MA41867A - Anticorps dirigés contre l'immunoglobuline de cellule t et protéine 3 de mucine (tim-3) - Google Patents
Anticorps dirigés contre l'immunoglobuline de cellule t et protéine 3 de mucine (tim-3)Info
- Publication number
- MA41867A MA41867A MA041867A MA41867A MA41867A MA 41867 A MA41867 A MA 41867A MA 041867 A MA041867 A MA 041867A MA 41867 A MA41867 A MA 41867A MA 41867 A MA41867 A MA 41867A
- Authority
- MA
- Morocco
- Prior art keywords
- mucine
- tim
- antibodies
- protein
- cell immunoglobulin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2815—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD8
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562141353P | 2015-04-01 | 2015-04-01 | |
| PCT/US2016/025532 WO2016161270A1 (fr) | 2015-04-01 | 2016-04-01 | Anticorps dirigés contre l'immunoglobuline de cellule t et protéine 3 de mucine (tim-3) |
| EP16774301.2A EP3277321B1 (fr) | 2015-04-01 | 2016-04-01 | Anticorps dirigés contre l'immunoglobuline de cellule t et protéine 3 de mucine (tim-3) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MA41867A true MA41867A (fr) | 2018-02-06 |
| MA41867B1 MA41867B1 (fr) | 2024-11-29 |
Family
ID=57007695
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA41867A MA41867B1 (fr) | 2015-04-01 | 2016-04-01 | Anticorps dirigés contre l'immunoglobuline de cellule t et protéine 3 de mucine (tim-3) |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US10508149B2 (fr) |
| EP (2) | EP4442712A3 (fr) |
| JP (1) | JP6949717B2 (fr) |
| KR (1) | KR102711906B1 (fr) |
| CN (2) | CN107847589B (fr) |
| AU (1) | AU2016242964C1 (fr) |
| DK (1) | DK3277321T3 (fr) |
| EA (1) | EA201792184A1 (fr) |
| ES (1) | ES2988351T3 (fr) |
| FI (1) | FI3277321T3 (fr) |
| HR (1) | HRP20241498T1 (fr) |
| HU (1) | HUE068448T2 (fr) |
| IL (2) | IL283006B2 (fr) |
| LT (1) | LT3277321T (fr) |
| MA (1) | MA41867B1 (fr) |
| MX (1) | MX383216B (fr) |
| PL (1) | PL3277321T3 (fr) |
| PT (1) | PT3277321T (fr) |
| RS (1) | RS66030B1 (fr) |
| SG (2) | SG11201707705UA (fr) |
| SI (1) | SI3277321T1 (fr) |
| SM (1) | SMT202400420T1 (fr) |
| WO (1) | WO2016161270A1 (fr) |
| ZA (1) | ZA201706740B (fr) |
Families Citing this family (138)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3812387A1 (fr) | 2011-07-21 | 2021-04-28 | Sumitomo Dainippon Pharma Oncology, Inc. | Inhibiteurs de protéine kinase hétérocycliques |
| WO2015048312A1 (fr) | 2013-09-26 | 2015-04-02 | Costim Pharmaceuticals Inc. | Méthodes de traitement de cancers hématologiques |
| PE20170255A1 (es) | 2014-01-24 | 2017-03-22 | Dana Farber Cancer Inst Inc | Moleculas de anticuerpo que se unen a pd-1 y usos de las mismas |
| HUE045065T2 (hu) | 2014-01-31 | 2019-12-30 | Novartis Ag | TIM-3 antitest molekulák és felhasználásaik |
| KR102442436B1 (ko) | 2014-03-14 | 2022-09-15 | 노파르티스 아게 | Lag-3에 대한 항체 분자 및 그의 용도 |
| KR20170060042A (ko) | 2014-09-13 | 2017-05-31 | 노파르티스 아게 | Alk 억제제의 조합 요법 |
| PE20171790A1 (es) | 2015-03-23 | 2017-12-28 | Bayer Pharma AG | Anticuerpos anti-ceacam6 y sus usos |
| FI3277321T3 (fi) | 2015-04-01 | 2024-10-31 | Anaptysbio Inc | T-soluimmunoglobuliinia ja musiiniproteiini 3:a (tim-3) vastaan suunnattuja vasta-aineita |
| KR102608921B1 (ko) | 2015-05-18 | 2023-12-01 | 스미토모 파마 온콜로지, 인크. | 생체 이용률이 증가된 알보시딥 프로드러그 |
| HRP20211058T8 (hr) | 2015-07-29 | 2021-11-26 | Novartis Ag | Kombinirane terapije koje sadrže molekule antitijela protiv lag-3 |
| EP3464360B1 (fr) | 2016-05-27 | 2025-11-12 | Agenus Inc. | Anticorps anti-tim-3 et leurs méthodes d'utilisation |
| CN109715196A (zh) | 2016-06-13 | 2019-05-03 | 转矩医疗股份有限公司 | 用于促进免疫细胞功能的组合物和方法 |
| RU2769282C2 (ru) | 2016-06-20 | 2022-03-30 | Кимаб Лимитед | Анти-PD-L1 и IL-2 цитокины |
| CN109757103B (zh) | 2016-07-14 | 2024-01-02 | 百时美施贵宝公司 | 针对tim3的抗体及其用途 |
| JOP20190013A1 (ar) | 2016-08-25 | 2019-01-31 | Lilly Co Eli | أجسام مضادة لـ (تي آي ام -3) |
| JP2019533458A (ja) * | 2016-11-01 | 2019-11-21 | アナプティスバイオ インコーポレイティッド | プログラム死1(pd−1)に対する抗体 |
| MX2019005116A (es) | 2016-11-01 | 2019-11-12 | Anaptysbio Inc | Anticuerpos dirigidos contra la proteina de inmunoglobulina de linfocitos t y de mucina 3 (tim-3). |
| WO2018094275A1 (fr) | 2016-11-18 | 2018-05-24 | Tolero Pharmaceuticals, Inc. | Promédicaments de l'alvocidib et leur utilisation en tant qu'inhibiteurs de protéines kinases |
| CN108101989A (zh) * | 2016-11-24 | 2018-06-01 | 复旦大学 | 针对人tim-3的全人源单域抗体及应用 |
| JOP20190133A1 (ar) * | 2016-12-08 | 2019-06-02 | Innovent Biologics Suzhou Co Ltd | أجسام مضادة لـ Tim-3 لمزجها بأجسام مضادة لـ PD-1 |
| EP3551659A1 (fr) * | 2016-12-08 | 2019-10-16 | Eli Lilly and Company | Anticorps anti-tim-3 pour combinaison avec des anticorps anti-pd-l1 |
| TWI665216B (zh) * | 2016-12-29 | 2019-07-11 | 財團法人生物技術開發中心 | 抗人類tim-3抗體及其使用方法 |
| AU2018206481B2 (en) | 2017-01-09 | 2025-02-27 | Tesaro, Inc. | Methods of treating cancer with anti-PD-1 antibodies |
| WO2018129553A1 (fr) | 2017-01-09 | 2018-07-12 | Tesaro, Inc. | Méthodes de traitement du cancer au moyen d'anticorps anti-tim-3 |
| CN109983032B (zh) | 2017-02-27 | 2022-07-26 | 江苏恒瑞医药股份有限公司 | Tim-3抗体、其抗原结合片段及医药用途 |
| SG11201909395TA (en) | 2017-04-27 | 2019-11-28 | Tesaro Inc | Antibody agents directed against lymphocyte activation gene-3 (lag-3) and uses thereof |
| AR111651A1 (es) | 2017-04-28 | 2019-08-07 | Novartis Ag | Conjugados de anticuerpos que comprenden agonistas del receptor de tipo toll y terapias de combinación |
| TW202444417A (zh) | 2017-05-09 | 2024-11-16 | 美商提薩羅有限公司 | 治療癌症的組合療法 |
| KR20200005662A (ko) | 2017-05-18 | 2020-01-15 | 테사로, 인코포레이티드 | 암을 치료하기 위한 조합 요법 |
| WO2018229715A1 (fr) | 2017-06-16 | 2018-12-20 | Novartis Ag | Compositions comprenant des anticorps anti-cd32b et procédés d'utilisation correspondants |
| EP3642240A1 (fr) | 2017-06-22 | 2020-04-29 | Novartis AG | Molécules d'anticorps dirigées contre cd73 et utilisations correspondantes |
| CA3061874A1 (fr) | 2017-06-22 | 2018-12-27 | Novartis Ag | Utilisation d'anticorps de liaison il-1s dans le traitement du cancer |
| MY204117A (en) | 2017-06-22 | 2024-08-08 | Novartis Ag | Antibody molecules to cd73 and uses thereof |
| CA3066747A1 (fr) | 2017-06-27 | 2019-01-03 | Novartis Ag | Regimes posologiques pour anticorps anti-tim3 et leurs utilisations |
| JP2020527572A (ja) | 2017-07-20 | 2020-09-10 | ノバルティス アーゲー | 抗lag−3抗体の投薬量レジメンおよびその使用 |
| EP4039274A1 (fr) | 2017-07-28 | 2022-08-10 | Phanes Therapeutics, Inc. | Anticorps anti-tim-3 et leurs utilisations |
| BR112020003362A2 (pt) | 2017-08-28 | 2020-08-18 | Bristol-Myers Squibb Company | antagonistas de tim-3 para o tratamento e diagnóstico de cânceres |
| JP7196160B2 (ja) | 2017-09-12 | 2022-12-26 | スミトモ ファーマ オンコロジー, インコーポレイテッド | Mcl-1阻害剤アルボシジブを用いた、bcl-2阻害剤に対して非感受性である癌の治療レジメン |
| TWI843707B (zh) | 2017-09-26 | 2024-06-01 | 美商提薩羅有限公司 | 尼拉帕尼(niraparib)調配物 |
| MX2020003770A (es) | 2017-09-30 | 2020-07-29 | Tesaro Inc | Terapias de combinacion para tratar cancer. |
| EA202090655A1 (ru) | 2017-10-06 | 2020-12-07 | Тесаро, Инк. | Комбинированные терапевтические средства и их применение |
| WO2019081983A1 (fr) | 2017-10-25 | 2019-05-02 | Novartis Ag | Anticorps ciblant cd32b et leurs procédés d'utilisation |
| CN111655288A (zh) | 2017-11-16 | 2020-09-11 | 诺华股份有限公司 | 组合疗法 |
| US20200371091A1 (en) | 2017-11-30 | 2020-11-26 | Novartis Ag | Bcma-targeting chimeric antigen receptor, and uses thereof |
| US12539308B2 (en) | 2018-01-08 | 2026-02-03 | The Trustees Of The University Of Pennsylvania | Immune-enhancing RNAs for combination with chimeric antigen receptor therapy |
| AU2019215031C1 (en) | 2018-01-31 | 2026-02-26 | Novartis Ag | Combination therapy using a chimeric antigen receptor |
| US20200399383A1 (en) | 2018-02-13 | 2020-12-24 | Novartis Ag | Chimeric antigen receptor therapy in combination with il-15r and il15 |
| EP3768715A1 (fr) | 2018-03-23 | 2021-01-27 | Bristol-Myers Squibb Company | Anticorps contre mica et/ou micb et leurs utilisations |
| US11807683B2 (en) | 2018-04-12 | 2023-11-07 | Nanjing Leads Biolabs Co., Ltd. | Antibody binding TIM-3 and use thereof |
| US20210147547A1 (en) | 2018-04-13 | 2021-05-20 | Novartis Ag | Dosage Regimens For Anti-Pd-L1 Antibodies And Uses Thereof |
| WO2019204646A1 (fr) | 2018-04-18 | 2019-10-24 | Xencor, Inc. | Protéines de fusion hétérodimères ciblant lag-3 contenant des protéines de fusion fc d'il-15/il-15ra et domaines de liaison à l'antigène de lag-3 |
| EP3781598A1 (fr) * | 2018-04-18 | 2021-02-24 | Xencor, Inc. | Protéines de fusion hétérodimères ciblant tim-3 contenant des protéines de fusion fc d'il-15/il-15ra et domaines de liaison à l'antigène de tim-3 |
| TWI869346B (zh) | 2018-05-30 | 2025-01-11 | 瑞士商諾華公司 | Entpd2抗體、組合療法、及使用該等抗體和組合療法之方法 |
| WO2019232244A2 (fr) | 2018-05-31 | 2019-12-05 | Novartis Ag | Molécules d'anticorps anti-cd73 et leurs utilisations |
| KR102870868B1 (ko) | 2018-06-01 | 2025-10-15 | 노파르티스 아게 | Bcma에 대한 결합 분자 및 이의 용도 |
| BR122022012697B1 (pt) | 2018-07-10 | 2023-04-04 | Novartis Ag | Usos de derivados de 3-(5-hidróxi-1-oxoisoindolin-2-il)piperidina-2,6- diona, e kit |
| AR116109A1 (es) | 2018-07-10 | 2021-03-31 | Novartis Ag | Derivados de 3-(5-amino-1-oxoisoindolin-2-il)piperidina-2,6-diona y usos de los mismos |
| JP2021531306A (ja) | 2018-07-25 | 2021-11-18 | アドバンスド アクセラレーター アプリケーションズ エスエー | 神経内分泌腫瘍の処置の方法 |
| BR112021002096A2 (pt) | 2018-08-20 | 2021-06-01 | Jiangsu Hengrui Medicine Co., Ltd. | uso de anticorpos tim-3 na preparação de medicamentos para o tratamento de tumores |
| KR20210053294A (ko) | 2018-08-28 | 2021-05-11 | 지앙수 헨그루이 메디슨 컴퍼니 리미티드 | 항-tim3 항체 제약 조성물 및 이의 용도 |
| TWI852940B (zh) | 2018-09-04 | 2024-08-21 | 美商泰沙羅公司 | 治療癌症之方法 |
| EP3858369A4 (fr) | 2018-09-26 | 2022-07-20 | Astellas Pharma Inc. | Thérapie anticancéreuse dans laquelle un virus de la vaccine oncolytique et un inhibiteur des points de contrôle immunitaire sont utilisés en combinaison, et composition pharmaceutique et médicament combiné utilisés dans celle-ci |
| CN113166071B (zh) | 2018-10-03 | 2025-03-21 | 特沙诺有限公司 | 尼拉帕利盐 |
| JP2022504228A (ja) | 2018-10-03 | 2022-01-13 | テサロ, インコーポレイテッド | ニラパリブ遊離塩基の結晶形態 |
| US11034710B2 (en) | 2018-12-04 | 2021-06-15 | Sumitomo Dainippon Pharma Oncology, Inc. | CDK9 inhibitors and polymorphs thereof for use as agents for treatment of cancer |
| WO2020119719A1 (fr) * | 2018-12-12 | 2020-06-18 | Wuxi Biologics (Shanghai) Co. Ltd. | Anticorps anti-tim-3 et leurs utilisations |
| EP3897844B1 (fr) | 2018-12-19 | 2023-11-15 | Deutsches Krebsforschungszentrum | Combinaison pharmaceutique des anticoprs anti-ceacam6 et anti-tim3 |
| EP3897648B1 (fr) | 2018-12-20 | 2023-08-23 | Novartis AG | Régimes à faible dose étendue pour inhibiteurs de mdm2 |
| KR20210106437A (ko) | 2018-12-20 | 2021-08-30 | 노파르티스 아게 | 3-(1-옥소이소인돌린-2-일)피페리딘-2,6-디온 유도체를 포함하는 투약 요법 및 약학적 조합물 |
| CN113438961A (zh) | 2018-12-20 | 2021-09-24 | Xencor股份有限公司 | 含有IL-15/IL-15Rα和NKG2D抗原结合结构域的靶向异二聚体Fc融合蛋白 |
| WO2020128637A1 (fr) | 2018-12-21 | 2020-06-25 | Novartis Ag | UTILISATION D'ANTICORPS DE LIAISON À IL-1β DANS LE TRAITEMENT D'UN CANCER MSI-H |
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|---|---|---|
| MA41867A (fr) | Anticorps dirigés contre l'immunoglobuline de cellule t et protéine 3 de mucine (tim-3) | |
| MA46113A (fr) | Anticorps dirigés contre l'immunoglobuline de lymphocyte t et la protéine 3 de mucine (tim-3) | |
| PT3802608T (pt) | Anticorpos anti-cd3 e utilizações destes | |
| MA43859A (fr) | Anticorps monoclonaux humainisés immunostimulants dirigés contre l'interleukine -2 humaine, et leurs protéines de fusion | |
| MA43955A (fr) | Anticorps anti-bcma et anti-cd3 bispécifiques de format bite | |
| SG11202000366WA (en) | Anti-ctla-4 antibodies and uses thereof | |
| DK3459597T3 (da) | Enkeltdomæne-antistof mod ctla4 og deraf afledt protein | |
| PL3710484T3 (pl) | Przeciwciała wiążące ctla-4 i ich zastosowania | |
| EP3430058A4 (fr) | Protéines de fusion à fab multispécifiques et leur utilisation | |
| PL3436079T3 (pl) | Antygen chimeryczny i receptory komórek t oraz sposoby ich stosowania | |
| EP3383913A4 (fr) | Anticorps ciblant la protéine de type récepteur fc 5 et procédés d'utilisation | |
| MA42446A (fr) | Anticorps spécifiques de la protéine tau hyperphosphorylée et leurs procédés d'utilisation | |
| PL3176181T3 (pl) | Przeciwciało monoklonalne anty-CTLA4 lub jego fragment wiążący antygen, kompozycja lecznicza i zastosowanie | |
| EP3587453A4 (fr) | Anticorps anti-pd-l1 et son application | |
| EP3841125A4 (fr) | Anticorps monoclonaux contre tim-3 humain | |
| EP3733705A4 (fr) | Anticorps monoclonaux et procédés de leur utilisation | |
| EP3387019A4 (fr) | Protéines de fusion d'immunoglobuline de relaxine et procédés d'utilisation | |
| DK3380122T3 (da) | Anti-5t4 antistoffer og antistoflægemiddel konjugater | |
| EP3464355A4 (fr) | Anticorps monoclonal dirigé contre dsg2 et son utilisation | |
| MA49250A (fr) | Nouveaux anticorps anti-cd3 | |
| MA43738A (fr) | Anticorps anti-tnfalpha et leurs fragments fonctionnels | |
| EP3416986A4 (fr) | Protéine de fusion à un anticorps et compositions associées permettant de cibler un cancer | |
| MA44777A (fr) | Anticorps humanisés anti-basigine et leur utilisation | |
| EP3404042A4 (fr) | Anticorps monoclonal fnab8 et son utilisation | |
| EP3411070A4 (fr) | Anticorps monoclonaux spécifiques de egfl6 et procédés pour les utiliser |