MA49971A - Vésicules extracellulaires modifiées et leurs utilisations - Google Patents

Vésicules extracellulaires modifiées et leurs utilisations

Info

Publication number
MA49971A
MA49971A MA049971A MA49971A MA49971A MA 49971 A MA49971 A MA 49971A MA 049971 A MA049971 A MA 049971A MA 49971 A MA49971 A MA 49971A MA 49971 A MA49971 A MA 49971A
Authority
MA
Morocco
Prior art keywords
extracellular vesicles
modified extracellular
modified
vesicles
extracellular
Prior art date
Application number
MA049971A
Other languages
English (en)
Other versions
MA49971B1 (fr
Inventor
Kevin P Dooley
Rane A Harrison
Sonya Haupt
Damian J Houde
John D Kulman
Russell E Mcconnell
Douglas E Williams
Ke Xu
Madeleine Youniss
Original Assignee
Codiak Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=70732111&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA49971(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Codiak Biosciences Inc filed Critical Codiak Biosciences Inc
Publication of MA49971A publication Critical patent/MA49971A/fr
Publication of MA49971B1 publication Critical patent/MA49971B1/fr

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/385Haptens or antigens, bound to carriers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08Peptides having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10Peptides having 12 to 20 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/08Clostridium, e.g. Clostridium tetani
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/08Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55555Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/60Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/60Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031Proteins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2509/00Methods for the dissociation of cells, e.g. specific use of enzymes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
MA49971A 2019-04-17 2019-05-22 Vésicules extracellulaires modifiées et leurs utilisations MA49971B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962835430P 2019-04-17 2019-04-17
PCT/US2019/033629 WO2020101740A1 (fr) 2018-11-16 2019-05-22 Vésicules extracellulaires modifiées et leurs utilisations

Publications (2)

Publication Number Publication Date
MA49971A true MA49971A (fr) 2020-07-01
MA49971B1 MA49971B1 (fr) 2022-01-31

Family

ID=70732111

Family Applications (1)

Application Number Title Priority Date Filing Date
MA49971A MA49971B1 (fr) 2019-04-17 2019-05-22 Vésicules extracellulaires modifiées et leurs utilisations

Country Status (28)

Country Link
EP (3) EP4628099A3 (fr)
JP (2) JP7538795B2 (fr)
KR (1) KR20210098473A (fr)
CN (2) CN113286603B (fr)
AU (1) AU2019378591A1 (fr)
BR (1) BR112021009231A2 (fr)
CA (1) CA3119720A1 (fr)
CL (1) CL2021001278A1 (fr)
CY (1) CY1124897T1 (fr)
DK (1) DK3672614T3 (fr)
EA (1) EA202191334A1 (fr)
ES (1) ES2907967T3 (fr)
HR (1) HRP20220020T1 (fr)
HU (1) HUE057300T2 (fr)
IL (1) IL283167A (fr)
LT (1) LT3672614T (fr)
MA (1) MA49971B1 (fr)
MD (1) MD3672614T2 (fr)
MX (1) MX2021005636A (fr)
PH (1) PH12021551088A1 (fr)
PL (1) PL3672614T3 (fr)
PT (1) PT3672614T (fr)
RS (1) RS62863B1 (fr)
SG (1) SG11202104956QA (fr)
SI (1) SI3672614T1 (fr)
SM (1) SMT202200156T1 (fr)
TW (2) TW202438105A (fr)
WO (1) WO2020101740A1 (fr)

Families Citing this family (39)

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US20220323519A1 (en) * 2019-04-17 2022-10-13 Codiak Biosciences, Inc. Compositions of exosomes and aav
US20220251200A1 (en) 2019-07-03 2022-08-11 Codiak Biosciences, Inc. Extracellular vesicles targeting t cells and uses thereof
JP2022544289A (ja) * 2019-08-14 2022-10-17 コディアック バイオサイエンシーズ, インコーポレイテッド Stat6を標的とする細胞外小胞-aso構築物
BR112022002690A2 (pt) * 2019-08-14 2022-08-23 Codiak Biosciences Inc Construtos de vesícula-aso extracelular tendo como alvo cebp/beta
CN114641570A (zh) 2019-08-14 2022-06-17 科迪亚克生物科学公司 具有靶向kras的反义寡核苷酸的细胞外囊泡
WO2021030769A1 (fr) 2019-08-14 2021-02-18 Codiak Biosciences, Inc. Vésicules extracellulaires avec des oligonucléotides antisens de nras
JP2022549328A (ja) 2019-09-25 2022-11-24 コディアック バイオサイエンシーズ, インコーポレイテッド 細胞外小胞組成物
WO2021062290A1 (fr) 2019-09-25 2021-04-01 Codiak Biosciences, Inc. Procédés de production de vésicules extracellulaires
WO2021062057A1 (fr) 2019-09-25 2021-04-01 Codiak Biosciences, Inc. Chargement exogène d'exosomes par lyophilisation
KR20220094221A (ko) 2019-09-25 2022-07-05 코디악 바이오사이언시즈, 인크. 종양의 치료를 위한 il-12 디스플레잉 엑소좀과 조합된 sting 효능제 포함 엑소좀
US12616712B2 (en) 2019-09-25 2026-05-05 Lonza Sales Ag Sting agonist comprising exosomes for treating neuroimmunological disorders
JP2023517992A (ja) 2020-03-12 2023-04-27 インスティチュート フォー ベーシック サイエンス ゲノム配列変異を有する細胞死滅誘導用組成物及び該組成物を用いた細胞死滅誘導方法
WO2021184020A1 (fr) 2020-03-13 2021-09-16 Codiak Biosciences, Inc. Méthodes de traitement d'une neuro-inflammation
US20230114434A1 (en) 2020-03-13 2023-04-13 Codiak Biosciences, Inc. Extracellular vesicles for treating neurological disorders
WO2021184021A1 (fr) 2020-03-13 2021-09-16 Codiak Biosciences, Inc. Constructions de vésicules extracellulaires - aso ciblant pmp22
JP2023518414A (ja) 2020-03-20 2023-05-01 コディアック バイオサイエンシーズ, インコーポレイテッド 治療のための細胞外小胞
WO2021248133A1 (fr) 2020-06-05 2021-12-09 Codiak Biosciences, Inc. Vésicules extracellulaires anti-transferrine
KR20230042754A (ko) * 2020-08-07 2023-03-29 아미쿠스 세라퓨틱스, 인코포레이티드 소포 표적화 단백질 및 이의 용도
US20240241020A1 (en) 2020-09-23 2024-07-18 Lonza Sales Ag Process for preparing extracellular vesicles
WO2022066883A1 (fr) 2020-09-23 2022-03-31 Codiak Biosciences, Inc. Vésicules extracellulaires comprenant des antigènes kras et leurs utilisations
WO2022066934A2 (fr) 2020-09-23 2022-03-31 Codiak Biosciences, Inc. Procédé de préparation de vésicules extracellulaires
GB202015399D0 (en) * 2020-09-29 2020-11-11 Evox Therapeutics Ltd Engineered extracellular vesicles displaying enhanced pharmacokinetics
WO2022076596A1 (fr) 2020-10-06 2022-04-14 Codiak Biosciences, Inc. Constructions vésicules extracellulaires-oas ciblant stat6
CN112410304A (zh) * 2020-11-12 2021-02-26 天津大学 一种基因修饰的外泌体及其制备方法和应用
CN112899307A (zh) * 2021-01-28 2021-06-04 苏州大学 GluN1和/或GluN2亚基羧基末端豆蔻酰化的NMDA受体的应用
US20240167036A1 (en) * 2021-02-17 2024-05-23 Lonza Sales Ag Extracellular vesicle-nlrp3 antagonist
EP4294375B1 (fr) 2021-02-17 2026-04-01 Lonza Sales AG Procédés de chargement de vésicules extracellulaires
KR20230166101A (ko) 2021-04-01 2023-12-06 론자 세일즈 아게 세포외 소포 조성물
CN114057893B (zh) * 2021-04-26 2022-12-30 苏州大学 一种编码线粒体定位的豆蔻酰化多肽及其制备方法与应用
CN117126886A (zh) * 2022-05-20 2023-11-28 谛邈生物科技(北京)有限公司 一种实现工程化EVs功能蛋白模块化装载的核酸构建体及其应用
EP4532514A1 (fr) * 2022-05-24 2025-04-09 Shiftbio Inc. Vésicules extracellulaires modifiées en surface et leurs utilisations thérapeutiques
WO2024215711A1 (fr) * 2023-04-10 2024-10-17 Wake Forest University Health Sciences Vésicules de mammifère modifiées et compositions et procédés associés
CN116769718A (zh) * 2023-04-21 2023-09-19 南京逸微健华生物科技有限公司 一种工程化细胞外囊泡及用途
WO2024226723A1 (fr) * 2023-04-26 2024-10-31 Northwestern University Chargement actif de cargo biomoléculaire dans des vésicules modifiées
CN118909084A (zh) * 2023-05-08 2024-11-08 天津外泌体科技有限公司 细胞外囊泡支架蛋白及其应用
EP4644537A1 (fr) 2024-04-30 2025-11-05 ConvEyXo Vésicule extracellulaire ciblée
WO2025232431A1 (fr) * 2024-05-08 2025-11-13 天津外泌体科技有限公司 Système et procédé de criblage de gène affectant l'absorption de vésicule extracellulaire
WO2026022863A1 (fr) * 2024-07-25 2026-01-29 Christian Medical College Vésicules extracellulaires et utilisations associées pour administration ciblée
WO2026055342A1 (fr) 2024-09-04 2026-03-12 Arsenal Biosciences, Inc. Activateurs de voie biologique de synthèse

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PL2254586T3 (pl) * 2008-02-22 2015-09-30 Agency For Science Tech And Research Astarstar Cząstki mezenchymalnych komórek macierzystych
FR2950350B1 (fr) 2009-09-24 2013-12-13 Centre Nat Rech Scient Nouveaux polynucleotides et polypeptides chimeriques permettant la secretion d'un polypeptide d'interet en association avec des exosomes et leurs utilisations
EP3164420A4 (fr) * 2014-06-30 2018-05-23 Tarveda Therapeutics, Inc. Conjugués ciblés, particules et préparations associées
US10501733B2 (en) * 2015-02-27 2019-12-10 University Of Washington Polypeptide assemblies and methods for the production thereof
WO2016172598A1 (fr) * 2015-04-22 2016-10-27 The Broad Institute Inc. Exosomes et leurs utilisations
JP2019501179A (ja) * 2015-12-30 2019-01-17 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 細胞由来ベシクルの向上された生成および単離のための方法
US10617768B2 (en) * 2016-07-12 2020-04-14 Santa Clara University Engineered exosomes for the delivery of bioactive cargo using transmembrane tetraspanins
US12622876B2 (en) * 2016-08-22 2026-05-12 Lonza Sales Ag Methods of suppressing delivery of exosomes to liver and spleen
WO2018112154A1 (fr) * 2016-12-15 2018-06-21 Codiak Biosciences, Inc. Procédés de mesure d'exosomes à l'aide d'une fluorescence intrinsèque
MX2020001790A (es) 2017-08-25 2020-07-22 Codiak Biosciences Inc Preparacion de exosomas terapeuticos mediante el uso de proteinas de membrana.
WO2019099942A1 (fr) * 2017-11-17 2019-05-23 Codiak Biosciences, Inc. Compositions d'exosomes modifiés et procédés de chargement de charges d'exosomes luminaux
WO2020041720A1 (fr) * 2018-08-24 2020-02-27 Codiak Biosciences, Inc. Vésicules extracellulaires ciblant des cellules dendritiques et utilisations associées

Also Published As

Publication number Publication date
TWI846697B (zh) 2024-07-01
PT3672614T (pt) 2022-02-11
HUE057300T2 (hu) 2022-05-28
RS62863B1 (sr) 2022-02-28
CN121102502A (zh) 2025-12-12
SI3672614T1 (sl) 2022-04-29
PH12021551088A1 (en) 2022-01-03
EA202191334A1 (ru) 2022-02-10
EP4628099A2 (fr) 2025-10-08
MA49971B1 (fr) 2022-01-31
TW202438105A (zh) 2024-10-01
CY1124897T1 (el) 2023-01-05
CN113286603A (zh) 2021-08-20
CN113286603B (zh) 2025-07-22
EP4059510C0 (fr) 2025-05-21
CA3119720A1 (fr) 2020-05-22
WO2020101740A9 (fr) 2021-06-10
HRP20220020T1 (hr) 2022-04-01
MX2021005636A (es) 2021-07-06
AU2019378591A1 (en) 2021-06-17
WO2020101740A1 (fr) 2020-05-22
JP7538795B2 (ja) 2024-08-22
MD3672614T2 (ro) 2022-04-30
EP3672614A1 (fr) 2020-07-01
JP2024097929A (ja) 2024-07-19
EP4628099A3 (fr) 2025-11-19
PL3672614T3 (pl) 2022-03-07
EP3672614B1 (fr) 2021-10-06
IL283167A (en) 2021-06-30
BR112021009231A2 (pt) 2021-08-10
EP4059510B1 (fr) 2025-05-21
EP4059510A1 (fr) 2022-09-21
DK3672614T3 (da) 2022-01-10
JP2022513049A (ja) 2022-02-07
KR20210098473A (ko) 2021-08-10
ES2907967T3 (es) 2022-04-27
SMT202200156T1 (it) 2022-05-12
LT3672614T (lt) 2022-04-11
CL2021001278A1 (es) 2022-03-11
TW202038993A (zh) 2020-11-01
SG11202104956QA (en) 2021-06-29

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