MA34229B1 - Compositions et méthodes de modulation des kinases et leurs indications - Google Patents

Compositions et méthodes de modulation des kinases et leurs indications

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Publication number
MA34229B1
MA34229B1 MA35365A MA35365A MA34229B1 MA 34229 B1 MA34229 B1 MA 34229B1 MA 35365 A MA35365 A MA 35365A MA 35365 A MA35365 A MA 35365A MA 34229 B1 MA34229 B1 MA 34229B1
Authority
MA
Morocco
Prior art keywords
disease
cancer
trkb
flt3
fms
Prior art date
Application number
MA35365A
Other languages
English (en)
Inventor
Jiazhong Zhang
Prabha N Ibrahim
Wayne Spevak
James Tsai
Todd Ewing
Ying Zhang
Chao Zhang
Original Assignee
Plexxikon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44816304&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA34229(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Plexxikon Inc filed Critical Plexxikon Inc
Publication of MA34229B1 publication Critical patent/MA34229B1/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
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    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Engineering & Computer Science (AREA)
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  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
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  • Diabetes (AREA)
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  • Hematology (AREA)
  • Pain & Pain Management (AREA)
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  • Cardiology (AREA)
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  • Obesity (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La présente invention concerne des composés et leurs sels, leurs conjugués, leurs dérivés, leurs formes, des formulations en contenant et leurs utilisations. Selon certains aspects et modes de réalisation, les composés décrits ou leurs sels, leurs conjugués, leurs dérivés, leurs formes, les formulations en contenant sont actifs sur une ou plusieurs des protéines kinases Fms, Kit, Flt3, TrkA, TrkB et TrkC. L'invention concerne également des méthodes d'utilisation de ces substances à des fins de traitement de maladies et d'affections, dont des maladies et affections associées à l'activité d'une ou plusieurs des protéines kinases Fms, Kit, Flt3, TrkA, TrkB et TrkC, cela comprenant la polyarthrite, l'arthrose, l'ostéoporose, l'ostéolyse périprothétique, la sclérodermie généralisée, les troubles de la démyélinisation, la sclérose en plaques, la maladie de Charcot-Marie-Tooth, la sclérose latérale amyotrophique, la maladie d'Alzheimer, la maladie de Parkinson, l'ischémie globale, la colite ulcéreuse, la maladie de Crohn, le purpura thrombocytopénique d'origine immunitaire, l'athérosclérose, le lupus érythémateux disséminé, la myélopréparation pour greffe autologue, le rejet de greffe, la glomérulonéphrite, la néphrite interstitielle, la néphropathie lupique, la nécrose tubulaire, la néphropathie diabétique, l'hypertrophie rénale, le diabète de type I, la douleur aiguë, la douleur inflammatoire, la douleur neuropathique, la leucémie myéloïde aiguë, le mélanome, le myélome multiple, le cancer du sein, le cancer de la prostate, le cancer du pancréas, le cancer du poumon, le cancer de l'ovaire, les gliomes, le glioblastome, la neurofibromatose, les métastases osseuses ostéolytiques, les métastases cérébrales, les tumeurs stromales gastro-intestinales et les tumeurs à cellules géantes.
MA35365A 2010-04-21 2011-04-20 Compositions et méthodes de modulation des kinases et leurs indications MA34229B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32662610P 2010-04-21 2010-04-21
PCT/US2011/033192 WO2011133637A2 (fr) 2010-04-21 2011-04-20 Compositions et méthodes de modulation des kinases et leurs indications

Publications (1)

Publication Number Publication Date
MA34229B1 true MA34229B1 (fr) 2013-05-02

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ID=44816304

Family Applications (1)

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MA35365A MA34229B1 (fr) 2010-04-21 2011-04-20 Compositions et méthodes de modulation des kinases et leurs indications

Country Status (39)

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US (3) US8901118B2 (fr)
EP (1) EP2560972B1 (fr)
JP (2) JP5808793B2 (fr)
KR (1) KR101799126B1 (fr)
CN (1) CN102947305B (fr)
AR (2) AR080940A1 (fr)
AU (1) AU2011242778B2 (fr)
BR (1) BR112012026927A2 (fr)
CA (1) CA2796998C (fr)
CL (1) CL2012002937A1 (fr)
CO (1) CO6620045A2 (fr)
CR (1) CR20120536A (fr)
CY (1) CY1120554T1 (fr)
DK (1) DK2560972T3 (fr)
EA (1) EA028105B1 (fr)
EC (1) ECSP12012245A (fr)
ES (1) ES2641643T3 (fr)
GE (1) GEP20156251B (fr)
HR (1) HRP20171660T1 (fr)
HU (1) HUE036461T2 (fr)
IL (1) IL222498A (fr)
LT (1) LT2560972T (fr)
MA (1) MA34229B1 (fr)
MX (1) MX336056B (fr)
MY (1) MY160780A (fr)
NZ (2) NZ603087A (fr)
PE (1) PE20130240A1 (fr)
PH (1) PH12012502103A1 (fr)
PL (1) PL2560972T3 (fr)
PT (1) PT2560972T (fr)
RS (1) RS56588B1 (fr)
SG (2) SG184874A1 (fr)
SI (1) SI2560972T1 (fr)
SM (1) SMT201700458T1 (fr)
TW (2) TWI510487B (fr)
UA (1) UA109128C2 (fr)
UY (1) UY33346A (fr)
WO (1) WO2011133637A2 (fr)
ZA (1) ZA201207898B (fr)

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NZ703538A (en) 2016-11-25
CO6620045A2 (es) 2013-02-15
GEP20156251B (en) 2015-02-25
PE20130240A1 (es) 2013-03-04
EA201290973A1 (ru) 2013-04-30
AR115233A2 (es) 2020-12-09
JP2013525363A (ja) 2013-06-20
CL2012002937A1 (es) 2013-01-25
AU2011242778A1 (en) 2012-11-22
TW201136929A (en) 2011-11-01
EP2560972A2 (fr) 2013-02-27
JP2016028073A (ja) 2016-02-25
DK2560972T3 (da) 2017-11-27
EP2560972A4 (fr) 2013-11-20
RS56588B1 (sr) 2018-02-28
UY33346A (es) 2011-10-31
HRP20171660T1 (hr) 2017-12-15
BR112012026927A2 (pt) 2017-10-10
US20110263595A1 (en) 2011-10-27
ECSP12012245A (es) 2012-11-30
TWI510487B (zh) 2015-12-01
CR20120536A (es) 2013-02-01
CA2796998C (fr) 2019-03-05
SG184874A1 (en) 2012-11-29
PT2560972T (pt) 2017-10-09
EP2560972B1 (fr) 2017-09-20
US8901118B2 (en) 2014-12-02
SI2560972T1 (sl) 2017-12-29
WO2011133637A3 (fr) 2012-02-09
US20170283423A1 (en) 2017-10-05
TWI619713B (zh) 2018-04-01
UA109128C2 (ru) 2015-07-27
HUE036461T2 (hu) 2018-07-30
MX336056B (es) 2016-01-07
ZA201207898B (en) 2016-09-28
SMT201700458T1 (it) 2017-11-15
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CY1120554T1 (el) 2019-07-10

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