MA37577A1 - 1h-pyrazolo[3,4-b]pyridines et leurs utilisations thérapeutiques - Google Patents

1h-pyrazolo[3,4-b]pyridines et leurs utilisations thérapeutiques

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Publication number
MA37577A1
MA37577A1 MA37577A MA37577A MA37577A1 MA 37577 A1 MA37577 A1 MA 37577A1 MA 37577 A MA37577 A MA 37577A MA 37577 A MA37577 A MA 37577A MA 37577 A1 MA37577 A1 MA 37577A1
Authority
MA
Morocco
Prior art keywords
pyrazolo
pyridines
therapeutic uses
disease
osteoarthritis
Prior art date
Application number
MA37577A
Other languages
English (en)
Other versions
MA37577B1 (fr
Inventor
John Hood
Sunil Kumar Kc
David Mark Wallace
Original Assignee
Samumed Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Samumed Llc filed Critical Samumed Llc
Publication of MA37577A1 publication Critical patent/MA37577A1/fr
Publication of MA37577B1 publication Critical patent/MA37577B1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • C07D—HETEROCYCLIC COMPOUNDS
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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Dispersion Chemistry (AREA)
  • Psychiatry (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Child & Adolescent Psychology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)

Abstract

L'invention concerne des composés selon les formules (i) ou (ii) et les sels pharmaceutiquement acceptables de ceux-ci, et des compositions les comprenant, destinées à être utilisées dans divers procédés, comprenant le traitement du cancer, de la prolifération cellulaire anormale, de l'angiogenèse, de la maladie d'alzheimer, de la maladie du poumon, de l'arthrose, de la fibrose pulmonaire idiopathique et des états/troubles/maladies neurologiques. Formule (i) et (ii).
MA37577A 2012-05-04 2013-05-03 1h-pyrazolo[3,4-b]pyridines et leurs utilisations thérapeutiques MA37577B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261642915P 2012-05-04 2012-05-04
PCT/US2013/039484 WO2013166396A2 (fr) 2012-05-04 2013-05-03 1h-pyrazolo[3,4-b]pyridines et leurs utilisations thérapeutiques

Publications (2)

Publication Number Publication Date
MA37577A1 true MA37577A1 (fr) 2016-11-30
MA37577B1 MA37577B1 (fr) 2018-05-31

Family

ID=49513001

Family Applications (1)

Application Number Title Priority Date Filing Date
MA37577A MA37577B1 (fr) 2012-05-04 2013-05-03 1h-pyrazolo[3,4-b]pyridines et leurs utilisations thérapeutiques

Country Status (33)

Country Link
US (8) US8883822B2 (fr)
EP (2) EP2770994B1 (fr)
JP (3) JP6209593B2 (fr)
KR (1) KR102223301B1 (fr)
CN (2) CN107417707A (fr)
AU (2) AU2013256141B2 (fr)
BR (1) BR112014024284B1 (fr)
CA (1) CA2854229C (fr)
CL (1) CL2014002983A1 (fr)
CO (1) CO7170178A2 (fr)
CY (1) CY1122703T1 (fr)
DK (1) DK2770994T3 (fr)
ES (1) ES2752192T3 (fr)
HR (1) HRP20191799T1 (fr)
HU (1) HUE046216T2 (fr)
IL (2) IL235018B (fr)
LT (1) LT2770994T (fr)
MA (1) MA37577B1 (fr)
ME (1) ME03573B (fr)
MX (1) MX362466B (fr)
MY (1) MY173049A (fr)
NZ (3) NZ629282A (fr)
PE (1) PE20142365A1 (fr)
PH (3) PH12014502369A1 (fr)
PL (1) PL2770994T3 (fr)
PT (1) PT2770994T (fr)
RS (1) RS59668B1 (fr)
RU (1) RU2689141C2 (fr)
SG (2) SG10201710585UA (fr)
SI (1) SI2770994T1 (fr)
SM (1) SMT201900618T1 (fr)
WO (1) WO2013166396A2 (fr)
ZA (2) ZA201406274B (fr)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
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PL2464232T3 (pl) 2009-08-10 2016-04-29 Samumed Llc Indazolowe inhibitory szlaku sygnałowego Wnt i ich zastosowania terapeutyczne
US8450340B2 (en) 2009-12-21 2013-05-28 Samumed, Llc 1H-pyrazolo[3,4-b]pyridines and therapeutic uses thereof
WO2012177647A2 (fr) 2011-06-20 2012-12-27 Kerry Lane Diagnostics de mycotoxine et procédés correspondants
EP3473099A1 (fr) 2011-09-14 2019-04-24 Samumed, LLC Indazole-3-carboxamides et leur utilisation en tant qu'inhibiteurs de la voie de signalisation par wnt/b-caténine
PH12017500997A1 (en) 2012-04-04 2018-02-19 Samumed Llc Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof
CN107417707A (zh) * 2012-05-04 2017-12-01 萨穆梅德有限公司 1H‑吡唑并[3,4‑b]吡啶及其治疗应用
WO2014110086A2 (fr) 2013-01-08 2014-07-17 Samumed, Llc Inhibiteurs de 3-(benzoimidazol-2-yl)-indazole de la voie de signalisation par wnt et leurs utilisations thérapeutiques
CA3161836A1 (fr) * 2013-12-11 2015-06-18 Celgene Quanticel Research, Inc. Inhibiteur de la demethylase-1 specifique de la lysine
EP3122739B1 (fr) * 2014-03-27 2019-01-16 Merck Patent GmbH Pyridyl-pipéridines
WO2016040190A1 (fr) 2014-09-08 2016-03-17 Samumed, Llc 3-(3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridine et ses utilisations thérapeutiques
WO2016040185A1 (fr) 2014-09-08 2016-03-17 Samumed, Llc 2-1h-indazol-3-yl)-3h-imidazo[4,5-b]pyridine et ses utilisations thérapeutiques
WO2016040184A1 (fr) 2014-09-08 2016-03-17 Samumed, Llc 3-3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine et ses utilisations thérapeutiques
WO2016040180A1 (fr) 2014-09-08 2016-03-17 Samumed, Llc 3-1h-benzo[d]imidazol-2-yl)-1h-pyrazolo[3,4-c]pyridine et ses utilisations thérapeutiques
WO2016040181A1 (fr) 2014-09-08 2016-03-17 Samumed, Llc 3-1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine et ses utilisations thérapeutiques
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