MA57908B1 - Composés macrocycliques substitués et méthodes de traitement associées - Google Patents
Composés macrocycliques substitués et méthodes de traitement associéesInfo
- Publication number
- MA57908B1 MA57908B1 MA57908A MA57908A MA57908B1 MA 57908 B1 MA57908 B1 MA 57908B1 MA 57908 A MA57908 A MA 57908A MA 57908 A MA57908 A MA 57908A MA 57908 B1 MA57908 B1 MA 57908B1
- Authority
- MA
- Morocco
- Prior art keywords
- methods
- processing
- macrocyclic compounds
- substituted macrocyclic
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
La présente invention concerne des composés (I) et (II) utiles pour le traitement de la narcolepsie ou de la cataplexie chez un sujet qui le nécessite. L'invention concerne également des compositions pharmaceutiques et des méthodes associées.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962939825P | 2019-11-25 | 2019-11-25 | |
| US202063030979P | 2020-05-28 | 2020-05-28 | |
| EP20828463.8A EP4065585B1 (fr) | 2019-11-25 | 2020-11-25 | Composés macrocycliques substitués et méthodes de traitement associées |
| PCT/US2020/062320 WO2021108628A1 (fr) | 2019-11-25 | 2020-11-25 | Composés macrocycliques substitués et méthodes de traitement associées |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA57908B1 true MA57908B1 (fr) | 2025-09-30 |
Family
ID=73856348
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA57908A MA57908B1 (fr) | 2019-11-25 | 2020-11-25 | Composés macrocycliques substitués et méthodes de traitement associées |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US11542276B2 (fr) |
| EP (2) | EP4628167A3 (fr) |
| JP (2) | JP7787812B2 (fr) |
| KR (1) | KR20220106793A (fr) |
| CN (1) | CN114761412B (fr) |
| AU (2) | AU2020394444B2 (fr) |
| BR (1) | BR112022009938A2 (fr) |
| CA (1) | CA3155885A1 (fr) |
| DK (1) | DK4065585T3 (fr) |
| ES (1) | ES3041424T3 (fr) |
| FI (1) | FI4065585T3 (fr) |
| HR (1) | HRP20251156T1 (fr) |
| HU (1) | HUE073461T2 (fr) |
| IL (2) | IL293240B2 (fr) |
| LT (1) | LT4065585T (fr) |
| MA (1) | MA57908B1 (fr) |
| MD (1) | MD4065585T2 (fr) |
| MX (1) | MX2022006206A (fr) |
| PT (1) | PT4065585T (fr) |
| RS (1) | RS67202B1 (fr) |
| SA (1) | SA522432691B1 (fr) |
| SI (1) | SI4065585T1 (fr) |
| SM (1) | SMT202500340T1 (fr) |
| WO (1) | WO2021108628A1 (fr) |
| ZA (1) | ZA202206482B (fr) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI4065585T3 (fi) | 2019-11-25 | 2025-09-26 | Alkermes Inc | Substituoituja makrosyklisiä yhdisteitä ja niihin liittyviä hoitomenetelmiä |
| US12503475B2 (en) | 2020-09-03 | 2025-12-23 | Centessa Pharmaceuticals (Uk) Limited | Bicyclic-heterocycle derivatives and their uses as orexin-2 receptor agonists |
| WO2022051583A1 (fr) * | 2020-09-03 | 2022-03-10 | Orexia Therapeutics Limited | Dérivés hétérocycliques substitués par un benzyle moyen cycle ou macrocyclique et leurs utilisations en tant qu'agonistes du récepteur de l'orexine 2 |
| WO2022109117A1 (fr) * | 2020-11-23 | 2022-05-27 | Merck Sharp & Dohme Corp. | Agonistes du récepteur de l'orexine de type 3-amino pyrrolidine et pipéridine macrocyclique |
| US12006330B2 (en) | 2020-12-21 | 2024-06-11 | Alkermes, Inc. | Substituted macrocyclic compounds and related methods of treatment |
| US11760747B2 (en) | 2020-12-21 | 2023-09-19 | Alkermes, Inc. | Substituted piperidino compounds and related methods of treatment |
| WO2022232025A1 (fr) * | 2021-04-26 | 2022-11-03 | Alkermes, Inc. | Composés macrocycliques d'amide substitués ayant une activité agoniste du récepteur de l'orexine 2 |
| EP4347046A1 (fr) * | 2021-05-26 | 2024-04-10 | Alkermes, Inc. | Composés macrocycliques bicycliques fusionnés substitués et méthodes de traitement associées |
| WO2022251304A1 (fr) * | 2021-05-26 | 2022-12-01 | Alkerme, Inc. | Composés macrocycliques de carbamate substitués et méthodes de traitement associées |
| KR20240157067A (ko) * | 2022-03-01 | 2024-10-31 | 센테사 파마슈티칼스 (유케이) 리미티드 | 미디엄- 또는 마크로-시클릭 벤질-치환된 헤테로사이클 유도체 및 관련 용도 |
| WO2024095158A1 (fr) * | 2022-10-31 | 2024-05-10 | Takeda Pharmaceutical Company Limited | Dosage d'agonistes du récepteur de type 2 de l'orexine |
| EP4622712A1 (fr) * | 2022-11-23 | 2025-10-01 | Vertex Pharmaceuticals Incorporated | Modulateurs d'amine macrocycliques substitués du récepteur 2 de l'orexine |
| TW202430169A (zh) | 2022-12-16 | 2024-08-01 | 日商第一三共股份有限公司 | 2-氮雜雙環[3.1.1]庚烷化合物 |
| EP4658660A1 (fr) | 2023-01-31 | 2025-12-10 | Jazz Pharmaceuticals Ireland Limited | Agonistes macrocycliques du récepteur de l'orexine et leurs utilisations |
| KR20250155550A (ko) | 2023-03-16 | 2025-10-30 | 다케다 야쿠힌 고교 가부시키가이샤 | 매크로시클릭 헤테로시클 화합물 및 이의 용도 |
| US20240425521A1 (en) * | 2023-06-01 | 2024-12-26 | H. Lundbeck A/S | Spiromacrocyclic orexin 2 receptor agonists |
| TW202502342A (zh) | 2023-06-02 | 2025-01-16 | 日商武田藥品工業股份有限公司 | 食慾素2受體促效劑用於改善睡眠期間之呼吸功能的用途 |
| AU2024361979A1 (en) * | 2023-10-20 | 2026-03-05 | Alkermes, Inc. | Compound for use in treating narcolepsy |
| WO2025096445A1 (fr) | 2023-10-30 | 2025-05-08 | Alkermes, Inc. | Synthèse d'intermédiaires pour la préparation de composés macrocycliques |
| WO2025124698A1 (fr) | 2023-12-12 | 2025-06-19 | Idorsia Pharmaceuticals Ltd | Dérivés d'arylsulfone et de sulfanone utilisés en tant que modulateurs du récepteur de l'orexine |
| TW202542165A (zh) | 2023-12-19 | 2025-11-01 | 瑞士商愛杜西亞製藥有限公司 | 大環食慾素激動劑 |
| TW202547576A (zh) * | 2024-04-04 | 2025-12-16 | 日商橘生藥品工業股份有限公司 | 取代磺醯胺巨環狀化合物 |
| WO2025224168A1 (fr) | 2024-04-24 | 2025-10-30 | Idorsia Pharmaceuticals Ltd | Dérivés d'arylsulfone et de sulfanone utilisés en tant que modulateurs du récepteur de l'orexine |
| WO2025229493A1 (fr) | 2024-04-29 | 2025-11-06 | Takeda Pharmaceutical Company Limited | Dosage d'agonistes du récepteur de l'orexine de type 2 |
| WO2026017128A1 (fr) * | 2024-07-17 | 2026-01-22 | 江苏恩华药业股份有限公司 | Dérivé de cycloalcène agissant en tant qu'agoniste du récepteur de l'orexine, composition et utilisation associées |
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