IL84515A - Rebeccamycin analogs,their production and pharmaceutical compositions containing them - Google Patents

Rebeccamycin analogs,their production and pharmaceutical compositions containing them

Info

Publication number: IL84515A
Authority: IL; Israel
Prior art keywords: alkyl; rebeccamycin; alkoxycarbonyl; carboxyl; mono
Prior art date: 1986-11-21

Application number

IL84515A

Other languages

English (en)

Other versions

IL84515A0 (en

Original Assignee

Bristol Myers Squibb Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-11-21

Filing date

1987-11-18

Publication date

1991-11-21

1987-11-18 Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co

1988-04-29 Publication of IL84515A0 publication Critical patent/IL84515A0/xx

1991-11-21 Publication of IL84515A publication Critical patent/IL84515A/xx

Links

INSACQSBHKIWNS-QZQSLCQPSA-N rebeccamycin Chemical class O[C@@H]1[C@@H](O)[C@H](OC)[C@@H](CO)O[C@H]1N1C2=C3N=C4[C](Cl)C=CC=C4C3=C3C(=O)NC(=O)C3=C2C2=CC=CC(Cl)=C21 INSACQSBHKIWNS-QZQSLCQPSA-N 0.000 title abstract 4
239000008194 pharmaceutical composition Substances 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 4
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
125000003545 alkoxy group Chemical group 0.000 abstract 3
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 3
125000003118 aryl group Chemical group 0.000 abstract 3
-1 nitro, carboxyl Chemical group 0.000 abstract 3
125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 2
ZGCSNRKSJLVANE-UHFFFAOYSA-N Aglycone-Rebeccamycin Natural products N1C2=C3NC4=C(Cl)C=CC=C4C3=C(C(=O)NC3=O)C3=C2C2=C1C(Cl)=CC=C2 ZGCSNRKSJLVANE-UHFFFAOYSA-N 0.000 abstract 2
QEHOIJJIZXRMAN-UHFFFAOYSA-N Rebeccamycin Natural products OC1C(O)C(OC)C(CO)OC1N1C2=C3NC4=C(Cl)C=CC=C4C3=C3C(=O)NC(=O)C3=C2C2=CC=CC(Cl)=C21 QEHOIJJIZXRMAN-UHFFFAOYSA-N 0.000 abstract 2
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
125000004663 dialkyl amino group Chemical group 0.000 abstract 2
125000001475 halogen functional group Chemical group 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
125000004356 hydroxy functional group Chemical group O* 0.000 abstract 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
239000012048 reactive intermediate Substances 0.000 abstract 2
229960005567 rebeccamycin Drugs 0.000 abstract 2
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
238000010171 animal model Methods 0.000 abstract 1
230000000118 anti-neoplastic effect Effects 0.000 abstract 1
239000002246 antineoplastic agent Substances 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/044—Pyrrole radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Compounds Of Unknown Constitution (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines Containing Plant Substances (AREA)

IL84515A 1986-11-21 1987-11-18 Rebeccamycin analogs,their production and pharmaceutical compositions containing them IL84515A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/933,428 US4785085A (en)	1986-11-21	1986-11-21	Rebeccamycin analogs

Publications (2)

Publication Number	Publication Date
IL84515A0 IL84515A0 (en)	1988-04-29
IL84515A true IL84515A (en)	1991-11-21

Family

ID=25463937

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL84515A IL84515A (en)	1986-11-21	1987-11-18	Rebeccamycin analogs,their production and pharmaceutical compositions containing them

Country Status (28)

Country	Link
US (1)	US4785085A (cs)
EP (1)	EP0269025B1 (cs)
JP (1)	JPS63198695A (cs)
KR (1)	KR910000897B1 (cs)
CN (1)	CN1019806B (cs)
AT (1)	ATE84539T1 (cs)
AU (1)	AU614068B2 (cs)
CA (1)	CA1287349C (cs)
CS (1)	CS265248B2 (cs)
CY (1)	CY1701A (cs)
DE (1)	DE3783577T2 (cs)
DK (1)	DK165986C (cs)
EG (1)	EG18409A (cs)
ES (1)	ES2053510T3 (cs)
FI (1)	FI86189C (cs)
GR (1)	GR3006776T3 (cs)
HK (1)	HK49093A (cs)
HU (1)	HU201773B (cs)
IE (1)	IE60595B1 (cs)
IL (1)	IL84515A (cs)
MX (1)	MX9202849A (cs)
MY (1)	MY102722A (cs)
NO (1)	NO167741C (cs)
NZ (1)	NZ222544A (cs)
PT (1)	PT86188B (cs)
SG (1)	SG25193G (cs)
YU (1)	YU46087B (cs)
ZA (1)	ZA878714B (cs)

Families Citing this family (51)

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JPH07113027B2 (ja) *	1987-12-24	1995-12-06	協和醗酵工業株式会社	Ｋ−２５２誘導体
US5438050A (en) *	1988-02-06	1995-08-01	Godecke Aktiengesellschaft	Indolocarbazole derivatives, processes for their preparation and compositions containing them
DE3835842A1 (de) *	1988-10-21	1990-04-26	Goedecke Ag	Indolocarbazol-derivate, verfahren zu deren herstellung und deren verwendung als arzneimittel
US5015578A (en) *	1989-03-23	1991-05-14	Bristol-Myers Squibb Company	BMY-41950 antitumor antibiotic
IL94274A0 (en) *	1989-05-05	1991-03-10	Goedecke Ag	Maleinimide derivatives,process for the preparation thereof and pharmaceutical compositions containing the same
US5496809A (en) *	1989-05-10	1996-03-05	Bristol-Myers Squibb Co	Stable solutions of rebeccamycin analog
IL97233A (en) *	1990-03-06	1995-03-30	Bristol Myers Squibb Co	Rebeccamycin analogs, their production and pharmaceutical compositions containing them
JPH0725787B2 (ja) *	1990-03-06	1995-03-22	ブリストル−マイヤーズスクイブカンパニー	臭化物前駆物質物質供給によるレベカマイシン類似体
US5344823A (en) *	1990-03-06	1994-09-06	Bristol-Myers Squibb Company	Antitumor antibiotic BMY-41219
US5158938A (en) *	1990-03-06	1992-10-27	Bristol-Myers Squibb Company	Rebeccamycin
US5478813A (en) *	1990-05-11	1995-12-26	Banyu Pharmaceutical Co., Ltd.	Antitumor substance BE-13793C derivatives
EP0528030B1 (en) *	1990-05-11	1997-09-17	Banyu Pharmaceutical Co., Ltd.	Antitumor be-13793c derivative
US5589365A (en) *	1991-11-29	1996-12-31	Banyu Pharmaceutical Co., Ltd.	Process for producing glycosylated indolopyrrolocarbazole derivatives by culturing certain microorganisms
US5437996A (en) *	1992-11-24	1995-08-01	Banyu Pharmaceutical Co., Ltd.	Microtetraspora strain for preparation of indolopyrrolocarbazole derivatives
NZ245203A (en) *	1991-11-29	1997-07-27	Banyu Pharma Co Ltd	5h-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6h)-dione derivatives substituted in position-13 by a pentose or hexose group; corresponding indolo-furano(anhydride)intermediates
US5591842A (en) *	1991-11-29	1997-01-07	Banyu Pharmaceutical Co., Ltd.	Indolopyrrolocarbazole derivatives
CA2130836A1 (en) *	1992-03-20	1993-09-30	Martin J. Slater	Further indole derivatives with antiviral activity
JP3603322B2 (ja) *	1992-12-14	2004-12-22	萬有製薬株式会社	インドロピロロカルバゾール誘導体の製造法
PL182124B1 (pl) *	1993-12-07	2001-11-30	Lilly Co Eli	Nowe zwiazki oraz srodek farmaceutyczny przeznaczony do leczenia powiklan cukrzycowych lub do leczenia nowotworów PL PL PL PL PL PL PL PL
US5843935A (en) *	1993-12-07	1998-12-01	Eli Lilly And Company	Protein kinase C inhibitors
US5624949A (en) *	1993-12-07	1997-04-29	Eli Lilly And Company	Protein kinase C inhibitors
US5723456A (en) *	1993-12-07	1998-03-03	Eli Lilly & Company	Therapeutic treatment for cardiovascular diseases
EP0657411B1 (en) *	1993-12-07	1999-06-09	Eli Lilly And Company	Synthesis of bisindolylmaleimides
US5541347A (en) *	1993-12-07	1996-07-30	Eli Lilly And Company	Synthesis of bisindolylmaleimides
US5545636A (en) *	1993-12-23	1996-08-13	Eli Lilly And Company	Protein kinase C inhibitors
DK0817627T3 (da) *	1993-12-23	2005-06-06	Lilly Co Eli	Inhibitorer af proteinkinase C
US5922860A (en) *	1994-05-09	1999-07-13	Banyu Pharmaceutical Co., Ltd.	Antitumor indolopyrrolocarbazole derivatives
US5804564A (en) *	1994-05-09	1998-09-08	Banyu Pharmaceutical Co., Ltd.	Antitumor indolopyrrolocarbazole derivatives
WO1995030682A1 (en) *	1994-05-09	1995-11-16	Banyu Pharmaceutical Co., Ltd.	Antitumor indolopyprolocarbazole derivative
JP3707075B2 (ja) *	1994-06-13	2005-10-19	萬有製薬株式会社	グリコシルトランスフェラーゼをコードする遺伝子及びその用途
US5491242A (en) *	1994-06-22	1996-02-13	Eli Lilly And Company	Protein kinase C inhibitors
US5481003A (en) *	1994-06-22	1996-01-02	Eli Lilly And Company	Protein kinase C inhibitors
ES2123873T3 (es) *	1994-08-04	1999-01-16	Hoffmann La Roche	Pirrolocarbazol.
AU6836696A (en) *	1995-09-05	1997-03-27	Banyu Pharmaceutical Co., Ltd.	Antitumor indolopyrrolocarbazole derivatives
KR20000064764A (ko) *	1996-03-20	2000-11-06	피터지.스트링거	인돌릴말레이미드의제조방법
US5859261A (en) *	1997-03-20	1999-01-12	Eli Lilly And Company	Synthesis of indolylmaleimides
US6610727B2 (en)	2000-10-06	2003-08-26	Bristol-Myers Squibb Company	Anhydro sugar derivatives of indolocarbazoles
US6677450B2 (en)	2000-10-06	2004-01-13	Bristol-Myers Squibb Company	Topoisomerase inhibitors
US6653290B2 (en) *	2000-10-06	2003-11-25	Bristol-Myers Squibb Company	Tumor proliferation inhibitors
JP2004534006A (ja)	2001-03-22	2004-11-11	ブリストル−マイヤーズ　スクイブ　カンパニー	インドロピロロカルバゾール化合物のトポイソメラーゼｉ選択的細胞毒シュガー誘導体
AU2002322720B2 (en)	2001-07-25	2008-11-13	Raptor Pharmaceutical Inc.	Compositions and methods for modulating blood-brain barrier transport
CA2393720C (en) *	2002-07-12	2010-09-14	Eli Lilly And Company	Crystalline 2,5-dione-3-(1-methyl-1h-indol-3-yl)-4-[1-(pyridin-2-ylmethyl)piperidin-4-yl]-1h-indol-3-yl]-1h-pyrrole mono-hydrochloride
EP1666485A1 (en) *	2003-09-16	2006-06-07	Banyu Pharmaceutical Co., Ltd.	Novel indolopyrrolocarbazole derivative with antitumor activity
CN102379684B (zh)	2005-04-28	2014-11-19	普罗透斯数字保健公司	药物信息系统
KR20090071598A (ko)	2006-09-18	2009-07-01	랩터 파마슈티컬 인코포레이티드	수용체 결합 단백질(ｒａｐ)-접합체 투여에 의한 간 질환의 치료
ES2326459B1 (es)	2008-04-08	2010-05-28	Universidad De Oviedo	Indolocarbazoles glicosilados, su procedimiento de obtencion y sus usos.
EP2398500B1 (en)	2009-02-20	2019-03-13	2-BBB Medicines B.V.	Glutathione-based drug delivery system
ES2942923T3 (es)	2009-05-06	2023-06-07	Laboratory Skin Care Inc	Composiciones de administración dérmica que comprenden complejos de agente activo-partículas de fosfato de calcio y métodos de uso de las mismas
US20120077778A1 (en)	2010-09-29	2012-03-29	Andrea Bourdelais	Ladder-Frame Polyether Conjugates
CN102898489B (zh) *	2010-11-24	2014-04-02	河南师范大学	具有抗癌活性的蝴蝶霉素类似物及合成方法
CN102125578B (zh) *	2010-11-24	2013-03-27	河南师范大学	具有抗癌活性的蝴蝶霉素类似物及合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4487925A (en) *	1983-01-28	1984-12-11	Bristol-Myers Company	Rebeccamycin and process for its preparation
US4552842A (en) *	1983-01-28	1985-11-12	Bristol-Myers Company	Process for producing rebeccamycin
US4524145A (en) *	1984-09-04	1985-06-18	Bristol-Myers Company	4'-Deschlororebeccamycin pharmaceutical composition and method of use
JPS62220196A (ja) *	1986-03-20	1987-09-28	Kyowa Hakko Kogyo Co Ltd	新規物質ｕｃｎ―０１

1986
- 1986-11-21 US US06/933,428 patent/US4785085A/en not_active Expired - Lifetime
1987
- 1987-11-12 AU AU81148/87A patent/AU614068B2/en not_active Expired
- 1987-11-13 NZ NZ222544A patent/NZ222544A/en unknown
- 1987-11-17 CS CS878249A patent/CS265248B2/cs not_active IP Right Cessation
- 1987-11-17 EG EG656/87A patent/EG18409A/xx active
- 1987-11-18 FI FI875091A patent/FI86189C/fi not_active IP Right Cessation
- 1987-11-18 YU YU208687A patent/YU46087B/sh unknown
- 1987-11-18 IL IL84515A patent/IL84515A/xx not_active IP Right Cessation
- 1987-11-20 IE IE315287A patent/IE60595B1/en not_active IP Right Cessation
- 1987-11-20 MY MYPI87003080A patent/MY102722A/en unknown
- 1987-11-20 DE DE8787117167T patent/DE3783577T2/de not_active Expired - Lifetime
- 1987-11-20 DK DK612987A patent/DK165986C/da not_active IP Right Cessation
- 1987-11-20 HU HU875164A patent/HU201773B/hu unknown
- 1987-11-20 PT PT86188A patent/PT86188B/pt unknown
- 1987-11-20 AT AT87117167T patent/ATE84539T1/de not_active IP Right Cessation
- 1987-11-20 JP JP62293854A patent/JPS63198695A/ja active Granted
- 1987-11-20 ES ES87117167T patent/ES2053510T3/es not_active Expired - Lifetime
- 1987-11-20 CN CN87107928A patent/CN1019806B/zh not_active Expired
- 1987-11-20 EP EP87117167A patent/EP0269025B1/en not_active Expired - Lifetime
- 1987-11-20 ZA ZA878714A patent/ZA878714B/xx unknown
- 1987-11-20 NO NO874857A patent/NO167741C/no not_active IP Right Cessation
- 1987-11-20 CA CA000552337A patent/CA1287349C/en not_active Expired - Lifetime
- 1987-11-20 KR KR1019870013102A patent/KR910000897B1/ko not_active Expired
1992
- 1992-06-12 MX MX9202849A patent/MX9202849A/es unknown
1993
- 1993-01-14 GR GR920402547T patent/GR3006776T3/el unknown
- 1993-03-06 SG SG251/93A patent/SG25193G/en unknown
- 1993-05-20 HK HK490/93A patent/HK49093A/en not_active IP Right Cessation
1994
- 1994-01-14 CY CY170194A patent/CY1701A/xx unknown

Also Published As

Publication number	Publication date
DK165986B (da)	1993-02-22
CS824987A2 (en)	1989-01-12
YU46087B (sh)	1992-12-21
CN1019806B (zh)	1992-12-30
CN87107928A (zh)	1988-08-10
AU614068B2 (en)	1991-08-22
JPS63198695A (ja)	1988-08-17
ES2053510T3 (es)	1994-08-01
ZA878714B (cs)	1988-05-20
FI875091A7 (fi)	1988-05-22
FI86189C (fi)	1992-07-27
SG25193G (en)	1993-05-21
MX9202849A (es)	1992-06-30
CY1701A (en)	1994-01-14
EP0269025B1 (en)	1993-01-13
KR910000897B1 (ko)	1991-02-12
FI875091A0 (fi)	1987-11-18
US4785085A (en)	1988-11-15
CS265248B2 (en)	1989-10-13
JPH05400B2 (cs)	1993-01-05
YU208687A (en)	1988-10-31
CA1287349C (en)	1991-08-06
DK612987D0 (da)	1987-11-20
DK165986C (da)	1993-07-19
AU8114887A (en)	1988-05-26
GR3006776T3 (cs)	1993-06-30
ATE84539T1 (de)	1993-01-15
NO874857D0 (no)	1987-11-20
EP0269025A2 (en)	1988-06-01
EG18409A (en)	1993-02-28
NO874857L (no)	1988-05-24
IL84515A0 (en)	1988-04-29
NZ222544A (en)	1990-11-27
PT86188B (pt)	1990-11-07
NO167741C (no)	1991-12-04
DE3783577T2 (de)	1993-05-19
HU201773B (en)	1990-12-28
DK612987A (da)	1988-05-22
HK49093A (en)	1993-05-27
FI86189B (fi)	1992-04-15
IE873152L (en)	1988-05-21
KR880006246A (ko)	1988-07-22
DE3783577D1 (de)	1993-02-25
PT86188A (en)	1987-12-01
MY102722A (en)	1992-09-30
NO167741B (no)	1991-08-26
HUT45543A (en)	1988-07-28
EP0269025A3 (en)	1990-08-29
IE60595B1 (en)	1994-07-27

Legal Events

Date	Code	Title
1998-04-05	KB	Patent renewed
2002-02-10	KB	Patent renewed
2006-02-05	KB	Patent renewed
2008-01-22	EXP	Patent expired

Publication	Publication Date	Title
IL84515A0 (en)	1988-04-29	Rebeccamycin analogs,their production and pharmaceutical compositions containing them
HUT59081A (en)	1992-04-28	Process for producing aryl- and heteroaryl-ethylene derivatives and pharmaceutical compositions containing them
PT83843A (en)	1987-01-01	Process for preparing prodrugs of rapamycin
ES8205771A1 (es)	1982-06-16	Un procedimiento para la obtencion de un derivado acilado sustituido de acido octahidro-1h-indol-2-carboxilico
PH23819A (en)	1989-11-23	Morpholinoethylester of mycophenolic acid and derivatives thereof
IL86080A0 (en)	1988-09-30	Bicyclic compounds,processes for preparation thereof and pharmaceutical composition comprising the same
ES8706610A1 (es)	1987-07-01	Proceso para preparar un derivado de aminoalcohol.
ES8100275A1 (es)	1980-11-01	Un procedimiento para la preparacion de derivados de 5-fluoruracilo
EP0223512A3 (en)	1988-08-31	2-pyridylacetic acid derivative, preparation process thereof and pharmaceutical composition containing the same
FI844184L (fi)	1985-04-26	Isokinolinderivat och foerfarande foer framstaellning daerav.
HUT45059A (en)	1988-05-30	Process for producing abeoergoline derivatives
EP0195374A3 (en)	1987-08-19	N-substituted 3,4-dihydropyrimidine derivatives, process for the production thereof and composition containing same for treating disorders of cardiovascular system
DE3473269D1 (en)	1988-09-15	(bis(substituted methyl)-methyl)-isoquinoline derivatives, process for their preparation and pharmaceutical compositions containing them
HUT57221A (en)	1991-11-28	Process for producing pyrrolo(2,1-b)thiazol derivatives and pahrmaceutical compositions contiaining them as active components
KR910021239A (ko)	1991-12-20	디아민 유도체 및 종양학에서의 그의 용도