MX2017003693A - Anticuerpo capaz de neutralizar una sustancia que tiene actividad alternativa para la funcion del factor de coagulacion viii (fviii). - Google Patents
Anticuerpo capaz de neutralizar una sustancia que tiene actividad alternativa para la funcion del factor de coagulacion viii (fviii).Info
- Publication number
- MX2017003693A MX2017003693A MX2017003693A MX2017003693A MX2017003693A MX 2017003693 A MX2017003693 A MX 2017003693A MX 2017003693 A MX2017003693 A MX 2017003693A MX 2017003693 A MX2017003693 A MX 2017003693A MX 2017003693 A MX2017003693 A MX 2017003693A
- Authority
- MX
- Mexico
- Prior art keywords
- fviii
- activity
- neutralize
- substance
- antibody
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/36—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4208—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
- C07K16/4241—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Cell Biology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Los presentes inventores intentaron producir anticuerpos que neutralizaran la actividad de una sustancia que tiene una actividad para sustituir funcionalmente el FVIII, que resultaran útiles en métodos para medir la reactividad del FVIII en presencia de sustancias que tuvieran una actividad para sustituir funcionalmente el FVIII. Como resultado, los inventores descubrieron que, mediante el uso de anticuerpos que produjeron, es posible medir con precisión la actividad del FVIII en el plasma de un paciente que padece hemofilia A por medio de un ensayo de coagulación de una sola etapa basado en el APTT, y también es posible medir con precisión el titulador del inhibidor del FVIII en el plasma de un paciente que padece hemofilia A y que ha sido sometido a un tratamiento con inhibidores del FVIII por medio de un ensayo de Bethesda basado en el APTT.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2014197207 | 2014-09-26 | ||
| PCT/JP2015/076854 WO2016047656A1 (ja) | 2014-09-26 | 2015-09-24 | 凝固第ｖｉｉｉ因子（ｆｖｉｉｉ）機能代替活性を有する物質を中和する抗体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2017003693A true MX2017003693A (es) | 2017-06-26 |
| MX388728B MX388728B (es) | 2025-03-20 |
Family
ID=55581180
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2017003693A MX388728B (es) | 2014-09-26 | 2015-09-24 | Anticuerpo capaz de neutralizar una sustancia que tiene actividad alternativa para la funcion del factor de coagulacion viii (fviii). |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US11214623B2 (es) |
| EP (1) | EP3199554A4 (es) |
| JP (2) | JP6702877B2 (es) |
| KR (1) | KR102517509B1 (es) |
| CN (1) | CN107108746B (es) |
| AR (1) | AR102092A1 (es) |
| AU (1) | AU2015322662B2 (es) |
| CA (1) | CA2961968C (es) |
| IL (1) | IL251111B (es) |
| MX (1) | MX388728B (es) |
| MY (1) | MY192018A (es) |
| NZ (1) | NZ730611A (es) |
| RU (1) | RU2737145C2 (es) |
| SG (1) | SG11201702259RA (es) |
| TW (1) | TWI700300B (es) |
| WO (1) | WO2016047656A1 (es) |
| ZA (1) | ZA201701844B (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH12016502073B1 (en) | 2010-11-17 | 2024-04-05 | Chugai Pharmaceutical Co Ltd | Multi-specific antigen-binding molecule having alternative function to function of blood coagulation factor viii |
| TWI700300B (zh) | 2014-09-26 | 2020-08-01 | 日商中外製藥股份有限公司 | 中和具有第ｖｉｉｉ凝血因子（ｆｖｉｉｉ）機能替代活性的物質之抗體 |
| TWI701435B (zh) * | 2014-09-26 | 2020-08-11 | 日商中外製藥股份有限公司 | 測定ｆｖｉｉｉ的反應性之方法 |
| MA44780A (fr) | 2016-04-28 | 2019-03-06 | Chugai Pharmaceutical Co Ltd | Préparation contenant un anticorps |
| CN110461358A (zh) * | 2017-03-31 | 2019-11-15 | 公立大学法人奈良县立医科大学 | 可用于预防和/或治疗凝血因子ⅸ异常、包含代替凝血因子ⅷ的功能的多特异性抗原结合分子的药物组合物 |
| GB201709970D0 (en) | 2017-06-22 | 2017-08-09 | Kymab Ltd | Bispecific antigen-binding molecules |
| CN107449925A (zh) * | 2017-09-22 | 2017-12-08 | 郑州大学第附属医院 | 一种用于凝血因子viii抑制物检测的缓冲液以及检测方法 |
| AU2018361430B2 (en) | 2017-11-01 | 2025-08-14 | Chugai Seiyaku Kabushiki Kaisha | Antibody variant and isoform with lowered biological activity |
| JP6761142B1 (ja) * | 2018-08-01 | 2020-09-23 | ノヴォ ノルディスク アー／エス | 改良された血液凝固促進抗体 |
| PL3723858T3 (pl) | 2018-12-21 | 2022-03-07 | Kymab Limited | Przeciwciało dwuswoiste fixaxfx o wspólnym łańcuchu lekkim |
| CA3127450A1 (en) * | 2019-01-22 | 2020-07-30 | Clemson University Research Foundation | Anti-elastin antibodies and methods of use |
| CN115667515A (zh) * | 2020-05-22 | 2023-01-31 | 中外制药株式会社 | 中和具有凝血因子viii(f.viii)功能替代活性的物质的抗体 |
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| MA44780A (fr) | 2016-04-28 | 2019-03-06 | Chugai Pharmaceutical Co Ltd | Préparation contenant un anticorps |
| CN110461358A (zh) | 2017-03-31 | 2019-11-15 | 公立大学法人奈良县立医科大学 | 可用于预防和/或治疗凝血因子ⅸ异常、包含代替凝血因子ⅷ的功能的多特异性抗原结合分子的药物组合物 |
| AU2018361430B2 (en) | 2017-11-01 | 2025-08-14 | Chugai Seiyaku Kabushiki Kaisha | Antibody variant and isoform with lowered biological activity |
-
2015
- 2015-09-23 TW TW104131372A patent/TWI700300B/zh active
- 2015-09-24 MY MYPI2017700979A patent/MY192018A/en unknown
- 2015-09-24 AU AU2015322662A patent/AU2015322662B2/en active Active
- 2015-09-24 CN CN201580059193.0A patent/CN107108746B/zh active Active
- 2015-09-24 MX MX2017003693A patent/MX388728B/es unknown
- 2015-09-24 SG SG11201702259RA patent/SG11201702259RA/en unknown
- 2015-09-24 NZ NZ730611A patent/NZ730611A/en unknown
- 2015-09-24 RU RU2017113732A patent/RU2737145C2/ru active
- 2015-09-24 CA CA2961968A patent/CA2961968C/en active Active
- 2015-09-24 JP JP2016550341A patent/JP6702877B2/ja active Active
- 2015-09-24 US US15/512,094 patent/US11214623B2/en active Active
- 2015-09-24 KR KR1020177011033A patent/KR102517509B1/ko active Active
- 2015-09-24 WO PCT/JP2015/076854 patent/WO2016047656A1/ja not_active Ceased
- 2015-09-24 EP EP15843808.5A patent/EP3199554A4/en active Pending
- 2015-09-25 AR ARP150103098A patent/AR102092A1/es unknown
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2017
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- 2017-03-15 ZA ZA2017/01844A patent/ZA201701844B/en unknown
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2020
- 2020-03-17 JP JP2020045941A patent/JP2020108395A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| RU2017113732A (ru) | 2018-10-23 |
| US20170275376A1 (en) | 2017-09-28 |
| IL251111A0 (en) | 2017-04-30 |
| JPWO2016047656A1 (ja) | 2017-07-13 |
| AR102092A1 (es) | 2017-02-01 |
| CA2961968C (en) | 2023-01-24 |
| TWI700300B (zh) | 2020-08-01 |
| CA2961968A1 (en) | 2016-03-31 |
| CN107108746B (zh) | 2021-06-08 |
| MX388728B (es) | 2025-03-20 |
| NZ730611A (en) | 2021-12-24 |
| JP6702877B2 (ja) | 2020-06-03 |
| ZA201701844B (en) | 2021-10-27 |
| TW201619201A (zh) | 2016-06-01 |
| KR102517509B1 (ko) | 2023-04-04 |
| RU2737145C2 (ru) | 2020-11-25 |
| EP3199554A4 (en) | 2018-07-18 |
| JP2020108395A (ja) | 2020-07-16 |
| SG11201702259RA (en) | 2017-04-27 |
| WO2016047656A1 (ja) | 2016-03-31 |
| BR112017005801A2 (pt) | 2017-12-19 |
| AU2015322662B2 (en) | 2020-12-10 |
| KR20170064539A (ko) | 2017-06-09 |
| AU2015322662A1 (en) | 2017-04-06 |
| MY192018A (en) | 2022-07-22 |
| EP3199554A1 (en) | 2017-08-02 |
| RU2017113732A3 (es) | 2019-01-30 |
| US11214623B2 (en) | 2022-01-04 |
| CN107108746A (zh) | 2017-08-29 |
| IL251111B (en) | 2021-03-25 |
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