NL2000291A1 - 1- (1- (2-ethoxyethyl)-3-ethyl-7- (4-methylpyridin-2-ylamino)-1H- pyrazool[4,3-d]pyrimidine-5-yl)piperidine-4-carbonzuur en zouten daarvan. - Google Patents

1- (1- (2-ethoxyethyl)-3-ethyl-7- (4-methylpyridin-2-ylamino)-1H- pyrazool[4,3-d]pyrimidine-5-yl)piperidine-4-carbonzuur en zouten daarvan.

Info

Publication number: NL2000291A1
Authority: NL; Netherlands
Prior art keywords: methylpyridin; ylamino; ethoxyethyl; pyrimidin; pyrazole
Prior art date: 2005-11-10

Application number

NL2000291A

Other languages

English (en)

Other versions

NL2000291C2 (nl

Inventor

Michael Brent Tollefson

Original Assignee

Pfizer Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-11-10

Filing date

2006-10-27

Publication date

2007-05-11

2006-10-27 Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

2007-05-11 Publication of NL2000291A1 publication Critical patent/NL2000291A1/nl

2009-02-17 Application granted granted Critical

2009-02-17 Publication of NL2000291C2 publication Critical patent/NL2000291C2/nl

Links

-1 2-ethoxyethyl Chemical group 0.000 title 1
SRJOCJYGOFTFLH-UHFFFAOYSA-N isonipecotic acid Chemical compound OC(=O)C1CCNCC1 SRJOCJYGOFTFLH-UHFFFAOYSA-N 0.000 title 1
125000004528 pyrimidin-5-yl group Chemical group N1=CN=CC(=C1)* 0.000 title 1
150000003839 salts Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A61P25/10—Antiepileptics; Anticonvulsants for petit-mal
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A61P25/12—Antiepileptics; Anticonvulsants for grand-mal
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Diabetes (AREA)
Cardiology (AREA)
Endocrinology (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Physical Education & Sports Medicine (AREA)
Reproductive Health (AREA)
Urology & Nephrology (AREA)
Hematology (AREA)
Ophthalmology & Optometry (AREA)
Orthopedic Medicine & Surgery (AREA)
Obesity (AREA)
Dermatology (AREA)
Psychiatry (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)
Vascular Medicine (AREA)
Rheumatology (AREA)
Addiction (AREA)
Psychology (AREA)
Hospice & Palliative Care (AREA)
Emergency Medicine (AREA)

NL2000291A 2005-11-10 2006-10-27 1-(1-(2-ethoxyethyl)-3-ethyl-7-(4-methylpyridin-2-ylamino)-1H- pyrazool(4,3-d)pyrimidine-5-yl)piperidine-4-carbonzuur en zouten daarvan. NL2000291C2 (nl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US73532005P	2005-11-10	2005-11-10
US73532005		2005-11-10

Publications (2)

Publication Number	Publication Date
NL2000291A1 true NL2000291A1 (nl)	2007-05-11
NL2000291C2 NL2000291C2 (nl)	2009-02-17

Family

ID=37685872

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NL2000291A NL2000291C2 (nl)	2005-11-10	2006-10-27	1-(1-(2-ethoxyethyl)-3-ethyl-7-(4-methylpyridin-2-ylamino)-1H- pyrazool(4,3-d)pyrimidine-5-yl)piperidine-4-carbonzuur en zouten daarvan.

Country Status (29)

Country	Link
US (2)	US20090156618A1 (nl)
EP (1)	EP1948661B1 (nl)
JP (1)	JP4208959B1 (nl)
KR (1)	KR101012592B1 (nl)
CN (1)	CN101305007B (nl)
AP (1)	AP2008004437A0 (nl)
AR (1)	AR057885A1 (nl)
AT (1)	ATE435865T1 (nl)
AU (1)	AU2006313486B2 (nl)
BR (1)	BRPI0618284A2 (nl)
CA (1)	CA2629339C (nl)
CR (1)	CR9966A (nl)
DE (1)	DE602006007728D1 (nl)
DK (1)	DK1948661T3 (nl)
DO (1)	DOP2006000248A (nl)
EA (1)	EA200800920A1 (nl)
EC (1)	ECSP088441A (nl)
ES (1)	ES2326919T3 (nl)
IL (1)	IL190456A (nl)
MA (1)	MA29943B1 (nl)
NL (1)	NL2000291C2 (nl)
NO (1)	NO20082593L (nl)
PE (1)	PE20070764A1 (nl)
RS (1)	RS20080197A (nl)
TN (1)	TNSN08209A1 (nl)
TW (1)	TW200738723A (nl)
UY (1)	UY29909A1 (nl)
WO (1)	WO2007054778A1 (nl)
ZA (1)	ZA200803173B (nl)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2011529918A (ja) *	2008-08-01	2011-12-15	バイオクライストファーマシューティカルズ，インコーポレイテッド	Ｊａｋ３阻害剤としてのピペリジン誘導体
WO2010043633A1 (en) *	2008-10-15	2010-04-22	Palau Pharma, S. A.	2h-pyrazolo [4,3-d]pyrimidin-5-amine derivatives as h4 histamine receptor antagonists for the treatment of allergic, immunological and inflammatory diseases
JP2013523809A (ja) *	2010-04-05	2013-06-17	エスケーケミカルズカンパニーリミテッド	Ｐｄｅ５抑制剤を含む皮膚しわ改善用組成物
WO2012118042A1 (ja) *	2011-02-28	2012-09-07	独立行政法人国立循環器病研究センター	悪性腫瘍転移抑制用医薬
AP2013007253A0 (en)	2011-04-21	2013-11-30	Origenis Gmbh	Pyrazolo [4,3-D] pyrimidines useful as kinase inhibitors
WO2014060112A1 (en)	2012-10-19	2014-04-24	Origenis Gmbh	Pyrazolo[4,3-d]pyrimidines as kinase inhibitors
MX2015005004A (es) *	2012-10-23	2015-07-17	Pfizer	Uso de un compuesto de pirazolo[4,3-d]pirimidina tetrasubstituida para tratar la nefropatia diabetica.
TN2017000029A1 (en)	2014-08-12	2018-07-04	Mezzion Pharma Co Ltd	Methods of improving myocardial performance in fontan patients using udenafil compositions
AU2020356193A1 (en)	2019-09-24	2022-05-19	Children's Hospital Of Philadelphia	Methods of improving exercise performance, single ventricular performance, and myocardial performance index (MPI) in single ventricle heart disease, using udenafil compositions

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2002514162A (ja)	1996-07-08	2002-05-14	デュポンファーマシューティカルズカンパニー	Ｘａ因子阻害薬およびトロンビン阻害薬としてのアミジノインドール類、アミジノアゾール類、およびそれらの類似体
RS50011B (sr)	1998-04-20	2008-09-29	Pfizer Inc.,	Derivati piridin-3-karboksilne kiseline i njihova upotreba kao intermedijera
GB9822238D0 (en) *	1998-10-12	1998-12-09	Pfizer Ltd	Process for preparation of pyrazolo[4,3-D]pyrimidin-7-ones and intermediates thereof
BR9915532A (pt)	1998-10-23	2001-08-14	Pfizer	Inibidores de cgmp pde5 de pirazolopirimidinona para tratamento da disfunção sexual
DE19942474A1 (de)	1999-09-06	2001-03-15	Merck Patent Gmbh	Pyrazolo[4,3-d]pyrimidine
AR028385A1 (es)	2000-04-28	2003-05-07	Acadia Pharm Inc	Agonistas muscarinicos
DE10031584A1 (de)	2000-06-29	2002-01-10	Merck Patent Gmbh	5-Aminoalkyl-pyrazolo[4,3-d]pyrimidine
AU2001277621A1 (en)	2000-08-09	2002-03-04	Astrazeneca Ab	Antiangiogenic bicyclic derivatives
ATE478872T1 (de)	2002-03-28	2010-09-15	Ustav Ex Botan Av Cr V V I I O	Pyrazoloä4,3-düpyrimidine, verfahren zu ihrer herstellung und therapeutische anwendung
OA13050A (en) *	2003-04-29	2006-11-10	Pfizer Ltd	5,7-diaminopyrazolo [4,3-D] pyrimidines useful in the treatment of hypertension.
CA2525946C (en)	2003-05-22	2013-01-29	Altana Pharma Ag	Composition comprising a pde4 inhibitor and a pde5 inhibitor
AU2004289303A1 (en)	2003-11-10	2005-05-26	Synta Pharmaceuticals, Corp.	Fused heterocyclic compounds
GB0327323D0 (en) *	2003-11-24	2003-12-31	Pfizer Ltd	Novel pharmaceuticals
GB0327319D0 (en) *	2003-11-24	2003-12-24	Pfizer Ltd	Novel pharmaceuticals
CA2562251C (en) *	2004-04-07	2009-04-28	Pfizer Inc.	Pyrazolo'4,3-d pyrimidines
US7977345B2 (en)	2004-07-02	2011-07-12	Exelixis, Inc.	c-MET modulators and method of use
EP1809632A2 (en) *	2004-10-28	2007-07-25	Pharmacia & Upjohn Company LLC	Pyrazolo[4,3-d]pyrimidine derivatives useful as pde-5 inhibitors

2006
- 2006-10-27 NL NL2000291A patent/NL2000291C2/nl not_active IP Right Cessation
- 2006-10-31 DE DE602006007728T patent/DE602006007728D1/de active Active
- 2006-10-31 DK DK06809195T patent/DK1948661T3/da active
- 2006-10-31 CA CA2629339A patent/CA2629339C/en not_active Expired - Fee Related
- 2006-10-31 EP EP06809195A patent/EP1948661B1/en active Active
- 2006-10-31 KR KR1020087011230A patent/KR101012592B1/ko not_active Expired - Fee Related
- 2006-10-31 AU AU2006313486A patent/AU2006313486B2/en not_active Ceased
- 2006-10-31 AP AP2008004437A patent/AP2008004437A0/xx unknown
- 2006-10-31 EA EA200800920A patent/EA200800920A1/ru unknown
- 2006-10-31 WO PCT/IB2006/003132 patent/WO2007054778A1/en not_active Ceased
- 2006-10-31 AT AT06809195T patent/ATE435865T1/de not_active IP Right Cessation
- 2006-10-31 BR BRPI0618284-4A patent/BRPI0618284A2/pt not_active Application Discontinuation
- 2006-10-31 CN CN2006800416985A patent/CN101305007B/zh not_active Expired - Fee Related
- 2006-10-31 JP JP2008539522A patent/JP4208959B1/ja not_active Expired - Fee Related
- 2006-10-31 RS RSP-2008/0197A patent/RS20080197A/sr unknown
- 2006-10-31 ES ES06809195T patent/ES2326919T3/es active Active
- 2006-11-07 PE PE2006001379A patent/PE20070764A1/es not_active Application Discontinuation
- 2006-11-08 AR ARP060104894A patent/AR057885A1/es unknown
- 2006-11-09 UY UY29909A patent/UY29909A1/es not_active Application Discontinuation
- 2006-11-09 TW TW095141515A patent/TW200738723A/zh unknown
- 2006-11-09 US US11/558,306 patent/US20090156618A1/en not_active Abandoned
- 2006-11-09 DO DO2006P000248A patent/DOP2006000248A/es unknown
2008
- 2008-03-26 IL IL190456A patent/IL190456A/en not_active IP Right Cessation
- 2008-04-10 ZA ZA200803173A patent/ZA200803173B/xx unknown
- 2008-05-08 EC EC2008008441A patent/ECSP088441A/es unknown
- 2008-05-09 CR CR9966A patent/CR9966A/es not_active Application Discontinuation
- 2008-05-09 MA MA30918A patent/MA29943B1/fr unknown
- 2008-05-09 TN TNP2008000209A patent/TNSN08209A1/fr unknown
- 2008-06-10 NO NO20082593A patent/NO20082593L/no not_active Application Discontinuation
2010
- 2010-11-17 US US12/948,387 patent/US8518956B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
RS20080197A (sr)	2009-05-06
NO20082593L (no)	2008-07-22
ES2326919T3 (es)	2009-10-21
CA2629339A1 (en)	2007-05-18
AP2008004437A0 (en)	2008-04-30
UY29909A1 (es)	2007-06-29
CN101305007A (zh)	2008-11-12
TNSN08209A1 (fr)	2009-10-30
HK1120803A1 (en)	2009-04-09
ZA200803173B (en)	2009-01-28
ECSP088441A (es)	2008-06-30
KR101012592B1 (ko)	2011-02-07
EA200800920A1 (ru)	2008-10-30
IL190456A (en)	2012-10-31
IL190456A0 (en)	2008-11-03
EP1948661B1 (en)	2009-07-08
BRPI0618284A2 (pt)	2011-08-23
WO2007054778A1 (en)	2007-05-18
KR20080063830A (ko)	2008-07-07
PE20070764A1 (es)	2007-08-13
US20090156618A1 (en)	2009-06-18
DOP2006000248A (es)	2007-10-15
JP4208959B1 (ja)	2009-01-14
US20110059993A1 (en)	2011-03-10
AU2006313486A1 (en)	2007-05-18
CA2629339C (en)	2010-07-27
AU2006313486B2 (en)	2011-10-27
MA29943B1 (fr)	2008-11-03
DK1948661T3 (da)	2009-09-07
US8518956B2 (en)	2013-08-27
EP1948661A1 (en)	2008-07-30
AR057885A1 (es)	2007-12-26
JP2009519215A (ja)	2009-05-14
NL2000291C2 (nl)	2009-02-17
ATE435865T1 (de)	2009-07-15
DE602006007728D1 (de)	2009-08-20
CN101305007B (zh)	2011-07-20
TW200738723A (en)	2007-10-16
CR9966A (es)	2008-06-16

Legal Events

Date	Code	Title	Description
2007-07-02	AD1A	A request for search or an international type search has been filed
2008-12-01	RD2N	Patents in respect of which a decision has been taken or a report has been made (novelty report)	Effective date: 20081014
2009-04-01	PD2B	A search report has been drawn up
2010-05-26	V1	Lapsed because of non-payment of the annual fee	Effective date: 20100501

Publication	Publication Date	Title
CY2024030I2 (el)	2026-02-25	Παραγωγα πυρρολο[2,3-d]πυριμιδινης ως αναστολεις πρωτεϊνικης κινασης β
AP2332A (en)	2011-12-05	Pyrazole-substituted aminoheteroaryl compounds as protein kinase inhibitors.
NL2000323A1 (nl)	2007-06-21	Pyrimidine-derivaten.
DK2173752T4 (en)	2022-08-01	Salte af janus-kinase-inhibitor (r)-3-(4-(7h-pyrrolo(2,3-d)pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropannitril
WO2009037473A3 (en)	2009-09-11	Nucleobase characterisation
ZA200700084B (en)	2008-02-27	2,4-DI(aminopheyl) pyrimidines AS PKL inhibitors
BRPI0812563A2 (pt)	2015-02-10	Metabólitos do inibidor de janus quinase de (r)-3-(4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il)-3 ciclopentilpropanonitrila
DK1824856T3 (da)	2014-01-27	2,4 (4,6)-pyrimidinderivater
AP2005003383A0 (en)	2005-09-30	Aminoheteroaryl compounds as protein kinase inhibitors.
IL184504A0 (en)	2007-10-31	4-(2,6-dichlorobenzoylamino)-1h-pyrazole-3-carboxylic acid piperidin-4-ylamid acid addition salts as kinase inhibitors
NL1028397A1 (nl)	2005-08-30	Werkwijze voor automatisch bepalen van het sagittale vlak.
NL2000284A1 (nl)	2007-05-07	Pyrazine-derivaten.
GB0607675D0 (en)	2006-05-31	Business Strategy Transaction Router
NL2000291A1 (nl)	2007-05-11	1- (1- (2-ethoxyethyl)-3-ethyl-7- (4-methylpyridin-2-ylamino)-1H- pyrazool[4,3-d]pyrimidine-5-yl)piperidine-4-carbonzuur en zouten daarvan.
AP2008004687A0 (en)	2008-12-31	Insecticidal methods using 4-amino-5-chloro-thieno(2,3-d)-pyrimidine compounds
PL1879909T3 (pl)	2015-03-31	Roztwór albuminy pozbawiony cząsteczek stabilizatora
NL1031705A1 (nl)	2006-11-01	Aminozuurderivaten.
NL1031384A1 (nl)	2006-09-20	Gesubstitueerde aryl-1,4-pyrazinederivaten.
ITTV20050061U1 (it)	2007-06-14	Portaoggetti per mobili.
Ejouamai	2006	Modular elliptic surfaces
Milićević	2005	Milanković u delima i slici
Berglund	2005	Upplåtelseformer i nybyggda flerbostadshus
HK1116786A (en)	2009-01-02	Pyrazolo(1, 5a) pyrimidines as protein kinase inhibitors
Cox et al.	2005	Produktplacering-Ett frö till något mycket större
ES1057575Y (es)	2004-12-16	Mueble perfeccionado.