MA38341A1 - Modulateurs d'enzymes de modification par méthylation, compositions et utilisations associées - Google Patents

Modulateurs d'enzymes de modification par méthylation, compositions et utilisations associées

Info

Publication number
MA38341A1
MA38341A1 MA38341A MA38341A MA38341A1 MA 38341 A1 MA38341 A1 MA 38341A1 MA 38341 A MA38341 A MA 38341A MA 38341 A MA38341 A MA 38341A MA 38341 A1 MA38341 A1 MA 38341A1
Authority
MA
Morocco
Prior art keywords
compositions
methylation modification
modification enzyme
enzyme modulators
modulators
Prior art date
Application number
MA38341A
Other languages
English (en)
Other versions
MA38341B1 (fr
Inventor
Brian Albrecht
James Audia
Andrew Cook
Les Dakin
Martin Duplessis
Victor Gehling
Jean-Christophe Harmange
Christopher Nasveschuk
Rishi Vaswani
Original Assignee
Constellation Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50239937&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA38341(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from PCT/US2013/025639 external-priority patent/WO2013120104A2/fr
Application filed by Constellation Pharmaceuticals Inc filed Critical Constellation Pharmaceuticals Inc
Publication of MA38341A1 publication Critical patent/MA38341A1/fr
Publication of MA38341B1 publication Critical patent/MA38341B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne des agents ayant la formule structurelle (ii) pour moduler des enzymes de modification par méthylation des histones, des compositions et des utilisations de ceux-ci, par exemple, en tant qu'agents anticancéreux.
MA38341A 2013-02-11 2014-02-11 Modulateurs d'enzymes de modification par méthylation, compositions et utilisations associées MA38341B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/US2013/025639 WO2013120104A2 (fr) 2012-02-10 2013-02-11 Modulateurs d'enzymes de modification par méthylation, leurs compositions et utilisations
PCT/US2014/015706 WO2014124418A1 (fr) 2013-02-11 2014-02-11 Modulateurs d'enzymes de modification par méthylation, compositions et utilisations associées

Publications (2)

Publication Number Publication Date
MA38341A1 true MA38341A1 (fr) 2018-01-31
MA38341B1 MA38341B1 (fr) 2018-11-30

Family

ID=50239937

Family Applications (1)

Application Number Title Priority Date Filing Date
MA38341A MA38341B1 (fr) 2013-02-11 2014-02-11 Modulateurs d'enzymes de modification par méthylation, compositions et utilisations associées

Country Status (16)

Country Link
EP (1) EP2953941B1 (fr)
KR (1) KR102219441B1 (fr)
CN (1) CN105102446B (fr)
CL (1) CL2015002239A1 (fr)
CR (1) CR20150457A (fr)
IL (1) IL239985B (fr)
MA (1) MA38341B1 (fr)
ME (1) ME02730B (fr)
PE (1) PE20160044A1 (fr)
PH (1) PH12015501720A1 (fr)
PL (1) PL2953941T3 (fr)
RS (1) RS56207B1 (fr)
SG (1) SG11201506077XA (fr)
SI (1) SI2953941T1 (fr)
TW (1) TWI629273B (fr)
WO (1) WO2014124418A1 (fr)

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WO2013075084A1 (fr) 2011-11-18 2013-05-23 Constellation Pharmaceuticals Modulateurs d'enzymes de modification par méthylation, compositions et utilisations associées
WO2013120104A2 (fr) 2012-02-10 2013-08-15 Constellation Pharmaceuticals Modulateurs d'enzymes de modification par méthylation, leurs compositions et utilisations
CA2887243C (fr) 2012-10-15 2024-04-09 Epizyme, Inc. Methodes de traitement du cancer
EP3033334A1 (fr) 2013-08-15 2016-06-22 Constellation Pharmaceuticals, Inc. Dérivés d'indole utilisés en tant que modulateurs d'enzymes de modification du méthyle, compositions et utilisations associées
EA032416B1 (ru) 2014-12-23 2019-05-31 Новартис Аг Соединения триазолопиримидина и их применения
WO2016130396A1 (fr) * 2015-02-13 2016-08-18 Constellation Pharmaceuticals, Inc. Modulateurs d'enzymes de modification méthylique, compositions et utilisations associées
US20180214519A1 (en) 2015-07-24 2018-08-02 Constellation Pharmaceuticals, Inc. Combination therapies for modulation of histone methyl modifying enzymes
HK1256604A1 (zh) 2015-08-03 2019-09-27 Constellation Pharmaceuticals, Inc. Ezh2抑制剂和调节性t细胞功能的调制
MX2018002344A (es) 2015-08-24 2018-07-06 Epizyme Inc Metodo para tratar el cancer.
TW201718598A (zh) 2015-08-27 2017-06-01 美國禮來大藥廠 Ｅｚｈ２抑制劑
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EP4309738A3 (fr) 2015-10-06 2024-07-17 Epizyme, Inc. Procédé de traitement du médulloblastome avec un inhibiteur d'ezh2
WO2017079738A1 (fr) 2015-11-05 2017-05-11 Epizyme, Inc. Cytométrie de flux permettant de surveiller l'état de la méthylation d'une histone h3
EP3407978A4 (fr) 2016-01-29 2020-01-15 Epizyme Inc Polythérapie pour le traitement du cancer
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US11147819B2 (en) 2016-06-17 2021-10-19 Epizyme, Inc. EZH2 inhibitors for treating cancer
WO2017221092A1 (fr) 2016-06-20 2017-12-28 Novartis Ag Composés de triazolopyridine et leurs utilisations
US10676479B2 (en) 2016-06-20 2020-06-09 Novartis Ag Imidazolepyridine compounds and uses thereof
EP3472168B1 (fr) 2016-06-20 2024-01-10 Novartis AG Formes cristallines d'un composé de triazolopyrimidine
CA3039059A1 (fr) 2016-10-19 2018-04-26 Constellation Pharmaceuticals, Inc. Synthese d'inhibiteurs d'ezh2
EP3548032A2 (fr) 2016-12-02 2019-10-09 Epizyme, Inc. Combinaison thérapeutique pour traiter le cancer
US11311524B2 (en) 2017-01-19 2022-04-26 Daiichi Sankyo Company, Limited Pharmaceutical composition used for treatment of HTLV-1-associated myelopathy
US10266542B2 (en) 2017-03-15 2019-04-23 Mirati Therapeutics, Inc. EZH2 inhibitors
US11642346B2 (en) 2017-03-31 2023-05-09 Epizyme, Inc. Combination therapy for treating cancer
WO2018231973A1 (fr) 2017-06-13 2018-12-20 Epizyme, Inc. Inhibiteurs de ezh2 et leurs méthodes d'utilisation
WO2019014191A1 (fr) 2017-07-10 2019-01-17 Constellation Pharmaceuticals, Inc. Expression génique induite par un inhibiteur d'ezh2
WO2019094552A1 (fr) * 2017-11-09 2019-05-16 Constellation Pharmaceuticals, Inc. Modulateurs d'enzymes de modification du méthyle, compositions et utilisations associées
EP3710057A1 (fr) 2017-11-14 2020-09-23 Pfizer Inc Polythérapies faisant appel à un inhibiteur de ezh2
CN109879790B (zh) * 2017-12-06 2022-09-20 华东师范大学 以吲哚或吲哚类似物为母核结构的酰胺类小分子有机化合物、用途及其制备方法
CN111757734A (zh) 2017-12-28 2020-10-09 星座制药公司 通过组合疗法的ezh2抑制剂的药代动力学增强
NZ766447A (en) 2018-01-31 2021-12-24 Mirati Therapeutics Inc Prc2 inhibitors
CN110229157B (zh) * 2018-03-06 2022-06-21 上海海和药物研究开发股份有限公司 嘧啶并五元芳香杂环类化合物、其制备方法及用途
CN110229151B (zh) * 2018-03-06 2021-09-10 上海海和药物研究开发股份有限公司 吲嗪类化合物、其制备方法及用途
CN118955490A (zh) 2018-03-14 2024-11-15 渤健马萨诸塞州股份有限公司 O-糖蛋白-2-乙酰氨基-2-脱氧-3-d-吡喃糖苷酶抑制剂
EP3797108B1 (fr) 2018-05-21 2022-07-20 Constellation Pharmaceuticals, Inc. Modulateurs de l'enzyme méthyl modifiant, compositions et leur utilisation.
EP3823671B1 (fr) 2018-07-09 2024-02-07 Fondation Asile Des Aveugles Inhibition de sous-unités de prc2 permettant de traiter des troubles oculaires
KR20210060513A (ko) 2018-09-19 2021-05-26 바이오젠 엠에이 인코포레이티드 O-당단백질-2-아세트아미도-2-데옥시-3-d-글루코피라노시다제 억제제
TW202039482A (zh) 2018-12-05 2020-11-01 美商百健Ｍａ公司 嗎啉基、哌嗪基、氧氮雜環庚烷基及二氮雜環庚烷基o-醣蛋白-2-乙醯胺基-2-去氧-3-d-葡萄哌喃醣苷酶抑制劑
WO2020139339A1 (fr) 2018-12-27 2020-07-02 Constellation Pharmaceuticals, Inc. Inhibiteurs de la signalisation de l'ezh2 et du récepteur des androgènes en tant qu'outils pour le ciblage du cancer de la prostate
JP7504898B2 (ja) 2019-02-04 2024-06-24 バイオジェン・エムエイ・インコーポレイテッド 二環式エーテルｏ－糖タンパク質－２－アセトアミド－２－デオキシ－３－ｄ－グルコピラノシダーゼ阻害剤
JP7663503B2 (ja) 2019-03-08 2025-04-16 バイオジェン・エムエイ・インコーポレイテッド アゼチジニルｏ－糖タンパク質－２－アセトアミド－２－デオキシ－３－ｄ－グルコピラノシダーゼ阻害剤
WO2020219448A1 (fr) 2019-04-22 2020-10-29 Mirati Therapeutics, Inc. Dérivés de naphtyridine en tant qu'inhibiteurs de prc2
JP7541538B2 (ja) 2019-06-05 2024-08-28 ミラティ セラピューティクス，インク． 癌を処置するためのｐｒｃ２阻害剤としてのイミダゾ［１，２－ｃ］ピリミジン誘導体
MD4003532T2 (ro) 2019-07-24 2025-01-31 Constellation Pharmaceuticals Inc Forme cristaline de 7-clor-2-(4-(3-metoxiazetidin-1-il)ciclohexil)-2,4-dimetil-N-((6-metil-4-(metiltio)-2-oxo-1,2-dihidropiridin-3-il)metil)benzo[d][1,3]dioxol-5-carboxamidă
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AR120324A1 (es) 2019-10-29 2022-02-09 Biogen Ma Inc Inhibidores de o-glucoproteína-2-acetamido-2-deoxi-3-d-glucopiranosidasa espirocíclica
PE20231168A1 (es) 2020-08-03 2023-07-26 Biogen Ma Inc Formas cristalinas de un inhibidor de la o-glucoproteina-2-acetamido-2-desoxi-3-d-glucopiranosidasa
CN112679505B (zh) * 2020-12-25 2022-04-22 杭州澳赛诺生物科技有限公司 一种4-甲基-7H-吡咯并[2,3-d]嘧啶的合成方法
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US20250049802A1 (en) 2021-12-14 2025-02-13 Pfizer Inc. Combination therapies and uses for treating cancer
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EA023788B1 (ru) * 2010-05-07 2016-07-29 ГЛЭКСОСМИТКЛАЙН ЭлЭлСи Производные индола и фармацевтические композиции на их основе
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WO2013120104A2 (fr) * 2012-02-10 2013-08-15 Constellation Pharmaceuticals Modulateurs d'enzymes de modification par méthylation, leurs compositions et utilisations

Also Published As

Publication number Publication date
EP2953941B1 (fr) 2017-04-05
EP2953941A1 (fr) 2015-12-16
CR20150457A (es) 2015-10-20
KR20150119201A (ko) 2015-10-23
CN105102446A (zh) 2015-11-25
HK1218648A1 (en) 2017-03-03
IL239985B (en) 2018-11-29
KR102219441B1 (ko) 2021-02-23
ME02730B (fr) 2017-10-20
TW201443038A (zh) 2014-11-16
CN105102446B (zh) 2018-01-23
IL239985A0 (en) 2015-09-24
SI2953941T1 (sl) 2017-08-31
CL2015002239A1 (es) 2016-02-05
SG11201506077XA (en) 2015-08-28
RS56207B1 (sr) 2017-11-30
PH12015501720B1 (en) 2015-11-09
PL2953941T3 (pl) 2017-11-30
WO2014124418A1 (fr) 2014-08-14
MA38341B1 (fr) 2018-11-30
PE20160044A1 (es) 2016-02-11
TWI629273B (zh) 2018-07-11
PH12015501720A1 (en) 2015-11-09

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