MEP17308A - Novel 1,3-dihydro-2h-indol-2-one derivatives and their use as ligands for v 1b and v 1a arginine-vasopressin receptors - Google Patents

Novel 1,3-dihydro-2h-indol-2-one derivatives and their use as ligands for v 1b and v 1a arginine-vasopressin receptors

Info

Publication number: MEP17308A
Authority: ME; Montenegro
Prior art keywords: arginine; indol; dihydro; ligands; derivatives
Prior art date: 2000-01-25

Application number

MEP-173/08A

Other languages

Bosnian (bs)

English (en)

Inventor

Richard Roux

Gal Claudine Serradeil-Le

Bernard Tonnerre

Jean Wagnon

Original Assignee

Sanofi Aventis

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-01-25

Filing date

2001-01-24

Publication date

2010-06-10

2001-01-24 Application filed by Sanofi Aventis filed Critical Sanofi Aventis

2010-06-10 Publication of MEP17308A publication Critical patent/MEP17308A/xx

Links

102000004136 Vasopressin Receptors Human genes 0.000 title abstract 2
108090000643 Vasopressin Receptors Proteins 0.000 title abstract 2
JYGFTBXVXVMTGB-UHFFFAOYSA-N indolin-2-one Chemical class C1=CC=C2NC(=O)CC2=C1 JYGFTBXVXVMTGB-UHFFFAOYSA-N 0.000 title 1
239000003446 ligand Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
150000004677 hydrates Chemical class 0.000 abstract 1
229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000011707 mineral Substances 0.000 abstract 1
150000007522 mineralic acids Chemical class 0.000 abstract 1
150000007524 organic acids Chemical class 0.000 abstract 1
235000005985 organic acids Nutrition 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Immunology (AREA)
Reproductive Health (AREA)
Hematology (AREA)
Cardiology (AREA)
Pulmonology (AREA)
Urology & Nephrology (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Obesity (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)
Ophthalmology & Optometry (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Rheumatology (AREA)
Psychology (AREA)
Emergency Medicine (AREA)
Dermatology (AREA)

MEP-173/08A 2000-01-25 2001-01-24 Novel 1,3-dihydro-2h-indol-2-one derivatives and their use as ligands for v 1b and v 1a arginine-vasopressin receptors MEP17308A (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
FR0000957A FR2804114B1 (fr)	2000-01-25	2000-01-25	Nouveaux derives de 1,3-dihydro-2h-indol-2-one, un procede pour leur preparation et les compositions pharmaceutiques en contenant
PCT/FR2001/000226 WO2001055130A2 (fr)	2000-01-25	2001-01-24	Derives de 1,3-dihydro-2h-indol-2-one et leur utilisation en tant que ligands des recepteurs v1b ou v1b et v1a de l'arginine-vasopressine
YUP-523/02A RS50290B (sr)	2000-01-25	2001-01-24	Novi derivati 1,3-dihidro-2h-indol-2-ona i njihova upotreba kao liganada za v1b i v1a receptore arginin-vazopresina

Publications (1)

Publication Number	Publication Date
MEP17308A true MEP17308A (en)	2010-06-10

Family

ID=8846307

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MEP-173/08A MEP17308A (en)	2000-01-25	2001-01-24	Novel 1,3-dihydro-2h-indol-2-one derivatives and their use as ligands for v 1b and v 1a arginine-vasopressin receptors

Country Status (35)

Country	Link
US (3)	US6730695B2 (da)
EP (1)	EP1255751B1 (da)
JP (1)	JP3992498B2 (da)
KR (1)	KR100689922B1 (da)
CN (1)	CN1193025C (da)
AR (1)	AR027263A1 (da)
AT (1)	ATE269326T1 (da)
AU (1)	AU778196B2 (da)
BG (1)	BG65796B1 (da)
BR (1)	BR0107807B1 (da)
CA (1)	CA2396814C (da)
CZ (1)	CZ300917B6 (da)
DE (1)	DE60103853T2 (da)
DK (1)	DK1255751T3 (da)
EA (1)	EA004628B1 (da)
EE (1)	EE04779B1 (da)
ES (1)	ES2222342T3 (da)
FR (1)	FR2804114B1 (da)
HR (1)	HRP20020626B1 (da)
HU (1)	HU229081B1 (da)
IL (2)	IL150539A0 (da)
IS (1)	IS2313B (da)
ME (1)	MEP17308A (da)
MX (1)	MXPA02007259A (da)
NO (1)	NO323607B1 (da)
PL (1)	PL204160B1 (da)
PT (1)	PT1255751E (da)
RS (1)	RS50290B (da)
SI (1)	SI1255751T1 (da)
SK (1)	SK286976B6 (da)
TR (1)	TR200402344T4 (da)
TW (1)	TWI283672B (da)
UA (1)	UA74354C2 (da)
WO (1)	WO2001055130A2 (da)
ZA (1)	ZA200205224B (da)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
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FR2804114B1 (fr) *	2000-01-25	2002-03-08	Sanofi Synthelabo	Nouveaux derives de 1,3-dihydro-2h-indol-2-one, un procede pour leur preparation et les compositions pharmaceutiques en contenant
FR2805536B1 (fr) *	2000-02-25	2002-08-23	Sanofi Synthelabo	Nouveaux derives de 1,3-dihydro-2h-indol-2-one, un procede pour leur preparation et les compositions pharmaceutiques en contenant
FR2842527B1 (fr) *	2002-07-19	2005-01-28	Sanofi Synthelabo	Derives d'acyloxypyrolidine, leur preparation et leur application en therapeutique
EP1659121A4 (en) *	2003-08-28	2008-11-26	Taisho Pharmaceutical Co Ltd	1,3-dihydro-2H-indol-2-one derivative
US8580842B2 (en)	2003-09-30	2013-11-12	Abbott Gmbh & Co. Kg	Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them
US20050070718A1 (en)	2003-09-30	2005-03-31	Abbott Gmbh & Co. Kg	Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them
US20050165082A1 (en) *	2003-12-16	2005-07-28	Wyeth	Methods of treating vasomotor symptoms
US7414052B2 (en)	2004-03-30	2008-08-19	Wyeth	Phenylaminopropanol derivatives and methods of their use
US7517899B2 (en)	2004-03-30	2009-04-14	Wyeth	Phenylaminopropanol derivatives and methods of their use
WO2006038119A1 (en) *	2004-10-08	2006-04-13	Warner-Lambert Company Llc	Stereoselective synthesis of n-protected alkoxy prolines
EP1842555A4 (en) *	2004-12-27	2009-08-19	Univ Kyoto	MEANS OF SUPPRESSING THE TOLERANCE DEVELOPMENT FOR NARCOTIC ANALGETICS
EP1831197A2 (de) *	2004-12-31	2007-09-12	Abbott GmbH & Co. KG	Substituierte oxindol-derivate, diese enthaltende arzneimittel und deren verwendung
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2000
- 2000-01-25 FR FR0000957A patent/FR2804114B1/fr not_active Expired - Fee Related
2001
- 2001-01-19 TW TW090101300A patent/TWI283672B/zh not_active IP Right Cessation
- 2001-01-23 AR ARP010100275A patent/AR027263A1/es not_active Application Discontinuation
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- 2001-01-24 EP EP01907685A patent/EP1255751B1/fr not_active Expired - Lifetime
- 2001-01-24 AT AT01907685T patent/ATE269326T1/de active
- 2001-01-24 SK SK1083-2002A patent/SK286976B6/sk not_active IP Right Cessation
- 2001-01-24 MX MXPA02007259A patent/MXPA02007259A/es active IP Right Grant
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Also Published As

Publication number	Publication date
EP1255751A2 (fr)	2002-11-13
ES2222342T3 (es)	2005-02-01
AR027263A1 (es)	2003-03-19
US20030114683A1 (en)	2003-06-19
IL150539A0 (en)	2003-02-12
HUP0204242A3 (en)	2004-05-28
RS50290B (sr)	2009-09-08
EA004628B1 (ru)	2004-06-24
TR200402344T4 (tr)	2004-12-21
PL357553A1 (en)	2004-07-26
BR0107807A (pt)	2002-10-22
ZA200205224B (en)	2004-03-09
CN1193025C (zh)	2005-03-16
HRP20020626A2 (en)	2003-10-31
EE04779B1 (et)	2007-02-15
HUP0204242A2 (en)	2003-05-28
DE60103853D1 (de)	2004-07-22
NO20023510L (no)	2002-09-25
NO323607B1 (no)	2007-06-18
JP3992498B2 (ja)	2007-10-17
SI1255751T1 (en)	2004-10-31
TWI283672B (en)	2007-07-11
CA2396814C (en)	2007-07-10
EA200200628A1 (ru)	2002-12-26
US6730695B2 (en)	2004-05-04
WO2001055130A2 (fr)	2001-08-02
US7297692B2 (en)	2007-11-20
US20070004703A1 (en)	2007-01-04
BR0107807B1 (pt)	2014-02-25
US7129240B2 (en)	2006-10-31
IS6451A (is)	2002-06-28
SK286976B6 (sk)	2009-08-06
PT1255751E (pt)	2004-10-29
UA74354C2 (uk)	2005-12-15
BG106947A (en)	2003-04-30
CN1404479A (zh)	2003-03-19
JP2003523351A (ja)	2003-08-05
HU229081B1 (en)	2013-07-29
WO2001055130A3 (fr)	2002-03-14
BG65796B1 (bg)	2009-12-31
CA2396814A1 (en)	2001-08-02
PL204160B1 (pl)	2009-12-31
SK10832002A3 (sk)	2003-03-04
YU52302A (sh)	2006-05-25
NO20023510D0 (no)	2002-07-23
HRP20020626B1 (en)	2009-04-30
EP1255751B1 (fr)	2004-06-16
AU3559401A (en)	2001-08-07
HK1050900A1 (en)	2003-07-11
KR20020067938A (ko)	2002-08-24
FR2804114A1 (fr)	2001-07-27
KR100689922B1 (ko)	2007-03-09
CZ300917B6 (cs)	2009-09-09
FR2804114B1 (fr)	2002-03-08
IL150539A (en)	2007-09-20
CZ20022497A3 (cs)	2002-10-16
ATE269326T1 (de)	2004-07-15
MXPA02007259A (es)	2003-01-28
US20040209938A1 (en)	2004-10-21
EE200200409A (et)	2003-12-15
IS2313B (is)	2007-11-15
DE60103853T2 (de)	2005-04-28
AU778196B2 (en)	2004-11-18
DK1255751T3 (da)	2004-10-18

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MEP24508A (en)	2010-10-10	Phenylsulfonyl-1,3-dihydro-2h-indole-2-one derivatives, their preparation and their therapeutic use
EA200200628A1 (ru)	2002-12-26	Новые производные 1,3-дигидро-2н-индол-2-она и их применение в качестве лигандов рецепторов аргинин-вазопрессина v1b и v1a
DK1254134T3 (da)	2003-11-03	Derivater af 1,3-dihydro-2H-indol-2-on og deres anvendelse som ligander for argininvasopressinreceptorerne V1B eller V1B og V1A
EA200200912A1 (ru)	2003-06-26	Новые производные индолин-2-она, их получение и их применение в качестве лигандов рецепторов окситоцина
FI934274A0 (fi)	1993-09-29	N-sulfonyl-2-oxi-indolderivat, deras framstaellning och dessa innehaollande farmaceutiska kompositioner
EA200200940A1 (ru)	2003-02-27	Производные азетидина, способ их получения и содержащие их фармацевтические композиции
EA200300453A1 (ru)	2003-10-30	Производные 3-ароилиндола и их применение в качестве агонистов рецепторов cb2
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MEP18808A (en)	2010-10-10	Triazolo-quinolin derivatives useful as adenosine receptor ligands
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