NO161675C - Analogifremgangsm te for fremstilling av terapeutisk aktive benzoyl-pyrrolo(1,2-a) pyrrol-karboksylsyrederivater. - Google Patents

Analogifremgangsm te for fremstilling av terapeutisk aktive benzoyl-pyrrolo(1,2-a) pyrrol-karboksylsyrederivater.

Info

Publication number: NO161675C
Authority: NO; Norway
Prior art keywords: pyrrolo; pyrrol; preparation; carboxylic acid; acid derivatives
Prior art date: 1983-01-17

Application number

NO840145A

Other languages

English (en)

Norwegian (no)

Other versions

NO840145L (no

NO161675B (no

Inventor

Joseph M Muchowski

Stefan H Unger

Original Assignee

Syntex Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-01-17

Filing date

1984-01-16

Publication date

1989-09-13

1984-01-16 Application filed by Syntex Inc filed Critical Syntex Inc

1984-07-18 Publication of NO840145L publication Critical patent/NO840145L/no

1989-06-05 Publication of NO161675B publication Critical patent/NO161675B/no

1989-09-13 Publication of NO161675C publication Critical patent/NO161675C/no

Links

-1 BENZOYL-PYRROLO (1,2-A) PYRROL-CARBOXYLIC ACID DERIVATIVES Chemical class 0.000 title 1
230000001225 therapeutic effect Effects 0.000 title 1
125000005907 alkyl ester group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Chemical group C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 abstract 1
125000001246 bromo group Chemical group Br* 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
125000001309 chloro group Chemical group Cl* 0.000 abstract 1
125000002534 ethynyl group Chemical group [H]C#C* 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
231100000252 nontoxic Toxicity 0.000 abstract 1
230000003000 nontoxic effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 abstract 1
229920002554 vinyl polymer Polymers 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Hematology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrrole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

NO840145A 1983-01-17 1984-01-16 Analogifremgangsm te for fremstilling av terapeutisk aktive benzoyl-pyrrolo(1,2-a) pyrrol-karboksylsyrederivater. NO161675C (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/458,243 US4560699A (en)	1983-01-17	1983-01-17	5-(4-Vinylbenzoyl)-1,2-dihydro-3H-pyrrolo-[1,2-a]-pyrrole-1-carboxylic acids and derivatives thereof and use as analgesics and anti-inflammatories

Publications (3)

Publication Number	Publication Date
NO840145L NO840145L (no)	1984-07-18
NO161675B NO161675B (no)	1989-06-05
NO161675C true NO161675C (no)	1989-09-13

Family

ID=23819967

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO840145A NO161675C (no)	1983-01-17	1984-01-16	Analogifremgangsm te for fremstilling av terapeutisk aktive benzoyl-pyrrolo(1,2-a) pyrrol-karboksylsyrederivater.

Country Status (15)

Country	Link
US (1)	US4560699A (de)
EP (1)	EP0114632B1 (de)
JP (1)	JPS59137483A (de)
KR (1)	KR840007413A (de)
AT (1)	ATE29721T1 (de)
AU (1)	AU558271B2 (de)
CA (1)	CA1229088A (de)
DE (1)	DE3466219D1 (de)
DK (1)	DK18984A (de)
FI (1)	FI78698C (de)
HU (1)	HU190543B (de)
IL (1)	IL70691A (de)
NO (1)	NO161675C (de)
NZ (1)	NZ206839A (de)
ZA (1)	ZA84326B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU198927B (en) *	1987-01-14	1989-12-28	Richter Gedeon Vegyeszet	Process for producing 1-/substituted aminomethyl/-octa-hydroindolo-(2,3-a)quinolizine derivatives, pharmaceutically applicable acid addition salts thereof, as well as pharmaceutical compositions comprising same
US4849526A (en) *	1987-01-14	1989-07-18	Syntex (U.S.A.) Inc.	Process for preparing (±)-2,3-dihydro-1H-pyrrolo[1,2-A]pyrrole-1,7-dicarboxylates
US4874872A (en) *	1987-01-14	1989-10-17	Syntex (U.S.A.) Inc.	Process for preparing (+)-2,3-dihydro-1H-pyrrolo[1,2-A]pyrrole-1,7-dicarboxylates
US4835288A (en) *	1987-01-14	1989-05-30	Syntex Inc.	Process for preparing (+)-2,3-dihydro-1H-pyrrolo[1,2-a]pyrrole-1,7-dicarboxylates
US5260451A (en) *	1989-05-11	1993-11-09	Merckle Gmbh	Substituted pyrrole compounds and use thereof in pharmaceutical compositions
DE4338770A1 (de) *	1993-11-12	1995-05-18	Matthias Dr Lehr	Indol-2-alkansäuren und ihre Derivate als Hemmstoffe der Phospholipase A¶2¶
KR0140134B1 (ko) *	1994-11-16	1998-06-01	강재헌	피롤리진 유도체의 제조방법
ES2449194T3 (es) *	2000-01-19	2014-03-18	Cadila Healthcare Limited	Compuestos que tienen actividades hipolipidémica e hipocolesterolémica, procedimiento para su preparación y composiciones farmacéuticas que los contienen
DE10004157A1 (de)	2000-02-01	2001-08-02	Merckle Gmbh Chem Pharm Fabrik	4-Pyridyl-und 2,4-Pyrimidinyl-substituierte Pyrrolderivate und ihre Anwendung in der Pharmazie

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4089969A (en) *	1976-07-14	1978-05-16	Syntex (U.S.A.) Inc.	5-Aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof
JPS584711B2 (ja) *	1978-08-02	1983-01-27	参天製薬株式会社	ピロリジン誘導体
US4347185A (en) *	1980-10-20	1982-08-31	Syntex (U.S.A.) Inc.	Processes for preparing 5-benzoyl-7-halo-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acids
US4347186A (en) *	1980-10-20	1982-08-31	Syntex (U.S.A.) Inc.	Process for preparing 5-aroyl 1,2-dihydro-3-H pyrrolo[1,2-a]pyrrole-1-carboxylic acids and novel intermediates therein
US4353829A (en) *	1980-11-21	1982-10-12	Syntex (U.S.A.) Inc.	Process for 5-aroylation of 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic esters
US4612325A (en) *	1982-06-08	1986-09-16	Syntex (U.S.A) Inc.	5-Aroyl-6-alkylthio-1,2-dihydro-3H-pyrrolo(1,2-A)pyrrole-1-carboxylic acids and use thereof as analgesics and anti-inflammatories

1983
- 1983-01-17 US US06/458,243 patent/US4560699A/en not_active Expired - Fee Related
1984
- 1984-01-14 JP JP59005500A patent/JPS59137483A/ja active Pending
- 1984-01-16 IL IL70691A patent/IL70691A/xx not_active IP Right Cessation
- 1984-01-16 CA CA000445355A patent/CA1229088A/en not_active Expired
- 1984-01-16 HU HU84151A patent/HU190543B/hu unknown
- 1984-01-16 KR KR1019840000149A patent/KR840007413A/ko not_active Ceased
- 1984-01-16 AU AU23518/84A patent/AU558271B2/en not_active Ceased
- 1984-01-16 DE DE8484100393T patent/DE3466219D1/de not_active Expired
- 1984-01-16 EP EP84100393A patent/EP0114632B1/de not_active Expired
- 1984-01-16 NZ NZ206839A patent/NZ206839A/en unknown
- 1984-01-16 DK DK18984A patent/DK18984A/da not_active Application Discontinuation
- 1984-01-16 ZA ZA84326A patent/ZA84326B/xx unknown
- 1984-01-16 FI FI840153A patent/FI78698C/fi not_active IP Right Cessation
- 1984-01-16 NO NO840145A patent/NO161675C/no unknown
- 1984-01-16 AT AT84100393T patent/ATE29721T1/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
ATE29721T1 (de)	1987-10-15
ZA84326B (en)	1985-09-25
FI78698C (fi)	1989-09-11
IL70691A0 (en)	1984-04-30
US4560699A (en)	1985-12-24
AU2351884A (en)	1984-07-19
FI78698B (fi)	1989-05-31
CA1229088A (en)	1987-11-10
EP0114632A1 (de)	1984-08-01
DE3466219D1 (en)	1987-10-22
NO840145L (no)	1984-07-18
FI840153A0 (fi)	1984-01-16
EP0114632B1 (de)	1987-09-16
HU190543B (en)	1986-09-29
IL70691A (en)	1986-08-31
FI840153L (fi)	1984-07-18
DK18984A (da)	1984-07-18
NZ206839A (en)	1987-09-30
DK18984D0 (da)	1984-01-16
NO161675B (no)	1989-06-05
AU558271B2 (en)	1987-01-22
KR840007413A (ko)	1984-12-07
JPS59137483A (ja)	1984-08-07

Publication	Publication Date	Title
IE780605L (en)	1978-09-30	1, 2-DIHYDRO-3H-PYRROLO [1,2-a] PYRROLES
NO162518C (no)	1990-01-10	Analogifremgangsmaate for fremstilling av nye, terapeutiskaktive 8-klor-1,5-benzothiazepinderivater.
AU557094B2 (en)	1986-12-04	9-(2-(3-indolyl)ethyl)-1-oxa-4,9-diazaspiro(5,5)undecan 3-ones
DE3370332D1 (en)	1987-04-23	6-amino-7-hydroxy-4,5,6,7-tetrahydroimidazo(4,5,1-j,k)(1)benzazepin-2(1h)-one derivatives, their salts, their preparation, their use as medicaments and compositions containing them
NO161675C (no)	1989-09-13	Analogifremgangsm te for fremstilling av terapeutisk aktive benzoyl-pyrrolo(1,2-a) pyrrol-karboksylsyrederivater.
IE780119L (en)	1978-07-20	IMIDAZO(1,2-a) QUINOLINE-2-CARBOXYLIC ACIDS
DE2963371D1 (en)	1982-09-09	Ergoline derivatives, their preparation and therapeutic composition containing them
FI910126A0 (fi)	1991-01-09	Menetelmä farmaseuttisesti käyttökelpoisen 4-(5,6,7,8-tetrahydroimidatso/1,5-a/pyridin-5-yyli)-bentsonitriilin hydrokloridin valmistamiseksi kiteisessä hemihydraattimuodossa
DK605484D0 (da)	1984-12-18	Imidazo-(1,2-a)-pyrimidiner og fremgangsmaade til fremstilling deraf
NO170580C (no)	1992-11-04	Analogifremgangsmaate for fremstilling av terapeutisk aktive piperidinderivater
DE2962503D1 (en)	1982-05-27	Imidazo (1,2-a) imidazoles, their acid addition salts, medicaments containing them and process for their preparation
AU551901B2 (en)	1986-05-15	Substituted thienobenzodiazepinones
IE42992L (en)	1977-01-10	PYRIMIDO [1,2-a] QUINOLINE DERIVATIVES
IE44999L (en)	1977-12-11	Hydrazinopyridazine derivatives.
ES8707489A1 (es)	1987-08-01	Un procedimiento para preparar un derivado de carbaciclina
IE780559L (en)	1978-10-06	Furoyl- and thenoyl-aryloxyalkyl carboxylic acid
NO151587C (no)	1985-05-08	Analogifremgangsmaate for fremstilling av terapeutisk aktive fenylamino-imidazolin-derivater
JPS568385A (en)	1981-01-28	2-allyl-imidazo 1,2-a imidazole derivative
UA6324A1 (uk)	1994-12-29	Спосіб одержання похідних 6-фтор-1, дігідро-4-оксо-7-заміщений піперазінілхінолін-3-карбонової кислоти або їх фармацевтично прийнятних солей