MA54298A - Dérivés amino triazolo quinazoline 9-substitués utiles en tant qu'antagonistes du récepteur de l'adénosine, compositions pharmaceutiques et leur utilisation - Google Patents

Dérivés amino triazolo quinazoline 9-substitués utiles en tant qu'antagonistes du récepteur de l'adénosine, compositions pharmaceutiques et leur utilisation

Info

Publication number
MA54298A
MA54298A MA054298A MA54298A MA54298A MA 54298 A MA54298 A MA 54298A MA 054298 A MA054298 A MA 054298A MA 54298 A MA54298 A MA 54298A MA 54298 A MA54298 A MA 54298A
Authority
MA
Morocco
Prior art keywords
pharmaceutical compositions
substituted amino
receptor antagonists
adenosine receptor
derivatives useful
Prior art date
Application number
MA054298A
Other languages
English (en)
Inventor
Amjad Ali
Jared Cumming
Duane Demong
Qiaolin Deng
Thomas H Graham
Elisabeth Hennessy
Andrew J Hoover
Matthew A Larsen
Kun Liu
Ping Liu
Umar Faruk Mansoor
Jianping Pan
Christopher W Plummer
Aaron Sather
Uma Swaminathan
Huijun Wang
Yonglian Zhang
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=69005832&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA54298(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of MA54298A publication Critical patent/MA54298A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
MA054298A 2018-11-30 2019-11-26 Dérivés amino triazolo quinazoline 9-substitués utiles en tant qu'antagonistes du récepteur de l'adénosine, compositions pharmaceutiques et leur utilisation MA54298A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201862774077P 2018-11-30 2018-11-30

Publications (1)

Publication Number Publication Date
MA54298A true MA54298A (fr) 2022-03-09

Family

ID=69005832

Family Applications (1)

Application Number Title Priority Date Filing Date
MA054298A MA54298A (fr) 2018-11-30 2019-11-26 Dérivés amino triazolo quinazoline 9-substitués utiles en tant qu'antagonistes du récepteur de l'adénosine, compositions pharmaceutiques et leur utilisation

Country Status (25)

Country Link
US (2) US11312719B2 (fr)
EP (1) EP3886988A1 (fr)
JP (1) JP7241871B2 (fr)
KR (1) KR102653800B1 (fr)
CN (1) CN113329791A (fr)
AR (1) AR117164A1 (fr)
AU (1) AU2019385905B2 (fr)
BR (1) BR112021010427B1 (fr)
CA (1) CA3120862C (fr)
CL (1) CL2021001406A1 (fr)
CO (1) CO2021006888A2 (fr)
CR (1) CR20210271A (fr)
DO (1) DOP2021000104A (fr)
EA (1) EA202191498A1 (fr)
EC (1) ECSP21036982A (fr)
IL (1) IL283334A (fr)
JO (2) JOP20210117A1 (fr)
MA (1) MA54298A (fr)
MX (1) MX2021006329A (fr)
NI (1) NI202100043A (fr)
PE (1) PE20211768A1 (fr)
PH (1) PH12021551196A1 (fr)
SG (1) SG11202105180PA (fr)
TW (1) TW202039496A (fr)
WO (1) WO2020112700A1 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2170959E (pt) 2007-06-18 2014-01-07 Merck Sharp & Dohme Anticorpos para o receptor humano de morte programada pd-1
US11466017B2 (en) 2011-03-10 2022-10-11 Board Of Regents, The University Of Texas System Heterocyclic inhibitors of PTPN11
WO2017210134A1 (fr) 2016-05-31 2017-12-07 Board Of Regents, University Of Texas System Inhibiteurs hétérocycliques de ptpn11
KR102611661B1 (ko) 2018-05-02 2023-12-08 나비레 파르마, 인코퍼레이티드 Ptpn11의 치환된 헤테로사이클릭 억제제
PL3833670T3 (pl) 2018-08-10 2024-08-19 Navire Pharma, Inc. Pochodne 6-(4-amino-3-metylo-2-oksa-8-azaspiro[4.5]dekan-8-ylo)-3-(2,3-dichlorofenylo)-2-metylopirymidyn-4(3h)-onu oraz powiązane związki jako inhibitory ptpn11 (shp2) do leczenia raka
US12414952B2 (en) 2018-11-20 2025-09-16 Merck Sharp & Dohme Llc Substituted amino triazolopyrimidine and amino triazolopyrazine adenosine receptor antagonists, pharmaceutical compositions and their use
JP2022507734A (ja) 2018-11-20 2022-01-18 メルク・シャープ・アンド・ドーム・コーポレーション 置換アミノトリアゾロピリミジン及びアミノトリアゾロピラジンアデノシン受容体アンタゴニスト、医薬組成物及びそれらの使用
AU2019389168A1 (en) 2018-11-30 2021-06-24 Comet Therapeutics, Inc. Pantetheine derivatives and uses thereof
JP2022511778A (ja) * 2018-11-30 2022-02-01 メルク・シャープ・アンド・ドーム・コーポレーション アデノシン受容体拮抗薬としての７－、８－及び１０－置換されたアミノトリアゾロキナゾリン誘導体、医薬組成物及びそれらの使用
US20240076297A1 (en) * 2020-07-24 2024-03-07 Merck Sharp & Dohme Llc Adenosine a2a and a2b receptor dual antagonists for immuno-oncology
WO2022020550A1 (fr) * 2020-07-24 2022-01-27 Merck Sharp & Dohme Corp. Antagonistes doubles du récepteur a2a et du récepteur a2b de l'adénosine pour l'immuno-oncologie
US20250171447A1 (en) * 2022-02-16 2025-05-29 Merck Sharp & Dohme Llc Adenosine receptor antagonists, pharmaceutical compositions and their use thereof
AU2023252914A1 (en) 2022-04-13 2024-10-17 Arcus Biosciences, Inc. Combination therapy for treating trop-2 expressing cancers
WO2024118460A1 (fr) * 2022-11-29 2024-06-06 Merck Sharp & Dohme Llc Antagonistes des récepteurs a2a et a2b de l'adénosine, compositions pharmaceutiques et leur utilisation
US20250230168A1 (en) 2023-12-22 2025-07-17 Gilead Sciences, Inc. Azaspiro wrn inhibitors
AU2024424270A1 (en) * 2024-02-01 2026-08-13 Foresight Therapeutics (Hefei) Co., Ltd. Spiro derivative serving as wrn inhibitor and use of spiro derivative

Family Cites Families (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3957766A (en) 1970-06-19 1976-05-18 Boehringer Mannheim G.M.B.H. Novel nitrofuran compounds and pharmaceutical compositions
DE2109577A1 (de) 1971-03-01 1972-09-14 Boehringer Mannheim Gmbh Antimikrobiell wirksame Nitrofuran Derivate und Verfahren zur Herstellung derselben
US4713383A (en) 1984-10-01 1987-12-15 Ciba-Geigy Corporation Triazoloquinazoline compounds, and their methods of preparation, pharmaceutical compositions, and uses
GB9524395D0 (en) 1995-11-29 1996-01-31 Nickerson Biocem Ltd Promoters
DE19629378A1 (de) 1996-07-20 1998-01-29 Boehringer Ingelheim Kg Neue Triazolopurine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
PT1283839E (pt) 2000-05-26 2005-08-31 Schering Corp Antagonistas do receptor a2a da adenosina
US6759759B2 (en) 2000-08-29 2004-07-06 Tamagawa Seiki Kabushiki Kaisha Rotary contactless connector and non-rotary contactless connector
JP4545437B2 (ja) 2001-10-15 2010-09-15 シェーリング コーポレイション アデノシンａ２ａ受容体アンタゴニストとしてのイミダゾ（４，３−ｅ）−１，２，４−トリアゾロ（１，５−ｃ）ピリミジン
AU2002346503A1 (en) 2001-11-30 2003-06-17 Schering Corporation Adenosine A2a receptor antagonists
TW200300686A (en) 2001-11-30 2003-06-16 Schering Corp Adenosine A2a receptor antagonists
DE60334303D1 (de) 2002-07-03 2010-11-04 Tasuku Honjo Immunpotenzierende zusammensetzungen
AU2003272886A1 (en) 2002-09-24 2004-04-19 Kyowa Hakko Kogyo Co., Ltd. (1,2,4)-TRIAZOLO(1,5-c)PYRIMIDINE DERIVATIVE
ES2367430T3 (es) 2002-12-23 2011-11-03 Wyeth Llc Anticuerpos contra pd-1 y sus usos.
US7563869B2 (en) 2003-01-23 2009-07-21 Ono Pharmaceutical Co., Ltd. Substance specific to human PD-1
EP1615931A1 (fr) 2003-04-09 2006-01-18 Biogen Idec MA Inc. Triazolopyrazines et procedes de preparation et d'utilisation ce celles-ci
DK1678182T3 (da) 2003-10-28 2007-06-04 Schering Corp Fremgangsmåde til fremstilling af substituerede 5-amino-pyrazolo[4,3-E]-1,2,4-triazolo-[1,5-C]pyrimidiner
ATE377599T1 (de) 2003-12-01 2007-11-15 Schering Corp Verfahren zur herstellung von substituierten 5- aminopyrazolo(4,3-e)-1,2,4-triazolo(1,5- c)pyrimidinen
ATE461932T1 (de) 2004-04-21 2010-04-15 Schering Corp Pyrazoloä4,3-eü-1,2,4-triazoloä1,5-cüpyrimidine als antagonisten des adenosin-a2a-rezeptors
US7472383B2 (en) 2004-08-13 2008-12-30 Sun Microsystems, Inc. System and method for providing exceptional flow control in protected code through memory layers
CN101119998A (zh) 2004-12-21 2008-02-06 先灵公司 吡唑并[1,5－A]嘧啶腺苷A2a受体拮抗剂
EP3530736A3 (fr) 2005-05-09 2019-11-06 ONO Pharmaceutical Co., Ltd. Anticorps monoclonaux humains pour mort programmée 1 (pd-1) et procédés de traitement du cancer à l'aide d'anticorps anti-pd-1 seuls ou combinés à d'autres formulations immunothérapeutiques
KR101704734B1 (ko) 2005-07-01 2017-02-09 이. 알. 스퀴부 앤드 선즈, 엘.엘.씨. 예정 사멸 리간드 1 (피디-엘1)에 대한 인간 모노클로날 항체
AR057817A1 (es) 2005-09-19 2007-12-19 Schering Corp Antagonistas del receptor a2a de 2-heteroaril-pirazolo-[4,3-e]-1,2,4-triazolo-[1,5-c]-pirimidin adenosina. composiciones farmaceuticas
AR056080A1 (es) 2005-09-23 2007-09-19 Schering Corp 7-[2-[4-(6-fluoro-3-metil-1,2-benciosoxazol-5-il)-1-piperazinil]etil]-2-(1-propinil)-7h-pirazol-[4,3-e]-[1,2,4]-triazol-[1,5-c] -pirimidin-5-amine
EP2038285B1 (fr) 2006-06-26 2010-02-17 Schering Corporation Antagonistes du récepteur a2a de l'adénosine
US7691869B2 (en) 2007-03-30 2010-04-06 King Pharmaceuticals Research And Development, Inc. Pyrrolotriazolopyrimidine derivatives, pharmaceutical compositions containing them and methods of treating conditions and diseases mediated by the adenosine A2A receptor activity
HUP0700395A2 (en) 2007-06-07 2009-03-02 Sanofi Aventis Substituted [1,2,4] triazolo [1,5-a] quinolines, process for their preparation, pharmaceutical compositions thereof, and intermediates
PT2170959E (pt) 2007-06-18 2014-01-07 Merck Sharp & Dohme Anticorpos para o receptor humano de morte programada pd-1
PE20091101A1 (es) 2007-12-18 2009-07-26 Pharminox Ltd AMIDAS DE ACIDO 3-SUBSTITUIDO-4-OXO-3,4-DIHIDRO-IMIDAZO[5,1-d] [1,2,3,5-TETRACINA-8-CARBOXILICO Y SU EMPLEO
WO2009111442A1 (fr) 2008-03-04 2009-09-11 Schering Corporation Amino-quinoxaline et composés amino-quinoline à utiliser en tant qu'antagonistes du récepteur a2a de l'adénosine
US8168757B2 (en) 2008-03-12 2012-05-01 Merck Sharp & Dohme Corp. PD-1 binding proteins
WO2010098788A2 (fr) 2008-08-25 2010-09-02 Amplimmune, Inc. Antagonistes de pd-i et procédés de traitement d'une maladie infectieuse
WO2010036959A2 (fr) 2008-09-26 2010-04-01 Dana-Farber Cancer Institute Anticorps anti-pd-1, pd-l1, et pd-l2 humains et leurs utilisations
MX356367B (es) 2008-12-09 2018-05-25 Genentech Inc Anticuerpos anti-pd-l1 y su uso para mejorar la funcion de celulas t.
WO2011060207A1 (fr) 2009-11-16 2011-05-19 Schering Corporation Composés tricycliques condensés possédant une activité antagoniste des récepteurs a2a de l'adénosine
EP2504028A4 (fr) 2009-11-24 2014-04-09 Amplimmune Inc Inhibition simultanée de pd-l1/pd-l2
WO2012135084A1 (fr) 2011-03-31 2012-10-04 Merck Sharp & Dohme Corp. Métabolites de 2-(furan-2-yl)-7-(2-(4-(4-(2-méthoxyéthoxy)phényl)pipérazin-1-yl)éthyl)-7h-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine et leur utilité en tant qu'antagonistes du récepteur a2a de l'adénosine
BR112014002353B1 (pt) 2011-08-01 2022-09-27 Genentech, Inc Usos de antagonistas de ligação do eixo pd-1 e inibidores de mek, composições farmacêuticas, e kit
US8751477B2 (en) 2012-10-05 2014-06-10 Iac Search & Media, Inc. Quality control system for providing results in response to queries
US9495379B2 (en) 2012-10-08 2016-11-15 Veritas Technologies Llc Locality aware, two-level fingerprint caching
WO2014101113A1 (fr) 2012-12-28 2014-07-03 Merck Sharp & Dohme Corp. Composés de 7-méthoxy-[1,2,4]triazolo[1,5-c]quinazoline-5-amine à substitution pipérazine présentant des propriétés d'antagoniste d'a2a
WO2014101120A1 (fr) 2012-12-28 2014-07-03 Merck Sharp & Dohme Corp. Composés de 7-méthoxy-[1,2,4]triazolo[1,5-c]quinazoline-5-amine à substitution hétérobicyclo présentant des propriétés d'antagoniste d'a2a
WO2015027431A1 (fr) 2013-08-29 2015-03-05 Merck Sharp & Dohme Corp. Antagonistes 2,2-difluorodioxolo du récepteur a2a
AU2015350315B2 (en) 2014-11-18 2020-06-25 Merck Sharp & Dohme Corp. Aminopyrazine compounds with A2A antagonist properties
US10085991B2 (en) 2014-12-04 2018-10-02 Merck Sharp & Dohme Corp. Formulation inhibiting effects of low acid environment
WO2016126570A1 (fr) 2015-02-06 2016-08-11 Merck Sharp & Dohme Corp. Composés d'aminoquinazoline comme antagonistes d'a2a
EP3307067B1 (fr) 2015-06-11 2022-11-02 Merck Sharp & Dohme LLC Composés d'aminopyrazine ayant des propriétés d'antagoniste a2a
US10207002B2 (en) 2015-06-26 2019-02-19 Merck Sharp & Dohme Corp. Sustained release formulation and tablets prepared therefrom
WO2017008205A1 (fr) 2015-07-10 2017-01-19 Merck Sharp & Dohme Corp. Composés d'aminoquinazoline substitués a titre d'antagonistes du récepteur a2a
MX389798B (es) 2017-01-20 2025-03-20 Arcus Biosciences Inc Azolopirimidina para el tratamiento de trastornos relacionados con el cáncer.
KR20190129851A (ko) 2017-03-16 2019-11-20 지앙수 헨그루이 메디슨 컴퍼니 리미티드 헤테로아릴[4,3-c]피리미딘-5-아민 유도체, 이의 제조 방법 및 이의 의학적 용도
EP3611174B1 (fr) 2017-04-07 2022-06-08 Medshine Discovery Inc. Dérivé de [1,2,4] triazolo [1,5-c] pyrimidine en tant qu'inhibiteur du récepteur a2a
AU2018294557A1 (en) 2017-06-30 2020-01-02 Ryvu Therapeutics S.A. Imidazo(1,2-a)pyrazine modulators of the adenosine A2A receptor
US11498923B2 (en) 2017-12-13 2022-11-15 Merck Sharp & Dohme Llc Substituted imidazo[1,2-c]quinazolines as A2A antagonists
EP3810610A1 (fr) 2018-05-18 2021-04-28 Incyte Corporation Dérivés de pyrimidine fusionnés utilisés en tant qu'inhibiteurs de a2a/a2b
PL3833670T3 (pl) 2018-08-10 2024-08-19 Navire Pharma, Inc. Pochodne 6-(4-amino-3-metylo-2-oksa-8-azaspiro[4.5]dekan-8-ylo)-3-(2,3-dichlorofenylo)-2-metylopirymidyn-4(3h)-onu oraz powiązane związki jako inhibitory ptpn11 (shp2) do leczenia raka
JP2022507734A (ja) 2018-11-20 2022-01-18 メルク・シャープ・アンド・ドーム・コーポレーション 置換アミノトリアゾロピリミジン及びアミノトリアゾロピラジンアデノシン受容体アンタゴニスト、医薬組成物及びそれらの使用
US12414952B2 (en) 2018-11-20 2025-09-16 Merck Sharp & Dohme Llc Substituted amino triazolopyrimidine and amino triazolopyrazine adenosine receptor antagonists, pharmaceutical compositions and their use
JP2022511778A (ja) 2018-11-30 2022-02-01 メルク・シャープ・アンド・ドーム・コーポレーション アデノシン受容体拮抗薬としての７－、８－及び１０－置換されたアミノトリアゾロキナゾリン誘導体、医薬組成物及びそれらの使用
US10870663B2 (en) 2018-11-30 2020-12-22 Glaxosmithkline Intellectual Property Development Limited Compounds useful in HIV therapy
PY1999867A (es) 2018-11-30 2020-10-19 Syngenta Crop Protection Ag Derivados de tiazol microbiocidas
AR117200A1 (es) 2018-11-30 2021-07-21 Syngenta Participations Ag Derivados de tiazol microbiocidas

Also Published As

Publication number Publication date
PH12021551196A1 (en) 2021-11-29
CL2021001406A1 (es) 2021-11-12
TW202039496A (zh) 2020-11-01
JOP20210116A1 (ar) 2023-01-30
JP2022511441A (ja) 2022-01-31
JP7241871B2 (ja) 2023-03-17
AR117164A1 (es) 2021-07-14
PE20211768A1 (es) 2021-09-07
ECSP21036982A (es) 2021-06-30
AU2019385905B2 (en) 2023-01-12
IL283334A (en) 2021-07-29
JOP20210117A1 (ar) 2023-01-30
EA202191498A1 (ru) 2021-08-20
US20220220117A1 (en) 2022-07-14
KR102653800B1 (ko) 2024-04-01
MX2021006329A (es) 2021-08-11
AU2019385905A1 (en) 2021-06-03
WO2020112700A1 (fr) 2020-06-04
DOP2021000104A (es) 2021-07-30
BR112021010427B1 (pt) 2022-09-27
US20210107904A1 (en) 2021-04-15
NI202100043A (es) 2021-08-13
CO2021006888A2 (es) 2021-06-10
BR112021010427A2 (pt) 2021-08-17
EP3886988A1 (fr) 2021-10-06
CR20210271A (es) 2021-07-14
US11312719B2 (en) 2022-04-26
CA3120862C (fr) 2024-05-07
CA3120862A1 (fr) 2020-06-04
KR20210096184A (ko) 2021-08-04
US12060357B2 (en) 2024-08-13
CN113329791A (zh) 2021-08-31
SG11202105180PA (en) 2021-06-29

Similar Documents

Publication Publication Date Title
IL283334A (en) Amino triazolo quinazoline derivatives substituted at position 9 as adenosine receptor antagonists, pharmaceutical preparations and their use
EP3887377A4 (fr) Dérivés d'amino triazolo quinazoline à substitution en positions 7, 8 et 10 utilisés en tant qu'antagonistes du récepteur de l'adénosine, compositions pharmaceutiques et leur utilisation
CY2024019I2 (el) Ν-ακυλ-(3-υποκατεστημενες)-(8-υποκατεστημενες)- 5,6-διϋδρο-[1,2,4]τριαζολο[4,3-α]πυραζινες ως επιλεκτικοι ανταγωνιστες του υποδοχεα νκ-3, φαρμακευτικη συνθεση, μεθοδοι για χρηση σε διαμεσολαβουμενες απο τον υποδοχεα νκ-3 διαταραχες
EP3883576A4 (fr) Composés amino-triazolopyrimidine et amino-triazolopyrazine substitués utilisés en tant qu'antagonistes de récepteur de l'adénosine, compositions pharmaceutiques et leur utilisation
MA55142A (fr) Amino-triazolopyrimidine et amino-triazolopyrazine substitués antagoniste du récepteur de l'adénosine, compositions pharmaceutiques et leur utilisation
MX390698B (es) Antagonistas del receptor 7/8 tipo toll (tlr7/8) y uso de los mismos.
JOP20190041B1 (ar) مركبات وتركيبات كمثبطات لمستقبلات شبيهة بالتول إندوسومية
WO2016142855A3 (fr) Dérivés de pyrazolo[1,5-a][1,3,5]triazine et de pyrazolo[1,5-a]pyrimidine utilisés en tant qu'inhibiteurs de cdk
IL281924A (en) New forms of pyrido[1,2-a]pyrimidin-4-one derivatives, its formulation and its process of making
MA46745A (fr) Dérivés d'indazole en tant qu'antagonistes de l'intégrine alpha v
HUE057549T2 (hu) Imidazo[1,2-a]pirimidinszármazékok, eljárás elõállításukra és alkalmazásaik
CL2015000898A1 (es) Compuestos derivados de pirrolo [3,2-d] pirimidinicos, moduladores de receptores toll (tlr); composicion farmaceutica que los comprende; su uso en el tratamiento de infecciones viricas, trastornos inmunitarios o inflamatorios.
MX379110B (es) Derivados de azaspiro como antagonistas de trpm8.
CL2015003444A1 (es) Compuestos de 3,4 dihidroisoquinolin-2(1h)-ilo
CY1121123T1 (el) Ενωσεις 6,7-διυδροπυραζολο[1,5-α]πυραζιν-4(5η)-ονης και η χρηση τους ως αρνητικοι αλλοστερικοι τροποποιητες των υποδοχεων mglu2
JO3368B1 (ar) مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
MA55821A (fr) Antagonistes 5-ht2a destinés à être utilisés dans le traitement de la dépression
EP3814356A4 (fr) Dérivés de triazolotriazine en tant qu'antagonistes du récepteur a2a
NZ736055A (en) Imidazopyrazines and pyrazolopyrimidines and their use as ampa receptor modulators
BR112017001726A2 (pt) compostos de 6,7-di-hidropirazolo [1,5-a]pirazin-4(5h)-ona e seus usos como moduladores alostéricos negativos de receptores mglur2
HRP20221098T1 (hr) Tretman kognitivnih i simptoma poremećaja raspoloženja kod neurodegenerativnih i neuropsihijatrijskih poremećaja agonistima gabaa receptora koji sadrže alfa5
LT3914600T (lt) Tiazolopiridino dariniai kaip adenozino receptoriaus antagonistai
EP3774813A4 (fr) Dérivés de pyrazolotriazolopyrimidine utilisés en tant qu'antagoniste du récepteur a2a
BR112017001998A2 (pt) compostos 6,7-di-hidropirazolo[1,5-a]pirazin-4(5h)-ona e seu uso como moduladores alostéricos negativos de receptores mglur2
EP4006033A4 (fr) Antagoniste du récepteur de l'adénosine