ES2015413A6 - Procedimiento para preparar peptidos analogos al factor libearador de corticotropina (crf)> - Google Patents
Procedimiento para preparar peptidos analogos al factor libearador de corticotropina (crf)>Info
- Publication number
- ES2015413A6 ES2015413A6 ES8902146A ES8902146A ES2015413A6 ES 2015413 A6 ES2015413 A6 ES 2015413A6 ES 8902146 A ES8902146 A ES 8902146A ES 8902146 A ES8902146 A ES 8902146A ES 2015413 A6 ES2015413 A6 ES 2015413A6
- Authority
- ES
- Spain
- Prior art keywords
- arg
- amino acids
- hydrogen
- peptides
- crf
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 4
- 239000000055 Corticotropin-Releasing Hormone Substances 0.000 abstract 3
- 102000012289 Corticotropin-Releasing Hormone Human genes 0.000 abstract 2
- 108010022152 Corticotropin-Releasing Hormone Proteins 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 240000006409 Acacia auriculiformis Species 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 102400000739 Corticotropin Human genes 0.000 abstract 1
- 101800000414 Corticotropin Proteins 0.000 abstract 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-N Fluorane Chemical compound F KRHYYFGTRYWZRS-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 108010069820 Pro-Opiomelanocortin Proteins 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 239000003246 corticosteroid Substances 0.000 abstract 1
- 229960001334 corticosteroids Drugs 0.000 abstract 1
- IDLFZVILOHSSID-OVLDLUHVSA-N corticotropin Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=C(O)C=C1 IDLFZVILOHSSID-OVLDLUHVSA-N 0.000 abstract 1
- 229960000258 corticotropin Drugs 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910000040 hydrogen fluoride Inorganic materials 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- 230000001681 protective effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
- C07K14/695—Corticotropin [ACTH]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57509—Corticotropin releasing factor [CRF] (Urotensin)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
- A61K38/35—Corticotropin [ACTH]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Vehicle Body Suspensions (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
- Amplifiers (AREA)
- Control Of Eletrric Generators (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
- Details Of Television Scanning (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Abstract
PROCEDIMIENTO PARA PREPARAR PEPTIDOS ANALOGOS AL FACTOR LIBERADOR DE CORTICOTROPINA (CRF) DE FORMULA (I): Y-RSI1-RSI2-RSI3-RSI4-RSI5-ILE-SER-RSI8-RSI9-LEU-RSI11-RSI12-RSI13-RSI14-LEU-ARG-RSI17-RSI18-RSI19-RSI20-RSI21-RSI22-RSI23-RSI24-RSI25-RSI26-RSI27-RSI28-RSI29-GLN-ALA-RSI32-RSI33-ASN-ARG-RSI36-RSI37-RSI38-RSI39-RSI40-RSI41-NHSI2 DONDE Y ES ACILO CON 7 O MENOS ATOMOS DE CARBONO O HIDROGENO, Y LOS SIMBOLOS R REPRESENTAN AMINOACIDOS. CNSISTE EN FORMAR UN PEPTIDO PRECURSOR QUE TIENE AL MENOS UN GRUPO PROTECTOR AÑADIENDO SECUENCIALMENTE AMINOACIDOS BLOQUEADOS A UN SOPORTE DE RESINA Y DESPROTEGIENDO CON ACIDO TRIFLUOROACETICO, ENTRE 0GC Y LA TEMPERATURA AMBIENTE, ESCINDIR TODOS LOS GRUPOS PROTECTORES Y EL ENLACE DE ANCLAJE A DICHO SOPORTE POR MEDIO DE FLUORURO DE HIDROGENO, A UNA TEMPERATURA DE -20GC A 0GC, Y, OPCIONALMENTE, CONVERTIR EL PEPTIDO RESULTANTE EN SUS SALES DE ADICION NO TOXICAS. LOS PEPTIDOS OBTENIDOS CON UTILES PARA REDUCIR LA TENSION ARTERIAL Y MODULAR LA SECRECION DE ACTH, CORTICOSTEROIDES Y PRODUCTOS DERIVADOS DEL GEN DE PRO-OPIOMELANOCORTINA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20953788A | 1988-06-21 | 1988-06-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2015413A6 true ES2015413A6 (es) | 1990-08-16 |
Family
ID=22779145
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES8902146A Expired - Lifetime ES2015413A6 (es) | 1988-06-21 | 1989-06-20 | Procedimiento para preparar peptidos analogos al factor libearador de corticotropina (crf)> |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0403591B1 (es) |
| JP (1) | JP2745157B2 (es) |
| KR (1) | KR0139799B1 (es) |
| AT (1) | ATE111486T1 (es) |
| AU (1) | AU617831B2 (es) |
| CA (1) | CA1341406C (es) |
| DE (1) | DE68918271T2 (es) |
| DK (1) | DK175402B1 (es) |
| ES (1) | ES2015413A6 (es) |
| FI (1) | FI94421C (es) |
| GR (1) | GR1000705B (es) |
| IE (1) | IE64788B1 (es) |
| NO (1) | NO178151C (es) |
| WO (1) | WO1989012646A1 (es) |
| ZA (1) | ZA894317B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU638823B2 (en) * | 1990-03-23 | 1993-07-08 | Salk Institute For Biological Studies, The | Crf analogs |
| US5235036A (en) * | 1991-05-31 | 1993-08-10 | The Salk Institute For Biological Studies | Crf analogs |
| US6039956A (en) * | 1994-09-12 | 2000-03-21 | Pennsylvania, Trustees Of The University Of, The | Corticotropin release inhibiting factor and methods of using same for treating behavioral symptoms in an anxiety disorder |
| WO1996008265A1 (en) * | 1994-09-12 | 1996-03-21 | The Trustees Of The University Of Pennsylvania | Corticotropin release inhibiting factor and methods of using same |
| EP0845035A2 (en) * | 1995-06-13 | 1998-06-03 | The Salk Institute For Biological Studies | Urocortin peptides |
| US6214797B1 (en) | 1995-06-13 | 2001-04-10 | The Salk Institute For Biological Studies | Urocortin peptides, nucleic acid encoding same methods for using same |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4415558A (en) | 1981-06-08 | 1983-11-15 | The Salk Institute For Biological Studies | CRF And analogs |
| US4489163A (en) | 1983-04-14 | 1984-12-18 | The Salk Institute For Biological Studies | rCRF and analogs |
| US4594329A (en) * | 1984-05-14 | 1986-06-10 | The Salk Institute For Biological Studies | CRF analogs |
| US4605642A (en) * | 1984-02-23 | 1986-08-12 | The Salk Institute For Biological Studies | CRF antagonists |
| EP0518391A1 (en) * | 1984-02-23 | 1992-12-16 | The Salk Institute For Biological Studies | CRF analogs |
-
1989
- 1989-05-20 IE IE200089A patent/IE64788B1/xx not_active IP Right Cessation
- 1989-06-07 ZA ZA894317A patent/ZA894317B/xx unknown
- 1989-06-09 CA CA000602342A patent/CA1341406C/en not_active Expired - Fee Related
- 1989-06-16 GR GR890100405A patent/GR1000705B/el not_active IP Right Cessation
- 1989-06-20 ES ES8902146A patent/ES2015413A6/es not_active Expired - Lifetime
- 1989-06-20 WO PCT/US1989/002695 patent/WO1989012646A1/en not_active Ceased
- 1989-06-20 DE DE68918271T patent/DE68918271T2/de not_active Expired - Lifetime
- 1989-06-20 EP EP89907609A patent/EP0403591B1/en not_active Expired - Lifetime
- 1989-06-20 KR KR1019900700356A patent/KR0139799B1/ko not_active Expired - Lifetime
- 1989-06-20 AT AT89907609T patent/ATE111486T1/de not_active IP Right Cessation
- 1989-06-20 JP JP1506941A patent/JP2745157B2/ja not_active Expired - Lifetime
- 1989-06-20 AU AU37706/89A patent/AU617831B2/en not_active Expired
-
1990
- 1990-02-14 FI FI900726A patent/FI94421C/fi active IP Right Grant
- 1990-02-19 NO NO900775A patent/NO178151C/no not_active IP Right Cessation
- 1990-02-21 DK DK199000459A patent/DK175402B1/da not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NO900775D0 (no) | 1990-02-19 |
| NO178151C (no) | 1996-01-31 |
| ZA894317B (en) | 1990-02-28 |
| DE68918271D1 (de) | 1994-10-20 |
| FI900726A0 (fi) | 1990-02-14 |
| WO1989012646A1 (en) | 1989-12-28 |
| KR0139799B1 (ko) | 1998-07-01 |
| DK175402B1 (da) | 2004-09-27 |
| IE892000L (en) | 1989-12-21 |
| JP2745157B2 (ja) | 1998-04-28 |
| CA1341406C (en) | 2002-12-03 |
| DE68918271T2 (de) | 1995-02-02 |
| GR890100405A (en) | 1990-05-11 |
| EP0403591A4 (en) | 1991-11-21 |
| ATE111486T1 (de) | 1994-09-15 |
| KR900701839A (ko) | 1990-12-04 |
| FI94421B (fi) | 1995-05-31 |
| AU617831B2 (en) | 1991-12-05 |
| DK45990A (da) | 1990-02-21 |
| DK45990D0 (da) | 1990-02-21 |
| NO900775L (no) | 1990-04-23 |
| FI94421C (fi) | 1995-09-11 |
| GR1000705B (el) | 1992-10-08 |
| EP0403591B1 (en) | 1994-09-14 |
| IE64788B1 (en) | 1995-09-06 |
| JPH03501616A (ja) | 1991-04-11 |
| NO178151B (no) | 1995-10-23 |
| AU3770689A (en) | 1990-01-12 |
| EP0403591A1 (en) | 1990-12-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20100315 |