NO173938C - Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrido-pyridazinon-eddiksyrer - Google Patents
Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrido-pyridazinon-eddiksyrerInfo
- Publication number
- NO173938C NO173938C NO902070A NO902070A NO173938C NO 173938 C NO173938 C NO 173938C NO 902070 A NO902070 A NO 902070A NO 902070 A NO902070 A NO 902070A NO 173938 C NO173938 C NO 173938C
- Authority
- NO
- Norway
- Prior art keywords
- compounds
- pyrido
- preparation
- therapeutically active
- acetic acids
- Prior art date
Links
- -1 Pyrido-Pyridazinone Acetic Acids Chemical class 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 235000011054 acetic acid Nutrition 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- 150000007513 acids Chemical class 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 208000002249 Diabetes Complications Diseases 0.000 abstract 1
- 206010012655 Diabetic complications Diseases 0.000 abstract 1
- 239000003288 aldose reductase inhibitor Substances 0.000 abstract 1
- 229940090865 aldose reductase inhibitors used in diabetes Drugs 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 125000004475 heteroaralkyl group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/350,417 US4996204A (en) | 1989-05-11 | 1989-05-11 | Pyrido[2,3-d]pyridazinones as aldose reductase inhibitors |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| NO902070D0 NO902070D0 (no) | 1990-05-10 |
| NO902070L NO902070L (no) | 1990-11-12 |
| NO173938B NO173938B (no) | 1993-11-15 |
| NO173938C true NO173938C (no) | 1994-02-23 |
Family
ID=23376622
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO902070A NO173938C (no) | 1989-05-11 | 1990-05-10 | Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrido-pyridazinon-eddiksyrer |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4996204A (fr) |
| EP (1) | EP0401981B1 (fr) |
| JP (1) | JPH0631235B2 (fr) |
| KR (1) | KR920003559B1 (fr) |
| AT (1) | ATE121743T1 (fr) |
| AU (1) | AU611610B2 (fr) |
| CA (1) | CA2016326C (fr) |
| DE (1) | DE69018876T2 (fr) |
| DK (1) | DK0401981T3 (fr) |
| ES (1) | ES2071016T3 (fr) |
| FI (1) | FI93013C (fr) |
| HU (1) | HU206714B (fr) |
| IE (1) | IE66029B1 (fr) |
| IL (1) | IL94302A (fr) |
| NO (1) | NO173938C (fr) |
| NZ (1) | NZ233599A (fr) |
| PT (1) | PT93984B (fr) |
| ZA (1) | ZA903564B (fr) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4954629A (en) * | 1989-05-11 | 1990-09-04 | Pfizer Inc. | Process and intermediates for the preparation of oxophthalazinyl acetic acids and analogs thereof |
| US5716954A (en) * | 1991-10-09 | 1998-02-10 | Syntex U.S.A. Inc. | Benzopyridazinone and pyridopyridazinone compounds |
| US5728704A (en) * | 1992-09-28 | 1998-03-17 | Pfizer Inc. | Substituted pyridmidines for control of diabetic complications |
| GB9314412D0 (en) * | 1993-07-13 | 1993-08-25 | Rhone Poulenc Agriculture | New compositions of matter |
| US6214991B1 (en) | 1998-03-31 | 2001-04-10 | The Institute For Pharmaceutical Discovery, Inc. | Substituted indolealkanoic acids |
| TNSN99224A1 (fr) | 1998-12-01 | 2005-11-10 | Inst For Pharm Discovery Inc | Methodes de reduction des niveaux de glucose et triglyceride en serum et pour suppression de l'antigenese utilisant les acides la indolealkanoique |
| WO2002043763A2 (fr) * | 2000-11-30 | 2002-06-06 | Pfizer Products Inc. | Combinaison de gaba-agonistes et d'inhibiteurs d'aldose-réductase |
| ATE297902T1 (de) | 2001-02-28 | 2005-07-15 | Pfizer Prod Inc | Sulfonyl-pyridazinon-derivate zur verwendung als aldose-reduktase-inhibitoren |
| EP1491541B1 (fr) | 2001-03-30 | 2007-01-24 | Pfizer Products Inc. | Pyridazinones, inhibiteurs d'aldose reductase. |
| CA2445871A1 (fr) * | 2001-04-30 | 2002-11-07 | Pfizer Products Inc. | Combinaisons d'inhibiteurs d'aldose reductase et inhibiteurs de cyclo-oxygenase 2 |
| AU761191B2 (en) | 2001-05-24 | 2003-05-29 | Pfizer Products Inc. | Therapies for tissue damage resulting from ischemia |
| US7572910B2 (en) * | 2003-02-20 | 2009-08-11 | Pfizer, Inc. | Pyridazinone aldose reductase inhibitors |
| HRP20221430T1 (hr) * | 2010-07-16 | 2023-01-06 | The Trustees Of Columbia University In The City Of New York | Inhibitori aldozoreduktaze i njihova uporaba |
| US8916563B2 (en) * | 2010-07-16 | 2014-12-23 | The Trustees Of Columbia University In The City Of New York | Aldose reductase inhibitors and uses thereof |
| RS61239B1 (sr) | 2016-06-21 | 2021-01-29 | Univ Columbia | Inhibitori aldozne reduktaze i postupci korišćenja |
| IL272246B2 (en) | 2017-07-28 | 2026-01-01 | Applied Therapeutics Inc | History of 2-(4-oxo/thioketone/azo-3-((substituted)benzo[d]thiazol-2-yl)methyl)- 3,4-dihydrothieno[3,4-d]pyridazin-1-yl)acetic acid for use as an aldose reductase inhibitor for the treatment of galactosemia or prevention of galactosemia-related complications |
| CA3132136A1 (fr) | 2019-04-01 | 2020-10-08 | Andrew Wasmuth | Inhibiteurs de l'aldose reductase |
| JP2022531466A (ja) | 2019-05-07 | 2022-07-06 | ユニバーシティ オブ マイアミ | 遺伝性ニューロパチーおよび関連障害の処置および検出 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3821383A (en) * | 1972-07-10 | 1974-06-28 | Ayerst Mckenna & Harrison | Compositions for and a method of treating diabetic complications |
| DE2708187A1 (de) * | 1977-02-25 | 1978-08-31 | Thomae Gmbh Dr K | Neue pyrido-pyridazin-one |
| IE47592B1 (en) * | 1977-12-29 | 1984-05-02 | Ici Ltd | Enzyme inhibitory phthalazin-4-ylacetic acid derivatives, pharmaceutical compositions thereof,and process for their manufacture |
| US4209527A (en) * | 1979-05-16 | 1980-06-24 | Pfizer Inc. | Benzimidazolone derivatives |
| CA1160518A (fr) * | 1979-07-06 | 1984-01-17 | E. I. Du Pont De Nemours And Company | Ustensiles de cuisson a revetement de ptfe |
| DE3684410D1 (de) * | 1985-11-07 | 1992-04-23 | Pfizer | Heterocyclische oxophthalazinylessigsaeure. |
| US4954629A (en) * | 1989-05-11 | 1990-09-04 | Pfizer Inc. | Process and intermediates for the preparation of oxophthalazinyl acetic acids and analogs thereof |
-
1989
- 1989-05-11 US US07/350,417 patent/US4996204A/en not_active Expired - Lifetime
-
1990
- 1990-05-06 IL IL9430290A patent/IL94302A/en not_active IP Right Cessation
- 1990-05-08 NZ NZ233599A patent/NZ233599A/en unknown
- 1990-05-09 PT PT93984A patent/PT93984B/pt not_active IP Right Cessation
- 1990-05-09 CA CA002016326A patent/CA2016326C/fr not_active Expired - Fee Related
- 1990-05-10 KR KR1019900006808A patent/KR920003559B1/ko not_active Expired
- 1990-05-10 ES ES90305015T patent/ES2071016T3/es not_active Expired - Lifetime
- 1990-05-10 EP EP90305015A patent/EP0401981B1/fr not_active Expired - Lifetime
- 1990-05-10 AU AU54905/90A patent/AU611610B2/en not_active Ceased
- 1990-05-10 AT AT90305015T patent/ATE121743T1/de not_active IP Right Cessation
- 1990-05-10 FI FI902335A patent/FI93013C/fi not_active IP Right Cessation
- 1990-05-10 DE DE69018876T patent/DE69018876T2/de not_active Expired - Fee Related
- 1990-05-10 DK DK90305015.1T patent/DK0401981T3/da active
- 1990-05-10 HU HU902996A patent/HU206714B/hu not_active IP Right Cessation
- 1990-05-10 NO NO902070A patent/NO173938C/no unknown
- 1990-05-10 ZA ZA903564A patent/ZA903564B/xx unknown
- 1990-05-11 IE IE170190A patent/IE66029B1/en unknown
- 1990-05-11 JP JP2122832A patent/JPH0631235B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2016326C (fr) | 1995-05-30 |
| DE69018876D1 (de) | 1995-06-01 |
| HU902996D0 (en) | 1990-09-28 |
| EP0401981B1 (fr) | 1995-04-26 |
| AU611610B2 (en) | 1991-06-13 |
| NO902070D0 (no) | 1990-05-10 |
| KR900018092A (ko) | 1990-12-20 |
| ZA903564B (en) | 1992-08-26 |
| HUT54683A (en) | 1991-03-28 |
| JPH035481A (ja) | 1991-01-11 |
| DK0401981T3 (da) | 1995-09-04 |
| NO902070L (no) | 1990-11-12 |
| NZ233599A (en) | 1991-07-26 |
| FI93013B (fi) | 1994-10-31 |
| JPH0631235B2 (ja) | 1994-04-27 |
| IE66029B1 (en) | 1995-11-29 |
| NO173938B (no) | 1993-11-15 |
| ES2071016T3 (es) | 1995-06-16 |
| DE69018876T2 (de) | 1995-08-24 |
| PT93984A (pt) | 1991-01-08 |
| IE901701L (en) | 1990-11-11 |
| EP0401981A1 (fr) | 1990-12-12 |
| IL94302A (en) | 1994-01-25 |
| AU5490590A (en) | 1990-11-15 |
| ATE121743T1 (de) | 1995-05-15 |
| IL94302A0 (en) | 1991-03-10 |
| CA2016326A1 (fr) | 1990-11-11 |
| FI902335A0 (fi) | 1990-05-10 |
| KR920003559B1 (ko) | 1992-05-04 |
| FI93013C (fi) | 1995-02-10 |
| HU206714B (en) | 1992-12-28 |
| US4996204A (en) | 1991-02-26 |
| PT93984B (pt) | 1996-11-29 |
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