NL8500855A - Farmaceutische of kosmetische preparaten. - Google Patents

Farmaceutische of kosmetische preparaten. Download PDF

Info

Publication number: NL8500855A
Authority: NL; Netherlands
Prior art keywords: acid; oxo; hydroxy; pharmaceutical; trimethyl
Prior art date: 1984-04-02

Application number

NL8500855A

Other languages

English (en)

Dutch (nl)

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-04-02

Filing date

1985-03-22

Publication date

1985-11-01

1985-03-22 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

1985-11-01 Publication of NL8500855A publication Critical patent/NL8500855A/nl

Links

238000002360 preparation method Methods 0.000 title claims description 9
239000002537 cosmetic Substances 0.000 title claims description 5
239000013543 active substance Substances 0.000 claims description 8
229960005280 isotretinoin Drugs 0.000 claims description 6
239000002775 capsule Substances 0.000 claims description 4
208000002874 Acne Vulgaris Diseases 0.000 claims description 3
206010039792 Seborrhoea Diseases 0.000 claims description 3
206010000496 acne Diseases 0.000 claims description 3
208000008742 seborrheic dermatitis Diseases 0.000 claims description 3
230000001225 therapeutic effect Effects 0.000 claims description 2
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 15
VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 12
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
239000002253 acid Substances 0.000 description 6
239000011541 reaction mixture Substances 0.000 description 5
239000012043 crude product Substances 0.000 description 4
239000000243 solution Substances 0.000 description 4
GGCUJPCCTQNTJF-FAOQNJJDSA-N 4-Oxoisotretinoin Chemical compound OC(=O)/C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)C(=O)CCC1(C)C GGCUJPCCTQNTJF-FAOQNJJDSA-N 0.000 description 3
WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
239000006210 lotion Substances 0.000 description 3
239000000203 mixture Substances 0.000 description 3
239000002453 shampoo Substances 0.000 description 3
-1 (E, E, Z, Z) -3,7-dimethyl-9- (2,6,6-trimethyl-3-oxo-1-cyclohexene -1-yl) -2,4,6,8-nonatetraenoic acid Chemical compound 0.000 description 2
IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Chemical compound OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
150000001875 compounds Chemical class 0.000 description 2
235000002639 sodium chloride Nutrition 0.000 description 2
239000011780 sodium chloride Substances 0.000 description 2
XRNPHZPFAWLRNJ-UHFFFAOYSA-N 2-hydroxy-3-methyl-2h-furan-5-one Chemical compound CC1=CC(=O)OC1O XRNPHZPFAWLRNJ-UHFFFAOYSA-N 0.000 description 1
229920003084 Avicel® PH-102 Polymers 0.000 description 1
YXHKONLOYHBTNS-UHFFFAOYSA-N Diazomethane Chemical compound C=[N+]=[N-] YXHKONLOYHBTNS-UHFFFAOYSA-N 0.000 description 1
108010010803 Gelatin Proteins 0.000 description 1
SHGAZHPCJJPHSC-NUEINMDLSA-N Isotretinoin Chemical class OC(=O)C=C(C)/C=C/C=C(C)C=CC1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-NUEINMDLSA-N 0.000 description 1
239000005913 Maltodextrin Substances 0.000 description 1
229920002774 Maltodextrin Polymers 0.000 description 1
229920000168 Microcrystalline cellulose Polymers 0.000 description 1
239000002202 Polyethylene glycol Substances 0.000 description 1
XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 description 1
RANZORNCENEFNN-UHFFFAOYSA-M [3-methyl-5-(2,6,6-trimethyl-3-oxocyclohexen-1-yl)penta-2,4-dienyl]-triphenylphosphanium bromide Chemical compound [Br-].O=C1C(=C(C(CC1)(C)C)C=CC(=CC[P+](C1=CC=CC=C1)(C1=CC=CC=C1)C1=CC=CC=C1)C)C RANZORNCENEFNN-UHFFFAOYSA-M 0.000 description 1
KXKVLQRXCPHEJC-UHFFFAOYSA-N acetic acid trimethyl ester Natural products COC(C)=O KXKVLQRXCPHEJC-UHFFFAOYSA-N 0.000 description 1
239000004480 active ingredient Substances 0.000 description 1
239000003963 antioxidant agent Substances 0.000 description 1
235000006708 antioxidants Nutrition 0.000 description 1
239000007900 aqueous suspension Substances 0.000 description 1
239000011230 binding agent Substances 0.000 description 1
239000012267 brine Substances 0.000 description 1
238000011097 chromatography purification Methods 0.000 description 1
238000002425 crystallisation Methods 0.000 description 1
230000008025 crystallization Effects 0.000 description 1
150000002148 esters Chemical class 0.000 description 1
239000000945 filler Substances 0.000 description 1
229920000159 gelatin Polymers 0.000 description 1
239000008273 gelatin Substances 0.000 description 1
239000007903 gelatin capsule Substances 0.000 description 1
235000019322 gelatine Nutrition 0.000 description 1
235000011852 gelatine desserts Nutrition 0.000 description 1
239000005457 ice water Substances 0.000 description 1
229940035034 maltodextrin Drugs 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
230000008018 melting Effects 0.000 description 1
238000002844 melting Methods 0.000 description 1
150000004702 methyl esters Chemical class 0.000 description 1
235000019813 microcrystalline cellulose Nutrition 0.000 description 1
239000008108 microcrystalline cellulose Substances 0.000 description 1
229940016286 microcrystalline cellulose Drugs 0.000 description 1
239000002245 particle Substances 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
229940072033 potash Drugs 0.000 description 1
BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Substances [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 1
235000015320 potassium carbonate Nutrition 0.000 description 1
239000000843 powder Substances 0.000 description 1
BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
238000001953 recrystallisation Methods 0.000 description 1
235000010378 sodium ascorbate Nutrition 0.000 description 1
PPASLZSBLFJQEF-RKJRWTFHSA-M sodium ascorbate Substances [Na+].OC[C@@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RKJRWTFHSA-M 0.000 description 1
229960005055 sodium ascorbate Drugs 0.000 description 1
229910000033 sodium borohydride Inorganic materials 0.000 description 1
239000012279 sodium borohydride Substances 0.000 description 1
PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 description 1
HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
239000002904 solvent Substances 0.000 description 1
238000001694 spray drying Methods 0.000 description 1
230000009897 systematic effect Effects 0.000 description 1
230000009885 systemic effect Effects 0.000 description 1
238000011200 topical administration Methods 0.000 description 1
230000000699 topical effect Effects 0.000 description 1
238000005406 washing Methods 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/008—Preparations for oily skin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
- C07C403/20—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by carboxyl groups or halides, anhydrides, or (thio)esters thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/92—Oral administration
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/09—Geometrical isomers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Organic Chemistry (AREA)
Dermatology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Medicinal Chemistry (AREA)
Birds (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Cosmetics (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

NL8500855A 1984-04-02 1985-03-22 Farmaceutische of kosmetische preparaten. NL8500855A (nl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
CH1645/84A CH658387A5 (de)	1984-04-02	1984-04-02	Pharmazeutische praeparate.
CH164584		1984-04-02

Publications (1)

Publication Number	Publication Date
NL8500855A true NL8500855A (nl)	1985-11-01

Family

ID=4215302

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NL8500855A NL8500855A (nl)	1984-04-02	1985-03-22	Farmaceutische of kosmetische preparaten.

Country Status (13)

Country	Link
JP (1)	JPS60218372A (da)
AU (1)	AU575386B2 (da)
BE (1)	BE902055A (da)
CA (1)	CA1243608A (da)
CH (1)	CH658387A5 (da)
DE (1)	DE3509455A1 (da)
DK (1)	DK99085A (da)
FR (1)	FR2565823A1 (da)
GB (1)	GB2156676B (da)
IT (1)	IT1184729B (da)
NL (1)	NL8500855A (da)
SE (1)	SE8501518L (da)
ZA (1)	ZA852279B (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1282326C (en) *	1984-12-14	1991-04-02	Paul J. Jarosz	Pharmaceutical composition containing 13-cis vitamin a acid as the active ingredient
US5955109A (en) *	1985-12-18	1999-09-21	Advanced Polymer Systems, Inc.	Methods and compositions for topical delivery of retinoic acid
US5879716A (en) *	1985-12-18	1999-03-09	Advanced Polymer Systems, Inc.	Methods and compositions for topical delivery of benzoyl peroxide
IL90069A (en) *	1988-04-26	1994-04-12	Us Health	The use of 31 cysts of retinoic acid in the preparation of a drug for the treatment of congenital conjunctivitis
EP0802181B1 (de) *	1996-04-15	1999-12-22	F. Hoffmann-La Roche Ag	Neue Retinoide
TW442459B (en) *	1996-04-15	2001-06-23	Hoffmann La Roche	Retinoid compounds, pharmaceutical composition comprising same and process for the preparation thereof
WO2007065289A2 (en) *	2005-12-09	2007-06-14	Basilea Pharmaceutica Ag	4-oxo-(iso)tretinoin for the topical treatment of severe dermatological disorders

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4169103A (en) *	1978-04-12	1979-09-25	Hoffmann-La Roche Inc.	Nonatetraenoic acid derivatives
DE3177177D1 (de) *	1981-02-17	1990-06-13	Gail S Bazzano	Die verwendung von retinoiden und ihren derivaten zum erhoehen des wachstumsgrades von menschlichen haaren und zum erhoehen des wachstumsgrades des pelzes bei bestimmten pelztieren.

1984
- 1984-04-02 CH CH1645/84A patent/CH658387A5/de not_active IP Right Cessation
1985
- 1985-03-04 DK DK99085A patent/DK99085A/da not_active Application Discontinuation
- 1985-03-08 CA CA000476065A patent/CA1243608A/en not_active Expired
- 1985-03-14 IT IT19907/85A patent/IT1184729B/it active
- 1985-03-15 DE DE19853509455 patent/DE3509455A1/de not_active Withdrawn
- 1985-03-22 NL NL8500855A patent/NL8500855A/nl not_active Application Discontinuation
- 1985-03-26 ZA ZA852279A patent/ZA852279B/xx unknown
- 1985-03-27 SE SE8501518A patent/SE8501518L/xx not_active Application Discontinuation
- 1985-03-29 JP JP60064065A patent/JPS60218372A/ja active Pending
- 1985-03-29 FR FR8504777A patent/FR2565823A1/fr active Pending
- 1985-03-29 BE BE0/214732A patent/BE902055A/fr not_active IP Right Cessation
- 1985-04-01 GB GB08508443A patent/GB2156676B/en not_active Expired
- 1985-04-02 AU AU40836/85A patent/AU575386B2/en not_active Ceased

Also Published As

Publication number	Publication date
GB2156676A (en)	1985-10-16
IT8519907A0 (it)	1985-03-14
JPS60218372A (ja)	1985-11-01
SE8501518L (sv)	1985-10-03
BE902055A (fr)	1985-09-30
DK99085D0 (da)	1985-03-04
FR2565823A1 (fr)	1985-12-20
GB8508443D0 (en)	1985-05-09
DK99085A (da)	1985-10-03
ZA852279B (en)	1985-11-27
CH658387A5 (de)	1986-11-14
CA1243608A (en)	1988-10-25
DE3509455A1 (de)	1985-10-10
IT1184729B (it)	1987-10-28
AU4083685A (en)	1985-10-10
GB2156676B (en)	1987-10-21
AU575386B2 (en)	1988-07-28
SE8501518D0 (sv)	1985-03-27

Legal Events

Date	Code	Title	Description
1990-11-01	BV	The patent application has lapsed

Publication	Publication Date	Title
CN105017187B (zh)	2017-10-24	用于治疗皮肤病症或疾病状态的tofa类似物
US5041639A (en)	1991-08-20	Polysubstituted derivatives of naphtalene, their process of preparation and their application in the cosmetic and pharmaceutical fields
EP0329460B1 (en)	1992-05-20	Stabilised macrolide compositions
JP2603620B2 (ja)	1997-04-23	エイコサトリインアミド−５，８，１１化合物，その製造方法および医薬品組成物
DK163585B (da)	1992-03-16	Retinoidcarboxylsyre-mono- og -disaccharidestere, disse estere til anvendelse som laegemidler, isaer til behandling af neoplasi, acne eller psoriasis, fremgangsmaade til fremstilling deraf, farmaceutiske praeparater indeholdende disse estere samt anvendelse af esterne til fremstilling af et middel til behandling af neoplasi, acne eller psoriasis
GB2156676A (en)	1985-10-16	Pharmaceutical preparations containing vitamin A derivatives
US4352813A (en)	1982-10-05	[(1-Benzyl-1H-indazol-3-yl)oxy] acetic acid salt with L. lysine
KR950013763B1 (ko)	1995-11-15	레티노산 글루쿠로나이드를 포함하는 약제학적 조성물
WO2021244051A1 (zh)	2021-12-09	一种11-o-罗汉果醇肟醚衍生物及其制备方法
US4696941A (en)	1987-09-29	1,8-diacyloxy-10-acylanthrones
US4755530A (en)	1988-07-05	1-hydroxy-8-acyloxy-10-acyl anthrones, process for their preparation and their use in human or veterinary medicines and in cosmetic formulations
JPH02142723A (ja)	1990-05-31	腎障害改善剤
JPH0859685A (ja)	1996-03-05	フェネチルアルコール配糖体誘導体および該誘導体を有効成分とする５−リポキシゲナーゼ阻害剤ならびにアルドースリダクターゼ阻害剤
RU2626954C2 (ru)	2017-08-02	Комплексные соединения германия с аминокислотами и липоевой кислотой
JPH04139179A (ja)	1992-05-13	キサントン類を有効成分とするアルドースリダクターゼ阻害剤
US5041648A (en)	1991-08-20	Phenylhydrazones of β-ionone
CA1127655A (en)	1982-07-13	N-benzoyl-retinylamines, their preparation and pharmaceutical formulations containing these compounds
CN116253771A (zh)	2023-06-13	人参皂苷衍生物及其制备方法与其抗炎应用
EP0802181B1 (de)	1999-12-22	Neue Retinoide
JPH0283389A (ja)	1990-03-23	新規イリドイド化合物
JPH07179342A (ja)	1995-07-18	脳機能改善剤
RU2084450C1 (ru)	1997-07-20	Основания шиффа 2-аминоиндола, проявляющие гепатопротекторную активность
HU210536A9 (en)	1995-04-28	Salts of 2-(2,6-dichloroanilino)-phenylacetic acid, a process for their preparation and their use for pharmaceutical preparations to be applied locally
JPH07179338A (ja)	1995-07-18	脳機能改善剤
JPH0459788A (ja)	1992-02-26	新規フラボン‐ｃ‐配糖体および該フラボン‐ｃ‐配糖体を有効成分とするアルドースリダクターゼ阻害剤