MA38250A1 - Nouveau dérivés d'hydantoïne pour leurs utilisations dans le traitement de maladies, comme l'osteoporose et la thrombocytopenie - Google Patents
Nouveau dérivés d'hydantoïne pour leurs utilisations dans le traitement de maladies, comme l'osteoporose et la thrombocytopenieInfo
- Publication number
- MA38250A1 MA38250A1 MA38250A MA38250A MA38250A1 MA 38250 A1 MA38250 A1 MA 38250A1 MA 38250 A MA38250 A MA 38250A MA 38250 A MA38250 A MA 38250A MA 38250 A1 MA38250 A1 MA 38250A1
- Authority
- MA
- Morocco
- Prior art keywords
- thrombocytopenia
- osteoporosis
- diseases
- treatment
- hydantoin derivatives
- Prior art date
Links
- 208000001132 Osteoporosis Diseases 0.000 title 1
- 229940053195 antiepileptics hydantoin derivative Drugs 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 150000001469 hydantoins Chemical class 0.000 title 1
- 206010043554 thrombocytopenia Diseases 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
Abstract
La présente invention concerne un composé qui peut être représenté par la formule générale (1) ou un sel pharmacologiquement permis de celui-ci. (1) (dans la formule, r1, r2, r3 et r4 sont tels que définis dans les revendications.)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012269178 | 2012-12-10 | ||
| PCT/JP2013/083022 WO2014092061A1 (fr) | 2012-12-10 | 2013-12-10 | Dérivé d'hydantoïne |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MA38250A1 true MA38250A1 (fr) | 2017-02-28 |
| MA38250B1 MA38250B1 (fr) | 2017-10-31 |
Family
ID=50934349
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA38250A MA38250B1 (fr) | 2012-12-10 | 2013-12-10 | Nouveau dérivés d'hydantoïne pour leurs utilisations dans le traitement de maladies, comme l'osteoporose et la thrombocytopenie |
Country Status (34)
| Country | Link |
|---|---|
| US (5) | US9428505B2 (fr) |
| EP (1) | EP2930176B1 (fr) |
| JP (1) | JP5951799B2 (fr) |
| KR (1) | KR102168738B1 (fr) |
| CN (1) | CN104854106B (fr) |
| AU (1) | AU2013358167B2 (fr) |
| BR (1) | BR112015012411B1 (fr) |
| CA (1) | CA2892621C (fr) |
| CL (2) | CL2015001391A1 (fr) |
| CR (1) | CR20150272A (fr) |
| DK (1) | DK2930176T3 (fr) |
| ES (1) | ES2663797T3 (fr) |
| HR (1) | HRP20180647T1 (fr) |
| HU (1) | HUE037530T2 (fr) |
| IL (1) | IL238277B (fr) |
| LT (1) | LT2930176T (fr) |
| MA (1) | MA38250B1 (fr) |
| MX (1) | MX2015007309A (fr) |
| MY (1) | MY178583A (fr) |
| NO (1) | NO2930176T3 (fr) |
| NZ (1) | NZ707946A (fr) |
| PE (1) | PE20151295A1 (fr) |
| PH (1) | PH12015501146B1 (fr) |
| PL (1) | PL2930176T3 (fr) |
| PT (1) | PT2930176T (fr) |
| RS (1) | RS57190B1 (fr) |
| RU (1) | RU2678984C2 (fr) |
| SA (1) | SA515360528B1 (fr) |
| SG (1) | SG11201504204XA (fr) |
| SI (1) | SI2930176T1 (fr) |
| TW (1) | TWI615394B (fr) |
| UA (1) | UA115072C2 (fr) |
| WO (1) | WO2014092061A1 (fr) |
| ZA (1) | ZA201503597B (fr) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI496782B (zh) | 2009-04-28 | 2015-08-21 | Chugai Pharmaceutical Co Ltd | Spiro haloperidone derivatives |
| MY178583A (en) * | 2012-12-10 | 2020-10-16 | Chugai Pharmaceutical Co Ltd | Hydantoin derivative |
| MX371090B (es) * | 2014-06-09 | 2020-01-16 | Chugai Pharmaceutical Co Ltd | Composicion farmaceutica que contiene derivado de hidantoina. |
| AU2019313853A1 (en) * | 2018-07-30 | 2021-03-04 | Chugai Seiyaku Kabushiki Kaisha | Solid dispersion of hydantoin derivative |
| CN110464002A (zh) * | 2019-09-12 | 2019-11-19 | 西南石油大学 | 一种天然冰粉的制备方法及其应用 |
| TW202440065A (zh) | 2022-12-28 | 2024-10-16 | 日商中外製藥股份有限公司 | 包含分散對象物質的固體分散體、包含其之醫藥組合物及其製造方法 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH1135470A (ja) * | 1997-07-23 | 1999-02-09 | Teijin Ltd | ビタミンｄ３誘導体を含有する副甲状腺ホルモン産生促進剤 |
| CN1132819C (zh) | 1998-12-11 | 2003-12-31 | 霍夫曼-拉罗奇有限公司 | 作为TNF－α抑制剂的环状肼衍生物 |
| WO2002017911A1 (fr) * | 2000-08-30 | 2002-03-07 | Teijin Limited | Inhibiteurs de la production de parathormone contenant des derives de vitamine d3 |
| CZ20031083A3 (cs) * | 2000-10-26 | 2004-03-17 | Pfizer Products Inc. | 5-Spiropyrimidin-2, 4, 6-trionové inhibitory metaloproteinasy |
| SE0100902D0 (sv) | 2001-03-15 | 2001-03-15 | Astrazeneca Ab | Compounds |
| AR038658A1 (es) * | 2001-06-15 | 2005-01-26 | Novartis Ag | Derivados de 4-aril-2(1h) quinazolinona y 4-aril-quinazolina 2-sustituidas, un proceso para su preparacion, composiciones farmaceuticas y el uso de dichos derivados para la preparacion de un medicamento |
| AU2003237424A1 (en) * | 2002-06-06 | 2003-12-22 | Donnelly Corporation | Interior rearview mirror system with compass |
| EP1713815A4 (fr) * | 2004-02-11 | 2009-03-11 | Smithkline Beecham Corp | Agonistes de pth |
| WO2005077918A1 (fr) | 2004-02-11 | 2005-08-25 | Smithkline Beecham Corporation | Agonistes de pth |
| US7659264B2 (en) | 2004-10-07 | 2010-02-09 | Merck Sharp & Dohme Corp. | CGRP receptor antagonists |
| WO2007135417A1 (fr) | 2006-05-19 | 2007-11-29 | James Black Foundation | Dérivés de benzotriazépinone |
| WO2007149873A2 (fr) | 2006-06-20 | 2007-12-27 | Wyeth | Inhibiteurs du canal potassique kv1.5 |
| DE602008003221D1 (de) | 2007-06-07 | 2010-12-09 | Hoffmann La Roche | Prolinamidderivate als nk3-antagonisten |
| BRPI0820669A2 (pt) | 2007-12-10 | 2020-08-04 | Novartis Ag | compostos orgânicos |
| US7981904B2 (en) | 2008-03-20 | 2011-07-19 | Takeda Pharmaceutical Company Limited | Acetyl CoA carboxylase inhibitors |
| EP2349325B1 (fr) | 2008-10-13 | 2018-05-30 | University Of Rochester | Teriparatide pour l'utillisation pour favoriser la réparation de cartilage articulaire |
| TWI496782B (zh) * | 2009-04-28 | 2015-08-21 | Chugai Pharmaceutical Co Ltd | Spiro haloperidone derivatives |
| MY178583A (en) * | 2012-12-10 | 2020-10-16 | Chugai Pharmaceutical Co Ltd | Hydantoin derivative |
| MX371090B (es) * | 2014-06-09 | 2020-01-16 | Chugai Pharmaceutical Co Ltd | Composicion farmaceutica que contiene derivado de hidantoina. |
-
2013
- 2013-12-10 MY MYPI2015701868A patent/MY178583A/en unknown
- 2013-12-10 NZ NZ70794613A patent/NZ707946A/en not_active IP Right Cessation
- 2013-12-10 LT LTEP13862318.6T patent/LT2930176T/lt unknown
- 2013-12-10 US US14/426,408 patent/US9428505B2/en active Active
- 2013-12-10 NO NO13862318A patent/NO2930176T3/no unknown
- 2013-12-10 CN CN201380064459.1A patent/CN104854106B/zh not_active Expired - Fee Related
- 2013-12-10 PT PT138623186T patent/PT2930176T/pt unknown
- 2013-12-10 CA CA2892621A patent/CA2892621C/fr active Active
- 2013-12-10 EP EP13862318.6A patent/EP2930176B1/fr active Active
- 2013-12-10 ES ES13862318.6T patent/ES2663797T3/es active Active
- 2013-12-10 TW TW102145318A patent/TWI615394B/zh not_active IP Right Cessation
- 2013-12-10 MA MA38250A patent/MA38250B1/fr unknown
- 2013-12-10 SG SG11201504204XA patent/SG11201504204XA/en unknown
- 2013-12-10 JP JP2014552040A patent/JP5951799B2/ja not_active Expired - Fee Related
- 2013-12-10 RU RU2015127624A patent/RU2678984C2/ru active
- 2013-12-10 PE PE2015000878A patent/PE20151295A1/es active IP Right Grant
- 2013-12-10 HR HRP20180647TT patent/HRP20180647T1/hr unknown
- 2013-12-10 MX MX2015007309A patent/MX2015007309A/es active IP Right Grant
- 2013-12-10 SI SI201331009T patent/SI2930176T1/en unknown
- 2013-12-10 BR BR112015012411-9A patent/BR112015012411B1/pt not_active IP Right Cessation
- 2013-12-10 KR KR1020157017844A patent/KR102168738B1/ko not_active Expired - Fee Related
- 2013-12-10 HU HUE13862318A patent/HUE037530T2/hu unknown
- 2013-12-10 RS RS20180517A patent/RS57190B1/sr unknown
- 2013-12-10 PL PL13862318T patent/PL2930176T3/pl unknown
- 2013-12-10 DK DK13862318.6T patent/DK2930176T3/en active
- 2013-12-10 UA UAA201504548A patent/UA115072C2/uk unknown
- 2013-12-10 WO PCT/JP2013/083022 patent/WO2014092061A1/fr not_active Ceased
- 2013-12-10 AU AU2013358167A patent/AU2013358167B2/en not_active Ceased
-
2015
- 2015-04-14 IL IL238277A patent/IL238277B/en active IP Right Grant
- 2015-05-21 CR CR20150272A patent/CR20150272A/es unknown
- 2015-05-21 ZA ZA2015/03597A patent/ZA201503597B/en unknown
- 2015-05-22 CL CL2015001391A patent/CL2015001391A1/es unknown
- 2015-05-22 PH PH12015501146A patent/PH12015501146B1/en unknown
- 2015-06-04 SA SA515360528A patent/SA515360528B1/ar unknown
-
2016
- 2016-07-20 US US15/214,729 patent/US20160326175A1/en not_active Abandoned
-
2017
- 2017-01-11 CL CL2017000069A patent/CL2017000069A1/es unknown
- 2017-12-20 US US15/848,267 patent/US20180237436A1/en not_active Abandoned
-
2020
- 2020-02-28 US US16/805,204 patent/US20210024524A1/en not_active Abandoned
-
2021
- 2021-05-25 US US17/330,200 patent/US20220162208A1/en not_active Abandoned
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