NO178151C - Analogifremgangsmåte for fremstilling av terapeutisk aktive peptider - Google Patents

Analogifremgangsmåte for fremstilling av terapeutisk aktive peptider

Info

Publication number: NO178151C
Authority: NO; Norway
Prior art keywords: leu; glu; ala; analogs; gln
Prior art date: 1988-06-21

Application number

NO900775A

Other languages

English (en)

Norwegian (no)

Other versions

NO900775D0 (no

NO178151B (no

NO900775L (no

Inventor

Jean Edouard Frederic Rivier

Jr Wylie Walker Vale

Original Assignee

Salk Inst For Biological Studi

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-06-21

Filing date

1990-02-19

Publication date

1996-01-31

1990-02-19 Application filed by Salk Inst For Biological Studi filed Critical Salk Inst For Biological Studi

1990-02-19 Publication of NO900775D0 publication Critical patent/NO900775D0/no

1990-04-23 Publication of NO900775L publication Critical patent/NO900775L/no

1995-10-23 Publication of NO178151B publication Critical patent/NO178151B/no

1996-01-31 Publication of NO178151C publication Critical patent/NO178151C/no

Links

108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title 1
102000004196 processed proteins & peptides Human genes 0.000 title 1
102100027467 Pro-opiomelanocortin Human genes 0.000 abstract 3
239000000055 Corticotropin-Releasing Hormone Substances 0.000 abstract 2
101800005049 Beta-endorphin Proteins 0.000 abstract 1
OMFXVFTZEKFJBZ-UHFFFAOYSA-N Corticosterone Natural products O=C1CCC2(C)C3C(O)CC(C)(C(CC4)C(=O)CO)C4C3CCC2=C1 OMFXVFTZEKFJBZ-UHFFFAOYSA-N 0.000 abstract 1
101800000414 Corticotropin Proteins 0.000 abstract 1
241000124008 Mammalia Species 0.000 abstract 1
125000000729 N-terminal amino-acid group Chemical group 0.000 abstract 1
108010069820 Pro-Opiomelanocortin Proteins 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
108010042362 beta-Lipotropin Proteins 0.000 abstract 1
WOPZMFQRCBYPJU-NTXHZHDSSA-N beta-endorphin Chemical compound C([C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)CC=1C=CC(O)=CC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)C1=CC=CC=C1 WOPZMFQRCBYPJU-NTXHZHDSSA-N 0.000 abstract 1
230000036772 blood pressure Effects 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
OMFXVFTZEKFJBZ-HJTSIMOOSA-N corticosterone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@H](CC4)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OMFXVFTZEKFJBZ-HJTSIMOOSA-N 0.000 abstract 1
IDLFZVILOHSSID-OVLDLUHVSA-N corticotropin Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=C(O)C=C1 IDLFZVILOHSSID-OVLDLUHVSA-N 0.000 abstract 1
229960000258 corticotropin Drugs 0.000 abstract 1
239000007788 liquid Substances 0.000 abstract 1
230000036651 mood Effects 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000007787 solid Substances 0.000 abstract 1
239000000021 stimulant Substances 0.000 abstract 1
238000006467 substitution reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
- C07K14/695—Corticotropin [ACTH]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57509—Corticotropin releasing factor [CRF] (Urotensin)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
- A61K38/35—Corticotropin [ACTH]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Organic Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Genetics & Genomics (AREA)
Immunology (AREA)
Toxicology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Endocrinology (AREA)
General Chemical & Material Sciences (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Vehicle Body Suspensions (AREA)
Amplifiers (AREA)
Diaphragms For Electromechanical Transducers (AREA)
Control Of Eletrric Generators (AREA)
Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
Details Of Television Scanning (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)

NO900775A 1988-06-21 1990-02-19 Analogifremgangsmåte for fremstilling av terapeutisk aktive peptider NO178151C (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US20953788A	1988-06-21	1988-06-21
PCT/US1989/002695 WO1989012646A1 (en)	1988-06-21	1989-06-20	Crf analogs

Publications (4)

Publication Number	Publication Date
NO900775D0 NO900775D0 (no)	1990-02-19
NO900775L NO900775L (no)	1990-04-23
NO178151B NO178151B (no)	1995-10-23
NO178151C true NO178151C (no)	1996-01-31

Family

ID=22779145

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO900775A NO178151C (no)	1988-06-21	1990-02-19	Analogifremgangsmåte for fremstilling av terapeutisk aktive peptider

Country Status (15)

Country	Link
EP (1)	EP0403591B1 (de)
JP (1)	JP2745157B2 (de)
KR (1)	KR0139799B1 (de)
AT (1)	ATE111486T1 (de)
AU (1)	AU617831B2 (de)
CA (1)	CA1341406C (de)
DE (1)	DE68918271T2 (de)
DK (1)	DK175402B1 (de)
ES (1)	ES2015413A6 (de)
FI (1)	FI94421C (de)
GR (1)	GR1000705B (de)
IE (1)	IE64788B1 (de)
NO (1)	NO178151C (de)
WO (1)	WO1989012646A1 (de)
ZA (1)	ZA894317B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE169639T1 (de) *	1990-03-23	1998-08-15	Salk Inst For Biological Studi	Crf-analoge
US5235036A (en) *	1991-05-31	1993-08-10	The Salk Institute For Biological Studies	Crf analogs
US6039956A (en) *	1994-09-12	2000-03-21	Pennsylvania, Trustees Of The University Of, The	Corticotropin release inhibiting factor and methods of using same for treating behavioral symptoms in an anxiety disorder
EP0781140A4 (de) *	1994-09-12	1999-11-03	Univ Pennsylvania	Die corticotropinfreisetzung inhibierender faktor und verfahren zu seiner nutzung
AU6277796A (en) *	1995-06-13	1997-01-15	Salk Institute For Biological Studies, The	Urocortin peptides
US6214797B1 (en)	1995-06-13	2001-04-10	The Salk Institute For Biological Studies	Urocortin peptides, nucleic acid encoding same methods for using same

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4415558A (en)	1981-06-08	1983-11-15	The Salk Institute For Biological Studies	CRF And analogs
US4489163A (en)	1983-04-14	1984-12-18	The Salk Institute For Biological Studies	rCRF and analogs
US4605642A (en) *	1984-02-23	1986-08-12	The Salk Institute For Biological Studies	CRF antagonists
US4594329A (en) *	1984-05-14	1986-06-10	The Salk Institute For Biological Studies	CRF analogs
EP0153845B1 (de) *	1984-02-23	1993-04-21	The Salk Institute For Biological Studies	CRF-Analoga

1989
- 1989-05-20 IE IE200089A patent/IE64788B1/xx not_active IP Right Cessation
- 1989-06-07 ZA ZA894317A patent/ZA894317B/xx unknown
- 1989-06-09 CA CA000602342A patent/CA1341406C/en not_active Expired - Fee Related
- 1989-06-16 GR GR890100405A patent/GR1000705B/el not_active IP Right Cessation
- 1989-06-20 WO PCT/US1989/002695 patent/WO1989012646A1/en not_active Ceased
- 1989-06-20 DE DE68918271T patent/DE68918271T2/de not_active Expired - Lifetime
- 1989-06-20 AU AU37706/89A patent/AU617831B2/en not_active Expired
- 1989-06-20 AT AT89907609T patent/ATE111486T1/de not_active IP Right Cessation
- 1989-06-20 ES ES8902146A patent/ES2015413A6/es not_active Expired - Lifetime
- 1989-06-20 KR KR1019900700356A patent/KR0139799B1/ko not_active Expired - Lifetime
- 1989-06-20 EP EP89907609A patent/EP0403591B1/de not_active Expired - Lifetime
- 1989-06-20 JP JP1506941A patent/JP2745157B2/ja not_active Expired - Lifetime
1990
- 1990-02-14 FI FI900726A patent/FI94421C/fi active IP Right Grant
- 1990-02-19 NO NO900775A patent/NO178151C/no not_active IP Right Cessation
- 1990-02-21 DK DK199000459A patent/DK175402B1/da not_active IP Right Cessation

Also Published As

Publication number	Publication date
CA1341406C (en)	2002-12-03
JP2745157B2 (ja)	1998-04-28
ATE111486T1 (de)	1994-09-15
AU617831B2 (en)	1991-12-05
DK45990A (da)	1990-02-21
GR1000705B (el)	1992-10-08
AU3770689A (en)	1990-01-12
KR900701839A (ko)	1990-12-04
EP0403591B1 (de)	1994-09-14
DK175402B1 (da)	2004-09-27
JPH03501616A (ja)	1991-04-11
FI900726A0 (fi)	1990-02-14
FI94421C (fi)	1995-09-11
DE68918271T2 (de)	1995-02-02
DK45990D0 (da)	1990-02-21
DE68918271D1 (de)	1994-10-20
FI94421B (fi)	1995-05-31
ES2015413A6 (es)	1990-08-16
EP0403591A4 (en)	1991-11-21
WO1989012646A1 (en)	1989-12-28
GR890100405A (en)	1990-05-11
ZA894317B (en)	1990-02-28
EP0403591A1 (de)	1990-12-27
NO900775D0 (no)	1990-02-19
KR0139799B1 (ko)	1998-07-01
IE892000L (en)	1989-12-21
IE64788B1 (en)	1995-09-06
NO178151B (no)	1995-10-23
NO900775L (no)	1990-04-23

Legal Events

Date	Code	Title	Description
2009-07-06	MK1K	Patent expired

Publication	Publication Date	Title
AU565699B2 (en)	1987-09-24	Crf analogs
FI900726A0 (fi)	1990-02-14	Menetelmä terapeuttisesti käyttökelpoisten peptidien valmistamiseksi
HU895788D0 (en)	1991-08-28	Process for producing peptides and medical products containing them
ATE169639T1 (de)	1998-08-15	Crf-analoge
DE3587276D1 (de)	1993-05-27	Crf-analoga.
EP0361954A3 (de)	1991-12-04	CRF-Analoge
DK169690A (da)	1990-07-13	Fiske-crf