intolerancia a la glucosa, diabetes tipo ii, entre otras enfermedades.
MA34234B1 (fr) Composes pyrazol-4-yl-heterocyclyle-carboxamide et leurs procedes d'utilisation
MX2009009581A (es) Indazoles usados para tratar trastornos mediados por el receptor de estrogenos beta.
Luo et al. Multifunctional thioxanthone derivatives with acetylcholinesterase, monoamine oxidases and β-amyloid aggregation inhibitory activities as potential agents against Alzheimer’s disease
WO2009102460A3 (fr) Inhibiteurs de 11beta-hydroxystéroïde deshydrogénase 1
MA37798B1 (fr) 4-méthyl-2,3,5,9,9b-pentaaza-cyclopenta[a]naphtalènes
MA48728B1 (fr) Niraparib, acétate d'abiratérone et prednisone pour le traitement du cancer de la prostate
EP2004177A4 (fr) Composes de nitrofurane utilises dans le traitement du cancer et de l'angiogenese
UY29316A1 (es) Miméticos de glucocorticoides, métodos para prepararlos, composiciones farmacéuticas, y usos de los mismos.
CR10387A (es) Derivados de 6,7,8,9-tetrahidro-5h-pirimido[4,5-d]azepin-4-il] amina como moduladores del potencial transitorio de receptor vaillinoide 1 para el tratamiento de dolor
MA33561B1 (fr) Dérivés d'isoxazolidine
MA32108B1 (fr) Derives d'indazole
WO2009039218A3 (fr) Compositions et procédés pour traiter une inflammation et des troubles liés à une inflammation à l'aide d'extraits de plectranthus amboinicus
MA43960B1 (fr) Triterpénoïdes modifiés en c-3 et c-17 utilisés comme inhibiteurs du vih-1
WO2007136910A3 (fr) Immunothérapie pour patients immunodéprimés
DE602006019911D1 (de) Mglur1-antagonisten als therapeutische wirkstoffe
Wagle et al. Influence of functional moiety in lupane-type triterpenoids in BACE1 inhibition