MA32628B1 - Agents antifongiques - Google Patents

Agents antifongiques

Info

Publication number
MA32628B1
MA32628B1 MA33691A MA33691A MA32628B1 MA 32628 B1 MA32628 B1 MA 32628B1 MA 33691 A MA33691 A MA 33691A MA 33691 A MA33691 A MA 33691A MA 32628 B1 MA32628 B1 MA 32628B1
Authority
MA
Morocco
Prior art keywords
compounds
hydrates
formulations
salts
methods
Prior art date
Application number
MA33691A
Other languages
Arabic (ar)
English (en)
Inventor
Mark L Greenlee
Robert WILKENING
James Apgar
Kenneth James Wildonger
Dongfang Meng
Dann L Parker Jr
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41669132&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA32628(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of MA32628B1 publication Critical patent/MA32628B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
    • A01N43/647—Triazoles; Hydrogenated triazoles
    • A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Agronomy & Crop Science (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Environmental Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cosmetics (AREA)

Abstract

La présente invention concerne des dérivés inédits de l'enfumafungine, ainsi que leurs sels, hydrates et promédicaments pharmaceutiquement acceptables. L'invention concerne également des compositions contenant lesdits composés, des procédés de préparation desdits composés et des procédés d'utilisation desdits composés en tant qu'agents antifongiques et/ou qu'inhibiteurs de la (1,3)-²-d-glucan synthase. Les composés décrits, leurs sels, hydrates et promédicaments pharmaceutiquement acceptables, ainsi que les compositions comprenant lesdits composés, sels, hydrates et promédicaments se révèlent utiles dans le cadre du traitement et/ou de la prévention des infections fongiques et des maladies et affections associées.
MA33691A 2008-08-12 2011-03-11 Agents antifongiques MA32628B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13610608P 2008-08-12 2008-08-12
PCT/US2009/004557 WO2010019203A1 (fr) 2008-08-12 2009-08-07 Agents antifongiques

Publications (1)

Publication Number Publication Date
MA32628B1 true MA32628B1 (fr) 2011-09-01

Family

ID=41669132

Family Applications (1)

Application Number Title Priority Date Filing Date
MA33691A MA32628B1 (fr) 2008-08-12 2011-03-11 Agents antifongiques

Country Status (30)

Country Link
EP (1) EP2326172B1 (fr)
KR (1) KR101686075B1 (fr)
AR (1) AR073037A1 (fr)
BR (1) BRPI0912074B1 (fr)
CL (1) CL2011000292A1 (fr)
CO (1) CO6351686A2 (fr)
CR (1) CR20110075A (fr)
DK (1) DK2326172T3 (fr)
DO (1) DOP2011000053A (fr)
EA (1) EA018337B1 (fr)
ES (1) ES2526652T3 (fr)
GT (1) GT201100039A (fr)
HN (1) HN2011000404A (fr)
HR (1) HRP20150009T1 (fr)
IL (2) IL210975A (fr)
MA (1) MA32628B1 (fr)
MX (1) MX2011001656A (fr)
MY (1) MY156955A (fr)
NI (1) NI201100035A (fr)
NZ (1) NZ590914A (fr)
PE (1) PE20110676A1 (fr)
PL (1) PL2326172T3 (fr)
PT (1) PT2326172E (fr)
RS (1) RS53731B1 (fr)
SI (1) SI2326172T1 (fr)
SV (1) SV2011003839A (fr)
TW (1) TWI439458B (fr)
UA (1) UA105639C2 (fr)
WO (1) WO2010019203A1 (fr)
ZA (1) ZA201100788B (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20220544T1 (hr) 2015-01-19 2022-08-05 Scynexis, Inc. Nove soli i polimorfi scy-078
MA49889A (fr) * 2017-04-10 2020-06-24 Scynexis Inc Agents antifongiques utilisés en association
KR102807716B1 (ko) 2017-08-04 2025-05-13 싸이넥시스, 인크. 산성 pH에서 증진된 활성을 갖는 항진균제
US20220117948A1 (en) * 2019-01-30 2022-04-21 Scynexis, Inc. Triterpenoid antifungals for the treatment of fungal osteo-articular infections
AU2020276595B2 (en) * 2019-05-16 2025-12-04 Scynexis, Inc. Antifungal Agents for Candida Auris Decolonization
EP4157356A1 (fr) 2020-05-29 2023-04-05 Centre National de la Recherche Scientifique Promédicaments antifongiques

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5756472A (en) 1996-01-31 1998-05-26 Merck & Co., Inc. Antifungal agent obtained from hormonema
DE69718141T2 (de) * 1996-01-31 2003-08-21 Merck & Co., Inc. Fungizid
US20050131041A1 (en) * 2002-04-17 2005-06-16 Mohammad Salman Azole derivatives as antifungal agents
JP5245057B2 (ja) 2006-04-03 2013-07-24 メルク・シャープ・アンド・ドーム・コーポレーション 抗真菌剤

Also Published As

Publication number Publication date
CL2011000292A1 (es) 2011-11-04
EP2326172A4 (fr) 2012-06-06
TW201011004A (en) 2010-03-16
IL242031A0 (en) 2015-11-30
NI201100035A (es) 2011-09-20
NZ590914A (en) 2011-11-25
ES2526652T3 (es) 2015-01-14
HK1158017A1 (en) 2012-07-13
ZA201100788B (en) 2012-05-01
EA018337B1 (ru) 2013-07-30
DOP2011000053A (es) 2011-04-30
PE20110676A1 (es) 2011-09-23
HN2011000404A (es) 2013-09-23
CR20110075A (es) 2011-06-03
WO2010019203A8 (fr) 2011-03-17
IL210975A (en) 2015-10-29
EP2326172A1 (fr) 2011-06-01
TWI439458B (zh) 2014-06-01
EP2326172B1 (fr) 2014-10-22
SI2326172T1 (sl) 2015-02-27
GT201100039A (es) 2013-08-21
HRP20150009T1 (hr) 2015-02-27
RS53731B1 (sr) 2015-06-30
SV2011003839A (es) 2011-07-06
EA201100350A1 (ru) 2011-08-30
PL2326172T3 (pl) 2015-03-31
MX2011001656A (es) 2011-05-25
UA105639C2 (uk) 2014-06-10
IL210975A0 (en) 2011-04-28
KR101686075B1 (ko) 2016-12-13
AR073037A1 (es) 2010-10-06
BRPI0912074A2 (pt) 2018-10-02
MY156955A (en) 2016-04-15
WO2010019203A1 (fr) 2010-02-18
CO6351686A2 (es) 2011-12-20
KR20110045054A (ko) 2011-05-03
DK2326172T3 (da) 2015-01-26
BRPI0912074B1 (pt) 2021-08-03
PT2326172E (pt) 2015-02-04

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