MEP48108A - Derivati 4-tetrazolil - 4- fenilpiperidina za liječenje bola - Google Patents

Derivati 4-tetrazolil - 4- fenilpiperidina za liječenje bola

Info

Publication number
MEP48108A
MEP48108A MEP-481/08A MEP48108A MEP48108A ME P48108 A MEP48108 A ME P48108A ME P48108 A MEP48108 A ME P48108A ME P48108 A MEP48108 A ME P48108A
Authority
ME
Montenegro
Prior art keywords
tetrazolyl
derivatives
treating pain
phenylpiperidine
opioid receptor
Prior art date
Application number
MEP-481/08A
Other languages
English (en)
Inventor
Zhengming Chen
Original Assignee
Euro Celtique Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euro Celtique Sa filed Critical Euro Celtique Sa
Publication of MEP48108A publication Critical patent/MEP48108A/bs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C07D211/64—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Ovdje su opisana 4-tetrazolil-4-fenilpiperidin jedinjenja, kompozicije koje sadrže djelotvorne količine 4-tetrazolil-4-fenilpiperidin jedinjenja, postupke za liječenje ili sprečavanje bola ili dijareje kod životinja koji obuhvataju davanje životinji kojoj je to potrebno djelotvorne količine 4-tetrazolil-4-fenilpiperidin jedinjenja i postupak za stimulaciju opoidno receptorske funkcije u ćeliji, koji se sastoji od kontaktiranja ćelije koja vrši ekpresiju opoidnog receptora sa djelotvornom količinom 4-tetrazolil-4-fenilpiperidin jedinjenja.
MEP-481/08A 2002-11-18 2003-11-17 Derivati 4-tetrazolil - 4- fenilpiperidina za liječenje bola MEP48108A (bs)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US42738102P 2002-11-18 2002-11-18
US46027803P 2003-04-03 2003-04-03
US48848803P 2003-07-17 2003-07-17
US10/714,066 US7202259B2 (en) 2002-11-18 2003-11-13 Therapeutic agents useful for treating pain
PCT/US2003/036742 WO2004046132A1 (en) 2002-11-18 2003-11-17 4-tetrazolyl-4phenylpiperidine derivatives for treating pain

Publications (1)

Publication Number Publication Date
MEP48108A true MEP48108A (bs) 2011-02-10

Family

ID=32777221

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-481/08A MEP48108A (bs) 2002-11-18 2003-11-17 Derivati 4-tetrazolil - 4- fenilpiperidina za liječenje bola

Country Status (36)

Country Link
US (3) US7202259B2 (bs)
EP (2) EP1803718B1 (bs)
JP (2) JP4601429B2 (bs)
KR (1) KR20050115221A (bs)
CN (2) CN101648941A (bs)
AP (1) AP2210A (bs)
AR (1) AR047008A1 (bs)
AT (2) ATE358674T1 (bs)
AU (2) AU2003294313B2 (bs)
BR (1) BR0316305A (bs)
CA (1) CA2506242C (bs)
CO (1) CO5690588A2 (bs)
CR (2) CR7877A (bs)
CY (2) CY1107682T1 (bs)
DE (2) DE60322451D1 (bs)
DK (2) DK1562932T3 (bs)
EA (1) EA008621B1 (bs)
EC (1) ECSP055840A (bs)
ES (2) ES2312150T3 (bs)
GE (1) GEP20084539B (bs)
IL (1) IL209352A0 (bs)
IS (2) IS2720B (bs)
MA (1) MA27565A1 (bs)
ME (1) MEP48108A (bs)
MX (1) MXPA05004669A (bs)
MY (1) MY135647A (bs)
NI (1) NI200500087A (bs)
NO (1) NO20052894L (bs)
NZ (2) NZ572685A (bs)
OA (1) OA13010A (bs)
PT (2) PT1803718E (bs)
RS (1) RS51047B (bs)
SG (1) SG165998A1 (bs)
SI (2) SI1562932T1 (bs)
TW (2) TWI343917B (bs)
WO (1) WO2004046132A1 (bs)

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Also Published As

Publication number Publication date
CY1108422T1 (el) 2014-04-09
AP2210A (en) 2011-02-25
AU2003294313A1 (en) 2004-06-15
JP2006525944A (ja) 2006-11-16
NO20052894D0 (no) 2005-06-14
KR20050115221A (ko) 2005-12-07
AU2003294313B2 (en) 2010-08-26
DE60322451D1 (de) 2008-09-04
ES2285235T3 (es) 2007-11-16
HK1086829A1 (zh) 2006-09-29
CA2506242A1 (en) 2004-06-03
JP2010163452A (ja) 2010-07-29
DE60313021D1 (de) 2007-05-16
DK1562932T3 (da) 2007-08-13
TW200418828A (en) 2004-10-01
EP1803718B1 (en) 2008-07-23
EP1562932B1 (en) 2007-04-04
OA13010A (en) 2006-11-10
US8026254B2 (en) 2011-09-27
IS2720B (is) 2011-02-15
SI1562932T1 (sl) 2007-08-31
IS8913A (is) 2010-07-21
CN101648941A (zh) 2010-02-17
IS7812A (is) 2005-04-19
CN100567288C (zh) 2009-12-09
US7202259B2 (en) 2007-04-10
MA27565A1 (fr) 2005-10-03
AU2010246411A1 (en) 2010-12-16
CR11037A (es) 2009-10-29
US20040152689A1 (en) 2004-08-05
DE60313021T2 (de) 2007-12-13
NO20052894L (no) 2005-06-14
PT1803718E (pt) 2008-09-26
TW200819436A (en) 2008-05-01
MY135647A (en) 2008-06-30
US20100069437A1 (en) 2010-03-18
ES2312150T3 (es) 2009-02-16
EA008621B1 (ru) 2007-06-29
BR0316305A (pt) 2005-09-27
ECSP055840A (es) 2005-08-11
EA200500726A1 (ru) 2005-10-27
JP4601429B2 (ja) 2010-12-22
ATE402167T1 (de) 2008-08-15
CY1107682T1 (el) 2013-04-18
SI1803718T1 (sl) 2008-12-31
NI200500087A (es) 2007-07-24
DK1803718T3 (da) 2008-10-27
AR047008A1 (es) 2006-01-04
US20070179141A1 (en) 2007-08-02
NZ572685A (en) 2010-06-25
NZ540068A (en) 2007-07-27
RS20050375A (sr) 2007-11-15
PT1562932E (pt) 2007-07-02
WO2004046132A1 (en) 2004-06-03
IL209352A0 (en) 2011-01-31
EP1803718A1 (en) 2007-07-04
ATE358674T1 (de) 2007-04-15
CO5690588A2 (es) 2006-10-31
TWI343917B (en) 2011-06-21
SG165998A1 (en) 2010-11-29
US7687518B2 (en) 2010-03-30
CR7877A (es) 2005-11-30
EP1562932A1 (en) 2005-08-17
GEP20084539B (en) 2008-11-25
AP2005003297A0 (en) 2005-06-30
RS51047B (sr) 2010-10-31
EP1562932B9 (en) 2007-09-12
CA2506242C (en) 2011-07-05
CN1711256A (zh) 2005-12-21
MXPA05004669A (es) 2005-06-08

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