MA41108A - Compositions anticancéreuses - Google Patents
Compositions anticancéreusesInfo
- Publication number
- MA41108A MA41108A MA041108A MA41108A MA41108A MA 41108 A MA41108 A MA 41108A MA 041108 A MA041108 A MA 041108A MA 41108 A MA41108 A MA 41108A MA 41108 A MA41108 A MA 41108A
- Authority
- MA
- Morocco
- Prior art keywords
- arn
- prostate cancer
- meth
- poly
- hormone
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 5
- 230000001093 anti-cancer Effects 0.000 title 1
- HJBWBFZLDZWPHF-UHFFFAOYSA-N apalutamide Chemical compound C1=C(F)C(C(=O)NC)=CC=C1N1C2(CCC2)C(=O)N(C=2C=C(C(C#N)=NC=2)C(F)(F)F)C1=S HJBWBFZLDZWPHF-UHFFFAOYSA-N 0.000 abstract 6
- 229920000193 polymethacrylate Polymers 0.000 abstract 5
- 208000018821 hormone-resistant prostate carcinoma Diseases 0.000 abstract 4
- 239000007962 solid dispersion Substances 0.000 abstract 3
- 206010060862 Prostate cancer Diseases 0.000 abstract 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 abstract 2
- 230000001394 metastastic effect Effects 0.000 abstract 2
- 206010061289 metastatic neoplasm Diseases 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 102000001307 androgen receptors Human genes 0.000 abstract 1
- 108010080146 androgen receptors Proteins 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 238000002512 chemotherapy Methods 0.000 abstract 1
- 229920001577 copolymer Polymers 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000001125 extrusion Methods 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 239000005556 hormone Substances 0.000 abstract 1
- 229940088597 hormone Drugs 0.000 abstract 1
- 230000000683 nonmetastatic effect Effects 0.000 abstract 1
- 230000007170 pathology Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 238000001694 spray drying Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
La présente invention concerne des formulations pharmaceutiques d'arn-509, qui peuvent être administrées à un mammifère, en particulier à un humain, souffrant d'une maladie ou d'une pathologie associée au récepteur des androgènes (ar), en particulier du cancer, plus particulièrement du cancer de la prostate, y compris mais de façon non limitative, du cancer de la prostate hormono-résistant, du cancer métastatique de la prostate hormono-résistant, du cancer métastatique de la prostate hormono-résistant qui n'a jamais été traité par chimiothérapie, d'une rechute biochimique du cancer de la prostate hormono-sensible, ou du cancer de la prostate hormono-résistant non métastatique à risque élevé. Selon un aspect, ces formulations comprennent une dispersion solide d'arn-509 et d'un copolymère de poly(méth)acrylate. Selon un aspect, la dispersion solide d'arn-509 et d'un copolymère de poly(méth)acrylate peut être obtenue, en particulier est obtenue, par extrusion à l'état fondu d'un mélange comprenant l'arn-509 et un copolymère de poly(méth)acrylate et ensuite éventuellement par broyage dudit mélange extrudé à l'état fondu. Selon un aspect, la dispersion solide d'arn-509 et d'un copolymère de poly(méth)acrylate peut être obtenue, en particulier est obtenue, par séchage par pulvérisation d'un mélange comprenant l'arn-509 et un copolymère de poly(méth)acrylate dans un solvant approprié.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14196591 | 2014-12-05 | ||
| PCT/US2015/063667 WO2016090101A1 (fr) | 2014-12-05 | 2015-12-03 | Compositions anticancéreuses |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MA41108A true MA41108A (fr) | 2016-06-09 |
| MA41108B1 MA41108B1 (fr) | 2021-03-31 |
Family
ID=52006905
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA055404A MA55404A (fr) | 2014-12-05 | 2015-12-03 | Compositions anticancéreuses |
| MA41108A MA41108B1 (fr) | 2014-12-05 | 2015-12-03 | Compositions anticancéreuses |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA055404A MA55404A (fr) | 2014-12-05 | 2015-12-03 | Compositions anticancéreuses |
Country Status (31)
| Country | Link |
|---|---|
| US (3) | US20170360707A1 (fr) |
| EP (2) | EP3842034B1 (fr) |
| JP (1) | JP6767368B2 (fr) |
| KR (1) | KR102348325B1 (fr) |
| CN (2) | CN115837010B (fr) |
| AR (1) | AR102924A1 (fr) |
| AU (1) | AU2015358493B2 (fr) |
| CA (1) | CA2969661C (fr) |
| CL (1) | CL2017001372A1 (fr) |
| CO (1) | CO2017005573A2 (fr) |
| CR (1) | CR20170217A (fr) |
| CY (1) | CY1123856T1 (fr) |
| DK (1) | DK3226842T3 (fr) |
| EA (1) | EA035988B1 (fr) |
| ES (2) | ES2839128T3 (fr) |
| HR (1) | HRP20201902T1 (fr) |
| HU (1) | HUE051888T2 (fr) |
| IL (1) | IL252324B (fr) |
| LT (1) | LT3226842T (fr) |
| MA (2) | MA55404A (fr) |
| MD (1) | MD3226842T2 (fr) |
| MX (1) | MX384382B (fr) |
| NI (1) | NI201700069A (fr) |
| PL (1) | PL3226842T3 (fr) |
| PT (1) | PT3226842T (fr) |
| RS (1) | RS61466B1 (fr) |
| SG (1) | SG11201704264UA (fr) |
| SI (1) | SI3226842T1 (fr) |
| TW (1) | TWI683662B (fr) |
| UA (1) | UA121123C2 (fr) |
| WO (1) | WO2016090101A1 (fr) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2836424T3 (es) | 2012-09-26 | 2021-06-25 | Aragon Pharmaceuticals Inc | Antiandrógenos para tratar el cáncer de próstata no metastásico y resistente a la castración |
| MX381829B (es) | 2014-12-05 | 2025-03-13 | Aragon Pharmaceuticals Inc | Composiciones anticancerígenas. |
| RS66323B1 (sr) | 2014-12-05 | 2025-01-31 | Aragon Pharmaceuticals Inc | Sastavi protiv raka |
| UA129105C2 (uk) | 2017-10-16 | 2025-01-15 | Арагон Фармасьютикалз, Інк. | Антиандрогени для лікування неметастатичного резистентного до кастрації раку передміхурової залози |
| EP3773509B1 (fr) * | 2018-04-06 | 2023-11-01 | Capsugel Belgium NV | Procédé de séchage par pulvérisation pour des particules à faible rapport d'aspect comprenant du poly[(méthacrylate de méthyle)-co-(acide méthacrylique)] |
| WO2020144649A1 (fr) | 2019-01-10 | 2020-07-16 | Aragon Pharmaceuticals, Inc. | Composition pharmaceutique comprenant de l'enzalutamide dispersé dans une compote de pomme |
| CN113365623B (zh) | 2019-01-30 | 2025-06-24 | 阿拉贡药品公司 | 用于治疗转移性去势敏感性前列腺癌的抗雄激素 |
| EP3918607A1 (fr) | 2019-01-30 | 2021-12-08 | Janssen Pharmaceutica NV | Méthodes de traitement du cancer de la prostate sur la base de sous-types moléculaires |
| WO2020239478A1 (fr) | 2019-05-28 | 2020-12-03 | Pharma Mar, S.A. | Trabectédine pour le traitement de sarcomes basé sur des marqueurs génomiques |
| JP2023500935A (ja) | 2019-11-04 | 2023-01-11 | アラゴン ファーマシューティカルズ，インコーポレイテッド | 重度の肝障害を有する対象における非転移性去勢抵抗性前立腺癌の治療のためのアンドロゲン受容体阻害剤 |
| WO2021245285A1 (fr) | 2020-06-05 | 2021-12-09 | Janssen Pharmaceutica Nv | Méthodes de traitement du cancer de la prostate sur la base de sous-types moléculaires |
| TW202228794A (zh) | 2020-09-04 | 2022-08-01 | 美商艾瑞岡醫藥公司 | 用於治療前列腺癌之方法 |
| WO2022195407A1 (fr) | 2021-03-19 | 2022-09-22 | Aragon Pharmaceuticals, Inc. | Méthodes de traitement du cancer de la prostate |
| WO2023152611A1 (fr) | 2022-02-11 | 2023-08-17 | Aragon Pharmaceuticals, Inc. | Apalutamide et relugolix pour le traitement du cancer de la prostate |
| WO2023209555A1 (fr) | 2022-04-26 | 2023-11-02 | Aragon Pharmaceuticals, Inc. | Produits médicamenteux approuvés et méthodes de traitement du cancer de la prostate |
| CN121038790A (zh) | 2023-03-16 | 2025-11-28 | 拜耳消费者护理股份有限公司 | 用于治疗激素敏感性前列腺癌生化复发患者的雄激素受体拮抗剂 |
| WO2026052846A1 (fr) | 2024-09-09 | 2026-03-12 | Synthon B.V. | Formulation pharmaceutique comprenant de l'apalutamide |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002080902A1 (fr) | 2001-04-02 | 2002-10-17 | Astrazeneca Ab | Composition pharmaceutique solide contenant 4-cyano-trifluoro-3-(4-fluorophenylsulfonyl)-2-hydroxy-2-methylpropiono-m-toluidiure et pvp |
| JPWO2003077827A1 (ja) * | 2002-03-19 | 2005-07-14 | 日本新薬株式会社 | 医薬固体分散体の製造方法 |
| WO2005055987A1 (fr) * | 2003-12-15 | 2005-06-23 | Council Of Scientific & Industrial Research | Compositions pharmaceutiques au gout masque comportant une medicament amer et un polymere sensible au ph |
| EP2656842B1 (fr) * | 2006-03-27 | 2016-08-10 | The Regents of The University of California | Modulateur de récepteur androgène pour le traitement du cancer de la prostate et de maladies associées au récepteur androgène |
| HUE037389T2 (hu) * | 2010-02-16 | 2018-08-28 | Aragon Pharmaceuticals Inc | Androgén receptor modulátorok és alkalmazásaik |
| US10071945B2 (en) * | 2011-06-15 | 2018-09-11 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Nuclear receptor modulators and their use for the treatment and prevention of cancer |
| WO2013152342A1 (fr) | 2012-04-06 | 2013-10-10 | OSI Pharmaceuticals, LLC | Inhibiteur de mtor anticancéreux et combinaison anti-androgène |
| EP3922629A1 (fr) | 2012-06-07 | 2021-12-15 | Aragon Pharmaceuticals, Inc. | Formes cristallines d'un modulateur de récepteur d'androgène |
| US10668156B2 (en) | 2012-06-22 | 2020-06-02 | Basf Se | Active-ingredient-containing solid dispersions based on diethylaminoethyl methacrylate copolymers |
| EP4450130A3 (fr) * | 2012-09-11 | 2025-01-08 | Medivation Prostate Therapeutics LLC | Formulations d'enzalutamide |
| ES2836424T3 (es) * | 2012-09-26 | 2021-06-25 | Aragon Pharmaceuticals Inc | Antiandrógenos para tratar el cáncer de próstata no metastásico y resistente a la castración |
| CA3105575A1 (fr) * | 2013-01-15 | 2014-07-24 | Aragon Pharmaceuticals, Inc. | Modulateur du recepteur des androgenes et ses utilisations |
| UA116004C2 (uk) * | 2013-01-22 | 2018-01-25 | Ф. Хоффманн-Ля Рош Аг | Фармацевтична композиція з покращеною біодоступністю |
| WO2014167428A2 (fr) | 2013-04-10 | 2014-10-16 | Shilpa Medicare Limited | 4-(3-(4-cyano-3-(trifluorométhyl)phényl)-5,5-diméthyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluoro-n-méthylbenzamide amorphe |
| WO2015023710A1 (fr) * | 2013-08-12 | 2015-02-19 | Tokai Pharmaceuticals, Inc. | Biomarqueurs pour le traitement de troubles néoplasiques à l'aide de thérapies ciblant les androgènes |
| EP3102183A1 (fr) * | 2014-02-05 | 2016-12-14 | LEK Pharmaceuticals d.d. | Compositions pharmaceutiques solides d'antagonistes du récepteur des androgènes |
-
2015
- 2015-12-03 ES ES15817642T patent/ES2839128T3/es active Active
- 2015-12-03 JP JP2017529637A patent/JP6767368B2/ja active Active
- 2015-12-03 UA UAA201707016A patent/UA121123C2/uk unknown
- 2015-12-03 WO PCT/US2015/063667 patent/WO2016090101A1/fr not_active Ceased
- 2015-12-03 HU HUE15817642A patent/HUE051888T2/hu unknown
- 2015-12-03 US US15/533,203 patent/US20170360707A1/en not_active Abandoned
- 2015-12-03 TW TW104140458A patent/TWI683662B/zh not_active IP Right Cessation
- 2015-12-03 PT PT158176420T patent/PT3226842T/pt unknown
- 2015-12-03 CA CA2969661A patent/CA2969661C/fr active Active
- 2015-12-03 HR HRP20201902TT patent/HRP20201902T1/hr unknown
- 2015-12-03 SI SI201531519T patent/SI3226842T1/sl unknown
- 2015-12-03 MA MA055404A patent/MA55404A/fr unknown
- 2015-12-03 RS RS20210184A patent/RS61466B1/sr unknown
- 2015-12-03 AU AU2015358493A patent/AU2015358493B2/en active Active
- 2015-12-03 EA EA201791252A patent/EA035988B1/ru unknown
- 2015-12-03 MA MA41108A patent/MA41108B1/fr unknown
- 2015-12-03 CR CR20170217A patent/CR20170217A/es unknown
- 2015-12-03 SG SG11201704264UA patent/SG11201704264UA/en unknown
- 2015-12-03 DK DK15817642.0T patent/DK3226842T3/da active
- 2015-12-03 LT LTEP15817642.0T patent/LT3226842T/lt unknown
- 2015-12-03 EP EP20209559.2A patent/EP3842034B1/fr active Active
- 2015-12-03 CN CN202211487545.0A patent/CN115837010B/zh active Active
- 2015-12-03 MD MDE20170153T patent/MD3226842T2/ro not_active IP Right Cessation
- 2015-12-03 ES ES20209559T patent/ES3021508T3/es active Active
- 2015-12-03 CN CN201580066192.9A patent/CN106999430A/zh active Pending
- 2015-12-03 MX MX2017007201A patent/MX384382B/es unknown
- 2015-12-03 PL PL15817642T patent/PL3226842T3/pl unknown
- 2015-12-03 KR KR1020177018240A patent/KR102348325B1/ko active Active
- 2015-12-03 EP EP15817642.0A patent/EP3226842B1/fr active Active
- 2015-12-04 AR ARP150103980A patent/AR102924A1/es unknown
-
2017
- 2017-05-16 IL IL252324A patent/IL252324B/en unknown
- 2017-05-29 CL CL2017001372A patent/CL2017001372A1/es unknown
- 2017-06-02 NI NI201700069A patent/NI201700069A/es unknown
- 2017-06-05 CO CONC2017/0005573A patent/CO2017005573A2/es unknown
-
2021
- 2021-01-27 CY CY20211100068T patent/CY1123856T1/el unknown
- 2021-12-13 US US17/549,495 patent/US20220151931A1/en not_active Abandoned
-
2024
- 2024-05-10 US US18/661,226 patent/US20240293321A1/en active Pending
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