ZA903564B - Pyrido-pyridazinone acetic acids for treating chronic diabetic complications - Google Patents

Pyrido-pyridazinone acetic acids for treating chronic diabetic complications

Info

Publication number: ZA903564B
Authority: ZA; South Africa
Prior art keywords: pyrido; compounds; diabetic complications; chronic diabetic; treating chronic
Prior art date: 1989-05-11

Application number

ZA903564A

Other languages

English (en)

Inventor

Banavara Lakshmana Mylari

Lakshmana Mylari Banavara

William James Zembrowski

James Zembrowski William

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-05-11

Filing date

1990-05-10

Publication date

1992-08-26

1990-05-10 Application filed by Pfizer filed Critical Pfizer

1992-08-26 Publication of ZA903564B publication Critical patent/ZA903564B/xx

Links

208000002249 Diabetes Complications Diseases 0.000 title abstract 2
206010012655 Diabetic complications Diseases 0.000 title abstract 2
230000001684 chronic effect Effects 0.000 title abstract 2
QGAQQANQFMOQTQ-UHFFFAOYSA-N acetic acid;2h-pyrido[3,2-c]pyridazin-3-one Chemical class CC(O)=O.N1=CC=CC2=NNC(=O)C=C21 QGAQQANQFMOQTQ-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
-1 6-substituted-5-oxo-6H-pyrido[2,3-d]pyridazine-8-ylacetic acid Chemical class 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 2
150000007513 acids Chemical class 0.000 abstract 2
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
239000003288 aldose reductase inhibitor Substances 0.000 abstract 1
229940090865 aldose reductase inhibitors used in diabetes Drugs 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
150000001768 cations Chemical class 0.000 abstract 1
125000004475 heteroaralkyl group Chemical group 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000007858 starting material Substances 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Obesity (AREA)
Hematology (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Ophthalmology & Optometry (AREA)
Neurosurgery (AREA)
Urology & Nephrology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Saccharide Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

ZA903564A 1989-05-11 1990-05-10 Pyrido-pyridazinone acetic acids for treating chronic diabetic complications ZA903564B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/350,417 US4996204A (en)	1989-05-11	1989-05-11	Pyrido[2,3-d]pyridazinones as aldose reductase inhibitors

Publications (1)

Publication Number	Publication Date
ZA903564B true ZA903564B (en)	1992-08-26

Family

ID=23376622

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA903564A ZA903564B (en)	1989-05-11	1990-05-10	Pyrido-pyridazinone acetic acids for treating chronic diabetic complications

Country Status (18)

Country	Link
US (1)	US4996204A (fr)
EP (1)	EP0401981B1 (fr)
JP (1)	JPH0631235B2 (fr)
KR (1)	KR920003559B1 (fr)
AT (1)	ATE121743T1 (fr)
AU (1)	AU611610B2 (fr)
CA (1)	CA2016326C (fr)
DE (1)	DE69018876T2 (fr)
DK (1)	DK0401981T3 (fr)
ES (1)	ES2071016T3 (fr)
FI (1)	FI93013C (fr)
HU (1)	HU206714B (fr)
IE (1)	IE66029B1 (fr)
IL (1)	IL94302A (fr)
NO (1)	NO173938C (fr)
NZ (1)	NZ233599A (fr)
PT (1)	PT93984B (fr)
ZA (1)	ZA903564B (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4954629A (en) *	1989-05-11	1990-09-04	Pfizer Inc.	Process and intermediates for the preparation of oxophthalazinyl acetic acids and analogs thereof
US5716954A (en) *	1991-10-09	1998-02-10	Syntex U.S.A. Inc.	Benzopyridazinone and pyridopyridazinone compounds
WO1994007867A1 (fr) *	1992-09-28	1994-04-14	Pfizer Inc.	Pyrimidines substituees pour le controle des complications diabetiques
GB9314412D0 (en) *	1993-07-13	1993-08-25	Rhone Poulenc Agriculture	New compositions of matter
AP2000001929A0 (en)	1998-03-31	2000-09-30	Inst For Pharm Discovery Inc	Substituted indolealkanoic acids.
TNSN99224A1 (fr)	1998-12-01	2005-11-10	Inst For Pharm Discovery Inc	Methodes de reduction des niveaux de glucose et triglyceride en serum et pour suppression de l'antigenese utilisant les acides la indolealkanoique
AP2001002359A0 (en) *	2000-11-30	2001-12-31	Pfizer Prod Inc	Combination of gaba agonists and aldose reductase inhibitors.
ES2240657T3 (es)	2001-02-28	2005-10-16	Pfizer Products Inc.	Compuestos de sulfonilpiridazinona utiles como inhibidores de aldosa reductasa.
GEP20053675B (en) *	2001-03-30	2005-11-25	Pfizer Prod Inc	Pyridazinone Aldose Reductase Inhibitors
JP2004528344A (ja) *	2001-04-30	2004-09-16	ファイザー・プロダクツ・インク	アルドースレダクターゼ阻害薬とシクロオキシゲナーゼ−２阻害薬の併用
AU761191B2 (en)	2001-05-24	2003-05-29	Pfizer Products Inc.	Therapies for tissue damage resulting from ischemia
US7572910B2 (en) *	2003-02-20	2009-08-11	Pfizer, Inc.	Pyridazinone aldose reductase inhibitors
US8916563B2 (en)	2010-07-16	2014-12-23	The Trustees Of Columbia University In The City Of New York	Aldose reductase inhibitors and uses thereof
US12653825B2 (en)	2010-07-16	2026-06-16	The Trustees Of Columbia University In The City Of New York	Aldose reductase inhibitors and uses thereof
HUE031506T2 (en) *	2010-07-16	2017-07-28	Univ Columbia	Aldose reductase inhibitors and their use
ES2966094T3 (es)	2016-06-21	2024-04-18	Univ Columbia	Compuestos 4-oxo-3,4-dihidrotieno[3,4-d]piridazina como inhibidores de la aldosa reductasa y métodos de uso de los mismos
IL272246B2 (en)	2017-07-28	2026-01-01	Applied Therapeutics Inc	History of 2-(4-oxo/thioketone/azo-3-((substituted)benzo[d]thiazol-2-yl)methyl)- 3,4-dihydrothieno[3,4-d]pyridazin-1-yl)acetic acid for use as an aldose reductase inhibitor for the treatment of galactosemia or prevention of galactosemia-related complications
CN113840825A (zh)	2019-04-01	2021-12-24	应用治疗公司	醛糖还原酶抑制剂
MX2021013511A (es)	2019-05-07	2022-02-23	Univ Miami	Tratamiento y deteccion de neuropatias heredadas y trastornos asociados.

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3821383A (en) *	1972-07-10	1974-06-28	Ayerst Mckenna & Harrison	Compositions for and a method of treating diabetic complications
DE2708187A1 (de) *	1977-02-25	1978-08-31	Thomae Gmbh Dr K	Neue pyrido-pyridazin-one
IE47592B1 (en) *	1977-12-29	1984-05-02	Ici Ltd	Enzyme inhibitory phthalazin-4-ylacetic acid derivatives, pharmaceutical compositions thereof,and process for their manufacture
US4209527A (en) *	1979-05-16	1980-06-24	Pfizer Inc.	Benzimidazolone derivatives
CA1160518A (fr) *	1979-07-06	1984-01-17	E. I. Du Pont De Nemours And Company	Ustensiles de cuisson a revetement de ptfe
IL80475A (en) *	1985-11-07	1993-01-31	Pfizer	Heterocyclic-substituted 4-oxo (or thio)-3h- phthalazinyl-acetic acid derivatives and pharmaceutical compositions containing them
US4954629A (en) *	1989-05-11	1990-09-04	Pfizer Inc.	Process and intermediates for the preparation of oxophthalazinyl acetic acids and analogs thereof

1989
- 1989-05-11 US US07/350,417 patent/US4996204A/en not_active Expired - Lifetime
1990
- 1990-05-06 IL IL9430290A patent/IL94302A/en not_active IP Right Cessation
- 1990-05-08 NZ NZ233599A patent/NZ233599A/en unknown
- 1990-05-09 CA CA002016326A patent/CA2016326C/fr not_active Expired - Fee Related
- 1990-05-09 PT PT93984A patent/PT93984B/pt not_active IP Right Cessation
- 1990-05-10 ES ES90305015T patent/ES2071016T3/es not_active Expired - Lifetime
- 1990-05-10 ZA ZA903564A patent/ZA903564B/xx unknown
- 1990-05-10 AU AU54905/90A patent/AU611610B2/en not_active Ceased
- 1990-05-10 DK DK90305015.1T patent/DK0401981T3/da active
- 1990-05-10 DE DE69018876T patent/DE69018876T2/de not_active Expired - Fee Related
- 1990-05-10 NO NO902070A patent/NO173938C/no unknown
- 1990-05-10 FI FI902335A patent/FI93013C/fi not_active IP Right Cessation
- 1990-05-10 EP EP90305015A patent/EP0401981B1/fr not_active Expired - Lifetime
- 1990-05-10 HU HU902996A patent/HU206714B/hu not_active IP Right Cessation
- 1990-05-10 KR KR1019900006808A patent/KR920003559B1/ko not_active Expired
- 1990-05-10 AT AT90305015T patent/ATE121743T1/de not_active IP Right Cessation
- 1990-05-11 IE IE170190A patent/IE66029B1/en unknown
- 1990-05-11 JP JP2122832A patent/JPH0631235B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE69018876D1 (de)	1995-06-01
EP0401981A1 (fr)	1990-12-12
FI902335A0 (fi)	1990-05-10
NO902070D0 (no)	1990-05-10
KR920003559B1 (ko)	1992-05-04
IE901701L (en)	1990-11-11
AU611610B2 (en)	1991-06-13
ES2071016T3 (es)	1995-06-16
JPH0631235B2 (ja)	1994-04-27
PT93984B (pt)	1996-11-29
NO902070L (no)	1990-11-12
IL94302A (en)	1994-01-25
HU206714B (en)	1992-12-28
CA2016326A1 (fr)	1990-11-11
HUT54683A (en)	1991-03-28
US4996204A (en)	1991-02-26
EP0401981B1 (fr)	1995-04-26
HU902996D0 (en)	1990-09-28
IL94302A0 (en)	1991-03-10
DK0401981T3 (da)	1995-09-04
FI93013B (fi)	1994-10-31
ATE121743T1 (de)	1995-05-15
CA2016326C (fr)	1995-05-30
NZ233599A (en)	1991-07-26
NO173938C (no)	1994-02-23
DE69018876T2 (de)	1995-08-24
AU5490590A (en)	1990-11-15
NO173938B (no)	1993-11-15
FI93013C (fi)	1995-02-10
PT93984A (pt)	1991-01-08
KR900018092A (ko)	1990-12-20
JPH035481A (ja)	1991-01-11
IE66029B1 (en)	1995-11-29

Publication	Publication Date	Title
CA2016326A1 (fr)	1990-11-11	Acides pyrido-pyridazinone acetiques pour traiter les complications chroniques du diabete
IE871843L (en)	1988-01-10	Indolinone derivatives.
AU6307590A (en)	1991-04-11	Biphenylmethane derivative and pharmacological use
EP0905255A3 (fr)	1999-04-14	Procédé de préparation de composés de thiazolidine ou d'oxazolidine pharmaceutiquement actifs au moyen d'une reductase
DE3071230D1 (en)	1985-12-19	Substituted 6-phenethyl-and phenylethenyl-3,4,5,6-tetrahydro-4-hydroxytetraydropyran-2-ones in the4-r trans stereoisomeric forms and the corresponding dihydroxy acids, process for preparing and pharmaceutical composition comprising them
PT72120A (en)	1980-12-01	Process for preparing 6-(1-hydroxyethyl)-2-(2-aminoethylthio)-1,1-disubstituted-1-carbadethiapen-2-em-3-carboxylic acids
IE801005L (en)	1980-11-16	Benzimidazolones.
HUT62855A (en)	1993-06-28	Process for producing glycerol derivatives and pharmaceutical compositions comprising same
EG18597A (en)	1993-08-30	Process for the production of phthalazineacetic acid ester derivatives and a novel intermediate
JPS6429363A (en)	1989-01-31	Heterocyclic derivative
MY103765A (en)	1993-09-30	Azolidinedione derivatives
AU2742288A (en)	1989-06-29	Novel compound effective as cerebral insufficiency improver
FI901994A0 (fi)	1990-04-20	Menetelmä terapeuttisesti käyttökelpoisten aminosubstituoitujen silta-atsabisyklisten kinolonikarboksyylihappojen ja -estereiden valmistamiseksi
JPS5632436A (en)	1981-04-01	Prostaglandin analog and its preparation