MX2020003341A - Compuestos de imidazo-piridina como inhibidores de pad. - Google Patents

Compuestos de imidazo-piridina como inhibidores de pad.

Info

Publication number
MX2020003341A
MX2020003341A MX2020003341A MX2020003341A MX2020003341A MX 2020003341 A MX2020003341 A MX 2020003341A MX 2020003341 A MX2020003341 A MX 2020003341A MX 2020003341 A MX2020003341 A MX 2020003341A MX 2020003341 A MX2020003341 A MX 2020003341A
Authority
MX
Mexico
Prior art keywords
formula
pharmaceutically acceptable
polymorphs
prodrugs
solvates
Prior art date
Application number
MX2020003341A
Other languages
English (en)
Inventor
Gurulingappa Hallur
Athisayamani Jeyaraj Duraiswamy
Buchi Reddy Purra
N V S K Rao
Sridharan Rajagopal
Rajendra Kristam
Original Assignee
Jubilant Epipad LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jubilant Epipad LLC filed Critical Jubilant Epipad LLC
Publication of MX2020003341A publication Critical patent/MX2020003341A/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)

Abstract

En el presente documento se describen compuestos heterocíclicos de fórmula (I), (II) y (III), junto con sus polimorfos, estereoisómeros, profármacos, solvatos, cocristales, intermedios, sales farmacéuticamente aceptables y metabolitos de los mismos. Los compuestos descritos en el presente documento, sus polimorfos, estereoisómeros, profármacos, solvatos, cocristales, intermedios, sales farmacéuticamente aceptables y metabolitos de los mismos son, por lo tanto, inhibidores de PAD4 y pueden ser útiles en el tratamiento de diversos trastornos, por ejemplo, artritis reumatoide, vasculitis, lupus eritematoso sistémico, lupus eritematoso cutáneo, colitis ulcerosa, cáncer, fibrosis quística, asma, esclerosis múltiple y psoriasis. También se describe el proceso de preparación de los compuestos de fórmula (I), (II) y (III), sus polimorfos, estereoisómeros, profármacos, solvatos, cocristales, intermedios, sales farmacéuticamente aceptables y metabolismos de los mismos, junto con una composición farmacéutica que comprende un compuesto de fórmula (I), fórmula (II), fórmula (III) o una sal farmacéuticamente aceptable de los mismos.
MX2020003341A 2017-10-18 2018-10-16 Compuestos de imidazo-piridina como inhibidores de pad. MX2020003341A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN201741037110 2017-10-18
PCT/IN2018/050671 WO2019077631A1 (en) 2017-10-18 2018-10-16 IMIDAZO-PYRIDINE COMPOUNDS FOR USE AS PAD INHIBITORS

Publications (1)

Publication Number Publication Date
MX2020003341A true MX2020003341A (es) 2020-09-17

Family

ID=64051641

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020003341A MX2020003341A (es) 2017-10-18 2018-10-16 Compuestos de imidazo-piridina como inhibidores de pad.

Country Status (20)

Country Link
US (1) US11426412B2 (es)
EP (1) EP3697785B1 (es)
JP (1) JP7307723B2 (es)
KR (1) KR102782563B1 (es)
CN (1) CN111225915B (es)
AU (1) AU2018352142B2 (es)
BR (1) BR112020007607A2 (es)
CA (1) CA3076476A1 (es)
DK (1) DK3697785T3 (es)
ES (1) ES2941512T3 (es)
FI (1) FI3697785T3 (es)
HU (1) HUE061607T2 (es)
IL (1) IL272667B (es)
MX (1) MX2020003341A (es)
PL (1) PL3697785T3 (es)
PT (1) PT3697785T (es)
RS (1) RS64104B1 (es)
SG (1) SG11202003463XA (es)
WO (1) WO2019077631A1 (es)
ZA (1) ZA202002770B (es)

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