MX373746B - Terapia para trastornos neurológicos a base de baclofeno y acamprosato. - Google Patents
Terapia para trastornos neurológicos a base de baclofeno y acamprosato.Info
- Publication number
- MX373746B MX373746B MX2016009146A MX2016009146A MX373746B MX 373746 B MX373746 B MX 373746B MX 2016009146 A MX2016009146 A MX 2016009146A MX 2016009146 A MX2016009146 A MX 2016009146A MX 373746 B MX373746 B MX 373746B
- Authority
- MX
- Mexico
- Prior art keywords
- disease
- baclofen
- neurological disorders
- acamprosate
- alzheimer
- Prior art date
Links
- KPYSYYIEGFHWSV-UHFFFAOYSA-N Baclofen Chemical compound OC(=O)CC(CN)C1=CC=C(Cl)C=C1 KPYSYYIEGFHWSV-UHFFFAOYSA-N 0.000 title abstract 2
- 208000012902 Nervous system disease Diseases 0.000 title abstract 2
- 208000025966 Neurological disease Diseases 0.000 title abstract 2
- 229960000794 baclofen Drugs 0.000 title abstract 2
- 238000002560 therapeutic procedure Methods 0.000 title abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 2
- 208000003130 Alcoholic Neuropathy Diseases 0.000 abstract 1
- 208000007848 Alcoholism Diseases 0.000 abstract 1
- 208000023105 Huntington disease Diseases 0.000 abstract 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- AFCGFAGUEYAMAO-UHFFFAOYSA-N acamprosate Chemical compound CC(=O)NCCCS(O)(=O)=O AFCGFAGUEYAMAO-UHFFFAOYSA-N 0.000 abstract 1
- 229960004047 acamprosate Drugs 0.000 abstract 1
- 201000007930 alcohol dependence Diseases 0.000 abstract 1
- 208000029650 alcohol withdrawal Diseases 0.000 abstract 1
- 208000020701 alcoholic polyneuropathy Diseases 0.000 abstract 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000003492 excitotoxic effect Effects 0.000 abstract 1
- 231100000063 excitotoxicity Toxicity 0.000 abstract 1
- 229930195712 glutamate Natural products 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 201000006417 multiple sclerosis Diseases 0.000 abstract 1
- 208000004296 neuralgia Diseases 0.000 abstract 1
- 208000021722 neuropathic pain Diseases 0.000 abstract 1
- 208000020431 spinal cord injury Diseases 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
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- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
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- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
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- A61K31/145—Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
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- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
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- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
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- A61K31/325—Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61K31/445—Non condensed piperidines, e.g. piperocaine
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Emergency Medicine (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychology (AREA)
- Vascular Medicine (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente invención se refiere a combinaciones y procedimientos para el tratamiento de trastornos neurológicos relacionados con la excitotoxicidad por glutamato y la toxicidad por ß amiloides. Más específicamente, la presente invención se refiere a nuevas terapias de combinación de esclerosis múltiple, enfermedad de Alzheimer, trastorno relacionado con la enfermedad de Alzheimer, esclerosis lateral amiotrófica, enfermedad de Parkinson, enfermedad de Huntington, dolor neuropático, neuropatía alcohólica, alcoholismo o síndrome de abstinencia por alcohol, o lesión de la médula espinal, a base de una combinación de baclofeno y acamprosato.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11305217 | 2011-03-01 | ||
| US201161468658P | 2011-03-29 | 2011-03-29 | |
| US201161493606P | 2011-06-06 | 2011-06-06 | |
| EP11305687 | 2011-06-06 | ||
| PCT/EP2012/053570 WO2012117076A2 (en) | 2011-03-01 | 2012-03-01 | Baclofen and acamprosate based therapy of neurogical disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX373746B true MX373746B (es) | 2020-05-20 |
Family
ID=46758335
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016009146A MX373746B (es) | 2011-03-01 | 2012-03-01 | Terapia para trastornos neurológicos a base de baclofeno y acamprosato. |
| MX2013010043A MX340568B (es) | 2011-03-01 | 2012-03-01 | Terapia para transtornos neurologicos a base de baclofeno y acampros ato. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2013010043A MX340568B (es) | 2011-03-01 | 2012-03-01 | Terapia para transtornos neurologicos a base de baclofeno y acampros ato. |
Country Status (26)
| Country | Link |
|---|---|
| US (7) | US9820978B2 (es) |
| EP (5) | EP3332781A1 (es) |
| JP (2) | JP5987008B2 (es) |
| KR (2) | KR101937782B1 (es) |
| CN (2) | CN103596562B (es) |
| AU (2) | AU2012222351B2 (es) |
| BR (1) | BR112013022112B1 (es) |
| CA (1) | CA2828765C (es) |
| CY (3) | CY1115074T1 (es) |
| DK (3) | DK2727588T3 (es) |
| EA (2) | EA023277B1 (es) |
| ES (5) | ES2698927T3 (es) |
| HR (1) | HRP20140131T1 (es) |
| HU (1) | HUE038653T2 (es) |
| IL (2) | IL228177B (es) |
| LT (2) | LT2796132T (es) |
| MX (2) | MX373746B (es) |
| PL (3) | PL2560631T3 (es) |
| PT (1) | PT2560631E (es) |
| RS (3) | RS53227B (es) |
| SG (2) | SG192968A1 (es) |
| SI (3) | SI2560631T1 (es) |
| SM (3) | SMT201800327T1 (es) |
| TR (1) | TR201809351T4 (es) |
| WO (2) | WO2012117075A2 (es) |
| ZA (1) | ZA201306039B (es) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2065038A1 (en) | 2007-11-30 | 2009-06-03 | Pharnext | New therapeutic approaches for treating Charcot-Marie-Tooth disease |
| EP2135607A1 (en) | 2008-06-18 | 2009-12-23 | Pharnext | Combination of pilocarpin and methimazol for treating Charcot-MarieTooth disease and related disorders |
| US9393241B2 (en) | 2009-06-02 | 2016-07-19 | Pharnext | Compositions for treating CMT and related disorders |
| EP2263665A1 (en) | 2009-06-02 | 2010-12-22 | Pharnext | New compositions for treating CMT and related disorders |
| US9387206B2 (en) | 2009-11-03 | 2016-07-12 | Pharnext | Therapeutic approaches for treating Alzheimer's disease |
| EP2322163A1 (en) | 2009-11-03 | 2011-05-18 | Pharnext | New therapeutics approaches for treating alzheimer disease |
| KR101937782B1 (ko) | 2011-03-01 | 2019-01-11 | 파넥스트 | 바클로펜 및 아캄프로세이트에 기초한 신경 장애의 치료 |
| US10010515B2 (en) | 2011-03-01 | 2018-07-03 | Pharnext | Therapeutic approaches for treating Parkinson's disease |
| EP2705842A1 (en) * | 2012-09-05 | 2014-03-12 | Pharnext | Therapeutic approaches for treating parkinson's disease |
| UA113165C2 (xx) * | 2011-03-01 | 2016-12-26 | Застосування комбінації баклофену і акампросату для лікування неврологічних захворювань та композиція, яка містить баклофен і акампросат | |
| US9241933B2 (en) | 2011-03-01 | 2016-01-26 | Pharnext | Compositions for treating amyotrophic lateral sclerosis |
| US9867837B2 (en) * | 2011-03-01 | 2018-01-16 | Pharnext | Compositions for treating neurological disorders |
| US9248111B2 (en) | 2011-03-01 | 2016-02-02 | Pharnext | Therapeutic approaches for treating parkinson's disease |
| US9931326B2 (en) | 2011-03-29 | 2018-04-03 | Pharnext | Composition comprising torasemide and baclofen for treating neurological disorders |
| GB2501457A (en) | 2012-02-10 | 2013-10-30 | Rational Intellectual Holdings Ltd | Assigning player positions in an online table game |
| AU2013224959B2 (en) * | 2012-03-01 | 2017-12-07 | Pharnext | New compositions for treating amyotrophic lateral sclerosis |
| SMT201700373T1 (it) * | 2012-03-01 | 2017-09-07 | Pharnext | Nuove composizioni per il trattamento della sclerosi laterale amiotrofica |
| NZ704280A (en) * | 2012-07-18 | 2017-06-30 | Pharnext | Baclofen and acamprosate based therapy of macular degeneration disorders |
| EP2705841A1 (en) | 2012-09-05 | 2014-03-12 | Pharnext | Combinations of nootropic agents for treating cognitive dysfunctions |
| GB201300684D0 (en) | 2013-01-15 | 2013-02-27 | Apitope Int Nv | Peptide |
| DK3003268T3 (en) | 2013-06-05 | 2018-11-05 | Pharnext | STABLE ORAL SOLUTIONS FOR COMBINED API |
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