MA45531A - Procédé de criblage d'un mutant dans une population d'organismes par application d'une approche de regroupement et de division - Google Patents

Procédé de criblage d'un mutant dans une population d'organismes par application d'une approche de regroupement et de division

Info

Publication number: MA45531A
Authority: MA; Morocco
Prior art keywords: mutant; grouping; organisms; population; screening
Prior art date: 2016-07-01

Application number

MA045531A

Other languages

English (en)

Inventor

Massimiliano Carciofi

Søren Knudsen

Ole Olsen

Magnus Wohlfahrt Rasmussen

Birgitte Skadhauge

Alexander Striebeck

Hanne Cecilie Thomsen

Toni Wendt

Original Assignee

Carlsberg As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2016-07-01

Filing date

2017-06-23

Publication date

2019-05-08

2017-06-23 Application filed by Carlsberg As filed Critical Carlsberg As

2019-05-08 Publication of MA45531A publication Critical patent/MA45531A/fr

Links

238000000034 method Methods 0.000 title 1
238000012216 screening Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
- C12Q1/6895—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for plants, fungi or algae
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
- A01H4/00—Plant reproduction by tissue culture techniques ; Tissue culture techniques therefor
- A01H4/005—Methods for micropropagation; Vegetative plant propagation using cell or tissue culture techniques
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
- A01H6/00—Angiosperms, i.e. flowering plants, characterised by their botanic taxonomy
- A01H6/46—Gramineae or Poaceae, e.g. ryegrass, rice, wheat or maize
- A01H6/4624—Hordeum vulgarus [barley]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/01—Preparation of mutants without inserting foreign genetic material therein; Screening processes therefor
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
- C12N15/1024—In vivo mutagenesis using high mutation rate "mutator" host strains by inserting genetic material, e.g. encoding an error prone polymerase, disrupting a gene for mismatch repair
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6858—Allele-specific amplification
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/686—Polymerase chain reaction [PCR]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B30/00—Methods of screening libraries
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/13—Plant traits
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Biotechnology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Microbiology (AREA)
General Health & Medical Sciences (AREA)
Biophysics (AREA)
Physics & Mathematics (AREA)
Biomedical Technology (AREA)
Analytical Chemistry (AREA)
Immunology (AREA)
Chemical Kinetics & Catalysis (AREA)
Plant Pathology (AREA)
Crystallography & Structural Chemistry (AREA)
Botany (AREA)
Developmental Biology & Embryology (AREA)
Environmental Sciences (AREA)
Physiology (AREA)
Natural Medicines & Medicinal Plants (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Cell Biology (AREA)
Mycology (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

MA045531A 2016-07-01 2017-06-23 Procédé de criblage d'un mutant dans une population d'organismes par application d'une approche de regroupement et de division MA45531A (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DKPA201670485		2016-07-01

Publications (1)

Publication Number	Publication Date
MA45531A true MA45531A (fr)	2019-05-08

Family

ID=56681913

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
MA045531A MA45531A (fr)	2016-07-01	2017-06-23	Procédé de criblage d'un mutant dans une population d'organismes par application d'une approche de regroupement et de division
MA054568A MA54568A (fr)	2016-07-01	2017-06-23	Substitutions de nucléotides prédéterminées
MA052594A MA52594A (fr)	2016-07-01	2017-06-23	Procédé d'identification d'un sous-ensemble comprenant un organisme mutant

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
MA054568A MA54568A (fr)	2016-07-01	2017-06-23	Substitutions de nucléotides prédéterminées
MA052594A MA52594A (fr)	2016-07-01	2017-06-23	Procédé d'identification d'un sous-ensemble comprenant un organisme mutant

Country Status (24)

Country	Link
US (2)	US11884972B2 (fr)
EP (3)	EP3792357B1 (fr)
JP (2)	JP7208797B2 (fr)
CN (2)	CN109477087B (fr)
AR (1)	AR110103A1 (fr)
AU (3)	AU2017288960B2 (fr)
CA (1)	CA3026016A1 (fr)
CL (1)	CL2018003710A1 (fr)
CO (1)	CO2019000828A2 (fr)
CR (1)	CR20190040A (fr)
CU (1)	CU20180158A7 (fr)
DK (1)	DK3478832T3 (fr)
EA (1)	EA201892809A1 (fr)
ES (2)	ES2916221T3 (fr)
IL (1)	IL263451B (fr)
MA (3)	MA45531A (fr)
MX (2)	MX2018016110A (fr)
PE (1)	PE20190228A1 (fr)
PL (2)	PL3478832T3 (fr)
PT (1)	PT3478832T (fr)
SG (1)	SG11201811021YA (fr)
UY (1)	UY37312A (fr)
WO (1)	WO2018001884A1 (fr)
ZA (3)	ZA201808218B (fr)

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PL3478832T3 (pl) *	2016-07-01	2022-06-06	Carlsberg A/S	Sposób skriningu populacji organizmów pod kątem mutanta poprzez zastosowanie podejścia polegającego na łączeniu i dzieleniu
US11690341B2 (en)	2017-12-28	2023-07-04	Carlsberg A/S	Cereal plants with improved cell wall properties
US20220362771A1 (en) *	2018-07-13	2022-11-17	Hifibio Sas	Use of droplet single cell epigenome profiling for patient stratification
WO2020012004A1 (fr) *	2018-07-13	2020-01-16	Hifibio Sas	Utilisation d'un profilage épigénétique de cellules uniques de gouttelettes pour la stratification de patients
CN108913698B (zh) *	2018-07-25	2021-10-26	安徽农业大学	一种与小麦穗发芽抗性/感性相关的caps标记及其应用
CN110724741B (zh) *	2019-07-24	2020-05-19	艾普拜生物科技(苏州)有限公司	一种检测微小残留白血病相关融合基因的引物、探针及其试剂盒
EP4013843A1 (fr)	2019-08-16	2022-06-22	Heineken Supply Chain B.V.	Production d'une boisson sans alcool
EP3785529A1 (fr)	2019-08-28	2021-03-03	Carlsberg A/S	Plantes d'orge avec une teneur en protéine modifiéé dans les graines
MX2022004361A (es)	2019-10-10	2022-05-03	Carlsberg As	Metodos para preparar plantas mutantes.
US20240043911A1 (en) *	2020-02-06	2024-02-08	The Administrators Of The Tulane Educational Fund	Crispr-based assay for detecting tb in bodily fluids
WO2021175786A1 (fr)	2020-03-02	2021-09-10	Carlsberg A/S	Plantes d'orge à activité dextrinase limite élevée
EP4029935A1 (fr)	2021-01-14	2022-07-20	Carlsberg A/S	Souche de s. eubayanus et ses hybrides
US20230250467A1 (en) *	2021-10-25	2023-08-10	Gt Molecular, Inc.	Off-target blocking sequences to improve target discrimination by polymerase chain reaction
EP4451853A1 (fr)	2021-12-22	2024-10-30	Basf Agricultural Solutions Seed Us Llc	Procédé de criblage amélioré pour des événements édités sur le génome
AR128756A1 (es)	2022-03-11	2024-06-12	Carlsberg As	Modulación de niveles de proteínas
AU2023379942A1 (en)	2022-11-16	2025-04-10	University Of Copenhagen	Plants with low seed glucosinolate content
WO2024133900A1 (fr)	2022-12-22	2024-06-27	University Of Copenhagen	Production de (-)-spartéine améliorée
WO2024227748A1 (fr)	2023-05-01	2024-11-07	Carlsberg A/S	Orge à propriétés améliorées
WO2025108936A1 (fr) *	2023-11-20	2025-05-30	Eth Zurich	Procédé de fourniture de cellules génétiquement modifiées
CN117965576B (zh) *	2024-02-01	2024-08-27	北京林业大学	一种王百合苷生物合成基因LlHCT1及其应用
EP4644572A1 (fr) *	2024-04-29	2025-11-05	KWS SAAT SE & Co. KGaA	Procédé d'analyse de pureté de caractères dans des grands volumes de semences
WO2025240938A2 (fr) *	2024-05-16	2025-11-20	Oath, Inc.	Production de consortiums microbiens
WO2026037962A1 (fr)	2024-08-15	2026-02-19	University Of Copenhagen	Légumineuses ou parties de celles-ci à teneur réduite en alcaloïdes de quinolizidine

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MX2022004361A (es) *	2019-10-10	2022-05-03	Carlsberg As	Metodos para preparar plantas mutantes.

2017
- 2017-06-23 PL PL17733800T patent/PL3478832T3/pl unknown
- 2017-06-23 ES ES17733800T patent/ES2916221T3/es active Active
- 2017-06-23 EP EP20200115.2A patent/EP3792357B1/fr active Active
- 2017-06-23 SG SG11201811021YA patent/SG11201811021YA/en unknown
- 2017-06-23 JP JP2018569004A patent/JP7208797B2/ja active Active
- 2017-06-23 EP EP17733800.1A patent/EP3478832B1/fr active Active
- 2017-06-23 AU AU2017288960A patent/AU2017288960B2/en active Active
- 2017-06-23 EA EA201892809A patent/EA201892809A1/ru unknown
- 2017-06-23 CN CN201780041101.5A patent/CN109477087B/zh active Active
- 2017-06-23 IL IL263451A patent/IL263451B/en unknown
- 2017-06-23 WO PCT/EP2017/065516 patent/WO2018001884A1/fr not_active Ceased
- 2017-06-23 PL PL20200115.2T patent/PL3792357T3/pl unknown
- 2017-06-23 US US16/311,450 patent/US11884972B2/en active Active
- 2017-06-23 CN CN202210633145.XA patent/CN114959098A/zh active Pending
- 2017-06-23 MX MX2018016110A patent/MX2018016110A/es unknown
- 2017-06-23 CR CR20190040A patent/CR20190040A/es unknown
- 2017-06-23 EP EP20163553.9A patent/EP3693458A1/fr active Pending
- 2017-06-23 MA MA045531A patent/MA45531A/fr unknown
- 2017-06-23 PE PE2018003333A patent/PE20190228A1/es unknown
- 2017-06-23 CA CA3026016A patent/CA3026016A1/fr active Pending
- 2017-06-23 CU CU2018000158A patent/CU20180158A7/es unknown
- 2017-06-23 MA MA054568A patent/MA54568A/fr unknown
- 2017-06-23 PT PT177338001T patent/PT3478832T/pt unknown
- 2017-06-23 DK DK17733800.1T patent/DK3478832T3/da active
- 2017-06-23 MA MA052594A patent/MA52594A/fr unknown
- 2017-06-23 ES ES20200115T patent/ES3032697T3/es active Active
- 2017-06-30 UY UY0001037312A patent/UY37312A/es not_active Application Discontinuation
- 2017-06-30 AR ARP170101817A patent/AR110103A1/es unknown
2018
- 2018-12-05 ZA ZA2018/08218A patent/ZA201808218B/en unknown
- 2018-12-18 MX MX2022014965A patent/MX2022014965A/es unknown
- 2018-12-20 CL CL2018003710A patent/CL2018003710A1/es unknown
2019
- 2019-01-29 CO CONC2019/0000828A patent/CO2019000828A2/es unknown
- 2019-11-20 AU AU2019268103A patent/AU2019268103B2/en active Active
- 2019-11-20 AU AU2019268102A patent/AU2019268102B2/en active Active
- 2019-11-25 ZA ZA2019/07775A patent/ZA201907775B/en unknown
- 2019-11-25 ZA ZA2019/07774A patent/ZA201907774B/en unknown
2022
- 2022-05-06 JP JP2022076471A patent/JP7539428B2/ja active Active
2023
- 2023-12-12 US US18/536,784 patent/US12428678B2/en active Active

Also Published As

Publication number	Publication date
JP2022101703A (ja)	2022-07-06
UY37312A (es)	2018-02-28
ZA201907775B (en)	2022-09-28
CN114959098A (zh)	2022-08-30
AR110103A1 (es)	2019-02-27
EP3792357B1 (fr)	2025-05-07
PL3478832T3 (pl)	2022-06-06
US11884972B2 (en)	2024-01-30
CA3026016A1 (fr)	2018-01-04
CL2018003710A1 (es)	2019-03-22
BR112018076429A2 (pt)	2019-10-01
EP3478832B1 (fr)	2022-02-23
SG11201811021YA (en)	2019-01-30
PE20190228A1 (es)	2019-02-13
US20240182961A1 (en)	2024-06-06
EA201892809A1 (ru)	2019-06-28
CO2019000828A2 (es)	2019-04-30
AU2017288960B2 (en)	2019-12-12
AU2019268103A1 (en)	2019-12-12
ZA201907774B (en)	2022-07-27
MX2018016110A (es)	2019-05-30
PL3792357T3 (pl)	2025-07-07
AU2019268102B2 (en)	2020-03-05
EP3693458A1 (fr)	2020-08-12
EP3478832A1 (fr)	2019-05-08
AU2019268103B2 (en)	2020-03-12
JP7539428B2 (ja)	2024-08-23
US20190194723A1 (en)	2019-06-27
NZ749382A (en)	2025-06-27
JP7208797B2 (ja)	2023-01-19
ZA201808218B (en)	2020-02-26
ES3032697T3 (en)	2025-07-23
IL263451A (en)	2019-01-31
MA54568A (fr)	2021-10-27
CN109477087A (zh)	2019-03-15
PT3478832T (pt)	2022-05-19
EP3792357C0 (fr)	2025-05-07
CU20180158A7 (es)	2019-08-06
CN109477087B (zh)	2022-06-24
MA52594A (fr)	2021-03-17
ES2916221T3 (es)	2022-06-29
AU2019268102A1 (en)	2019-12-12
MX2022014965A (es)	2023-01-11
DK3478832T3 (da)	2022-05-30
WO2018001884A1 (fr)	2018-01-04
JP2019524083A (ja)	2019-09-05
AU2017288960A1 (en)	2019-01-17
EP3792357A1 (fr)	2021-03-17
CR20190040A (es)	2019-05-09
IL263451B (en)	2022-08-01
US12428678B2 (en)	2025-09-30

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