NO20000285L - Terapeutisk eller profylaktisk middel for glomerulopati - Google Patents

Terapeutisk eller profylaktisk middel for glomerulopati

Info

Publication number: NO20000285L
Authority: NO; Norway
Prior art keywords: diyl; lower alkyl; thiophen; optionally substituted; phenyl
Prior art date: 1997-07-22

Application number

NO20000285A

Other languages

English (en)

Other versions

NO20000285D0 (no

Inventor

Hidetake Kurihara

Fumihiko Watanabe

Yoshinori Tamura

Toshihiro Sinosaki

Original Assignee

Shionogi & Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-07-22

Filing date

2000-01-20

Publication date

2000-03-22

2000-01-20 Application filed by Shionogi & Co filed Critical Shionogi & Co

2000-01-20 Publication of NO20000285D0 publication Critical patent/NO20000285D0/no

2000-03-22 Publication of NO20000285L publication Critical patent/NO20000285L/no

Links

208000022461 Glomerular disease Diseases 0.000 title abstract 2
230000000069 prophylactic effect Effects 0.000 title 1
230000001225 therapeutic effect Effects 0.000 title 1
-1 2,5-thiophendiyl Chemical group 0.000 abstract 10
125000000217 alkyl group Chemical group 0.000 abstract 7
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
125000004414 alkyl thio group Chemical group 0.000 abstract 3
125000003710 aryl alkyl group Chemical group 0.000 abstract 3
125000001475 halogen functional group Chemical group 0.000 abstract 3
125000001072 heteroaryl group Chemical group 0.000 abstract 3
125000000623 heterocyclic group Chemical group 0.000 abstract 3
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 3
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
125000004104 aryloxy group Chemical group 0.000 abstract 2
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
125000000753 cycloalkyl group Chemical group 0.000 abstract 2
125000002252 acyl group Chemical group 0.000 abstract 1
125000004423 acyloxy group Chemical group 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
125000000043 benzamido group Chemical group [H]N([*])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
125000002795 guanidino group Chemical group C(N)(=N)N* 0.000 abstract 1
125000001188 haloalkyl group Chemical group 0.000 abstract 1
125000004446 heteroarylalkyl group Chemical group 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000005415 substituted alkoxy group Chemical group 0.000 abstract 1
150000003456 sulfonamides Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
- C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
- C07C311/44—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
- C07C311/46—Y being a hydrogen or a carbon atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/18—Radicals substituted by singly bound hetero atoms other than halogen by sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Indole Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines Containing Plant Substances (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Enzymes And Modification Thereof (AREA)

NO20000285A 1997-07-22 2000-01-20 Terapeutisk eller profylaktisk middel for glomerulopati NO20000285L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP19541497		1997-07-22
PCT/JP1998/003226 WO1999004780A1 (en)	1997-07-22	1998-07-17	Therapeutic or prophylactic agent for glomerulopathy

Publications (2)

Publication Number	Publication Date
NO20000285D0 NO20000285D0 (no)	2000-01-20
NO20000285L true NO20000285L (no)	2000-03-22

Family

ID=16340702

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20000285A NO20000285L (no)	1997-07-22	2000-01-20	Terapeutisk eller profylaktisk middel for glomerulopati

Country Status (21)

Country	Link
US (2)	US6423729B1 (no)
EP (2)	EP1398027B1 (no)
JP (1)	JP3621427B2 (no)
KR (1)	KR100386148B1 (no)
CN (1)	CN1198607C (no)
AT (1)	ATE320801T1 (no)
AU (1)	AU737218B2 (no)
BR (1)	BR9811521A (no)
CA (1)	CA2297011C (no)
DE (2)	DE69836877D1 (no)
HU (1)	HUP0003851A3 (no)
ID (2)	ID24105A (no)
IL (1)	IL133933A0 (no)
NO (1)	NO20000285L (no)
NZ (1)	NZ502274A (no)
PL (1)	PL338235A1 (no)
RU (1)	RU2207849C2 (no)
SK (1)	SK262000A3 (no)
TR (2)	TR200000214T2 (no)
TW (2)	TW593249B (no)
WO (1)	WO1999004780A1 (no)

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JP3621427B2 (ja) *	1997-07-22	2005-02-16	塩野義製薬株式会社	糸球体障害治療または予防剤
JP4750272B2 (ja)	1998-02-04	2011-08-17	ノバルティスアーゲー	マトリックス分解メタロプロテイナーゼを阻害するスルホニルアミノ誘導体
US6410580B1 (en)	1998-02-04	2002-06-25	Novartis Ag	Sulfonylamino derivatives which inhibit matrix-degrading metalloproteinases
AU5647099A (en) *	1998-09-11	2000-04-03	Shionogi & Co., Ltd.	Remedal or preventive agent for congestive heart failure
AU765203B2 (en) *	1999-04-19	2003-09-11	Shionogi & Co., Ltd.	Sulfonamide derivatives having oxadiazole rings
FR2798589B1 (fr) *	1999-09-16	2001-11-30	Oreal	Composition cosmetique comprenant au moins un copolymere silicone/acrylate et au moins un agent epaississant
AU2709001A (en) *	2000-01-26	2001-08-07	Shionogi & Co., Ltd.	Substituted tryptophan derivatives
WO2001070675A2 (en) *	2000-03-24	2001-09-27	Methylgene, Inc.	Inhibitors of histone deacetylase
CN1199956C (zh) *	2000-04-21	2005-05-04	盐野义制药株式会社	具有抗癌作用的噁二唑衍生物
WO2001083464A1 (en) *	2000-04-21	2001-11-08	Shionogi & Co., Ltd.	Oxadiazole derivatives having therapeutic or preventive efficacies against glomerular disorders
AU4882101A (en)	2000-04-28	2001-11-12	Shionogi & Co., Ltd.	Mmp-12 inhibitors
AU2001248820A1 (en) *	2000-04-28	2001-11-12	Shionogi And Co., Ltd.	Thiazole and oxazole derivatives
CA2423885A1 (en) *	2000-09-29	2003-03-27	Shionogi & Co., Ltd.	Thiazole and oxazole derivatives
MXPA04003451A (es)	2001-10-09	2005-02-17	Dimensional Pharm Inc	Difeniloxazoles substituidos, la sintesis de los mismos y el uso de los mismo como detectores fluorescencia.
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EP1650199A4 (en)	2003-07-30	2008-11-19	Shionogi & Co	SULPHONAMIDE DERIVATIVE WITH ISOXAZOL RING
US7504431B2 (en) *	2004-04-16	2009-03-17	Bristol-Myers Squibb Company	Sulfonyl amide inhibitors of calcium channel function
AU2005250351A1 (en)	2004-05-11	2005-12-15	Merck & Co., Inc.	Process for making n-sulfonated-amino acid derivatives
JP2006036691A (ja) *	2004-07-27	2006-02-09	Shionogi & Co Ltd	腎炎の治療または予防剤
US20080119513A1 (en) *	2004-09-06	2008-05-22	Fumihiko Watanabe	Sulfonamide Derivative Selectively Inhibiting Mmp-13
US7576222B2 (en) *	2004-12-28	2009-08-18	Wyeth	Alkynyl-containing tryptophan derivative inhibitors of TACE/matrix metalloproteinase
WO2007102392A1 (ja)	2006-03-03	2007-09-13	Shionogi & Co., Ltd.	Ｍｍｐ－１３選択的阻害剤
WO2008053913A1 (en)	2006-11-02	2008-05-08	Shionogi & Co., Ltd.	Sulfonylurea derivative capable of selectively inhibiting mmp-13
US8765953B2 (en) *	2008-12-23	2014-07-01	Aquilus Pharmaceuticals, Inc.	Compounds and methods for the treatment of pain and other diseases
WO2019034729A1 (en) *	2017-08-17	2019-02-21	Glaxosmithkline Intellectual Property Development Limited	NOVEL TETRAZOLE COMPOUNDS AND THEIR USE IN THE TREATMENT OF TUBERCULOSIS

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BR9707010B1 (pt)	1996-01-23	2009-05-05		compostos, composição farmacêutica e composições para inibir metaloproteinase e colagenase do tipo iv.
CN1077885C (zh) *	1996-05-17	2002-01-16	沃尼尔·朗伯公司	联苯基磺酰胺基质金属蛋白酶抑制剂
WO1997045402A1 (fr) *	1996-05-24	1997-12-04	Ono Pharmaceutical Co., Ltd.	Derives de phenylsulfonamide
JP2000515153A (ja)	1996-07-22	2000-11-14	モンサントカンパニー	チオールスルホンアミドメタロプロテアーゼインヒビター
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JP3621427B2 (ja) *	1997-07-22	2005-02-16	塩野義製薬株式会社	糸球体障害治療または予防剤

1998
- 1998-07-17 JP JP50964999A patent/JP3621427B2/ja not_active Expired - Fee Related
- 1998-07-17 IL IL13393398A patent/IL133933A0/xx unknown
- 1998-07-17 AU AU82439/98A patent/AU737218B2/en not_active Ceased
- 1998-07-17 HU HU0003851A patent/HUP0003851A3/hu unknown
- 1998-07-17 TR TR2000/00214T patent/TR200000214T2/xx unknown
- 1998-07-17 ID IDW20000054A patent/ID24105A/id unknown
- 1998-07-17 NZ NZ502274A patent/NZ502274A/xx unknown
- 1998-07-17 CA CA002297011A patent/CA2297011C/en not_active Expired - Fee Related
- 1998-07-17 US US09/462,001 patent/US6423729B1/en not_active Expired - Fee Related
- 1998-07-17 CN CNB98809147XA patent/CN1198607C/zh not_active Expired - Fee Related
- 1998-07-17 DE DE69836877T patent/DE69836877D1/de not_active Expired - Lifetime
- 1998-07-17 SK SK26-2000A patent/SK262000A3/sk unknown
- 1998-07-17 RU RU2000103032/04A patent/RU2207849C2/ru not_active IP Right Cessation
- 1998-07-17 EP EP03023547A patent/EP1398027B1/en not_active Expired - Lifetime
- 1998-07-17 EP EP98932574A patent/EP1029541B1/en not_active Expired - Lifetime
- 1998-07-17 DE DE69833940T patent/DE69833940T2/de not_active Expired - Lifetime
- 1998-07-17 BR BR9811521-9A patent/BR9811521A/pt not_active Application Discontinuation
- 1998-07-17 ID IDW00200101551A patent/ID29293A/id unknown
- 1998-07-17 WO PCT/JP1998/003226 patent/WO1999004780A1/ja not_active Ceased
- 1998-07-17 PL PL98338235A patent/PL338235A1/xx unknown
- 1998-07-17 AT AT98932574T patent/ATE320801T1/de not_active IP Right Cessation
- 1998-07-17 KR KR10-2000-7000676A patent/KR100386148B1/ko not_active Expired - Fee Related
- 1998-07-17 TR TR2001/00389T patent/TR200100389T2/xx unknown
- 1998-09-30 TW TW087111798A patent/TW593249B/zh not_active IP Right Cessation
- 1998-09-30 TW TW092118405A patent/TWI249518B/zh not_active IP Right Cessation
2000
- 2000-01-20 NO NO20000285A patent/NO20000285L/no not_active Application Discontinuation
2002
- 2002-06-06 US US10/162,865 patent/US6878739B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
ATE320801T1 (de)	2006-04-15
US6423729B1 (en)	2002-07-23
TR200100389T2 (tr)	2001-08-21
DE69836877D1 (de)	2007-02-22
EP1029541A4 (en)	2000-08-23
SK262000A3 (en)	2001-01-18
CA2297011A1 (en)	1999-02-04
HUP0003851A3 (en)	2002-10-28
NO20000285D0 (no)	2000-01-20
TWI249518B (en)	2006-02-21
KR100386148B1 (ko)	2003-06-02
US6878739B2 (en)	2005-04-12
PL338235A1 (en)	2000-10-09
HUP0003851A2 (hu)	2001-07-30
DE69833940T2 (de)	2006-12-14
JP3621427B2 (ja)	2005-02-16
BR9811521A (pt)	2000-08-22
TW593249B (en)	2004-06-21
DE69833940D1 (de)	2006-05-11
ID24105A (id)	2000-07-06
KR20010022106A (ko)	2001-03-15
WO1999004780A1 (en)	1999-02-04
CN1198607C (zh)	2005-04-27
EP1398027B1 (en)	2007-01-10
EP1398027A1 (en)	2004-03-17
ID29293A (id)	1999-01-28
IL133933A0 (en)	2001-04-30
US20030078434A1 (en)	2003-04-24
TW200400934A (en)	2004-01-16
AU8243998A (en)	1999-02-16
NZ502274A (en)	2001-03-30
CA2297011C (en)	2007-01-30
AU737218B2 (en)	2001-08-09
CN1270518A (zh)	2000-10-18
TR200000214T2 (tr)	2000-09-21
RU2207849C2 (ru)	2003-07-10
EP1029541B1 (en)	2006-03-22
EP1029541A1 (en)	2000-08-23

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2005-05-02	FC2A	Withdrawal, rejection or dismissal of laid open patent application

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