MC1969A1 - Procedes pour preparer des composes antitumoraux,formulation pharmaceutique contenant ces composes,leurs utilisations en medecine et pharmacie,et composes intermediaires pour leur preparation - Google Patents

Procedes pour preparer des composes antitumoraux,formulation pharmaceutique contenant ces composes,leurs utilisations en medecine et pharmacie,et composes intermediaires pour leur preparation

Info

Publication number
MC1969A1
MC1969A1 MC882000A MC2000A MC1969A1 MC 1969 A1 MC1969 A1 MC 1969A1 MC 882000 A MC882000 A MC 882000A MC 2000 A MC2000 A MC 2000A MC 1969 A1 MC1969 A1 MC 1969A1
Authority
MC
Monaco
Prior art keywords
compound
formula
pyridazine
group
imidazo
Prior art date
Application number
MC882000A
Other languages
English (en)
French (fr)
Inventor
Teanby Hodgson Simon
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of MC1969A1 publication Critical patent/MC1969A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
MC882000A 1987-08-15 1988-08-11 Procedes pour preparer des composes antitumoraux,formulation pharmaceutique contenant ces composes,leurs utilisations en medecine et pharmacie,et composes intermediaires pour leur preparation MC1969A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878719368A GB8719368D0 (en) 1987-08-15 1987-08-15 Heterocyclic compounds

Publications (1)

Publication Number Publication Date
MC1969A1 true MC1969A1 (fr) 1989-09-29

Family

ID=10622364

Family Applications (1)

Application Number Title Priority Date Filing Date
MC882000A MC1969A1 (fr) 1987-08-15 1988-08-11 Procedes pour preparer des composes antitumoraux,formulation pharmaceutique contenant ces composes,leurs utilisations en medecine et pharmacie,et composes intermediaires pour leur preparation

Country Status (28)

Country Link
US (5) US5091531A (de)
EP (1) EP0305093B1 (de)
JP (1) JPS6468375A (de)
KR (1) KR890003764A (de)
CN (2) CN1031532A (de)
AP (1) AP89A (de)
AT (1) ATE103919T1 (de)
AU (1) AU613392B2 (de)
CA (1) CA1336432C (de)
DD (1) DD289529A5 (de)
DE (1) DE3888897T2 (de)
DK (1) DK168954B1 (de)
ES (1) ES2063039T3 (de)
FI (1) FI89600C (de)
GB (1) GB8719368D0 (de)
HU (1) HU204052B (de)
IL (1) IL87435A (de)
MC (1) MC1969A1 (de)
MX (1) MX12655A (de)
MY (1) MY103602A (de)
NO (1) NO168305C (de)
NZ (1) NZ225808A (de)
PH (1) PH25741A (de)
PL (3) PL160045B1 (de)
PT (1) PT88260B (de)
RU (3) RU1769759C (de)
YU (3) YU47200B (de)
ZA (1) ZA885996B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8719368D0 (en) * 1987-08-15 1987-09-23 Wellcome Found Heterocyclic compounds
PH27291A (en) * 1989-01-31 1993-05-04 Takeda Chemical Industries Ltd Imidazolpyrimidazines their production and use
EP0440119A1 (de) * 1990-01-31 1991-08-07 Takeda Chemical Industries, Ltd. Imidazopyridazinverbindungen, ihre Herstellung und Verwendung
EP0444549B1 (de) * 1990-03-01 1995-01-25 Takeda Chemical Industries, Ltd. Imidazopyridazine, ihre Herstellung und Verwendung
CN1329614A (zh) * 1998-10-21 2002-01-02 武田药品工业株式会社 稠合的哒嗪衍生物、它们的制备方法和用途
GEP20053688B (en) 2000-06-30 2005-12-12 Wyeth Corp Substituted-Triazolopyrimidines as Anticancer Agents
JP3767352B2 (ja) 2000-09-18 2006-04-19 トヨタ自動車株式会社 内燃機関の制御装置
US6960584B2 (en) * 2001-04-10 2005-11-01 Merck & Co., Inc. Inhibitors of Akt activity
AU2007279595A1 (en) * 2006-08-04 2008-02-07 Takeda Pharmaceutical Company Limited Fused heterocyclic derivative and use thereof
WO2008058126A2 (en) * 2006-11-06 2008-05-15 Supergen, Inc. Imidazo[1,2-b]pyridazine and pyrazolo[1,5-a]pyrimidine derivatives and their use as protein kinase inhibitors
US8431608B2 (en) 2007-08-17 2013-04-30 Icagen Inc. Heterocycles as potassium channel modulators
ES2400604T3 (es) * 2007-08-17 2013-04-11 Icagen, Inc. Heterociclos como moduladores del canal de potasio
UY31676A1 (es) * 2008-02-28 2009-09-30 "derivados de 3-metil-imidiazo-[1,2-b]-piridazina"
EP2277881A4 (de) * 2008-04-18 2011-09-07 Shionogi & Co Heterocyclische verbindung mit inhibierender wirkung auf p13k
UY32049A (es) * 2008-08-14 2010-03-26 Takeda Pharmaceutical Inhibidores de cmet
TW201437211A (zh) * 2013-03-01 2014-10-01 Bayer Pharma AG 經取代咪唑并嗒□

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB305093A (en) * 1928-01-30 1929-07-25 British Continental Motors Ltd Improvements relating to induction passages of sleeve-valve internal combustion engines
US3809691A (en) * 1967-10-23 1974-05-07 Eastman Kodak Co Novel cyanine dyes with fused imidazolo nuclei
US3615639A (en) * 1967-10-23 1971-10-26 Eastman Kodak Co Direct positive silver halide emulsions containing dyes as electron acceptors and spectral sensitizers
DE2043811A1 (en) * 1970-09-03 1972-03-09 E.I. du Pont de Nemours and Co., Wilmington, Del. (V.StA.) Fungicidal and acaricidal alkyl 2-benzimi- - dazole carbomate derivs
US3725407A (en) * 1971-04-08 1973-04-03 American Cyanamid Co 6-substituted amino-3-nitroimidazo(1,2-b)pyridazines and methods of preparing the same
FR2315507A1 (fr) * 1975-06-26 1977-01-21 Roussel Uclaf Imidazo /1,2-b/ pyridazines substituees, procede de preparation et compositions pesticides les renfermant
US4105767A (en) * 1977-03-28 1978-08-08 Merck & Co., Inc. Imidazo [1,2-a] pyridines substituted with a thienyl, thiazolyl, or thiadiazolyl group
US4166851A (en) * 1977-05-16 1979-09-04 Merck & Co., Inc. Certain imidazo(1,2a)pyridine derivatives
US4154835A (en) * 1977-10-12 1979-05-15 Merck & Co., Inc. Anthelmintic imidazo [1,2-a] pyridines
US4330543A (en) * 1978-12-14 1982-05-18 Merck & Co., Inc. Imidazoazines and imidazodiazines
US4221796A (en) * 1979-09-19 1980-09-09 E. R. Squibb & Sons, Inc. Substituted imidazolo-pyridines and method
DE3131365A1 (de) * 1981-08-07 1983-02-24 Henkel KGaA, 4000 Düsseldorf Neue diglycidyl-substituierte heterocyclische verbindungen, verfahren zu ihrer herstellung und ihre verwendung in arzneimittelzubereitungen mit cytostatischer wirksamkeit
JPS58126887A (ja) * 1981-09-26 1983-07-28 Takeda Chem Ind Ltd 新規７−デアザプリン誘導体
US4460773A (en) * 1982-02-05 1984-07-17 Lion Corporation 1-Phenyl-1H-pyrazolo [3,4-b]pyrazine derivatives and process for preparing same
US4464372A (en) * 1982-08-16 1984-08-07 Schering Corporation Imidazo[1,2-b]pyridazines
IL69417A (en) * 1982-08-27 1987-12-20 Roussel Uclaf 2-acyl imidazo(1,2-a)pyrimidines,their preparation and pharmaceutical compositions containing them
US4654347A (en) * 1983-06-23 1987-03-31 American Cyanamid Company Aryl and heteroaryl[[7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]methanones
DE3401911A1 (de) * 1984-01-20 1985-08-01 A. Nattermann & Cie GmbH, 5000 Köln Substituierte 4,5-dihydro-6-vinyl-3(2h)-pyridazinone und 6-vinyl-3(2h)-pyridazinone sowie verfahren zu ihrer herstellung
DE3423092A1 (de) * 1984-06-22 1986-01-02 Dr. Karl Thomae Gmbh, 7950 Biberach Neue 8-alkylthio-2-piperazino-pyrimido(5,4-d) pyrimidine, ihre herstellung und diese verbindungen enthaltende arzneimittel
US4569934A (en) * 1984-10-09 1986-02-11 American Cyanamid Company Imidazo[1,2-b]pyridazines
DE3446812A1 (de) * 1984-12-21 1986-06-26 Dr. Karl Thomae Gmbh, 7950 Biberach Neue imidazoderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel
DE3446778A1 (de) * 1984-12-21 1986-07-03 Dr. Karl Thomae Gmbh, 7950 Biberach Neue imidazoderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel
DE3527036A1 (de) * 1985-07-27 1987-02-05 Merck Patent Gmbh 6-arylalkenylpyridazinone
DE3542661A1 (de) * 1985-12-03 1987-06-04 Bayer Ag Imidazopyridazinalkensaeureamide, verfahren zu ihrer herstellung, zwischenprodukte zu ihrer herstellung
WO1989001333A1 (en) * 1987-08-07 1989-02-23 The Australian National University IMIDAZO[1,2-b]PYRIDAZINES
WO1989001478A1 (en) * 1987-08-07 1989-02-23 The Australian National University ARYLOXY- AND ARALKYLTHIO-IMIDAZO[1,2-b]PYRIDAZINES
GB8719368D0 (en) * 1987-08-15 1987-09-23 Wellcome Found Heterocyclic compounds

Also Published As

Publication number Publication date
JPS6468375A (en) 1989-03-14
NO168305B (no) 1991-10-28
AP8800098A0 (en) 1988-08-01
CN1085901A (zh) 1994-04-27
PH25741A (en) 1991-10-18
PT88260B (pt) 1995-03-01
CN1031532A (zh) 1989-03-08
US5380759A (en) 1995-01-10
YU47130B (sh) 1994-12-28
ZA885996B (en) 1990-04-25
IL87435A0 (en) 1989-01-31
DK451588A (da) 1989-02-16
US5447956A (en) 1995-09-05
RU2017741C1 (ru) 1994-08-15
DK451588D0 (da) 1988-08-12
PT88260A (pt) 1989-09-14
US5091531A (en) 1992-02-25
DE3888897T2 (de) 1994-10-20
DE3888897D1 (de) 1994-05-11
RU1836372C (ru) 1993-08-23
DD289529A5 (de) 1991-05-02
HUT50473A (en) 1990-02-28
CA1336432C (en) 1995-07-25
US5538970A (en) 1996-07-23
PL160044B1 (pl) 1993-02-26
YU47200B (sh) 1995-01-31
US5371219A (en) 1994-12-06
NZ225808A (en) 1991-07-26
AU2097988A (en) 1989-02-16
PL274216A1 (en) 1989-05-02
AP89A (en) 1990-06-14
HU204052B (en) 1991-11-28
FI883758A0 (fi) 1988-08-12
PL159008B1 (pl) 1992-11-30
AU613392B2 (en) 1991-08-01
RU1769759C (ru) 1992-10-15
EP0305093B1 (de) 1994-04-06
FI89600B (fi) 1993-07-15
IL87435A (en) 1993-01-31
DK168954B1 (da) 1994-07-18
FI883758A7 (fi) 1989-02-16
PL160045B1 (en) 1993-02-26
FI89600C (fi) 1993-10-25
GB8719368D0 (en) 1987-09-23
NO883613D0 (no) 1988-08-12
EP0305093A1 (de) 1989-03-01
YU47212B (sh) 1995-01-31
MY103602A (en) 1993-08-28
YU156988A (en) 1990-04-30
YU202789A (en) 1990-04-30
NO883613L (no) 1989-02-16
ATE103919T1 (de) 1994-04-15
MX12655A (es) 1993-10-01
KR890003764A (ko) 1989-04-17
YU202889A (en) 1990-04-30
ES2063039T3 (es) 1995-01-01
NO168305C (no) 1992-02-05

Similar Documents

Publication Publication Date Title
JP4824165B2 (ja) ピロロベンゾジアゼピン類
EP3418273B1 (de) Flavaglin-derivate
MC1969A1 (fr) Procedes pour preparer des composes antitumoraux,formulation pharmaceutique contenant ces composes,leurs utilisations en medecine et pharmacie,et composes intermediaires pour leur preparation
MC1068A1 (fr) Derives de la purine et medicaments qui en contienprocede de preparation de derives de la purine nent
KR20020038730A (ko) 이성질체 접합 피롤로카르바졸 및 이소인돌론
EP0010029A2 (de) Durch eine Polyaminkette in Stellung 1 substituierte Ellipticinen, ihre Synthese und sie enthaltende Arzneimittel
FR2662163A1 (fr) Nouvelles 8-amino-1,2,4-triazolo(4,3-a) pyrazines, procedes de preparation et medicaments les contenant.
CA3080116A1 (fr) Derives macrocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP0446141B1 (de) Imidazo[1,2-c]chinazolinderivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen
CH633796A5 (fr) Dipyridoindoles therapeutiquement actifs.
FR2477016A1 (fr) Compositions pharmaceutiques a base de derives de mitomycine pour le traitement de maladie neoplastique chez les animaux
EP0431991B1 (de) 1,8-Benzonaphthyridinderivate, ihre Herstellung und diese enthaltende Zusammensetzungen
EP0690050A1 (de) (Thia)cycloalkyl(b)indolderivate als 5-lipoxygenase Inhibitoren
EP2185561B1 (de) 1,2,3,4-Tetrahydropyrrolo(1,2-a)pyrazin-6-carboxamid und 2,3,4,5-Tetrahydropyrrolo(1,2-a)-diazepin-7-carboxamid- Derivate, ihre Herstellung und therapeutische Verwendung
WO2014020101A1 (fr) Derives de griseofulvine
JP2005530691A (ja) 新規なチロインジシンとその関連プロセス、薬学的組成物および方法
FR2611718A1 (fr) Analogues d'amino prostaglandines 7-oxabicycloheptane substitues, a action therapeutique
EP1664055B1 (de) 9-aminopodophyllotoxinderivate, verfahren zu deren herstellung und pharmazeutische zusammensetzungen, die diese derivate enthalten
WO2004069843A1 (fr) Derives d'azepines tricycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
MC1708A1 (fr) Composes polycycliques biocides,procedes et intermediaires pour leur synthese et preparations pharmaceutiques les contenant
FR2569696A1 (fr) Nouveaux analogues de la mitomycine, leur procede de preparation et leur application pharmaceutique
KR20090063869A (ko) 퀴놀린 카복실산 아마이드 유도체 또는 이의 약학적으로허용가능한 염, 이의 제조방법 및 이를 유효성분으로함유하는 항균 조성물
EP0982308B1 (de) 8H-(2,3-b)-Pyrrolozin-8-one Derivate, Verfahren zur ihre Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
FR2665162A1 (fr) Derives du 6h-pyrido[3,2-b] carbazole, leur procede de preparation et leur application en therapeutique.
JPH07188181A (ja) グルタミナーゼ阻害剤

Legal Events

Date Code Title Description
YP Annual fee paid