NO180486C - Nye indolforbindelser og anvendelse av disse i farmasöytiske preparater - Google Patents

Nye indolforbindelser og anvendelse av disse i farmasöytiske preparater

Info

Publication number
NO180486C
NO180486C NO921505A NO921505A NO180486C NO 180486 C NO180486 C NO 180486C NO 921505 A NO921505 A NO 921505A NO 921505 A NO921505 A NO 921505A NO 180486 C NO180486 C NO 180486C
Authority
NO
Norway
Prior art keywords
loweralkyl
hydrogen
chem
arylloweralkyl
pharmaceutical preparations
Prior art date
Application number
NO921505A
Other languages
English (en)
Norwegian (no)
Other versions
NO180486B (no
NO921505D0 (no
NO921505L (no
Inventor
Richard Charles Effland
Joseph Thomas Klein
Lawrence Leo Martin
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Publication of NO921505D0 publication Critical patent/NO921505D0/no
Publication of NO921505L publication Critical patent/NO921505L/no
Publication of NO180486B publication Critical patent/NO180486B/no
Publication of NO180486C publication Critical patent/NO180486C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO921505A 1991-04-17 1992-04-15 Nye indolforbindelser og anvendelse av disse i farmasöytiske preparater NO180486C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/688,964 US5177088A (en) 1991-04-17 1991-04-17 Substituted 3-(pyridinylamino)-indoles

Publications (4)

Publication Number Publication Date
NO921505D0 NO921505D0 (no) 1992-04-15
NO921505L NO921505L (no) 1992-10-19
NO180486B NO180486B (no) 1997-01-20
NO180486C true NO180486C (no) 1997-04-30

Family

ID=24766519

Family Applications (1)

Application Number Title Priority Date Filing Date
NO921505A NO180486C (no) 1991-04-17 1992-04-15 Nye indolforbindelser og anvendelse av disse i farmasöytiske preparater

Country Status (25)

Country Link
US (1) US5177088A (cs)
EP (1) EP0509402B1 (cs)
JP (1) JP2617650B2 (cs)
KR (1) KR100254027B1 (cs)
AT (1) ATE161840T1 (cs)
AU (1) AU655253B2 (cs)
BG (1) BG61034B1 (cs)
CA (1) CA2066332C (cs)
CS (1) CS117192A3 (cs)
DE (1) DE69223837T2 (cs)
DK (1) DK0509402T3 (cs)
ES (1) ES2111580T3 (cs)
FI (1) FI105096B (cs)
GR (1) GR3026317T3 (cs)
HU (1) HU215113B (cs)
IE (1) IE921235A1 (cs)
IL (1) IL101599A (cs)
MX (1) MX9201759A (cs)
NO (1) NO180486C (cs)
NZ (1) NZ242359A (cs)
PL (1) PL168905B1 (cs)
RO (1) RO109847B1 (cs)
RU (1) RU2060254C1 (cs)
TW (1) TW200477B (cs)
ZA (1) ZA922807B (cs)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5264442A (en) * 1990-08-13 1993-11-23 Hoechst-Roussel Pharmaceuticals Incorporated Carbamoyl-1-(pyridinylalkyl)-1H-indoles, indolines and related analogs
US5328920A (en) * 1991-04-17 1994-07-12 Hoechst-Roussel Pharmaceuticals Incorporated Substituted (pyridinylamino)-indoles
US5185350A (en) * 1991-09-23 1993-02-09 Hoechst-Roussel Pharmaceuticals Incorporated Substituted pyridinylamino-1h-indoles,1h-indazoles,2h-indazoles, benzo (b)thiophenes and 1,2-benzisothiazoles
US5356910A (en) * 1993-07-19 1994-10-18 Hoechst-Roussel Pharmaceuticals Inc. Use of N-(pyridinyl)-1H-indol-1-amines for the treatment of obsessive-compulsive disorder
DK0833820T3 (da) * 1995-06-06 2001-04-17 Aventis Pharma Inc Benzisoxazol- og indazolderivater som antipsykotiske midler
US5668154A (en) * 1995-06-06 1997-09-16 Hoechst Marion Roussel Inc. Pyridiniminyl-1,2-benzisoxazoles and -benzisothiazoles
KR20000062358A (ko) * 1996-12-27 2000-10-25 게리 디. 스트리트, 스티븐 엘. 네스비트 알츠하이머병 및 울병 치료용 ｎ-(피리디닐아미노)이소인돌린
US7125903B1 (en) 1999-09-14 2006-10-24 Aventis Pharmaceuticals Inc. Thienoisoxazolyl-and thienylpyrrazolyl-phenoxy substituted propyl derivatives useful as D4 antagonists
US7091199B1 (en) 1999-09-14 2006-08-15 Aventis Pharmaceuticals Inc. Thienoisoxazole phenoxy unsubstituted ethyl and propyl derivatives useful as d4 antagonists
US7253165B2 (en) * 1999-09-14 2007-08-07 Aventis Pharmaceuticals Inc. Benzisoxazolyl-, pyridoisoxazolyl-and benzthienyl-phenoxy derivatives useful as D4 antagonists
PT1216244E (pt) * 1999-09-14 2003-12-31 Aventis Pharma Inc Derivados de benzisoxazolil- piridoisoxazolil- e benztienil-fenoxi uteis como antagonistas d4
DE10029371A1 (de) * 2000-06-20 2002-01-03 Merck Patent Gmbh Heterocyclische Aminoalkylpyridinderivate als Psychopharmaka
GB0217920D0 (en) * 2002-04-23 2002-09-11 Aventis Pharm Prod Inc Interleukin-4 Gene Expression inhibitors
ES2340180T3 (es) 2004-06-01 2010-05-31 F.Hoffmann-La Roche Ag 3-amino-1-arilpropil-indoles como inhibidores de reabsorcion de monoaminas.
JP2009517430A (ja) 2005-11-30 2009-04-30 エフ．ホフマン−ラ ロシュ アーゲー ３−アミノ−１−アリールプロピルインドール類及びアザ置換インドール類
ATE442368T1 (de) 2005-11-30 2009-09-15 Hoffmann La Roche 3-amino-2-arylpropylazaindole und anwendungen davon
EP2351737A1 (en) * 2005-11-30 2011-08-03 F. Hoffmann-La Roche AG 3-Amino-1-arylpropyl indoles and aza-substituted indoles
EP2230238B1 (en) * 2008-01-04 2013-12-11 LG Life Sciences Ltd. Indole and indazole derivatives having a cell-, tissue- and organ-preserving effect

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0049779B1 (en) * 1980-09-18 1984-10-31 Asahi Kasei Kogyo Kabushiki Kaisha 3-aminoindazole derivatives and process for preparation thereof
IE58370B1 (en) * 1985-04-10 1993-09-08 Lundbeck & Co As H Indole derivatives
US4717658A (en) * 1985-12-03 1988-01-05 Miles Inc. Gram negative bacteria screening method with horseshoe crab amebocyte lysate (LAL)
US4970218A (en) * 1987-04-24 1990-11-13 Hoechst-Roussel Pharmaceuticals Inc. N-(pyridinyl)-1H-indol-1-amines
US4806554A (en) * 1988-01-11 1989-02-21 Hoechst-Roussel Pharmaceuticals, Inc. Pyrazol and indazolpyridinamines
US4954502A (en) * 1988-06-10 1990-09-04 Bristol-Myers Squibb Company 1-indolyalkyl-4-(substituted-pyridinyl)piperazines
ES2076253T3 (es) * 1989-05-19 1995-11-01 Hoechst Roussel Pharma N-(ariloxialquil)-heteroarilpiperidinas y -heteroarilpiperazinas, un procedimiento para su preparacion y su uso como medicamentos.
US4983615A (en) * 1989-06-28 1991-01-08 Hoechst-Roussel Pharmaceuticals Inc. Heteroarylamino- and heteroaryloxypyridinamine compounds which are useful in treating skin disorders
US4954503A (en) * 1989-09-11 1990-09-04 Hoechst-Roussel Pharmaceuticals, Inc. 3-(1-substituted-4-piperazinyl)-1H-indazoles
CA2030051C (en) * 1989-11-17 2001-08-07 Haruhiko Kikuchi Indole derivatives

Also Published As

Publication number Publication date
EP0509402A1 (en) 1992-10-21
KR920019777A (ko) 1992-11-20
CA2066332A1 (en) 1992-10-18
RO109847B1 (ro) 1995-06-30
FI921693A7 (fi) 1992-10-18
NZ242359A (en) 1995-03-28
JP2617650B2 (ja) 1997-06-04
AU655253B2 (en) 1994-12-08
PL168905B1 (pl) 1996-05-31
IL101599A0 (en) 1992-12-30
IL101599A (en) 1996-05-14
CA2066332C (en) 2003-07-29
TW200477B (cs) 1993-02-21
JPH05117266A (ja) 1993-05-14
KR100254027B1 (ko) 2000-05-01
DK0509402T3 (da) 1998-09-07
BG96202A (bg) 1993-12-24
BG61034B1 (bg) 1996-09-30
NO180486B (no) 1997-01-20
CS117192A3 (en) 1992-11-18
ES2111580T3 (es) 1998-03-16
GR3026317T3 (en) 1998-06-30
NO921505D0 (no) 1992-04-15
AU1512192A (en) 1992-10-22
IE921235A1 (en) 1992-10-21
DE69223837D1 (de) 1998-02-12
US5177088A (en) 1993-01-05
RU2060254C1 (ru) 1996-05-20
FI105096B (fi) 2000-06-15
PL294239A1 (en) 1993-06-14
ZA922807B (en) 1992-11-25
ATE161840T1 (de) 1998-01-15
MX9201759A (es) 1992-10-01
EP0509402B1 (en) 1998-01-07
HUT62572A (en) 1993-05-28
HU215113B (hu) 1998-12-28
NO921505L (no) 1992-10-19
HU9201297D0 (en) 1992-07-28
FI921693A0 (fi) 1992-04-15
DE69223837T2 (de) 1998-06-25

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