NO177715C - Analogifremgangsmåte for fremstilling av cykliske neurokinin A-antagonister - Google Patents

Analogifremgangsmåte for fremstilling av cykliske neurokinin A-antagonister

Info

Publication number: NO177715C
Authority: NO; Norway
Prior art keywords: antagonists; preparation; analogous procedure; neurokinin; cyclic
Prior art date: 1989-08-10

Application number

NO903513A

Other languages

English (en)

Norwegian (no)

Other versions

NO177715B (no

NO903513L (no

NO903513D0 (no

Inventor

Scott Lee Harbeson

Stephen Hendersen Buck

Original Assignee

Merrell Dow Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-08-10

Filing date

1990-08-09

Publication date

1995-11-08

1990-08-09 Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma

1990-08-09 Publication of NO903513D0 publication Critical patent/NO903513D0/no

1991-02-11 Publication of NO903513L publication Critical patent/NO903513L/no

1995-07-31 Publication of NO177715B publication Critical patent/NO177715B/no

1995-11-08 Publication of NO177715C publication Critical patent/NO177715C/no

Links

HEAUFJZALFKPBA-YRVBCFNBSA-N Neurokinin A Chemical compound C([C@@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)C(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CC=1NC=NC=1)C(C)O)C1=CC=CC=C1 HEAUFJZALFKPBA-YRVBCFNBSA-N 0.000 title 1
102400000097 Neurokinin A Human genes 0.000 title 1
101800000399 Neurokinin A Proteins 0.000 title 1
239000005557 antagonist Substances 0.000 title 1
125000004122 cyclic group Chemical group 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/22—Tachykinins, e.g. Eledoisins, Substance P; Related peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Pulmonology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Neurology (AREA)
Pain & Pain Management (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Cardiology (AREA)
Rheumatology (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Dermatology (AREA)
Transplantation (AREA)
Heart & Thoracic Surgery (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Virology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

NO903513A 1989-08-10 1990-08-09 Analogifremgangsmåte for fremstilling av cykliske neurokinin A-antagonister NO177715C (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US39223689A	1989-08-10	1989-08-10

Publications (4)

Publication Number	Publication Date
NO903513D0 NO903513D0 (no)	1990-08-09
NO903513L NO903513L (no)	1991-02-11
NO177715B NO177715B (no)	1995-07-31
NO177715C true NO177715C (no)	1995-11-08

Family

ID=23549831

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO903513A NO177715C (no)	1989-08-10	1990-08-09	Analogifremgangsmåte for fremstilling av cykliske neurokinin A-antagonister

Country Status (22)

Country	Link
US (1)	US5731286A (fr)
EP (1)	EP0412542B1 (fr)
JP (1)	JP2829779B2 (fr)
KR (1)	KR0169123B1 (fr)
CN (1)	CN1035056C (fr)
AR (1)	AR246087A1 (fr)
AT (1)	ATE132503T1 (fr)
AU (1)	AU638264B2 (fr)
CA (1)	CA2022740C (fr)
DD (1)	DD297168A5 (fr)
DE (1)	DE69024555T2 (fr)
DK (1)	DK0412542T3 (fr)
ES (1)	ES2084627T3 (fr)
FI (1)	FI95913C (fr)
GR (1)	GR3018984T3 (fr)
HU (1)	HU206729B (fr)
IE (1)	IE69382B1 (fr)
IL (1)	IL95309A (fr)
NO (1)	NO177715C (fr)
NZ (1)	NZ234814A (fr)
PT (1)	PT94952B (fr)
ZA (1)	ZA906188B (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZA894533B (en) *	1988-06-20	1990-03-28	Merrell Dow Pharma	Neurokinin a antogonists
DE4034829A1 (de) *	1990-11-02	1992-05-07	Merck Patent Gmbh	Cyclopeptide
FR2676055B1 (fr) *	1991-05-03	1993-09-03	Sanofi Elf	Composes polycycliques amines et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
US5625060A (en) *	1991-05-03	1997-04-29	Elf Sanofi	Polycyclic amine compounds and their enantiomers, their method of preparation and pharmaceutical compositions on which they are present
JPH06509571A (ja) *	1991-08-08	1994-10-27	エイ・メナリニ・インダストリー・ファーマシューティケ・リウニテ・エスアールエル	タキキニン拮抗薬としての環状ヘキサペプチドの製法およびその薬学的化合物
US5731285A (en) *	1992-04-15	1998-03-24	A. Menatini Industrie Farmaceutiche	Tachiquinine antagonist tricyclic compounds, preparation of same and pharmaceutical compositions containing such compounds
ES2634431T3 (es) *	2009-03-16	2017-09-27	The Governing Council Of The University Of Toronto	Moléculas de aminoácidos cíclicos y procedimientos de preparación de las mismas
EP3377471A4 (fr)	2015-11-11	2019-11-20	Encycle Therapeutics, Inc.	Synthèse de fragments de peptides cycliques
EP3939989A1 (fr)	2016-11-11	2022-01-19	Zealand Pharma A/S	Multimères de peptides cycliques ciblant l'intégrine alpha 4bêta 7
KR20200015540A (ko)	2017-05-10	2020-02-12	인사이클 세라퓨틱스, 인코포레이티드	α4β7 인테그린을 타겟팅하는 호모데틱 사이클릭 펩타이드

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4742156A (en) *	1985-09-30	1988-05-03	Mcneilab, Inc.	Peptide antagonists of neurokinin B and opthalmic solutions containing them
US4665157A (en) *	1985-09-30	1987-05-12	Mcneilab, Inc.	Peptide antagonists of neurokinin B
DE3711335A1 (de) *	1987-04-03	1988-10-20	Merck Patent Gmbh	Aminosaeurederivate
GB8807246D0 (en) *	1988-03-25	1988-04-27	Merck Sharp & Dohme	Therapeutic agents
ZA894533B (en) *	1988-06-20	1990-03-28	Merrell Dow Pharma	Neurokinin a antogonists
FI97540C (fi) *	1989-11-06	1997-01-10	Sanofi Sa	Menetelmä terapeuttisesti käyttökelpoisten, aromaattisesti substituoitujen piperidiini- ja piperatsiinijohdannaisten valmistamiseksi
IL99320A (en) *	1990-09-05	1995-07-31	Sanofi Sa	Arylalkylamines, their preparation and pharmaceutical compositions containing them
FR2677361A1 (fr) *	1991-06-04	1992-12-11	Adir	Nouveaux peptides et pseudopeptides, derives de tachykinines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.

1990
- 1990-08-06 ZA ZA906188A patent/ZA906188B/xx unknown
- 1990-08-06 AU AU60222/90A patent/AU638264B2/en not_active Expired
- 1990-08-07 AR AR90317547A patent/AR246087A1/es active
- 1990-08-07 CA CA002022740A patent/CA2022740C/fr not_active Expired - Lifetime
- 1990-08-07 IL IL9530990A patent/IL95309A/en not_active IP Right Cessation
- 1990-08-08 NZ NZ234814A patent/NZ234814A/en unknown
- 1990-08-08 FI FI903922A patent/FI95913C/fi active IP Right Grant
- 1990-08-09 EP EP90115309A patent/EP0412542B1/fr not_active Expired - Lifetime
- 1990-08-09 PT PT94952A patent/PT94952B/pt not_active IP Right Cessation
- 1990-08-09 CN CN90106972A patent/CN1035056C/zh not_active Expired - Fee Related
- 1990-08-09 DK DK90115309.8T patent/DK0412542T3/da active
- 1990-08-09 KR KR1019900012226A patent/KR0169123B1/ko not_active Expired - Fee Related
- 1990-08-09 JP JP2209390A patent/JP2829779B2/ja not_active Expired - Lifetime
- 1990-08-09 ES ES90115309T patent/ES2084627T3/es not_active Expired - Lifetime
- 1990-08-09 DE DE69024555T patent/DE69024555T2/de not_active Expired - Lifetime
- 1990-08-09 HU HU904952A patent/HU206729B/hu not_active IP Right Cessation
- 1990-08-09 AT AT90115309T patent/ATE132503T1/de not_active IP Right Cessation
- 1990-08-09 NO NO903513A patent/NO177715C/no unknown
- 1990-08-09 IE IE288690A patent/IE69382B1/en not_active IP Right Cessation
- 1990-08-10 DD DD90343398A patent/DD297168A5/de unknown
1996
- 1996-02-14 GR GR960400385T patent/GR3018984T3/el unknown
1997
- 1997-03-05 US US08/811,913 patent/US5731286A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
PT94952A (pt)	1991-04-18
DE69024555T2 (de)	1996-05-15
GR3018984T3 (en)	1996-05-31
KR0169123B1 (ko)	1999-01-15
CA2022740C (fr)	2000-05-02
IE902886A1 (en)	1991-02-27
EP0412542A2 (fr)	1991-02-13
DD297168A5 (de)	1992-01-02
EP0412542B1 (fr)	1996-01-03
AR246087A1 (es)	1994-03-30
ATE132503T1 (de)	1996-01-15
JP2829779B2 (ja)	1998-12-02
ZA906188B (en)	1991-06-26
CN1049353A (zh)	1991-02-20
NZ234814A (en)	1992-03-26
JPH03141295A (ja)	1991-06-17
EP0412542A3 (en)	1991-07-24
IE69382B1 (en)	1996-09-04
NO177715B (no)	1995-07-31
DK0412542T3 (da)	1996-01-29
US5731286A (en)	1998-03-24
FI903922A0 (fi)	1990-08-08
HU904952D0 (en)	1991-01-28
NO903513L (no)	1991-02-11
NO903513D0 (no)	1990-08-09
HUT54713A (en)	1991-03-28
HU206729B (en)	1992-12-28
IL95309A0 (en)	1991-06-30
AU638264B2 (en)	1993-06-24
FI95913B (fi)	1995-12-29
FI95913C (fi)	1996-04-10
KR910004665A (ko)	1991-03-29
IL95309A (en)	1995-07-31
PT94952B (pt)	1997-07-31
AU6022290A (en)	1991-05-16
DE69024555D1 (de)	1996-02-15
ES2084627T3 (es)	1996-05-16
CA2022740A1 (fr)	1991-02-11
CN1035056C (zh)	1997-06-04

Publication	Publication Date	Title
NO914429D0 (no)	1991-11-12	Fremgangsmaate for fremstilling av piperidinylkamfersulfonyloxytocin-antagonister
FI914765A7 (fi)	1991-10-09	Hidastetusti vapauttava oraalinen lääkeannosmuoto
PT91631A (pt)	1990-03-30	A process for the preparation of cyclic graf-analogs ii
NO171678C (no)	1993-04-21	Fremgangsmaate for fremstilling av cykliske sulfater
NO934897D0 (no)	1993-12-29	Fremgangsmaate for fremstilling av et farmasoeytisk preparat
PT89570A (pt)	1989-10-04	Processo para a preparacao de novos compostos de 1,3-dicarbonilo ciclicos
NO901232D0 (no)	1990-03-16	Fremgangsmaate for fremstilling av et farmasoeytisk preparat
NO870177D0 (no)	1987-01-15	Fremgangsmaate for fremstilling av et soetemiddel.
AU638264B2 (en)	1993-06-24	Cyclic neurokinin a antagonists
IT1211268B (it)	1989-10-12	Procedimento per la fabbricazione di un capo di vestiario modellato lavorato a maglia
FI891111A7 (fi)	1989-09-09	Menetelmä 1,4-dihydropyridiinijohdannaisten valmistamiseksi
FI102613B1 (fi)	1999-01-15	Menetelmä NMDA-antagonistien valmistamiseksi
NO905373L (no)	1991-06-20	Fremgangsmaate for fremstilling av nye fosfolipid-derivater
FI93363C (fi)	1995-03-27	Uusi menetelmä 2-diatso-3-trisubstituoitujen silyylioksi-3-butenoaattien valmistamiseksi
PT87528A (pt)	1989-05-31	Process for the preparation of vasopressin antagonists
NO893006L (no)	1990-01-23	Fremgangsmaate for fremstilling av nye allylaminoetylazoler
DK0421319T3 (da)	1994-01-31	Fremgangsmåde til fremstilling af et aromastof
BR9005401A (pt)	1991-09-17	Preparacao de iminodiacetonitrila a partir de glicolonitrila
FI904571A7 (fi)	1991-03-20	Menetelmä uusien alkanofenonien valmistamiseksi II
IT9047639A0 (it)	1990-02-16	Dispositivo per la produzione di filato di fiocco
SE8902501D0 (sv)	1989-07-11	Foerfarande foer framstaellning av effektgarn
NO180296C (no)	1997-03-26	Fremgangsmåte for fremstilling av cykliske aminosyre-forbindelser
IE862569L (en)	1987-03-30	Decapeptide antagonists of neurokinin b
RO96842A (fr)	1989-04-28	Procede pour preparer 4,4-dimethyle-1,3-dioxane
NO930481L (no)	1990-08-17	Fremgangsmaate for fremstilling av klormetaner