MY102722A - Rebeccamycin analogs - Google Patents

Rebeccamycin analogs

Info

Publication number: MY102722A
Authority: MY; Malaysia
Prior art keywords: rebecamycin; reacting; rebeccamycin; reactive intermediate; analogs
Prior art date: 1986-11-21

Application number

MYPI87003080A

Other languages

English (en)

Inventor

Kaneko Takushi

S Wong Henry

J Utzig Jacob

Original Assignee

Bristol Myers Squibb Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-11-21

Filing date

1987-11-20

Publication date

1992-09-30

1987-11-20 Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co

1992-09-30 Publication of MY102722A publication Critical patent/MY102722A/en

Links

INSACQSBHKIWNS-QZQSLCQPSA-N rebeccamycin Chemical class O[C@@H]1[C@@H](O)[C@H](OC)[C@@H](CO)O[C@H]1N1C2=C3N=C4[C](Cl)C=CC=C4C3=C3C(=O)NC(=O)C3=C2C2=CC=CC(Cl)=C21 INSACQSBHKIWNS-QZQSLCQPSA-N 0.000 title abstract 2
239000012048 reactive intermediate Substances 0.000 abstract 2
ZGCSNRKSJLVANE-UHFFFAOYSA-N Aglycone-Rebeccamycin Natural products N1C2=C3NC4=C(Cl)C=CC=C4C3=C(C(=O)NC3=O)C3=C2C2=C1C(Cl)=CC=C2 ZGCSNRKSJLVANE-UHFFFAOYSA-N 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
QEHOIJJIZXRMAN-UHFFFAOYSA-N Rebeccamycin Natural products OC1C(O)C(OC)C(CO)OC1N1C2=C3NC4=C(Cl)C=CC=C4C3=C3C(=O)NC(=O)C3=C2C2=CC=CC(Cl)=C21 QEHOIJJIZXRMAN-UHFFFAOYSA-N 0.000 abstract 1
238000010171 animal model Methods 0.000 abstract 1
239000002246 antineoplastic agent Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229960005567 rebeccamycin Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/044—Pyrrole radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Compounds Of Unknown Constitution (AREA)
Medicines Containing Plant Substances (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

MYPI87003080A 1986-11-21 1987-11-20 Rebeccamycin analogs MY102722A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/933,428 US4785085A (en)	1986-11-21	1986-11-21	Rebeccamycin analogs

Publications (1)

Publication Number	Publication Date
MY102722A true MY102722A (en)	1992-09-30

Family

ID=25463937

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MYPI87003080A MY102722A (en)	1986-11-21	1987-11-20	Rebeccamycin analogs

Country Status (28)

Country	Link
US (1)	US4785085A (cs)
EP (1)	EP0269025B1 (cs)
JP (1)	JPS63198695A (cs)
KR (1)	KR910000897B1 (cs)
CN (1)	CN1019806B (cs)
AT (1)	ATE84539T1 (cs)
AU (1)	AU614068B2 (cs)
CA (1)	CA1287349C (cs)
CS (1)	CS265248B2 (cs)
CY (1)	CY1701A (cs)
DE (1)	DE3783577T2 (cs)
DK (1)	DK165986C (cs)
EG (1)	EG18409A (cs)
ES (1)	ES2053510T3 (cs)
FI (1)	FI86189C (cs)
GR (1)	GR3006776T3 (cs)
HK (1)	HK49093A (cs)
HU (1)	HU201773B (cs)
IE (1)	IE60595B1 (cs)
IL (1)	IL84515A (cs)
MX (1)	MX9202849A (cs)
MY (1)	MY102722A (cs)
NO (1)	NO167741C (cs)
NZ (1)	NZ222544A (cs)
PT (1)	PT86188B (cs)
SG (1)	SG25193G (cs)
YU (1)	YU46087B (cs)
ZA (1)	ZA878714B (cs)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH07113027B2 (ja) *	1987-12-24	1995-12-06	協和醗酵工業株式会社	Ｋ−２５２誘導体
DE3835842A1 (de) *	1988-10-21	1990-04-26	Goedecke Ag	Indolocarbazol-derivate, verfahren zu deren herstellung und deren verwendung als arzneimittel
US5438050A (en) *	1988-02-06	1995-08-01	Godecke Aktiengesellschaft	Indolocarbazole derivatives, processes for their preparation and compositions containing them
US5015578A (en) *	1989-03-23	1991-05-14	Bristol-Myers Squibb Company	BMY-41950 antitumor antibiotic
IL94274A0 (en) *	1989-05-05	1991-03-10	Goedecke Ag	Maleinimide derivatives,process for the preparation thereof and pharmaceutical compositions containing the same
US5496809A (en) *	1989-05-10	1996-03-05	Bristol-Myers Squibb Co	Stable solutions of rebeccamycin analog
US5344823A (en) *	1990-03-06	1994-09-06	Bristol-Myers Squibb Company	Antitumor antibiotic BMY-41219
US5158938A (en) *	1990-03-06	1992-10-27	Bristol-Myers Squibb Company	Rebeccamycin
IL97233A (en) *	1990-03-06	1995-03-30	Bristol Myers Squibb Co	Rebeccamycin analogs, their production and pharmaceutical compositions containing them
CA2037596C (en) *	1990-03-06	1995-07-18	Kin Sing Lam	Rebeccamycin analog by bromide precursor feeding
ATE158298T1 (de) *	1990-05-11	1997-10-15	Banyu Pharma Co Ltd	Be-13793c-derivat mit antitumorwirkung
US5478813A (en) *	1990-05-11	1995-12-26	Banyu Pharmaceutical Co., Ltd.	Antitumor substance BE-13793C derivatives
US5589365A (en) *	1991-11-29	1996-12-31	Banyu Pharmaceutical Co., Ltd.	Process for producing glycosylated indolopyrrolocarbazole derivatives by culturing certain microorganisms
US5591842A (en) *	1991-11-29	1997-01-07	Banyu Pharmaceutical Co., Ltd.	Indolopyrrolocarbazole derivatives
US5437996A (en) *	1992-11-24	1995-08-01	Banyu Pharmaceutical Co., Ltd.	Microtetraspora strain for preparation of indolopyrrolocarbazole derivatives
NZ245203A (en) *	1991-11-29	1997-07-27	Banyu Pharma Co Ltd	5h-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6h)-dione derivatives substituted in position-13 by a pentose or hexose group; corresponding indolo-furano(anhydride)intermediates
WO1993018766A1 (en) *	1992-03-20	1993-09-30	The Wellcome Foundation Limited	Further indole derivatives with antiviral activity
JP3603322B2 (ja) *	1992-12-14	2004-12-22	萬有製薬株式会社	インドロピロロカルバゾール誘導体の製造法
DE69418978T2 (de) *	1993-12-07	1999-10-28	Eli Lilly And Co., Indianapolis	Synthese von Bisindolylmaleimiden
US5723456A (en) *	1993-12-07	1998-03-03	Eli Lilly & Company	Therapeutic treatment for cardiovascular diseases
CA2137203C (en) *	1993-12-07	2006-11-28	William Francis Heath Jr.	Protein kinase c inhibitors
US5624949A (en) *	1993-12-07	1997-04-29	Eli Lilly And Company	Protein kinase C inhibitors
US5541347A (en) *	1993-12-07	1996-07-30	Eli Lilly And Company	Synthesis of bisindolylmaleimides
US5843935A (en) *	1993-12-07	1998-12-01	Eli Lilly And Company	Protein kinase C inhibitors
ATE456367T1 (de) *	1993-12-23	2010-02-15	Lilly Co Eli	Proteinkinase c inhibitoren
US5545636A (en) *	1993-12-23	1996-08-13	Eli Lilly And Company	Protein kinase C inhibitors
US5804564A (en) *	1994-05-09	1998-09-08	Banyu Pharmaceutical Co., Ltd.	Antitumor indolopyrrolocarbazole derivatives
US5922860A (en) *	1994-05-09	1999-07-13	Banyu Pharmaceutical Co., Ltd.	Antitumor indolopyrrolocarbazole derivatives
WO1995030682A1 (en) *	1994-05-09	1995-11-16	Banyu Pharmaceutical Co., Ltd.	Antitumor indolopyprolocarbazole derivative
DE69531686T2 (de) *	1994-06-13	2004-07-15	Banyu Pharmaceutical Co., Ltd.	Glycosyltransferase kodierendes gen und seine verwendung
US5491242A (en) *	1994-06-22	1996-02-13	Eli Lilly And Company	Protein kinase C inhibitors
US5481003A (en) *	1994-06-22	1996-01-02	Eli Lilly And Company	Protein kinase C inhibitors
ATE172463T1 (de) *	1994-08-04	1998-11-15	Hoffmann La Roche	Pyrrolocarbazol
AU6836696A (en) *	1995-09-05	1997-03-27	Banyu Pharmaceutical Co., Ltd.	Antitumor indolopyrrolocarbazole derivatives
US5919946A (en) *	1996-03-20	1999-07-06	Eli Lilly And Company	Synthesis of indolylmaleimides
US5859261A (en) *	1997-03-20	1999-01-12	Eli Lilly And Company	Synthesis of indolylmaleimides
US6610727B2 (en)	2000-10-06	2003-08-26	Bristol-Myers Squibb Company	Anhydro sugar derivatives of indolocarbazoles
US6677450B2 (en)	2000-10-06	2004-01-13	Bristol-Myers Squibb Company	Topoisomerase inhibitors
US6653290B2 (en) *	2000-10-06	2003-11-25	Bristol-Myers Squibb Company	Tumor proliferation inhibitors
EE200300456A (et)	2001-03-22	2004-02-16	Bristol-Myers Squibb Company	Indolopürrolokarbasoolide topoisomeraas I selektiivsed tsütotoksilised suhkruderivaadid ning nende kasutamine
EP2147679B1 (en)	2001-07-25	2014-06-25	Raptor Pharmaceutical, Inc.	Compositions for blood-brain barrier transport
CA2393720C (en) *	2002-07-12	2010-09-14	Eli Lilly And Company	Crystalline 2,5-dione-3-(1-methyl-1h-indol-3-yl)-4-[1-(pyridin-2-ylmethyl)piperidin-4-yl]-1h-indol-3-yl]-1h-pyrrole mono-hydrochloride
US20070042975A1 (en) *	2003-09-16	2007-02-22	Koji Yamada	Novel indolopyrrolocarbazole derivative with antitumor activity
EP2392258B1 (en)	2005-04-28	2014-10-08	Proteus Digital Health, Inc.	Pharma-informatics system
CN101594878A (zh)	2006-09-18	2009-12-02	雷普特药品公司	通过给予受体相关蛋白（rap）-缀合物对肝病症的治疗
ES2326459B1 (es)	2008-04-08	2010-05-28	Universidad De Oviedo	Indolocarbazoles glicosilados, su procedimiento de obtencion y sus usos.
PL3395372T3 (pl)	2009-02-20	2022-07-25	EnhanX Biopharm Inc.	Układ do dostarczania leków na bazie glutationu
CN102458374A (zh)	2009-05-06	2012-05-16	实验室护肤股份有限公司	包含活性剂-磷酸钙颗粒复合物的皮肤递送组合物及其使用方法
US20120077778A1 (en)	2010-09-29	2012-03-29	Andrea Bourdelais	Ladder-Frame Polyether Conjugates
CN102125578B (zh) *	2010-11-24	2013-03-27	河南师范大学	具有抗癌活性的蝴蝶霉素类似物及合成方法
CN102898489B (zh) *	2010-11-24	2014-04-02	河南师范大学	具有抗癌活性的蝴蝶霉素类似物及合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4487925A (en) *	1983-01-28	1984-12-11	Bristol-Myers Company	Rebeccamycin and process for its preparation
US4552842A (en) *	1983-01-28	1985-11-12	Bristol-Myers Company	Process for producing rebeccamycin
US4524145A (en) *	1984-09-04	1985-06-18	Bristol-Myers Company	4'-Deschlororebeccamycin pharmaceutical composition and method of use
JPS62220196A (ja) *	1986-03-20	1987-09-28	Kyowa Hakko Kogyo Co Ltd	新規物質ｕｃｎ―０１

1986
- 1986-11-21 US US06/933,428 patent/US4785085A/en not_active Expired - Lifetime
1987
- 1987-11-12 AU AU81148/87A patent/AU614068B2/en not_active Expired
- 1987-11-13 NZ NZ222544A patent/NZ222544A/en unknown
- 1987-11-17 EG EG656/87A patent/EG18409A/xx active
- 1987-11-17 CS CS878249A patent/CS265248B2/cs not_active IP Right Cessation
- 1987-11-18 FI FI875091A patent/FI86189C/fi not_active IP Right Cessation
- 1987-11-18 IL IL84515A patent/IL84515A/xx not_active IP Right Cessation
- 1987-11-18 YU YU208687A patent/YU46087B/sh unknown
- 1987-11-20 ZA ZA878714A patent/ZA878714B/xx unknown
- 1987-11-20 ES ES87117167T patent/ES2053510T3/es not_active Expired - Lifetime
- 1987-11-20 JP JP62293854A patent/JPS63198695A/ja active Granted
- 1987-11-20 AT AT87117167T patent/ATE84539T1/de not_active IP Right Cessation
- 1987-11-20 DE DE8787117167T patent/DE3783577T2/de not_active Expired - Lifetime
- 1987-11-20 MY MYPI87003080A patent/MY102722A/en unknown
- 1987-11-20 CA CA000552337A patent/CA1287349C/en not_active Expired - Lifetime
- 1987-11-20 PT PT86188A patent/PT86188B/pt unknown
- 1987-11-20 IE IE315287A patent/IE60595B1/en not_active IP Right Cessation
- 1987-11-20 CN CN87107928A patent/CN1019806B/zh not_active Expired
- 1987-11-20 EP EP87117167A patent/EP0269025B1/en not_active Expired - Lifetime
- 1987-11-20 DK DK612987A patent/DK165986C/da not_active IP Right Cessation
- 1987-11-20 HU HU875164A patent/HU201773B/hu unknown
- 1987-11-20 NO NO874857A patent/NO167741C/no not_active IP Right Cessation
- 1987-11-20 KR KR1019870013102A patent/KR910000897B1/ko not_active Expired
1992
- 1992-06-12 MX MX9202849A patent/MX9202849A/es unknown
1993
- 1993-01-14 GR GR920402547T patent/GR3006776T3/el unknown
- 1993-03-06 SG SG251/93A patent/SG25193G/en unknown
- 1993-05-20 HK HK490/93A patent/HK49093A/en not_active IP Right Cessation
1994
- 1994-01-14 CY CY170194A patent/CY1701A/xx unknown

Also Published As

Publication number	Publication date
AU8114887A (en)	1988-05-26
NO167741B (no)	1991-08-26
FI875091A0 (fi)	1987-11-18
DE3783577T2 (de)	1993-05-19
EP0269025A2 (en)	1988-06-01
CN1019806B (zh)	1992-12-30
DK165986C (da)	1993-07-19
IE60595B1 (en)	1994-07-27
NO874857L (no)	1988-05-24
NO167741C (no)	1991-12-04
ES2053510T3 (es)	1994-08-01
FI86189C (fi)	1992-07-27
CY1701A (en)	1994-01-14
GR3006776T3 (cs)	1993-06-30
JPS63198695A (ja)	1988-08-17
DK165986B (da)	1993-02-22
NZ222544A (en)	1990-11-27
CA1287349C (en)	1991-08-06
EP0269025B1 (en)	1993-01-13
FI86189B (fi)	1992-04-15
IE873152L (en)	1988-05-21
ZA878714B (cs)	1988-05-20
EG18409A (en)	1993-02-28
YU46087B (sh)	1992-12-21
AU614068B2 (en)	1991-08-22
HK49093A (en)	1993-05-27
DE3783577D1 (de)	1993-02-25
JPH05400B2 (cs)	1993-01-05
HU201773B (en)	1990-12-28
US4785085A (en)	1988-11-15
FI875091A7 (fi)	1988-05-22
PT86188A (en)	1987-12-01
MX9202849A (es)	1992-06-30
CS824987A2 (en)	1989-01-12
KR880006246A (ko)	1988-07-22
CN87107928A (zh)	1988-08-10
DK612987D0 (da)	1987-11-20
IL84515A (en)	1991-11-21
SG25193G (en)	1993-05-21
PT86188B (pt)	1990-11-07
HUT45543A (en)	1988-07-28
DK612987A (da)	1988-05-22
IL84515A0 (en)	1988-04-29
YU208687A (en)	1988-10-31
EP0269025A3 (en)	1990-08-29
CS265248B2 (en)	1989-10-13
NO874857D0 (no)	1987-11-20
KR910000897B1 (ko)	1991-02-12
ATE84539T1 (de)	1993-01-15

Publication	Publication Date	Title
MY102722A (en)	1992-09-30	Rebeccamycin analogs
PT82736A (en)	1986-07-01	Process for preparing hybrid interferons
CA1262357A (en)	1989-10-17	N-HYDROXYL PROTECTIVE GROUPS AND METHOD FOR THE PREPARATION OF 3-ACYLAMINO-1-HYDROXY-2-AZETIDINONES
ES8701723A1 (es)	1986-12-01	Procedimiento para preparar 2,2,6,6-tetraalquil-4-piperidilaminas
ES459497A1 (es)	1978-04-16	Un metodo para la preparacion industrial de naftalimidas y sus derivados.
ES8706792A1 (es)	1987-07-01	Procedimiento de exaltacion de la fluorescencia de un ion detierra rara
FI890068A0 (fi)	1989-01-06	Menetelmä terapeuttisesti käyttökelpoisten 1,2-bis(aminometyyli)syklobutaani-platinakompleksien valmistamiseksi
ES461644A1 (es)	1978-06-16	Un procedimiento para preparar nuevos derivados de bencimi- dazol.
ES8604258A1 (es)	1986-01-16	Un procedimiento para preparar una adenosina sustituida en n6
DE3564571D1 (en)	1988-09-29	Process for preparing (hydrocarbylthio)cyclic amines
HUT61202A (en)	1992-12-28	Process for producing pharmaceutical compositions neutralizing procoagulant activity caused by tumour cells
PT78019B (en)	1986-06-18	Process for preparing rebeccamycin and of pharmaceutical compositions containing the same
EP0193903A3 (en)	1988-01-07	Production of cytosine nucleosides
EP0714900A3 (de)	1996-07-31	Alkylhydrogenchlorsilane, Verfahren zu deren Herstellung und deren Verwendung
UA8017A1 (uk)	1995-12-26	Спосіб отримання похідних хінолінкарбонової кислоти
ZA853197B (en)	1986-01-29	N-substituted neuraminic acid derivatives and process for preparation thereof
UA8020A1 (uk)	1995-12-26	Спосіб отримання 2,4-діхлор-5-фторбензойної кислоти
SE8504657D0 (sv)	1985-10-08	Nya 5-fluor-2'-deoxiuridinderivat och slater derav, forfarande for deras framstellning och antitumormedel innehallande dessa
DE3767728D1 (en)	1991-03-07	Hydroxylierte 1,2-diamincyclohexan platinkomplexe.
ES8607313A1 (es)	1986-05-16	Un metodo de preparar espiro-(benzofuran-azalcanos)
EP0099081A3 (en)	1984-08-29	6-substituted tetrahydroimidazo(2,1-a)-phthalazines
FR2402648A1 (fr)	1979-04-06	Procede de preparation de bromure de trimethylsulfoxonium
ES2000677A6 (es)	1988-03-16	Procedimiento para la obtencion de superficies permanentemente antiestaticas
DE3564568D1 (en)	1988-09-29	Pentaerythritol derivatives and a process for preparing the same
ES8305314A1 (es)	1983-04-01	"procedimiento para la fabricacion de derivados de la nitrosourea".