MA56480A - Agonistes du récepteur glp-1 et leurs utilisations - Google Patents

Agonistes du récepteur glp-1 et leurs utilisations

Info

Publication number
MA56480A
MA56480A MA056480A MA56480A MA56480A MA 56480 A MA56480 A MA 56480A MA 056480 A MA056480 A MA 056480A MA 56480 A MA56480 A MA 56480A MA 56480 A MA56480 A MA 56480A
Authority
MA
Morocco
Prior art keywords
glp
receptor agonists
agonists
receptor
Prior art date
Application number
MA056480A
Other languages
English (en)
Other versions
MA56480B1 (fr
Inventor
Gary Erik Aspnes
Scott W Bagley
John M Curto
Matthew S Dowling
David James Edmonds
Mark E Flanagan
Kentaro Futatsugi
David A Griffith
Kim Huard
Gajendra Ingle
Wenhua Jiao
Chris Limberakis
Alan M Mathiowetz
David W Piotrowski
Roger B Ruggeri
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=60702906&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA56480(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer filed Critical Pfizer
Publication of MA56480A publication Critical patent/MA56480A/fr
Publication of MA56480B1 publication Critical patent/MA56480B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Psychology (AREA)
MA56480A 2016-12-16 2017-12-01 Agonistes du récepteur glp-1 et leurs utilisations MA56480B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662435533P 2016-12-16 2016-12-16
PCT/IB2017/057577 WO2018109607A1 (fr) 2016-12-16 2017-12-01 Agonistes du récepteur glp-1 et leurs utilisations

Publications (2)

Publication Number Publication Date
MA56480A true MA56480A (fr) 2022-04-27
MA56480B1 MA56480B1 (fr) 2022-12-30

Family

ID=60702906

Family Applications (1)

Application Number Title Priority Date Filing Date
MA56480A MA56480B1 (fr) 2016-12-16 2017-12-01 Agonistes du récepteur glp-1 et leurs utilisations

Country Status (40)

Country Link
US (7) US10208019B2 (fr)
EP (1) EP3555064B9 (fr)
JP (2) JP6637641B1 (fr)
KR (2) KR102314286B1 (fr)
CN (1) CN110325530B (fr)
AR (1) AR110387A1 (fr)
AU (1) AU2017374860B2 (fr)
CA (1) CA2988721C (fr)
CL (1) CL2019001651A1 (fr)
CO (1) CO2019006046A2 (fr)
CR (1) CR20190289A (fr)
CU (1) CU24573B1 (fr)
CY (1) CY1125716T1 (fr)
DK (1) DK3555064T5 (fr)
DO (1) DOP2019000166A (fr)
EA (1) EA037318B1 (fr)
EC (1) ECSP19041071A (fr)
ES (1) ES2934789T3 (fr)
FI (1) FI3555064T3 (fr)
GE (2) GEAP202115110A (fr)
HR (1) HRP20221437T1 (fr)
HU (1) HUE060533T2 (fr)
IL (1) IL267288B (fr)
LT (1) LT3555064T (fr)
MA (1) MA56480B1 (fr)
MD (1) MD3555064T2 (fr)
MX (1) MX387259B (fr)
MY (1) MY195385A (fr)
PE (1) PE20191501A1 (fr)
PH (1) PH12019501360B1 (fr)
PL (1) PL3555064T3 (fr)
PT (1) PT3555064T (fr)
RS (1) RS63849B9 (fr)
RU (1) RU2740135C1 (fr)
SI (1) SI3555064T1 (fr)
TW (1) TWI713809B (fr)
UA (1) UA122035C2 (fr)
UY (1) UY37514A (fr)
WO (1) WO2018109607A1 (fr)
ZA (1) ZA201904616B (fr)

Families Citing this family (171)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT3640251T (lt) 2016-10-24 2022-03-10 Astrazeneca Ab 6,7,8,9-tetrahidro-3h-pirazolo[4,3-f]izochinolino dariniai, tinkami vėžio gydymui
KR102314286B1 (ko) 2016-12-16 2021-10-21 화이자 인코포레이티드 Glp-1 수용체 작용제 및 이의 용도
AU2017377069B2 (en) 2016-12-16 2020-07-23 Janssen Pharmaceutica Nv Small molecule inhibitors of the JAK family of kinases
TWI831738B (zh) 2016-12-16 2024-02-11 美商瑞塔醫藥有限責任公司 用於抑制ＲＯＲγ及其他用途的嘧啶三環烯酮衍生物
JOP20190144A1 (ar) 2016-12-16 2019-06-16 Janssen Pharmaceutica Nv إيميدازو بيرولو بيريدين كمثبطات لعائلة jak الخاصة بإنزيمات الكيناز
MX2019008438A (es) 2017-01-30 2019-10-30 Astrazeneca Ab Moduladores del receptor de estrogeno.
US12372530B2 (en) * 2017-11-15 2025-07-29 Beth Israel Deaconess Medical Center, Inc. Markers for the diagnosis and treatment of non-alcoholic steatohepatitis (NASH) and advanced liver fibrosis
MA52940A (fr) 2018-05-18 2021-04-28 Incyte Corp Dérivés de pyrimidine fusionnés utilisés en tant qu'inhibiteurs de a2a/a2b
TWI707683B (zh) * 2018-06-13 2020-10-21 美商輝瑞股份有限公司 Ｇｌｐ－１受體促效劑及其用途
TW202016110A (zh) 2018-06-15 2020-05-01 比利時商健生藥品公司 Ｊａｋ激酶家族之小分子抑制劑
IL279348B2 (en) 2018-06-15 2026-01-01 Reata Pharmaceuticals Inc Decahydro-2h-naphth[1,2-d]imidazole compounds for inhibition of IL-17 and ROR-gamma
RU2765721C1 (ru) 2018-06-15 2022-02-02 Пфайзер Инк. Агонисты glp-1 рецептора и их применение
US12060340B2 (en) 2018-06-20 2024-08-13 Reata Pharmaceuticals, Inc Cysteine-dependent inverse agonists of nuclear receptors ROR-gamma/ROR-gamma-t and methods of treating diseases or disorders therewith
CN113166153B (zh) 2018-07-05 2024-11-01 因赛特公司 作为a2a/a2b抑制剂的稠合吡嗪衍生物
AU2019329884B2 (en) 2018-08-31 2022-01-27 Pfizer Inc. Combinations for treatment of NASH/NAFLD and related diseases
CN113227068B (zh) * 2018-11-22 2023-06-13 上海齐鲁锐格医药研发有限公司 Glp-1r激动剂及其用途
CN121081472A (zh) 2018-12-13 2025-12-09 拓臻股份有限公司 一种THRβ受体激动剂化合物及其制备方法和用途
TWI829857B (zh) 2019-01-29 2024-01-21 美商英塞特公司 作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶
US10954221B2 (en) 2019-04-12 2021-03-23 Qilu Regor Therapeutics Inc. GLP-1R agonists and uses thereof
PH12021552557A1 (en) * 2019-04-12 2022-07-04 Qilu Regor Therapeutics Inc Glp-1r agonists and uses thereof
EP3963329A1 (fr) 2019-04-29 2022-03-09 Confo Therapeutics N.V. Procédés de criblage et dosages destinés à être utilisés avec des protéines transmembranaires, en particulier avec des gpcr
EP4578460A3 (fr) * 2019-05-20 2025-08-27 Pfizer Inc. Combinaisons comprenant du benzodioxol en tant qu'agonistes de glp-1r destinées à être utilisées dans le traitement de la nash/nafld et de maladies associées
JP7498199B2 (ja) 2019-06-28 2024-06-11 ファイザー・インク 種々の疾患を処置するために有用なｂｃｋｄｋ阻害剤としての５－（チオフェン－２－イル）－１ｈ－テトラゾール誘導体
TW202115086A (zh) 2019-06-28 2021-04-16 美商輝瑞大藥廠 Bckdk抑制劑
TWI751585B (zh) 2019-06-28 2022-01-01 美商美國禮來大藥廠 類升糖素肽1受體促效劑
WO2021018023A1 (fr) * 2019-08-01 2021-02-04 济南泰达领创医药技术有限公司 Modulateur du récepteur glp-1 à petites molécules
CN119874700A (zh) 2019-09-13 2025-04-25 林伯士萨顿公司 Hpk1拮抗剂和其用途
TWI771766B (zh) 2019-10-04 2022-07-21 美商輝瑞股份有限公司 二醯基甘油醯基轉移酶２ 抑制劑
JP7558267B2 (ja) 2019-10-25 2024-09-30 ギリアード サイエンシーズ， インコーポレイテッド Ｇｌｐ－１ｒ調節化合物
JP7386997B2 (ja) * 2019-11-15 2023-11-27 イルドン ファーマシューティカル カンパニー リミテッド Ｇｌｐ－１受容体アゴニストおよびその使用
KR20210059584A (ko) * 2019-11-15 2021-05-25 일동제약(주) Glp-1 수용체 작용제 및 이의 용도
US12421205B2 (en) 2019-12-02 2025-09-23 Hyundai Pharm Co., Ltd. GLP-1 receptor agonist
MX2022007105A (es) * 2019-12-10 2022-07-11 Pfizer Formas solidas de sal de 1,3-dihidroxi-2-(hidroximetil)propan-2-am ina de acido 2-((4-((s)-2-(5-cloropiridin-2-il)-2-metilbenzo[d][1, 3] dioxol-4-il)piperidin-1-il)metil)-1-(((s)-oxetan-2-il) metil)-1h- benzo[d]imidazol-6-carboxilico.
SI4073051T1 (sl) 2019-12-10 2024-04-30 Eli Lilly And Company Postopek in intermediat za pripravo oksetan-2-ilmetanamina
CN120518596A (zh) 2020-01-29 2025-08-22 吉利德科学公司 Glp-1r调节化合物
FI4097099T3 (fi) 2020-02-07 2024-07-30 Gasherbrum Bio Inc Heterosyklisiä glp-1-agonisteja
CN115697999A (zh) * 2020-02-13 2023-02-03 加舒布鲁姆生物公司 杂环glp-1激动剂
JP2021134211A (ja) 2020-02-24 2021-09-13 ファイザー・インク Ｎａｆｌｄ／ｎａｓｈおよび関連疾患の処置のための組合せ
JP2022058085A (ja) 2020-02-24 2022-04-11 ファイザー・インク ジアシルグリセロールアシルトランスフェラーゼ２阻害剤とアセチル－ＣｏＡカルボキシラーゼ阻害剤との組合せ
EP4119555A4 (fr) * 2020-03-18 2023-08-23 Lg Chem, Ltd. Agoniste du récepteur glp-1, composition pharmaceutique le comprenant et son procédé de préparation
TWI825398B (zh) * 2020-03-18 2023-12-11 南韓商Ｌｇ化學股份有限公司 Glp-1 受體促效劑、包含該促效劑之醫藥組成物及其製備方法
CA3176569A1 (fr) * 2020-03-27 2021-09-30 Pfizer Inc. Traitement du diabete de type 2 ou de l'obesite ou du surpoids avec de l'acide 2-[(4-{6-[(4-cyano-2-fluorobenzyl) oxy]pyridin-2-yl}piperidin-1-yl)methyl]-1-[(2s)-oxetan-2-ylmethyl ]-1h-benzimidazole-6-carboxylique ou un sel pharmaceutiquement acceptable correspondant
TW202144340A (zh) * 2020-04-03 2021-12-01 大陸商江蘇恆瑞醫藥股份有限公司 稠合咪唑類衍生物、其製備方法及其在醫藥上的應用
CN113493447B (zh) * 2020-04-03 2024-06-11 轩竹(北京)医药科技有限公司 Glp-1受体激动剂
JP7719796B2 (ja) 2020-04-24 2025-08-06 アストラゼネカ・アクチエボラーグ 医薬製剤
IL297216A (en) 2020-04-24 2022-12-01 Astrazeneca Ab Dosage regimen for the treatment of cancer
PL4143183T3 (pl) 2020-04-29 2026-03-02 Gasherbrum Bio, Inc. Heterocykliczni agoniści glp-1
CA3179890A1 (fr) * 2020-05-27 2021-12-02 Qilu Regor Therapeutics Inc. Formes salines et cristallines d'agonistes de glp-1r et leurs utilisations
CA3181120C (fr) * 2020-06-04 2024-01-02 Tao Yu Compose imidazole heteroaromatique a cinq chainons et son utilisation
PT4161927T (pt) 2020-06-09 2024-10-08 Pfizer Compostos de espiro como antagonistas do recetor de melanocortina 4 e utilizações dos mesmos
CN113773310B (zh) * 2020-06-10 2023-12-22 重庆康丁医药技术有限公司 一种具有心血管益处的glp-1小分子
EP4166142A4 (fr) * 2020-06-10 2024-06-26 Medshine Discovery Inc. Composé de benzobisoxazole à substitution méthyle et son utilisation
TW202214610A (zh) * 2020-06-19 2022-04-16 大陸商江蘇恆瑞醫藥股份有限公司 ６－側氧－３，６－二氫吡啶類衍生物、其製備方法及其在醫藥上的應用
CN113816948B (zh) * 2020-06-19 2023-08-11 江苏恒瑞医药股份有限公司 稠合咪唑类衍生物、其制备方法及其在医药上的应用
WO2021259309A1 (fr) * 2020-06-24 2021-12-30 广州市恒诺康医药科技有限公司 Agoniste du récepteur glp-1, composition pharmaceutique et utilisation associées
TW202214622A (zh) 2020-08-06 2022-04-16 大陸商上海齊魯銳格醫藥研發有限公司 Ｇｌｐ－１ｒ促效劑及其用途
MX2023001311A (es) * 2020-08-06 2023-04-18 Gasherbrum Bio Inc Agonistas heterociclicos de glp-1.
EP4199919A4 (fr) * 2020-08-21 2024-12-25 Terns Pharmaceuticals, Inc. Composés en tant qu'agonistes de glp-1r
WO2022042691A1 (fr) * 2020-08-28 2022-03-03 Gasherbrum Bio, Inc. Agonistes hétérocycliques de glp-1
CN119930603A (zh) 2020-09-01 2025-05-06 江苏恒瑞医药股份有限公司 稠合咪唑类衍生物、其制备方法及其在医药上的应用
CN116438200A (zh) 2020-09-10 2023-07-14 普雷西里克斯公司 针对fap的抗体片段
WO2022068772A1 (fr) * 2020-09-29 2022-04-07 深圳信立泰药业股份有限公司 Dérivé de benzimidazole, son procédé de préparation et son utilisation médicale
CN116348464A (zh) * 2020-10-12 2023-06-27 杭州中美华东制药有限公司 苯并咪唑酮类glp-1受体激动剂及其用途
JP2023546055A (ja) * 2020-10-13 2023-11-01 ガシャーブラム・バイオ・インコーポレイテッド ヘテロ環ｇｌｐ－１アゴニスト
JP2023546054A (ja) * 2020-10-13 2023-11-01 ガシャーブラム・バイオ・インコーポレイテッド ヘテロ環ｇｌｐ－１アゴニスト
EP4228753B1 (fr) 2020-10-14 2025-07-30 Qilu Regor Therapeutics Inc. Formes cristallines d'agonistes de glp-1 r et leurs utilisations
CN114478497B (zh) * 2020-11-12 2023-10-20 杭州中美华东制药有限公司 芳基烷基酸类glp-1受体激动剂及其用途
US11851419B2 (en) 2020-11-20 2023-12-26 Gilead Sciences, Inc. GLP-1R modulating compounds
CN115461334B (zh) * 2020-11-27 2024-06-21 深圳信立泰药业股份有限公司 一种苯并咪唑类衍生物及其制备方法和医药用途
CN114591308B (zh) * 2020-12-03 2024-03-08 苏州闻泰医药科技有限公司 一类glp-1r受体激动剂化合物及其用途
US12065434B2 (en) * 2020-12-15 2024-08-20 Pfizer Inc. Metabolites of GLP1R agonists
US20220193063A1 (en) * 2020-12-15 2022-06-23 Pfizer Inc. Metabolites of glp1r agonists
CN115667238B (zh) * 2020-12-25 2024-08-23 西藏海思科制药有限公司 一种五并五元环衍生物及其在医药上的应用
CN114805336A (zh) * 2021-01-20 2022-07-29 江苏恒瑞医药股份有限公司 稠合咪唑类化合物、其制备方法及其在医药上的应用
KR20230152011A (ko) * 2021-01-28 2023-11-02 카모트 테라퓨틱스, 인크. Gpcr 수용체 작용제, 이를 포함하는 제약 조성물, 및 그 사용 방법
CN117043154A (zh) * 2021-01-28 2023-11-10 卡莫特医疗有限公司 Gpcr受体激动剂、包含其的药物组合物以及它们的使用方法
US12252488B2 (en) 2021-02-12 2025-03-18 Nimbus Saturn, Inc. HPK1 antagonists and uses thereof
WO2022184849A1 (fr) 2021-03-04 2022-09-09 Les Laboratoires Servier Agonistes de glp-1r, utilisations et compositions pharmaceutiques associées
US11926625B2 (en) 2021-03-05 2024-03-12 Nimbus Saturn, Inc. HPK1 antagonists and uses thereof
AU2022233254A1 (en) 2021-03-11 2023-10-26 Janssen Pharmaceutica Nv Lorpucitinib for use in the treatment of jak mediated disorders
US12091404B2 (en) 2021-03-11 2024-09-17 Gilead Sciences, Inc. GLP-1R modulating compounds
EP4304712A1 (fr) * 2021-03-11 2024-01-17 Gilead Sciences, Inc. Composés modulateurs de glp-1r
WO2022199458A1 (fr) 2021-03-22 2022-09-29 杭州中美华东制药有限公司 Agoniste du récepteur de glp-1 de type thiophène et son utilisation
JP7772778B2 (ja) * 2021-03-24 2025-11-18 塩野義製薬株式会社 縮合環を有するｇｌｐ－１受容体作動薬を含有する医薬組成物
JP2024513011A (ja) 2021-03-29 2024-03-21 ニンバス サターン， インコーポレイテッド Ｈｐｋ１アンタゴニスト及びその使用
IL306110A (en) * 2021-04-21 2023-11-01 Gilead Sciences Inc Carboxy-benzimidazole glp-1r modulating compounds
MX2023012918A (es) * 2021-05-03 2024-03-13 Carmot Therapeutics Inc Agonistas del receptor del péptido 1 similar al glucagón (glp-1) de bencimidazoilo, composiciones farmacéuticas que los comprenden y métodos para su uso.
TWI843104B (zh) 2021-05-20 2024-05-21 美商美國禮來大藥廠 類升糖素肽1受體促效劑
AU2022300055A1 (en) 2021-06-24 2024-01-18 Hangzhou Zhongmeihuadong Pharmaceutical Co., Ltd. Glp-1 receptor agonist and composition and use thereof
JP2024525900A (ja) * 2021-07-21 2024-07-12 ヘパジーン セラピューティクス（エイチケー）リミティド グルカゴン様ペプチド－１受容体モジュレーター及びその使用
CN113480534B (zh) * 2021-07-23 2022-05-13 广州必贝特医药股份有限公司 苯并咪唑或氮杂苯并咪唑-6-羧酸类化合物及其应用
WO2023011395A1 (fr) * 2021-08-02 2023-02-09 深圳信立泰药业股份有限公司 Sel de composé agoniste de glp-1r, son procédé de préparation et son utilisation pharmaceutique
US20240360109A1 (en) * 2021-08-04 2024-10-31 Shanghai Hansoh Biomedical Co., Ltd. Cycloalkene derivative regulator, preparation method therefor, and application thereof
US20250066337A1 (en) 2021-08-26 2025-02-27 Pfizer Inc. Amorphous Form of (S)-2-(5-((3-Ethoxypyridin-2-YL)Oxy)Pyridin-3-YL)-N-(Tetrahydrofuran-3-YL)Pyrimidine-5-Carboxamide
KR20240053617A (ko) 2021-08-30 2024-04-24 민드랭크 에이아이 리미티드 Glp1r 작용제로서의 신규 아릴 에테르 치환 헤테로시클릭 화합물
AU2022336407A1 (en) * 2021-08-31 2024-02-22 Pfizer Inc. Solid forms of 2-[(4-{6-[(4-cyano-2-fluorobenzyl)oxy]pyridin-2-yl}piperidin-1-yl)methyl]-1-[(2s)-oxetan-2-ylmethyl]-1h-benzimidazole-6-carboxylic acid, 1,3-dihydroxy-2-(hydroxymethyl)propan-2-amine salt
CN113548982B (zh) * 2021-09-03 2022-05-06 上海三牧化工技术有限公司 一种4-氰基-2-氟苄醇的制备方法
CN118215478A (zh) 2021-09-08 2024-06-18 盐野义制药株式会社 用于预防和治疗与抗肥胖作用有关的疾病的药物
LT4408840T (lt) * 2021-09-27 2025-10-10 Benzimidazolo karboksilinės rūgštys kaip glp-1r agonistai
MX2024004131A (es) 2021-10-05 2024-04-22 Astrazeneca Ab Ciertos 2,5-diazabiciclo[4.2.0]octanos como moduladores del receptor de glp-1.
US20250115612A1 (en) 2021-10-05 2025-04-10 Astrazeneca Ab Certain 2,5-diazabicyclo[4.2.0]octanes and octahydrofuro[3,4-b]pyrazines as glp-1 receptor modulators
US20250236627A1 (en) 2021-10-05 2025-07-24 Astrazeneca Ab Certain octahydrofuro[3,4- b]pyrazines as glp-1 receptor modulators
TWI843243B (zh) * 2021-10-22 2024-05-21 大陸商盛世泰科生物醫藥技術（蘇州）股份有限公司 作為glp-1受體激動劑的化合物、包含其的藥物組成物及其用途
WO2023076237A1 (fr) 2021-10-25 2023-05-04 Terns Pharmaceuticals, Inc. Composés utilisés en tant qu'agonistes de glp-1r
MX2024006739A (es) 2021-12-01 2024-06-19 Pfizer Derivados de acido 3-fenil-1-benzotiofeno-2-carboxilico como inhibidores de alfa cetoacido deshidrogenasa quinasa de cadena ramificada para el tratamiento de diabetes, enfermedad renal, esteatohepatitis no alcoholica (nash) e insuficiencia cardiaca.
US20250154161A1 (en) * 2021-12-03 2025-05-15 Hangzhou Sciwind Biosciences Co., Ltd. Crystal forms of thienoimidazole compound and preparation method thereof
CA3241470A1 (fr) 2021-12-06 2023-06-15 Pfizer Inc. Antagonistes du recepteur 4 de la melanocortine et leurs utilisations
WO2023106310A1 (fr) * 2021-12-07 2023-06-15 塩野義製薬株式会社 Dérivé hétérocyclique aromatique ayant une activité agoniste du récepteur glp-1
US20250066338A1 (en) 2021-12-16 2025-02-27 Astrazeneca Ab Certain 3-azabicyclo[3.1.0]hexanes as glp-1 receptor modulators
WO2023111145A1 (fr) 2021-12-16 2023-06-22 Astrazeneca Ab Certains 3-azabicyclo[3.1.0] hexanes utilisés en tant que modulateurs du récepteur de glp-1
CN118434745A (zh) * 2021-12-29 2024-08-02 西藏海思科制药有限公司 一种glp-1激动剂的盐及其晶型和在医药上的应用
CN118613476A (zh) * 2022-01-10 2024-09-06 西藏海思科制药有限公司 一种glp-1激动剂盐及其晶型及在医药上的应用
US20250177362A1 (en) * 2022-02-09 2025-06-05 Gasherbrum Bio, Inc. Heterocyclic glp-1 agonists
WO2023151575A1 (fr) * 2022-02-09 2023-08-17 Gasherbrum Bio Inc. Agonistes hétérocycliques de glp-1
JP2025508812A (ja) * 2022-02-23 2025-04-10 ターンズ・ファーマシューティカルズ・インコーポレイテッド Ｇｌｐ－１ｒアゴニストとしての化合物
JP2025508097A (ja) * 2022-03-08 2025-03-21 広州市聯瑞制葯有限公司 ベンゾビシクロ系化合物及びその製造方法と応用
WO2023169456A1 (fr) * 2022-03-09 2023-09-14 Gasherbrum Bio , Inc. Agonistes hétérocycliques de glp-1
EP4496797A1 (fr) 2022-03-21 2025-01-29 Gasherbrum Bio, Inc. Dérivés de 5,8-dihydro-1,7-naphtyridine utiles en tant qu'agonistes de glp-1 pour le traitement du diabète
CN119212991A (zh) * 2022-03-25 2024-12-27 日东制药株式会社 Glp-1受体激动剂化合物之新颖盐类、其制备方法以及包含其的药物组合物
US20250250269A1 (en) 2022-04-14 2025-08-07 Gasherbrum Bio, Inc. Heterocyclic glp-1 agonists
WO2023203135A1 (fr) 2022-04-22 2023-10-26 Precirix N.V. Anticorps radiomarqué amélioré
JP2025517625A (ja) 2022-05-02 2025-06-10 プレシリックス・ナームローゼ・ベンノートシヤープ プレターゲティング
CN117003744B (zh) * 2022-07-18 2025-08-15 厦门市博瑞来医药科技有限公司 五元并六元化合物、其中间体、制备方法、组合物和应用
CA3262491A1 (fr) * 2022-07-22 2024-01-25 Pfizer Inc. Procédés et intermédiaires pour la préparation de sel de 1,3-dihydroxy-2-(hydroxyméthyl)propan-2-amine d'acide 2- [(4-6-[(4-cyano-2-fluorobenzyl)oxy]pyridin-2-yl}pipéridin-1-yl)méthyl]-1-[(2s)-oxétan-2-ylméthyl] -1 h-benzimidazole-6-carboxylique,
CN115536638B (zh) * 2022-08-15 2023-10-13 上海交通大学 一种三氮唑类化合物及其应用
WO2024051700A1 (fr) * 2022-09-05 2024-03-14 德睿智药(苏州)新药研发有限公司 Nouveau composé hétérocyclique substitué par un éther benzylique deutéré d'aryle utilisé en tant qu'agoniste de glp1r
JP2025530809A (ja) * 2022-09-06 2025-09-17 徳睿智薬（蘇州）新薬研発有限公司 Ｇｌｐ－１ｒアゴニスト化合物の結晶多形物及びその製造方法と使用
CN119907794A (zh) 2022-09-22 2025-04-29 盐野义制药株式会社 具有glp-1受体激动剂作用的稠环化合物
EP4598908A1 (fr) 2022-10-07 2025-08-13 Pfizer Inc. Inhibiteurs et/ou agents de dégradation de hsd17b13
JP2025535295A (ja) 2022-10-18 2025-10-24 ファイザー・インク パタチン様ホスホリパーゼドメイン含有タンパク質３（ｐｎｐｌａ３）修飾因子
WO2024102625A1 (fr) 2022-11-11 2024-05-16 Eli Lilly And Company Agonistes de récepteur du peptide 1 de type glucagon
KR20250085816A (ko) 2022-11-16 2025-06-12 일라이 릴리 앤드 캄파니 글루카곤-유사 펩티드 1 수용체 효능제
EP4635951A1 (fr) * 2022-12-13 2025-10-22 Hangzhou Zhongmeihuadong Pharmaceutical Co., Ltd. Agoniste du récepteur glp-1 de type sel, forme cristalline de celui-ci, procédé de préparation, composition pharmaceutique et utilisation associés
JP2025541231A (ja) 2022-12-16 2025-12-18 ファイザー・インク ３－フルオロ－４－ヒドロキシベンズアミド含有阻害剤および／または分解剤ならびにそれらの使用
JP2026500865A (ja) 2023-01-13 2026-01-08 中国科学院上海薬物研究所 Ｇｌｐ－１受容体アゴニストとして使用される４－アルコキシベンゾイミダゾール－６－カルボン酸誘導体
CN120530107A (zh) * 2023-02-02 2025-08-22 江苏豪森药业集团有限公司 一种环烯类化合物的盐、晶型及其制备方法和应用
CN118496200A (zh) * 2023-02-14 2024-08-16 成都康弘药业集团股份有限公司 吲唑啉酮类化合物及其制备方法和用途
AU2024222719A1 (en) 2023-02-16 2025-08-21 Gasherbrum Bio, Inc. Heterocyclic glp-1 agonists
US20240360122A1 (en) * 2023-03-29 2024-10-31 Terns (Suzhou) Biotechnology Co., Ltd. Polymorphic forms and salts of a glp-1r agonist
WO2024211898A1 (fr) 2023-04-07 2024-10-10 Terns Pharmaceuticals, Inc. Association comprenant un agoniste thrbeta anda glp-1r destiné à être utilisé dans le traitement d'un trouble du foie ou d'une maladie cardiométabolique
WO2024212742A1 (fr) * 2023-04-10 2024-10-17 上海研健新药研发有限公司 Agoniste de glp-1r, son procédé de préparation et son utilisation
PE20252756A1 (es) 2023-04-14 2025-12-05 Pfizer Antagonistas del receptor de polipeptido insulinotropico dependiente de glucosa y usos de estos
CN118812522A (zh) * 2023-04-21 2024-10-22 苏州闻泰医药科技有限公司 一种glp-1r受体激动剂化合物盐、其晶型、其制备方法和应用
WO2025011664A1 (fr) 2023-07-12 2025-01-16 歌礼制药(中国)有限公司 Préparation d'agoniste de glp-1r et son procédé de préparation
WO2025015269A1 (fr) 2023-07-13 2025-01-16 Aconcagua Bio, Inc. Composés, compositions et procédés
TW202521528A (zh) 2023-07-13 2025-06-01 美商雅空嘉閣生物公司 化合物、組合物及方法
WO2025021048A1 (fr) 2023-07-21 2025-01-30 石药集团中奇制药技术（石家庄）有限公司 Composé polycyclique et son utilisation
CN116675680B (zh) * 2023-08-02 2023-10-20 药康众拓(北京)医药科技有限公司 一种氘代化合物及其制备方法、药物和应用
US12234236B1 (en) 2023-09-14 2025-02-25 Ascletis Pharma (China) Co., Limited GLP-1R agonist and therapeutic method thereof
KR20250043306A (ko) * 2023-09-21 2025-03-28 유노비아 주식회사 치환된 융합 이미다졸 유도체의 제조 방법
WO2025069009A1 (fr) 2023-09-29 2025-04-03 Graviton Bioscience Bv Inhibiteurs de rock2 dans le traitement de l'obésité
WO2025083727A1 (fr) * 2023-10-20 2025-04-24 Dr. Reddy's Laboratories Limited Dispersons solides amorphes d'acide libre de danuglipron et leur procédé
WO2025099561A1 (fr) 2023-11-07 2025-05-15 Pfizer Inc. Formulations de matrice à libération contrôlée orales d'acide 2-[(4-{6-[(4-cyano-2-fluorobenzyl)oxy]pyridin-2-yl}pipéridin-1-yl)méthyl]-1-[(2s)-oxétan-2-ylméthyl]-1h-benzimidazole-6-carboxylique ou d'un sel pharmaceutiquement acceptable de celui-ci
US20250163168A1 (en) 2023-11-17 2025-05-22 Pfizer Inc. Novel antibodies and antibody conjugates for the treatment of metabolic disorders
TW202521534A (zh) 2023-11-24 2025-06-01 香港商歌禮製藥(中國)有限公司 Glp-1r 激動劑及其治療方法
WO2025140533A1 (fr) * 2023-12-27 2025-07-03 Insilico Medicine Ip Limited Nouveaux composés utilisés en tant qu'agonistes de glp-1 r et leurs utilisations
WO2025140532A1 (fr) * 2023-12-27 2025-07-03 Insilico Medicine Ip Limited Nouveaux composés utilisés en tant qu'agonistes de glp-1r et leurs utilisations
WO2025158275A1 (fr) * 2024-01-24 2025-07-31 Pfizer Inc. Polythérapie utilisant des composés antagonistes du récepteur du polypeptide insulinotrope glucose-dépendant et des composés agonistes du récepteur glp-1
TW202539633A (zh) 2024-02-01 2025-10-16 美商輝瑞股份有限公司 葡萄糖依賴性促胰島素多肽受體拮抗劑及其用途
WO2025171340A1 (fr) 2024-02-08 2025-08-14 Aconcagua Bio, Inc. Traitement d'états associés au récepteur de la calcitonine et/ou de l'amyline
WO2025171341A2 (fr) 2024-02-08 2025-08-14 Aconcagua Bio, Inc. Composés et compositions pour traiter des états associés au récepteur de la calcitonine et/ou à l'activité du récepteur de l'amyline
KR20250125490A (ko) 2024-02-14 2025-08-22 주식회사 종근당 Glp-1 수용체 작용제 및 이의 용도
WO2025171806A1 (fr) * 2024-02-18 2025-08-21 Rezubio Pharmaceuticals Co., Ltd Méthodes de gestion du poids et d'atténuation du malaise viscéral
WO2025189141A1 (fr) 2024-03-08 2025-09-12 Annapurna Bio, Inc. Méthodes de traitement de l'obésité et d'augmentation de la perte de poids
KR20250152464A (ko) * 2024-04-16 2025-10-23 한미약품 주식회사 흡입제 조성물
WO2025224599A1 (fr) 2024-04-22 2025-10-30 Pfizer Inc. Antagonistes du récepteur du polypeptide insulinotrope dépendant du glucose à base de pyrrolidine et leurs utilisations
WO2025252098A1 (fr) * 2024-06-05 2025-12-11 杭州中美华东制药有限公司 Composition pharmaceutique orale d'agoniste du récepteur glp-1 et son procédé de préparation
WO2026013531A1 (fr) 2024-07-10 2026-01-15 Pfizer Inc. Composés spiro[2,5]octane
WO2026033382A1 (fr) 2024-08-07 2026-02-12 Pfizer Inc. Modulateurs hétérocycliques de glp-1 r
WO2026042018A1 (fr) 2024-08-21 2026-02-26 Pfizer Inc. Dérivés d'acide 4-4-[(1-{[4-(propan-2-yl) phényl] carbamoyl)-d-prolyl)amino]cyclohexyl}benzoïque en tant qu'antagonistes de gipr pour le traitement du diabète
WO2026051998A1 (fr) 2024-09-04 2026-03-12 Aconcagua Bio, Inc. Composés, compositions et procédés

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US4485045A (en) 1981-07-06 1984-11-27 Research Corporation Synthetic phosphatidyl cholines useful in forming liposomes
US4544545A (en) 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
US5013556A (en) 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
GB9305623D0 (en) 1993-03-18 1993-05-05 Merck Sharp & Dohme Therapeutic agents
EP0689535B1 (fr) 1993-03-18 1998-09-23 MERCK SHARP & DOHME LTD. Derives benzimidazoliques
US20020169166A1 (en) * 2001-03-09 2002-11-14 Cowart Marlon D. Benzimidazoles that are useful in treating sexual dysfunction
US6960589B2 (en) * 2001-03-09 2005-11-01 Abbott Laboratories Benzimidazoles that are useful in treating sexual dysfunction
SE0100903D0 (sv) * 2001-03-15 2001-03-15 Astrazeneca Ab Compounds
US20040127504A1 (en) * 2002-09-06 2004-07-01 Cowart Marlon D. Benzimidazoles that are useful in treating sexual dysfunction
US20090264426A1 (en) 2005-09-07 2009-10-22 Shunji Sakuraba Bicyclic aromatic substituted pyridone derivative
WO2008012623A1 (fr) 2006-07-25 2008-01-31 Pfizer Products Inc. Composés de benzimidazolyle constituant des potentialisateurs du sous-type de récepteur de glutamate mglur2
WO2010022055A2 (fr) 2008-08-20 2010-02-25 Amgen Inc. Inhibiteurs de canaux sodiques sensibles au potentiel
AU2010233917B2 (en) 2009-04-02 2015-07-02 Merck Serono S.A. Dihydroorotate dehydrogenase inhibitors
SG185515A1 (en) 2010-05-13 2012-12-28 Amgen Inc Nitrogen heterocyclic compounds useful as pde10 inhibitors
CA2826649C (fr) 2011-02-25 2016-07-26 Merck Sharp & Dohme Corp. Nouveaux derives d'azabenzimidazole cyclique utiles en tant qu'agents antidiabetiques
KR102314286B1 (ko) 2016-12-16 2021-10-21 화이자 인코포레이티드 Glp-1 수용체 작용제 및 이의 용도

Also Published As

Publication number Publication date
AR110387A1 (es) 2019-03-27
GEAP202115110A (en) 2021-02-25
US11512070B2 (en) 2022-11-29
JP6982054B2 (ja) 2021-12-17
US20250257052A1 (en) 2025-08-14
WO2018109607A1 (fr) 2018-06-21
EP3555064B1 (fr) 2022-11-23
HUE060533T2 (hu) 2023-03-28
DK3555064T3 (da) 2022-12-12
MA56480B1 (fr) 2022-12-30
MX387259B (es) 2025-03-18
CU20190056A7 (es) 2020-01-03
LT3555064T (lt) 2023-01-10
MX2019007077A (es) 2019-08-01
BR112019012211A2 (pt) 2019-11-12
HRP20221437T1 (hr) 2023-02-03
CO2019006046A2 (es) 2019-06-19
DOP2019000166A (es) 2019-07-31
JP2020063287A (ja) 2020-04-23
AU2017374860B2 (en) 2021-09-02
MY195385A (en) 2023-01-18
JP6637641B1 (ja) 2020-01-29
ES2934789T3 (es) 2023-02-27
IL267288A (en) 2019-08-29
US20230124938A1 (en) 2023-04-20
CA2988721A1 (fr) 2018-06-16
US20240034725A1 (en) 2024-02-01
PL3555064T3 (pl) 2023-03-06
US20200255406A1 (en) 2020-08-13
US20210047298A1 (en) 2021-02-18
EP3555064A1 (fr) 2019-10-23
RU2740135C1 (ru) 2021-01-11
DK3555064T5 (da) 2023-05-01
AU2017374860A1 (en) 2019-06-20
TWI713809B (zh) 2020-12-21
EP3555064B9 (fr) 2023-03-01
PT3555064T (pt) 2023-01-20
CR20190289A (es) 2019-08-21
GEP20217265B (en) 2021-06-25
UY37514A (es) 2018-07-31
CA2988721C (fr) 2023-09-05
RS63849B9 (sr) 2023-06-30
CN110325530A (zh) 2019-10-11
EA201991193A1 (ru) 2020-01-15
US10851081B2 (en) 2020-12-01
MD3555064T2 (ro) 2023-08-31
US20190119255A1 (en) 2019-04-25
PH12019501360B1 (en) 2024-02-21
TW201835066A (zh) 2018-10-01
PE20191501A1 (es) 2019-10-22
KR102466418B1 (ko) 2022-11-14
KR20210127782A (ko) 2021-10-22
SI3555064T1 (sl) 2023-02-28
FI3555064T3 (fi) 2023-01-31
NZ754428A (en) 2024-05-31
US12319669B2 (en) 2025-06-03
US10669259B2 (en) 2020-06-02
RS63849B1 (sr) 2023-01-31
JP2020511411A (ja) 2020-04-16
EA037318B1 (ru) 2021-03-11
ES2934789T9 (es) 2023-04-26
CU24573B1 (es) 2022-01-13
KR102314286B1 (ko) 2021-10-21
US11802121B2 (en) 2023-10-31
UA122035C2 (uk) 2020-08-25
ZA201904616B (en) 2021-05-26
IL267288B (en) 2021-06-30
CY1125716T1 (el) 2024-02-16
CN110325530B (zh) 2022-01-11
PH12019501360A1 (en) 2020-02-10
US20180170908A1 (en) 2018-06-21
CL2019001651A1 (es) 2019-10-04
US10208019B2 (en) 2019-02-19
KR20190094433A (ko) 2019-08-13
ECSP19041071A (es) 2019-06-30

Similar Documents

Publication Publication Date Title
MA56480A (fr) Agonistes du récepteur glp-1 et leurs utilisations
EP3350165A4 (fr) Agonistes du récepteur x farnésoïde et leurs utilisations
EP3350166A4 (fr) Agonistes du récepteur x farnésoïde et leurs utilisations
EP3350158A4 (fr) Agonistes du récepteur x farnésoïde et leurs utilisations
EP3350164A4 (fr) Agonistes du récepteur x farnésoïde et leurs utilisations
EP3732191A4 (fr) Récepteurs antigéniques chimériques améliorés et leurs utilisations
IL272232A (en) Glp-1 compositions and uses thereof
MA50502A (fr) Adénovirus et utilisations associées
EP3658163A4 (fr) Récepteurs antigéniques chimériques améliorés et leurs utilisations
MA50618A (fr) Polyrhérapies et leurs utilisations
MA53145A (fr) Agents de liaison cd123 et leurs utilisations
MA43417A (fr) Agonistes améliorés du récepteur de l'apéline (apj) et leurs utilisations
EP3334706A4 (fr) Pillararènes et utilisations de ceux-ci
EP3490565A4 (fr) Modulateurs de récepteurs de chimiokine et leurs utilisations
MA49537A (fr) Anticorps anti-lag3 et leurs utilisations
DK3368060T3 (da) Glugacon-receptor-agonister
DK3149042T3 (da) PD-L1-antistoffer og anvendelser deraf
MA42622A (fr) Agents de liaison à tigit et leurs utilisations
EP3356558A4 (fr) Biomarqueurs pathogènes et utilisations associées
EP3509589A4 (fr) Nouvelles utilisations
IL258079B (en) Antigen receptors and uses thereof
EP3347021A4 (fr) Cyano-thiénotriazoloazépines et leurs utilisations
EP3347020A4 (fr) Acétamide thiénotriazoldiazépines et leurs utilisations
MA46901A (fr) Agents psychotropes et leurs utilisations
EP3370771A4 (fr) Conjugués anti-cd3-folate et leurs utilisations