MY102722A - Rebeccamycin analogs - Google Patents

Rebeccamycin analogs

Info

Publication number: MY102722A
Authority: MY; Malaysia
Prior art keywords: rebecamycin; reacting; rebeccamycin; reactive intermediate; analogs
Prior art date: 1986-11-21

Application number

MYPI87003080A

Other languages

English (en)

Inventor

Kaneko Takushi

S Wong Henry

J Utzig Jacob

Original Assignee

Bristol Myers Squibb Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-11-21

Filing date

1987-11-20

Publication date

1992-09-30

1987-11-20 Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co

1992-09-30 Publication of MY102722A publication Critical patent/MY102722A/en

Links

INSACQSBHKIWNS-QZQSLCQPSA-N rebeccamycin Chemical class O[C@@H]1[C@@H](O)[C@H](OC)[C@@H](CO)O[C@H]1N1C2=C3N=C4[C](Cl)C=CC=C4C3=C3C(=O)NC(=O)C3=C2C2=CC=CC(Cl)=C21 INSACQSBHKIWNS-QZQSLCQPSA-N 0.000 title abstract 2
239000012048 reactive intermediate Substances 0.000 abstract 2
ZGCSNRKSJLVANE-UHFFFAOYSA-N Aglycone-Rebeccamycin Natural products N1C2=C3NC4=C(Cl)C=CC=C4C3=C(C(=O)NC3=O)C3=C2C2=C1C(Cl)=CC=C2 ZGCSNRKSJLVANE-UHFFFAOYSA-N 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
QEHOIJJIZXRMAN-UHFFFAOYSA-N Rebeccamycin Natural products OC1C(O)C(OC)C(CO)OC1N1C2=C3NC4=C(Cl)C=CC=C4C3=C3C(=O)NC(=O)C3=C2C2=CC=CC(Cl)=C21 QEHOIJJIZXRMAN-UHFFFAOYSA-N 0.000 abstract 1
238000010171 animal model Methods 0.000 abstract 1
239000002246 antineoplastic agent Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229960005567 rebeccamycin Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/044—Pyrrole radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Compounds Of Unknown Constitution (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines Containing Plant Substances (AREA)

MYPI87003080A 1986-11-21 1987-11-20 Rebeccamycin analogs MY102722A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/933,428 US4785085A (en)	1986-11-21	1986-11-21	Rebeccamycin analogs

Publications (1)

Publication Number	Publication Date
MY102722A true MY102722A (en)	1992-09-30

Family

ID=25463937

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MYPI87003080A MY102722A (en)	1986-11-21	1987-11-20	Rebeccamycin analogs

Country Status (28)

Country	Link
US (1)	US4785085A (cs)
EP (1)	EP0269025B1 (cs)
JP (1)	JPS63198695A (cs)
KR (1)	KR910000897B1 (cs)
CN (1)	CN1019806B (cs)
AT (1)	ATE84539T1 (cs)
AU (1)	AU614068B2 (cs)
CA (1)	CA1287349C (cs)
CS (1)	CS265248B2 (cs)
CY (1)	CY1701A (cs)
DE (1)	DE3783577T2 (cs)
DK (1)	DK165986C (cs)
EG (1)	EG18409A (cs)
ES (1)	ES2053510T3 (cs)
FI (1)	FI86189C (cs)
GR (1)	GR3006776T3 (cs)
HK (1)	HK49093A (cs)
HU (1)	HU201773B (cs)
IE (1)	IE60595B1 (cs)
IL (1)	IL84515A (cs)
MX (1)	MX9202849A (cs)
MY (1)	MY102722A (cs)
NO (1)	NO167741C (cs)
NZ (1)	NZ222544A (cs)
PT (1)	PT86188B (cs)
SG (1)	SG25193G (cs)
YU (1)	YU46087B (cs)
ZA (1)	ZA878714B (cs)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH07113027B2 (ja) *	1987-12-24	1995-12-06	協和醗酵工業株式会社	Ｋ−２５２誘導体
DE3835842A1 (de) *	1988-10-21	1990-04-26	Goedecke Ag	Indolocarbazol-derivate, verfahren zu deren herstellung und deren verwendung als arzneimittel
US5438050A (en) *	1988-02-06	1995-08-01	Godecke Aktiengesellschaft	Indolocarbazole derivatives, processes for their preparation and compositions containing them
US5015578A (en) *	1989-03-23	1991-05-14	Bristol-Myers Squibb Company	BMY-41950 antitumor antibiotic
CA2015996C (en) *	1989-05-05	2001-08-28	Hartmut Osswald	Bis-(1h-indol-3-yl)-maleinimide derivatives and their use as pharmaceuticals
US5496809A (en) *	1989-05-10	1996-03-05	Bristol-Myers Squibb Co	Stable solutions of rebeccamycin analog
IL97233A (en) *	1990-03-06	1995-03-30	Bristol Myers Squibb Co	Rebeccamycin analogs, their production and pharmaceutical compositions containing them
JPH0725787B2 (ja) *	1990-03-06	1995-03-22	ブリストル−マイヤーズスクイブカンパニー	臭化物前駆物質物質供給によるレベカマイシン類似体
US5158938A (en) *	1990-03-06	1992-10-27	Bristol-Myers Squibb Company	Rebeccamycin
US5344823A (en) *	1990-03-06	1994-09-06	Bristol-Myers Squibb Company	Antitumor antibiotic BMY-41219
US5478813A (en) *	1990-05-11	1995-12-26	Banyu Pharmaceutical Co., Ltd.	Antitumor substance BE-13793C derivatives
EP0528030B1 (en) *	1990-05-11	1997-09-17	Banyu Pharmaceutical Co., Ltd.	Antitumor be-13793c derivative
US5589365A (en) *	1991-11-29	1996-12-31	Banyu Pharmaceutical Co., Ltd.	Process for producing glycosylated indolopyrrolocarbazole derivatives by culturing certain microorganisms
US5437996A (en) *	1992-11-24	1995-08-01	Banyu Pharmaceutical Co., Ltd.	Microtetraspora strain for preparation of indolopyrrolocarbazole derivatives
US5591842A (en) *	1991-11-29	1997-01-07	Banyu Pharmaceutical Co., Ltd.	Indolopyrrolocarbazole derivatives
NZ245203A (en) *	1991-11-29	1997-07-27	Banyu Pharma Co Ltd	5h-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6h)-dione derivatives substituted in position-13 by a pentose or hexose group; corresponding indolo-furano(anhydride)intermediates
US5547976A (en) *	1992-03-20	1996-08-20	Burroughs Wellcome Co.	Further indole derivatives with antiviral activity
JP3603322B2 (ja) *	1992-12-14	2004-12-22	萬有製薬株式会社	インドロピロロカルバゾール誘導体の製造法
US5723456A (en) *	1993-12-07	1998-03-03	Eli Lilly & Company	Therapeutic treatment for cardiovascular diseases
PT657458E (pt) *	1993-12-07	2002-02-28	Lilly Co Eli	Inibidores de proteina cinase c
US5541347A (en) *	1993-12-07	1996-07-30	Eli Lilly And Company	Synthesis of bisindolylmaleimides
US5843935A (en) *	1993-12-07	1998-12-01	Eli Lilly And Company	Protein kinase C inhibitors
US5624949A (en) *	1993-12-07	1997-04-29	Eli Lilly And Company	Protein kinase C inhibitors
EP0657411B1 (en) *	1993-12-07	1999-06-09	Eli Lilly And Company	Synthesis of bisindolylmaleimides
US5545636A (en) *	1993-12-23	1996-08-13	Eli Lilly And Company	Protein kinase C inhibitors
CA2179650C (en) *	1993-12-23	2007-10-30	William Francis Heath, Jr.	Bisindolemaleimides and their use as protein kinase c inhibitors
WO1995030682A1 (en) *	1994-05-09	1995-11-16	Banyu Pharmaceutical Co., Ltd.	Antitumor indolopyprolocarbazole derivative
US5922860A (en) *	1994-05-09	1999-07-13	Banyu Pharmaceutical Co., Ltd.	Antitumor indolopyrrolocarbazole derivatives
US5804564A (en) *	1994-05-09	1998-09-08	Banyu Pharmaceutical Co., Ltd.	Antitumor indolopyrrolocarbazole derivatives
DE69531686T2 (de) *	1994-06-13	2004-07-15	Banyu Pharmaceutical Co., Ltd.	Glycosyltransferase kodierendes gen und seine verwendung
US5481003A (en) *	1994-06-22	1996-01-02	Eli Lilly And Company	Protein kinase C inhibitors
US5491242A (en) *	1994-06-22	1996-02-13	Eli Lilly And Company	Protein kinase C inhibitors
EP0695755B1 (en) *	1994-08-04	1998-10-21	F. Hoffmann-La Roche AG	Pyrrolocarbazole
WO1997009339A1 (fr) *	1995-09-05	1997-03-13	Banyu Pharmaceutical Co., Ltd.	Derives antitumoraux d'indolopyrrolocarbazole
US5919946A (en) *	1996-03-20	1999-07-06	Eli Lilly And Company	Synthesis of indolylmaleimides
US5859261A (en) *	1997-03-20	1999-01-12	Eli Lilly And Company	Synthesis of indolylmaleimides
US6610727B2 (en)	2000-10-06	2003-08-26	Bristol-Myers Squibb Company	Anhydro sugar derivatives of indolocarbazoles
US6653290B2 (en)	2000-10-06	2003-11-25	Bristol-Myers Squibb Company	Tumor proliferation inhibitors
US6677450B2 (en)	2000-10-06	2004-01-13	Bristol-Myers Squibb Company	Topoisomerase inhibitors
RU2003131269A (ru)	2001-03-22	2005-05-10	Бристол-Маерс Сквибб Компани (Us)	Производные индолопирролокарбазолов и сахаров, цитотоксические и селективные по отношению к топоизомеразе i
AU2002322720B2 (en)	2001-07-25	2008-11-13	Raptor Pharmaceutical Inc.	Compositions and methods for modulating blood-brain barrier transport
CA2393720C (en) *	2002-07-12	2010-09-14	Eli Lilly And Company	Crystalline 2,5-dione-3-(1-methyl-1h-indol-3-yl)-4-[1-(pyridin-2-ylmethyl)piperidin-4-yl]-1h-indol-3-yl]-1h-pyrrole mono-hydrochloride
US20070042975A1 (en) *	2003-09-16	2007-02-22	Koji Yamada	Novel indolopyrrolocarbazole derivative with antitumor activity
CA2789262C (en)	2005-04-28	2016-10-04	Proteus Digital Health, Inc.	Pharma-informatics system
EP2063905B1 (en)	2006-09-18	2014-07-30	Raptor Pharmaceutical Inc	Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates
ES2326459B1 (es)	2008-04-08	2010-05-28	Universidad De Oviedo	Indolocarbazoles glicosilados, su procedimiento de obtencion y sus usos.
TR201908314T4 (tr)	2009-02-20	2019-06-21	2 Bbb Medicines B V	Glutatyon bazlı ilaç dağıtım sistemi.
KR101909711B1 (ko)	2009-05-06	2018-12-19	라보라토리 스킨 케어, 인크.	활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법
US20120077778A1 (en)	2010-09-29	2012-03-29	Andrea Bourdelais	Ladder-Frame Polyether Conjugates
CN102125578B (zh) *	2010-11-24	2013-03-27	河南师范大学	具有抗癌活性的蝴蝶霉素类似物及合成方法
CN102898489B (zh) *	2010-11-24	2014-04-02	河南师范大学	具有抗癌活性的蝴蝶霉素类似物及合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4552842A (en) *	1983-01-28	1985-11-12	Bristol-Myers Company	Process for producing rebeccamycin
US4487925A (en) *	1983-01-28	1984-12-11	Bristol-Myers Company	Rebeccamycin and process for its preparation
US4524145A (en) *	1984-09-04	1985-06-18	Bristol-Myers Company	4'-Deschlororebeccamycin pharmaceutical composition and method of use
JPS62220196A (ja) *	1986-03-20	1987-09-28	Kyowa Hakko Kogyo Co Ltd	新規物質ｕｃｎ―０１

1986
- 1986-11-21 US US06/933,428 patent/US4785085A/en not_active Expired - Lifetime
1987
- 1987-11-12 AU AU81148/87A patent/AU614068B2/en not_active Expired
- 1987-11-13 NZ NZ222544A patent/NZ222544A/en unknown
- 1987-11-17 CS CS878249A patent/CS265248B2/cs not_active IP Right Cessation
- 1987-11-17 EG EG656/87A patent/EG18409A/xx active
- 1987-11-18 FI FI875091A patent/FI86189C/fi not_active IP Right Cessation
- 1987-11-18 YU YU208687A patent/YU46087B/sh unknown
- 1987-11-18 IL IL84515A patent/IL84515A/xx not_active IP Right Cessation
- 1987-11-20 MY MYPI87003080A patent/MY102722A/en unknown
- 1987-11-20 ZA ZA878714A patent/ZA878714B/xx unknown
- 1987-11-20 CN CN87107928A patent/CN1019806B/zh not_active Expired
- 1987-11-20 AT AT87117167T patent/ATE84539T1/de not_active IP Right Cessation
- 1987-11-20 DK DK612987A patent/DK165986C/da not_active IP Right Cessation
- 1987-11-20 EP EP87117167A patent/EP0269025B1/en not_active Expired - Lifetime
- 1987-11-20 KR KR1019870013102A patent/KR910000897B1/ko not_active Expired
- 1987-11-20 CA CA000552337A patent/CA1287349C/en not_active Expired - Lifetime
- 1987-11-20 ES ES87117167T patent/ES2053510T3/es not_active Expired - Lifetime
- 1987-11-20 HU HU875164A patent/HU201773B/hu unknown
- 1987-11-20 NO NO874857A patent/NO167741C/no not_active IP Right Cessation
- 1987-11-20 JP JP62293854A patent/JPS63198695A/ja active Granted
- 1987-11-20 PT PT86188A patent/PT86188B/pt unknown
- 1987-11-20 IE IE315287A patent/IE60595B1/en not_active IP Right Cessation
- 1987-11-20 DE DE8787117167T patent/DE3783577T2/de not_active Expired - Lifetime
1992
- 1992-06-12 MX MX9202849A patent/MX9202849A/es unknown
1993
- 1993-01-14 GR GR920402547T patent/GR3006776T3/el unknown
- 1993-03-06 SG SG251/93A patent/SG25193G/en unknown
- 1993-05-20 HK HK490/93A patent/HK49093A/en not_active IP Right Cessation
1994
- 1994-01-14 CY CY170194A patent/CY1701A/xx unknown

Also Published As

Publication number	Publication date
YU208687A (en)	1988-10-31
AU8114887A (en)	1988-05-26
KR910000897B1 (ko)	1991-02-12
DK612987D0 (da)	1987-11-20
PT86188B (pt)	1990-11-07
FI86189C (fi)	1992-07-27
IE873152L (en)	1988-05-21
CN87107928A (zh)	1988-08-10
ES2053510T3 (es)	1994-08-01
PT86188A (en)	1987-12-01
FI875091A7 (fi)	1988-05-22
YU46087B (sh)	1992-12-21
IL84515A (en)	1991-11-21
CA1287349C (en)	1991-08-06
IE60595B1 (en)	1994-07-27
CS265248B2 (en)	1989-10-13
CY1701A (en)	1994-01-14
SG25193G (en)	1993-05-21
NO167741B (no)	1991-08-26
NO874857L (no)	1988-05-24
EP0269025A2 (en)	1988-06-01
DE3783577D1 (de)	1993-02-25
MX9202849A (es)	1992-06-30
HUT45543A (en)	1988-07-28
JPS63198695A (ja)	1988-08-17
FI86189B (fi)	1992-04-15
NO874857D0 (no)	1987-11-20
ATE84539T1 (de)	1993-01-15
DK165986C (da)	1993-07-19
NO167741C (no)	1991-12-04
EP0269025A3 (en)	1990-08-29
ZA878714B (cs)	1988-05-20
FI875091A0 (fi)	1987-11-18
KR880006246A (ko)	1988-07-22
DK612987A (da)	1988-05-22
AU614068B2 (en)	1991-08-22
HK49093A (en)	1993-05-27
US4785085A (en)	1988-11-15
EG18409A (en)	1993-02-28
DK165986B (da)	1993-02-22
GR3006776T3 (cs)	1993-06-30
HU201773B (en)	1990-12-28
JPH05400B2 (cs)	1993-01-05
NZ222544A (en)	1990-11-27
DE3783577T2 (de)	1993-05-19
EP0269025B1 (en)	1993-01-13
IL84515A0 (en)	1988-04-29
CN1019806B (zh)	1992-12-30
CS824987A2 (en)	1989-01-12

Publication	Publication Date	Title
MY102722A (en)	1992-09-30	Rebeccamycin analogs
PT82736A (en)	1986-07-01	Process for preparing hybrid interferons
CA1262357A (en)	1989-10-17	N-HYDROXYL PROTECTIVE GROUPS AND METHOD FOR THE PREPARATION OF 3-ACYLAMINO-1-HYDROXY-2-AZETIDINONES
ES8701723A1 (es)	1986-12-01	Procedimiento para preparar 2,2,6,6-tetraalquil-4-piperidilaminas
ES8706792A1 (es)	1987-07-01	Procedimiento de exaltacion de la fluorescencia de un ion detierra rara
FI890068A0 (fi)	1989-01-06	Menetelmä terapeuttisesti käyttökelpoisten 1,2-bis(aminometyyli)syklobutaani-platinakompleksien valmistamiseksi
DE3564571D1 (en)	1988-09-29	Process for preparing (hydrocarbylthio)cyclic amines
PT78019A (en)	1984-02-01	Process for preparing rebeccamycin and of pharmaceutical compositions containing the same
EP0193903A3 (en)	1988-01-07	Production of cytosine nucleosides
EP0714900A3 (de)	1996-07-31	Alkylhydrogenchlorsilane, Verfahren zu deren Herstellung und deren Verwendung
UA8017A1 (uk)	1995-12-26	Спосіб отримання похідних хінолінкарбонової кислоти
ZA853197B (en)	1986-01-29	N-substituted neuraminic acid derivatives and process for preparation thereof
UA8020A1 (uk)	1995-12-26	Спосіб отримання 2,4-діхлор-5-фторбензойної кислоти
ES2038665T3 (es)	1993-08-01	Procedimiento de sintesis de penems.
HUT39605A (en)	1986-10-29	Process for producing improved antiinflammation preparation
SE8504657L (sv)	1986-04-10	Nya 5-fluor-2'-deoxiuridinderivat och salter derav, forfarande for deras framstellning och antitumormedel innehallande dessa
DE3767728D1 (en)	1991-03-07	Hydroxylierte 1,2-diamincyclohexan platinkomplexe.
ES8607313A1 (es)	1986-05-16	Un metodo de preparar espiro-(benzofuran-azalcanos)
EP0290169A3 (en)	1990-08-01	Diamineplatinum complexes with phosphonocarboxylate and substituted phosphonocarboxylate ligands as antitumor agents
EP0099081A3 (en)	1984-08-29	6-substituted tetrahydroimidazo(2,1-a)-phthalazines
ES2000677A6 (es)	1988-03-16	Procedimiento para la obtencion de superficies permanentemente antiestaticas
ES2019839A6 (es)	1991-07-01	Procedimiento de obtencion de derivados polifosforilados de galactosa con actividad insulinica.
DE3564568D1 (en)	1988-09-29	Pentaerythritol derivatives and a process for preparing the same
ES8305314A1 (es)	1983-04-01	"procedimiento para la fabricacion de derivados de la nitrosourea".
GB1329369A (en)	1973-09-05	Process for preparing 4-aminopyrimidine derivatives