ME02810B - Antigen-specifični t ćelijski receptori i t ćelijski epitopi - Google Patents

Antigen-specifični t ćelijski receptori i t ćelijski epitopi

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Publication number
ME02810B
ME02810B MEP-2017-163A MEP16317A ME02810B ME 02810 B ME02810 B ME 02810B ME P16317 A MEP16317 A ME P16317A ME 02810 B ME02810 B ME 02810B
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ME
Montenegro
Prior art keywords
cell
antigen
nucleic acid
reactive
providing
Prior art date
Application number
MEP-2017-163A
Other languages
German (de)
English (en)
French (fr)
Inventor
Ugur Sahin
Özlem Türeci
Petra Simon
Tana Omokoko
Original Assignee
Biontech Cell & Gene Therapies Gmbh
Tron Translationale Onkologie An Der Univ Der Johannes Gutenberg Univ Mainz Gemeinnuetzige Gmbh
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Publication date
Application filed by Biontech Cell & Gene Therapies Gmbh, Tron Translationale Onkologie An Der Univ Der Johannes Gutenberg Univ Mainz Gemeinnuetzige Gmbh filed Critical Biontech Cell & Gene Therapies Gmbh
Publication of ME02810B publication Critical patent/ME02810B/me

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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/32—T-cell receptors [TCR]
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    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
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    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
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    • A61K40/4267—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
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Claims (4)

1. Postupak za obezbeđivanje antigen-specifičnih limfoidnih ćelija koji sadrži korake:(a) obezbeđivanja T ćelije reaktivne na jedan antigen iz uzorka koji sadrži T ćelije, pri čemu je navedeni uzorak dobijen od subjekta koji je prethodno izložen navedenom antigenu i pri čemu je navedena T ćelija reaktivna na jedan antigen izolovana iz uzorka koji sadrži T ćelije upotrebom protočne citometrije;(b) obezbedivanja nukleinske kiseline koja kodira T ćelijski receptor koji ima specifičnost T ćelijskog receptora navedene T ćelije reaktivne na jedan antigen; i(e) uvođenja navedene nukleinske kiseline u limfoidnu ćeliju da bi se obezbedile navedene antigen-specifične limfoidne ćelije.
2. Postupak prema patentnom zahtjevu 1, naznačen time što je navedena nukleinska kiselina RNK.
3. Postupak prema patentnom zahtjevu 1 ili 2, naznačen time što navedeni korak obezbeđivanja nukleinske kiseline koja kodira T ćelijski receptor koji ima specifičnost T ćelijskog receptora navedene T ćelije reaktivne na jedan antigen sadrži obezbeđivanje nukleinske kiseline koja kodira T ćelijski receptor koji sadrži najmanje CDR sekvence, poželjno najmanje varijabilni region T ćelijskog receptora navedene T ćelije reaktivne na jedan antigen.
4. Postupak prema bilo kom od patentnih zahtjeva 1 do 3, naznačen time što je navedeni subjekat seropozitivan za navedeni antigen ili agens koji sadrži navedeni antigen.
MEP-2017-163A 2010-09-20 2011-09-19 Antigen-specifični t ćelijski receptori i t ćelijski epitopi ME02810B (me)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP10009990 2010-09-20
EP11000045 2011-01-05
EP11761508.8A EP2618835B1 (en) 2010-09-20 2011-09-19 Antigen-specific t cell receptors and t cell epitopes
PCT/EP2011/004674 WO2012038055A1 (en) 2010-09-20 2011-09-19 Antigen-specific t cell receptors and t cell epitopes

Publications (1)

Publication Number Publication Date
ME02810B true ME02810B (me) 2018-01-20

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US (4) US9586997B2 (me)
EP (3) EP3213765B1 (me)
JP (5) JP6378485B2 (me)
CN (4) CN117756916A (me)
AU (4) AU2011304728A1 (me)
BR (2) BR112013006718B1 (me)
CA (3) CA2812153C (me)
CY (1) CY1119332T1 (me)
DK (1) DK2618835T3 (me)
ES (1) ES2635335T3 (me)
HK (1) HK1243003A1 (me)
HR (1) HRP20171164T1 (me)
LT (1) LT2618835T (me)
ME (1) ME02810B (me)
PL (1) PL2618835T3 (me)
PT (1) PT2618835T (me)
RS (1) RS56339B1 (me)
SI (1) SI2618835T1 (me)
SM (1) SMT201700393T1 (me)
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CA2812153A1 (en) 2012-03-29
CA3088393C (en) 2021-08-17
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US10117918B2 (en) 2018-11-06
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