NO20001043L - Massespektrometrisk deteksjon av polypeptider - Google Patents

Massespektrometrisk deteksjon av polypeptider

Info

Publication number
NO20001043L
NO20001043L NO20001043A NO20001043A NO20001043L NO 20001043 L NO20001043 L NO 20001043L NO 20001043 A NO20001043 A NO 20001043A NO 20001043 A NO20001043 A NO 20001043A NO 20001043 L NO20001043 L NO 20001043L
Authority
NO
Norway
Prior art keywords
polypeptides
mass spectrometric
spectrometric detection
identity
target polypeptide
Prior art date
Application number
NO20001043A
Other languages
English (en)
Norwegian (no)
Other versions
NO20001043D0 (no
Inventor
Daniel Little
Hubert Koester
Scott G Higgins
David M Lough
Original Assignee
Sequenom Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sequenom Inc filed Critical Sequenom Inc
Publication of NO20001043D0 publication Critical patent/NO20001043D0/no
Publication of NO20001043L publication Critical patent/NO20001043L/no

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848Methods of protein analysis involving mass spectrometry
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6818Sequencing of polypeptides
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848Methods of protein analysis involving mass spectrometry
    • G01N33/6851Methods of protein analysis involving laser desorption ionisation mass spectrometry
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Optics & Photonics (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
NO20001043A 1997-09-02 2000-03-01 Massespektrometrisk deteksjon av polypeptider NO20001043L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/922,201 US6207370B1 (en) 1997-09-02 1997-09-02 Diagnostics based on mass spectrometric detection of translated target polypeptides
PCT/US1998/018311 WO1999012040A2 (en) 1997-09-02 1998-09-02 Mass spectrometric detection of polypeptides

Publications (2)

Publication Number Publication Date
NO20001043D0 NO20001043D0 (no) 2000-03-01
NO20001043L true NO20001043L (no) 2000-05-02

Family

ID=25446684

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20001043A NO20001043L (no) 1997-09-02 2000-03-01 Massespektrometrisk deteksjon av polypeptider

Country Status (9)

Country Link
US (4) US6207370B1 (de)
EP (2) EP1010008B1 (de)
JP (1) JP2001515209A (de)
AT (2) ATE433112T1 (de)
AU (1) AU744266B2 (de)
CA (1) CA2300356A1 (de)
DE (3) DE19882657C2 (de)
NO (1) NO20001043L (de)
WO (1) WO1999012040A2 (de)

Families Citing this family (200)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5605798A (en) 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
US5830655A (en) 1995-05-22 1998-11-03 Sri International Oligonucleotide sizing using cleavable primers
AU2069597A (en) * 1996-03-04 1997-09-22 Genetrace Systems, Inc. Methods of screening nucleic acids using mass spectrometry
US6329180B1 (en) 1996-09-13 2001-12-11 Alex M. Garvin Genetic analysis using peptide tagged in-vitro synthesized proteins
US5777324A (en) 1996-09-19 1998-07-07 Sequenom, Inc. Method and apparatus for maldi analysis
US5965363A (en) 1996-09-19 1999-10-12 Genetrace Systems Inc. Methods of preparing nucleic acids for mass spectrometric analysis
EP1164203B1 (de) * 1996-11-06 2007-10-10 Sequenom, Inc. DNA-Diagnostik mittels Massenspektrometrie
US7285422B1 (en) 1997-01-23 2007-10-23 Sequenom, Inc. Systems and methods for preparing and analyzing low volume analyte array elements
EP0963443B1 (de) * 1996-12-10 2006-03-08 Sequenom, Inc. Abspaltbare, nicht-flüchtige moleküle zur massenmarkierung
NZ516848A (en) * 1997-06-20 2004-03-26 Ciphergen Biosystems Inc Retentate chromatography apparatus with applications in biology and medicine
CA2243230A1 (en) * 1998-07-15 2000-01-15 Aled Edwards A device and method for the determination of protein domain boundaries
US7198896B2 (en) * 1998-09-04 2007-04-03 Cell Signaling Technology, Inc. Immunoaffinity isolation of modified peptides from complex mixtures
US20120244594A9 (en) * 1998-09-04 2012-09-27 Cell Signaling Technology, Inc. Immunoaffinity isolation of modified peptides from complex mixtures
US7300753B2 (en) * 1998-09-04 2007-11-27 John Rush Immunoaffinity isolation of modified peptides from complex mixtures
US20030194700A1 (en) * 1998-12-01 2003-10-16 Toshiaki Ito Biochip and method for producing the same
CA2355134A1 (en) * 1998-12-16 2000-06-22 Sequel Genetics, Incorporated Methods and products for peptide-based dna sequence characterization and analysis
JP2003524394A (ja) * 1999-02-11 2003-08-19 マキシジェン, インコーポレイテッド ハイスループット質量分析法
US7166475B2 (en) * 1999-02-26 2007-01-23 Cyclacel Ltd. Compositions and methods for monitoring the modification state of a pair of polypeptides
US20020009394A1 (en) 1999-04-02 2002-01-24 Hubert Koster Automated process line
US6994969B1 (en) * 1999-04-30 2006-02-07 Methexis Genomics, N.V. Diagnostic sequencing by a combination of specific cleavage and mass spectrometry
US6306628B1 (en) * 1999-08-25 2001-10-23 Ambergen, Incorporated Methods for the detection, analysis and isolation of Nascent proteins
DE19943743C2 (de) * 1999-09-03 2002-02-07 Jerini Biotools Gmbh Verfahren zur Identifizierung von Bindungspartnern mit positions-spezifischen Arrays
WO2001025791A2 (en) * 1999-10-07 2001-04-12 Ciphergen Biosystems, Inc. Prostate cancer marker proteins
US20030207297A1 (en) * 1999-10-13 2003-11-06 Hubert Koster Methods for generating databases and databases for identifying polymorphic genetic markers
US7917301B1 (en) 2000-09-19 2011-03-29 Sequenom, Inc. Method and device for identifying a biological sample
US7668658B2 (en) * 1999-10-13 2010-02-23 Sequenom, Inc. Methods for generating databases and databases for identifying polymorphic genetic markers
US20020155445A1 (en) * 1999-12-16 2002-10-24 Jarvik Jonathan W. Methods and products for peptide based DNA sequence identification and analysis
US7060506B2 (en) 2000-01-31 2006-06-13 Cyclacel, Ltd. Compositions and methods for monitoring the modification of modification dependent binding partner polypeptides
US7816098B2 (en) * 2000-01-31 2010-10-19 Sense Proteomic Limited Methods of making and using a protein array
US6625546B2 (en) 2000-02-03 2003-09-23 Nanoscale Combinatorial Synthesis, Inc. Structure identification methods using mass measurements
US6569383B1 (en) * 2000-03-11 2003-05-27 Intrinsic Bioprobes, Inc. Bioactive chip mass spectrometry
DE60137722D1 (de) * 2000-06-13 2009-04-02 Univ Boston Verwendung von mass-matched nukleotide in der analyse von oligonukleotidmischungen sowie in der hoch-multiplexen nukleinsäuresequenzierung
US7244701B2 (en) * 2000-06-16 2007-07-17 Zealand Phama A/S Diuretic peptide conjugate
US7550425B2 (en) * 2000-06-16 2009-06-23 Zealand Pharma A/S Diuretic peptide conjugates
US6680203B2 (en) * 2000-07-10 2004-01-20 Esperion Therapeutics, Inc. Fourier transform mass spectrometry of complex biological samples
US6958214B2 (en) 2000-07-10 2005-10-25 Sequenom, Inc. Polymorphic kinase anchor proteins and nucleic acids encoding the same
CA2419490C (en) * 2000-08-15 2010-01-26 Discerna Limited Functional protein arrays
AU4338502A (en) * 2000-10-23 2002-06-24 Genetics Inst Acid-labile isotope-coded extractant (alice) and its use in quantitative mass spectrometric analysis of protein mixtures
US20020142483A1 (en) 2000-10-30 2002-10-03 Sequenom, Inc. Method and apparatus for delivery of submicroliter volumes onto a substrate
US6649419B1 (en) * 2000-11-28 2003-11-18 Large Scale Proteomics Corp. Method and apparatus for protein manipulation
US20020115056A1 (en) 2000-12-26 2002-08-22 Goodlett David R. Rapid and quantitative proteome analysis and related methods
EP1739424B1 (de) * 2000-12-26 2011-08-24 The Institute for Systems Biology Schnelle und quantitative Proteomanalyse und entsprechende Verfahren
US6800453B2 (en) 2001-01-23 2004-10-05 President And Fellows Of Harvard College Nucleic-acid programmable protein arrays
US7166436B2 (en) 2001-01-26 2007-01-23 Syngenta Participations, Ag Differential labeling for quantitative analysis of complex protein mixtures
US6969757B2 (en) 2001-01-26 2005-11-29 Syngenta Participations Ag Differential labeling for quantitative analysis of complex protein mixtures
WO2002061047A2 (en) * 2001-02-01 2002-08-08 Ciphergen Biosystems, Inc. Improved methods for protein identification, characterization and sequencing by tandem mass spectrometry
DE10106339A1 (de) * 2001-02-09 2002-08-22 Hans-Joachim Mueller Verfahren zum Hochdurchsatz-Screening von Kandidaten-Verbindungen über die Hochdurchsatz-Direktsynthese von rekombinanten Polypeptiden
US6707038B2 (en) 2001-02-14 2004-03-16 Picoliter Inc. Method and system using acoustic ejection for selective fluid deposition on a nonuniform sample surface
EP1366356B1 (de) 2001-02-14 2010-07-21 Picoliter, Inc. Einführung akustischer proben zur analyse und/oder verarbeitung
US6855925B2 (en) 2001-02-14 2005-02-15 Picoliter Inc. Methods, devices, and systems using acoustic ejection for depositing fluid droplets on a sample surface for analysis
US7666588B2 (en) 2001-03-02 2010-02-23 Ibis Biosciences, Inc. Methods for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy
WO2004060278A2 (en) 2002-12-06 2004-07-22 Isis Pharmaceuticals, Inc. Methods for rapid identification of pathogens in humans and animals
EP1370867B1 (de) * 2001-03-02 2010-08-04 Activx Biosciences, Inc. Plattform für protein-profiling
US7226739B2 (en) 2001-03-02 2007-06-05 Isis Pharmaceuticals, Inc Methods for rapid detection and identification of bioagents in epidemiological and forensic investigations
US7718354B2 (en) 2001-03-02 2010-05-18 Ibis Biosciences, Inc. Methods for rapid identification of pathogens in humans and animals
US20030027135A1 (en) 2001-03-02 2003-02-06 Ecker David J. Method for rapid detection and identification of bioagents
US20040121309A1 (en) 2002-12-06 2004-06-24 Ecker David J. Methods for rapid detection and identification of bioagents in blood, bodily fluids, and bodily tissues
US20020137106A1 (en) * 2001-03-09 2002-09-26 Ciphergen Biosystems, Inc. Detection of biological pathway components
US20030036057A1 (en) * 2001-03-09 2003-02-20 Andreas Braun Genes and polymorphisms associated with cardiovascular disease and their use
WO2002081752A2 (en) * 2001-04-03 2002-10-17 Thermo Finnigan Corporation Methods and kits useful for the simplification of complex peptide mixtures
WO2002084250A2 (en) 2001-04-17 2002-10-24 Femtolink Biotechnologies Llc Methods for mass spectrometry detection and quantification of specific target proteins in complex biological samples
CN1463291A (zh) * 2001-04-19 2003-12-24 赛弗根生物系统股份有限公司 用质谱法和亲和标记物鉴定生物分子的特性
WO2002086081A2 (en) * 2001-04-20 2002-10-31 Carnegie Mellon University Methods and systems for identifying proteins
US20020155587A1 (en) 2001-04-20 2002-10-24 Sequenom, Inc. System and method for testing a biological sample
US6620786B2 (en) * 2001-04-30 2003-09-16 Syn X Pharma, Inc. Biopolymer marker indicative of disease state having molecular weight of 2937 daltons
US6593298B2 (en) * 2001-04-30 2003-07-15 Syn X Pharma, Inc. Biopolymer marker indicative of disease state having a molecular weight of 1690 daltons
US6677303B2 (en) * 2001-04-30 2004-01-13 Syn X Pharma Biopolymer marker indicative of disease state having a molecular weight of 1097 daltons
US6693080B2 (en) * 2001-04-30 2004-02-17 Syn X Pharma Biopolymer marker indicative of disease state having a molecular weight of 1521 daltons
US6627607B2 (en) * 2001-04-30 2003-09-30 Syn X Pharma, Inc. Biopolymer marker indicative of disease state having a molecular weight of 1845 daltons
US6617308B2 (en) * 2001-04-30 2003-09-09 Syn X Pharma, Inc. Biopolymer marker indicative of disease state having a molecular weight of 1865 daltons
US6627606B2 (en) * 2001-04-30 2003-09-30 Syn X Pharma, Inc. Biopolymer marker indicative of disease state having a molecular weight of 1465 daltons
US6703366B2 (en) * 2001-04-30 2004-03-09 George Jackowski Biopolymer marker indicative of disease state having a molecular weight of 1,896 daltons
US6627608B2 (en) * 2001-04-30 2003-09-30 Syn X Pharma, Inc. Biopolymer marker indicative of disease state having a molecular weight of 1206 daltons
US7074570B2 (en) * 2001-05-23 2006-07-11 Ge Healthcare Bio-Sciences Ab Peptide fragmentation
WO2002097392A2 (en) * 2001-05-25 2002-12-05 Waters Investments Limited Sample concentration maldi plates for maldi mass spectrometry
JP2002372517A (ja) * 2001-05-31 2002-12-26 Inst Of Physical & Chemical Res 質量分析法によるタンパク質の構造解析方法
US7074558B2 (en) * 2001-06-07 2006-07-11 Pbi Technology, Inc. Nucleic acid amplification using an RNA polymerase and DNA/RNA mixed polymer intermediate products
US20110111424A1 (en) * 2001-06-21 2011-05-12 Cell Signaling Technology, Inc. Analysis of ubiquitinated polypeptides
US7217510B2 (en) 2001-06-26 2007-05-15 Isis Pharmaceuticals, Inc. Methods for providing bacterial bioagent characterizing information
US8073627B2 (en) * 2001-06-26 2011-12-06 Ibis Biosciences, Inc. System for indentification of pathogens
US6800449B1 (en) 2001-07-13 2004-10-05 Syngenta Participations Ag High throughput functional proteomics
WO2003092581A2 (en) * 2001-07-16 2003-11-13 Hk Pharmaceuticals, Inc. Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions
US20030143576A1 (en) * 2001-08-22 2003-07-31 Heman Chao Method and device for integrated protein expression, purification and detection
US7133864B2 (en) 2001-08-23 2006-11-07 Syngenta Participations Ag System and method for accessing biological data
WO2003021226A2 (en) * 2001-08-31 2003-03-13 Pharmacia Corporation Peptide biomarker and method of identification
US7148343B2 (en) * 2001-10-12 2006-12-12 Gentra Systems, Inc. Compositions and methods for using a solid support to purify RNA
US20030111494A1 (en) * 2001-10-26 2003-06-19 Sequenom, Inc. Method and apparatus for high-throughput sample handling process line
US20030091976A1 (en) * 2001-11-14 2003-05-15 Ciphergen Biosystems, Inc. Methods for monitoring polypeptide production and purification using surface enhanced laser desorption/ionization mass spectrometry
US20030153729A1 (en) * 2001-12-28 2003-08-14 Duewel Henry S. Enzyme/chemical reactor based protein processing method for proteomics analysis by mass spectrometry
US20040053356A1 (en) * 2001-12-28 2004-03-18 Mds Proteomics Inc. Enzyme/chemical reactor based protein processing method for proteomics analysis by mass spectrometry
US20040009567A1 (en) * 2001-12-28 2004-01-15 Mds Proteomics Inc. Enzyme/chemical reactor based protein processing method for proteomics analysis by mass spectrometry
AU2003224674A1 (en) * 2002-03-11 2003-09-29 Hk Pharmaceuticals, Inc. Compounds and methods for analyzing the proteome
WO2003093296A2 (en) * 2002-05-03 2003-11-13 Sequenom, Inc. Kinase anchor protein muteins, peptides thereof, and related methods
US20040171070A1 (en) * 2002-05-20 2004-09-02 Ramagauri Bhikhabhai Peptide analysis using a solid support
US6770871B1 (en) 2002-05-31 2004-08-03 Michrom Bioresources, Inc. Two-dimensional tandem mass spectrometry
GB0305796D0 (en) 2002-07-24 2003-04-16 Micromass Ltd Method of mass spectrometry and a mass spectrometer
US6624409B1 (en) 2002-07-30 2003-09-23 Agilent Technologies, Inc. Matrix assisted laser desorption substrates for biological and reactive samples
US7632686B2 (en) 2002-10-03 2009-12-15 Anderson Forschung Group High sensitivity quantitation of peptides by mass spectrometry
AU2003284227A1 (en) * 2002-10-15 2004-05-04 The Regents Of The University Of Michigan Multidimensional protein separation system
AU2003298733B2 (en) * 2002-11-27 2009-06-18 Agena Bioscience, Inc. Fragmentation-based methods and systems for sequence variation detection and discovery
DE10393861B4 (de) * 2002-12-09 2016-12-15 Waters Technologies Corp. (N.D.Ges.D. Staates Delaware) Vorrichtung für eine Gefrier-Tau-Ventilschaltung und Verfahren zum Schalten eines Gefrier-Tau-Ventils
US20040185473A1 (en) * 2002-12-17 2004-09-23 Affymetrix, Inc. Releasable polymer arrays
US20040248162A1 (en) * 2002-12-17 2004-12-09 Affymetrix, Inc. Releasable polymer arrays
WO2004061422A2 (en) * 2002-12-31 2004-07-22 Rodi Pharma, Inc. Bindingzyme arrays and high-throughput proteomic methods
US7422865B2 (en) * 2003-01-13 2008-09-09 Agilent Technologies, Inc. Method of identifying peptides in a proteomic sample
WO2004064972A2 (en) * 2003-01-16 2004-08-05 Hk Pharmaceuticals, Inc. Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions
US20070141570A1 (en) * 2003-03-07 2007-06-21 Sequenom, Inc. Association of polymorphic kinase anchor proteins with cardiac phenotypes and related methods
US8046171B2 (en) 2003-04-18 2011-10-25 Ibis Biosciences, Inc. Methods and apparatus for genetic evaluation
EP1618216A2 (de) * 2003-04-25 2006-01-25 Sequenom, Inc. Auf fragmentierung beruhende verfahren und systeme zur de-novo-sequenzierung
US8057993B2 (en) 2003-04-26 2011-11-15 Ibis Biosciences, Inc. Methods for identification of coronaviruses
US7368290B2 (en) * 2003-05-12 2008-05-06 Sandia National Laboratories Structural determination of intact proteins using mass spectrometry
US7964343B2 (en) 2003-05-13 2011-06-21 Ibis Biosciences, Inc. Method for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture
US8158354B2 (en) 2003-05-13 2012-04-17 Ibis Biosciences, Inc. Methods for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture
US7425700B2 (en) * 2003-05-22 2008-09-16 Stults John T Systems and methods for discovery and analysis of markers
US20040236603A1 (en) * 2003-05-22 2004-11-25 Biospect, Inc. System of analyzing complex mixtures of biological and other fluids to identify biological state information
EP2107129B1 (de) 2003-07-31 2012-08-22 Sequenom, Inc. Verfahren für Multiplex-Polymerasekettenreaktionen auf hohem Niveau und homogene Massenausdehnungsreaktionen zur Genotypisierung von Polymorphismen
AU2004288132A1 (en) * 2003-08-12 2005-05-19 Massachusetts Institute Of Technology Sample preparation methods and devices
US20050277204A1 (en) * 2003-08-12 2005-12-15 Massachusetts Institute Of Technology Sample preparation methods and devices
WO2005024068A2 (en) * 2003-09-05 2005-03-17 Sequenom, Inc. Allele-specific sequence variation analysis
US8546082B2 (en) 2003-09-11 2013-10-01 Ibis Biosciences, Inc. Methods for identification of sepsis-causing bacteria
US8242254B2 (en) 2003-09-11 2012-08-14 Ibis Biosciences, Inc. Compositions for use in identification of bacteria
US8097416B2 (en) 2003-09-11 2012-01-17 Ibis Biosciences, Inc. Methods for identification of sepsis-causing bacteria
US20070087448A1 (en) * 2004-02-16 2007-04-19 Nelsestuen Gary L Biological profiles and methods of use
US20050181513A1 (en) * 2004-02-18 2005-08-18 Viorica Lopez-Avila Methods and compositions for assessing a sample by MAILDI mass spectrometry
US7666592B2 (en) 2004-02-18 2010-02-23 Ibis Biosciences, Inc. Methods for concurrent identification and quantification of an unknown bioagent
US8119336B2 (en) 2004-03-03 2012-02-21 Ibis Biosciences, Inc. Compositions for use in identification of alphaviruses
US7608394B2 (en) 2004-03-26 2009-10-27 Sequenom, Inc. Methods and compositions for phenotype identification based on nucleic acid methylation
CA2561381C (en) * 2004-03-26 2015-05-12 Sequenom, Inc. Base specific cleavage of methylation-specific amplification products in combination with mass analysis
WO2006073436A2 (en) * 2004-04-29 2006-07-13 The Trustees Of Columbia University In The City Of New York Mass tag pcr for multiplex diagnostics
US20050244973A1 (en) * 2004-04-29 2005-11-03 Predicant Biosciences, Inc. Biological patterns for diagnosis and treatment of cancer
ES2641832T3 (es) 2004-05-24 2017-11-14 Ibis Biosciences, Inc. Espectrometría de masas con filtración de iones selectiva por establecimiento de umbrales digitales
US20050266411A1 (en) 2004-05-25 2005-12-01 Hofstadler Steven A Methods for rapid forensic analysis of mitochondrial DNA
US7785843B2 (en) 2004-06-23 2010-08-31 Sequenom, Inc. Target-specific compomers and methods of use
US7811753B2 (en) 2004-07-14 2010-10-12 Ibis Biosciences, Inc. Methods for repairing degraded DNA
US7563598B2 (en) * 2004-07-30 2009-07-21 Ambergen, Inc. Detection of truncation mutations by mass spectrometry
WO2006135400A2 (en) 2004-08-24 2006-12-21 Isis Pharmaceuticals, Inc. Methods for rapid identification of recombinant organisms
US7786261B2 (en) * 2004-09-02 2010-08-31 National Research Council Of Canada Coiled-coil fusion proteins comprising cell receptor domains
DE102004042530B4 (de) * 2004-09-02 2006-10-19 Mosaiques Diagnostics And Therapeutics Ag Verfahren zur Diagnose von Arteriosklerose
JP2008512129A (ja) * 2004-09-10 2008-04-24 セクエノム,インコーポレイティド 核酸の広範囲配列分析法
US20060073534A1 (en) * 2004-10-05 2006-04-06 The University Of Georgia Research Foundation, Inc Method for cleaving and deglycosylating antibodies to promote ligand binding
US20060105372A1 (en) 2004-11-05 2006-05-18 Bair Robert J Compositions and methods for purifying nucleic acids from stabilization reagents
US7547775B2 (en) * 2004-12-31 2009-06-16 Affymetrix, Inc. Parallel preparation of high fidelity probes in an array format
US20060205040A1 (en) 2005-03-03 2006-09-14 Rangarajan Sampath Compositions for use in identification of adventitious viruses
US8084207B2 (en) 2005-03-03 2011-12-27 Ibis Bioscience, Inc. Compositions for use in identification of papillomavirus
US8343710B1 (en) * 2005-03-11 2013-01-01 The Regents Of The University Of Colorado, A Body Corporate Photodegradable groups for tunable polymeric materials
US9180196B2 (en) 2005-03-11 2015-11-10 The Regents Of The University Of Colorado, A Body Corporate Photodegradable groups for tunable polymeric materials
JP2009502137A (ja) 2005-07-21 2009-01-29 アイシス ファーマシューティカルズ インコーポレイティッド 核酸変種の迅速な同定および定量のための方法
WO2007035864A2 (en) * 2005-09-20 2007-03-29 Cell Biosciences, Inc. Electrophoresis standards, methods and kits
JP2007108015A (ja) * 2005-10-13 2007-04-26 Biologica:Kk 分析用の保持体及びその利用
BRPI0618609A2 (pt) 2005-11-16 2011-09-06 Novartis Ag biomarcadores para tratamento com anticorpo anti-nogo-a em danos à medula espinhal
US7889347B2 (en) 2005-11-21 2011-02-15 Plexera Llc Surface plasmon resonance spectrometer with an actuator driven angle scanning mechanism
US7463358B2 (en) 2005-12-06 2008-12-09 Lumera Corporation Highly stable surface plasmon resonance plates, microarrays, and methods
EP2010679A2 (de) 2006-04-06 2009-01-07 Ibis Biosciences, Inc. Zusammensetzungen für die identifizierung von pilzen
US20100285973A1 (en) * 2006-05-30 2010-11-11 Synergenz Bioscience Limited of Sea Meadow House Methods and compositions for assessment of pulmonary function and disorders
US8178316B2 (en) 2006-06-29 2012-05-15 President And Fellows Of Harvard College Evaluating proteins
US20150232540A1 (en) 2006-07-11 2015-08-20 Cell Signaling Technology, Inc. Analysis of ubiquitnated polypeptides
US9149473B2 (en) 2006-09-14 2015-10-06 Ibis Biosciences, Inc. Targeted whole genome amplification method for identification of pathogens
EP2126132B1 (de) 2007-02-23 2013-03-20 Ibis Biosciences, Inc. Verfahren für schnelle forensische dna-analyse
WO2008151023A2 (en) 2007-06-01 2008-12-11 Ibis Biosciences, Inc. Methods and compositions for multiple displacement amplification of nucleic acids
WO2009039122A2 (en) 2007-09-17 2009-03-26 Sequenom, Inc. Integrated robotic sample transfer device
US8357277B2 (en) * 2007-11-27 2013-01-22 Laboratory Corp. of America Holdings Enhanced method for detecting and/or quantifying an analyte in a sample
US8530182B2 (en) 2007-12-05 2013-09-10 Centers For Disease Control And Prevention Viral protein quantification process and vaccine quality control therewith
US8004669B1 (en) 2007-12-18 2011-08-23 Plexera Llc SPR apparatus with a high performance fluid delivery system
WO2009117785A1 (en) * 2008-03-28 2009-10-01 Newsouth Innovations Pty Limited Method of hla tissue typing
US20090311727A1 (en) * 2008-04-21 2009-12-17 Bio-Rad Laboratories, Inc. Recombinant deamidated gliadin antigen
WO2009155103A2 (en) * 2008-05-30 2009-12-23 Ibis Biosciences, Inc. Compositions for use in identification of tick-borne pathogens
WO2009148995A2 (en) * 2008-06-02 2009-12-10 Ibis Biosciences, Inc. Compositions for use in identification of adventitious viruses
AU2009266924B2 (en) 2008-07-01 2015-12-10 Genocea Biosciences, Inc. Antigen screening system
US20100159506A1 (en) * 2008-07-25 2010-06-24 Cellscape Corporation Methods and systems for genetic analysis of fetal nucleated red blood cells
US8426807B2 (en) * 2008-08-01 2013-04-23 Brown University System and methods for determining molecules using mass spectrometry and related techniques
US8148163B2 (en) 2008-09-16 2012-04-03 Ibis Biosciences, Inc. Sample processing units, systems, and related methods
WO2010033625A1 (en) 2008-09-16 2010-03-25 Ibis Biosciences, Inc. Microplate handling systems and related computer program products and methods
US8550694B2 (en) 2008-09-16 2013-10-08 Ibis Biosciences, Inc. Mixing cartridges, mixing stations, and related kits, systems, and methods
WO2010039870A1 (en) * 2008-10-03 2010-04-08 Ibis Biosciences, Inc. Compositions for use in identification of neisseria, chlamydia, and/or chlamydophila bacteria
WO2010039848A2 (en) * 2008-10-03 2010-04-08 Ibis Biosciences, Inc. Compositions for use in identification of streptococcus pneumoniae
EP2396803A4 (de) 2009-02-12 2016-10-26 Ibis Biosciences Inc Ionisationssondenanordnungen
EP2226637A1 (de) * 2009-03-04 2010-09-08 Centre National de la Recherche Scientifique (CNRS) Vernetzungsmittel auf solidem Träger
US9719083B2 (en) 2009-03-08 2017-08-01 Ibis Biosciences, Inc. Bioagent detection methods
WO2010114842A1 (en) 2009-03-30 2010-10-07 Ibis Biosciences, Inc. Bioagent detection systems, devices, and methods
US8945511B2 (en) 2009-06-25 2015-02-03 Paul Weinberger Sensitive methods for detecting the presence of cancer associated with the over-expression of galectin-3 using biomarkers derived from galectin-3
EP2454000A4 (de) 2009-07-17 2016-08-10 Ibis Biosciences Inc Systeme zur identifizierung von biowirkstoffen
US8950604B2 (en) 2009-07-17 2015-02-10 Ibis Biosciences, Inc. Lift and mount apparatus
WO2011014811A1 (en) 2009-07-31 2011-02-03 Ibis Biosciences, Inc. Capture primers and capture sequence linked solid supports for molecular diagnostic tests
EP3098325A1 (de) 2009-08-06 2016-11-30 Ibis Biosciences, Inc. Basenzusammensetzungen ohne massenbestimmung zur nukleinsäureerkennung
US20110065111A1 (en) * 2009-08-31 2011-03-17 Ibis Biosciences, Inc. Compositions For Use In Genotyping Of Klebsiella Pneumoniae
EP2488656B1 (de) 2009-10-15 2015-06-03 Ibis Biosciences, Inc. Mehrfache verschiebungsverstärkung
US8774488B2 (en) 2010-03-11 2014-07-08 Cellscape Corporation Method and device for identification of nucleated red blood cells from a maternal blood sample
US9758840B2 (en) 2010-03-14 2017-09-12 Ibis Biosciences, Inc. Parasite detection via endosymbiont detection
RU2445000C2 (ru) * 2010-03-22 2012-03-20 Общество с ограниченной ответственностью "ЭкоБиоФарм" Способ диагностики онкологических заболеваний предстательной железы на основе ацилкарнитина и арахидоноил амина
ES2676183T3 (es) 2010-07-02 2018-07-17 Ventana Medical Systems, Inc. Detección de dianas usando marcas de masa y espectrometría de masas
US8629093B2 (en) 2010-09-01 2014-01-14 The Procter & Gamble Company Detergent composition comprising mixture of chelants
WO2017026241A1 (ja) * 2015-08-07 2017-02-16 国立大学法人愛媛大学 質量分析を用いたb型肝炎ウイルスの測定方法
GB201603291D0 (en) * 2016-02-25 2016-04-13 Binding Site Group The Ltd Antibodies
CN105699476B (zh) * 2016-03-29 2018-03-13 武汉大学 一种多肽化衍生方法及其在maldi‑tof‑ms检测小分子化合物中的应用
KR101953800B1 (ko) * 2016-10-12 2019-03-04 주식회사 엘지화학 초고온용 에어로겔 블랭킷, 이의 제조방법 및 이의 시공방법
JP2022505162A (ja) * 2018-10-18 2022-01-14 ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド 質量分析システムとの使用のための試料採取要素の官能化
CN117169534A (zh) 2019-08-05 2023-12-05 禧尔公司 用于样品制备、数据生成和蛋白质冠分析的系统和方法
MX2022001664A (es) 2019-08-09 2022-07-19 Nutcracker Therapeutics Inc Aparato microfluídico y metodos de uso del mismo.
US20230151406A1 (en) * 2020-02-19 2023-05-18 Chan Zuckerberg Biohub, Inc. Nucleic acid sequence detection by endonuclease digestion and mass spectrometry
CN116773840B (zh) * 2023-08-25 2023-10-27 四川徕伯益自动化技术有限公司 一种样本溶液的溯源方法及介质

Family Cites Families (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2739829C2 (de) 1977-09-03 1986-04-10 Gesellschaft für Strahlen- und Umweltforschung mbH, 8000 München Anordnung zur Analyse einer Probenschicht durch Beschuß mit elektromagnetischer Strahlung
US4356270A (en) 1977-11-08 1982-10-26 Genentech, Inc. Recombinant DNA cloning vehicle
US4442354A (en) 1982-01-22 1984-04-10 Atom Sciences, Inc. Sputter initiated resonance ionization spectrometry
DE3329892A1 (de) 1983-08-18 1985-03-07 Köster, Hubert, Prof. Dr., 2000 Hamburg Verfahren zur herstellung von oligonucleotiden
US4983521A (en) 1983-10-26 1991-01-08 The Regents Of The University Of California Transmembrane integrator sequences
US4683194A (en) 1984-05-29 1987-07-28 Cetus Corporation Method for detection of polymorphic restriction sites and nucleic acid sequences
US5118605A (en) 1984-10-16 1992-06-02 Chiron Corporation Polynucleotide determination with selectable cleavage sites
GB2168478A (en) * 1984-11-26 1986-06-18 Scan Limited M Analysis of protein etc using mass spectrometry
JPS61200524A (ja) 1985-03-01 1986-09-05 Fuji Photo Film Co Ltd 光走査装置
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4766072A (en) 1985-07-17 1988-08-23 Promega Corporation Vectors for in vitro production of RNA copies of either strand of a cloned DNA sequence
US5604099A (en) 1986-03-13 1997-02-18 Hoffmann-La Roche Inc. Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids
JP2640812B2 (ja) 1986-10-21 1997-08-13 協和醗酵工業株式会社 粉粒体の高濃度気力輸送方法及びその装置
GB8626075D0 (en) 1986-10-31 1986-12-03 Vg Instr Group Time-of-flight mass spectrometer
US5670381A (en) 1988-01-29 1997-09-23 Abbott Laboratories Devices for performing ion-capture binding assays
DE3809504C1 (de) 1988-03-22 1989-09-21 Bruker - Franzen Analytik Gmbh, 2800 Bremen, De
ATE241014T2 (de) 1988-06-14 2003-06-15 Qiagen Gmbh Hiv-2 varianten
US5237016A (en) 1989-01-05 1993-08-17 Siska Diagnostics, Inc. End-attachment of oligonucleotides to polyacrylamide solid supports for capture and detection of nucleic acids
US4920264A (en) 1989-01-17 1990-04-24 Sri International Method for preparing samples for mass analysis by desorption from a frozen solution
CA2032490A1 (en) 1989-05-19 1990-11-20 Chin Kai Meng Multiply charged ions and a method for determining the molecular weight of large molecules
US5118937A (en) 1989-08-22 1992-06-02 Finnigan Mat Gmbh Process and device for the laser desorption of an analyte molecular ions, especially of biomolecules
US5045694A (en) 1989-09-27 1991-09-03 The Rockefeller University Instrument and method for the laser desorption of ions in mass spectrometry
US5410068A (en) 1989-10-23 1995-04-25 Perseptive Biosystems, Inc. Succinimidyl trityl compounds and a process for preparing same
US5288644A (en) 1990-04-04 1994-02-22 The Rockefeller University Instrument and method for the sequencing of genome
US5135870A (en) 1990-06-01 1992-08-04 Arizona Board Of Regents Laser ablation/ionizaton and mass spectrometric analysis of massive polymers
DE4019005C2 (de) 1990-06-13 2000-03-09 Finnigan Mat Gmbh Vorrichtungen zur Analyse von Ionen hoher Masse
DE69132531T2 (de) 1990-12-06 2001-09-13 Affymetrix, Inc. (N.D.Ges.D.Staates Delaware) Verbindungen und ihre Verwendung in einer binären Synthesestrategie
US5210412A (en) 1991-01-31 1993-05-11 Wayne State University Method for analyzing an organic sample
WO1992013629A1 (en) 1991-01-31 1992-08-20 Wayne State University A method for analyzing an organic sample
US5198531A (en) 1991-06-14 1993-03-30 Research Diagnostic Antibodies Polymeric resin for peptide synthesis
US5492817A (en) 1993-11-09 1996-02-20 Promega Corporation Coupled transcription and translation in eukaryotic cell-free extract
ATE147104T1 (de) 1991-10-11 1997-01-15 Promega Corp Gekoppelte transkription und translation in zellfreien eukaryoten-extrakten
IL103674A0 (en) 1991-11-19 1993-04-04 Houston Advanced Res Center Method and apparatus for molecule detection
CA2124087C (en) 1991-11-22 2002-10-01 James L. Winkler Combinatorial strategies for polymer synthesis
DE4202123C2 (de) 1992-01-27 1995-04-06 Bruker Franzen Analytik Gmbh Vorrichtung für die massenspektrometrische Untersuchung schneller organischer Ionen
US5382793A (en) 1992-03-06 1995-01-17 Hewlett-Packard Company Laser desorption ionization mass monitor (LDIM)
EP1130399B1 (de) 1992-05-29 2009-04-01 The Rockefeller University Verfahren zur Bestimmung der Folge von Peptiden unter Verwendung eines Massenspektrometers
US5792664A (en) 1992-05-29 1998-08-11 The Rockefeller University Methods for producing and analyzing biopolymer ladders
WO1994000562A1 (en) 1992-06-24 1994-01-06 The Mt. Sinai School Of Medicine Of The City University Of New York A novel human immunodeficiency virus
US5503980A (en) 1992-11-06 1996-04-02 Trustees Of Boston University Positional sequencing by hybridization
US5795714A (en) 1992-11-06 1998-08-18 Trustees Of Boston University Method for replicating an array of nucleic acid probes
US5605798A (en) 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
US6194144B1 (en) 1993-01-07 2001-02-27 Sequenom, Inc. DNA sequencing by mass spectrometry
DE69433811T2 (de) 1993-01-07 2005-06-23 Sequenom, Inc., San Diego Dns - sequenzierung durch massenspektronomie
ATE239797T1 (de) 1993-01-25 2003-05-15 Takeda Chemical Industries Ltd Antikörper gegen beta-amyloid oder derivative davon und seine verwendung
US5628184A (en) 1993-02-03 1997-05-13 Santos; Rolando R. Apparatus for reducing the production of NOx in a gas turbine
CA2158642A1 (en) 1993-03-19 1994-09-29 Hubert Koster Dna sequencing by mass spectrometry via exonuclease degradation
US6074823A (en) 1993-03-19 2000-06-13 Sequenom, Inc. DNA sequencing by mass spectrometry via exonuclease degradation
US5381008A (en) 1993-05-11 1995-01-10 Mds Health Group Ltd. Method of plasma mass analysis with reduced space charge effects
US5376788A (en) 1993-05-26 1994-12-27 University Of Manitoba Apparatus and method for matrix-assisted laser desorption mass spectrometry
EP0700521B1 (de) 1993-05-28 2003-06-04 Baylor College Of Medicine Verfahren und massenspektrometer zur desorption und ionisierung von analyten
FR2709761B1 (fr) 1993-09-10 1995-11-24 Pasteur Institut Procédé de détection de molécules contenant des mésappariements nucléotidiques et de localisation de ces mésappariements, et application à la détection de substitutions ou de délétions de bases .
JPH07150956A (ja) 1993-11-26 1995-06-13 Mitsubishi Heavy Ind Ltd ターボクーリングエンジン
US5622829A (en) 1993-12-08 1997-04-22 The Regents Of The University Of California Genetic markers for breast, ovarian, and prostatic cancer
US5538897A (en) * 1994-03-14 1996-07-23 University Of Washington Use of mass spectrometry fragmentation patterns of peptides to identify amino acid sequences in databases
WO1995025737A1 (en) 1994-03-23 1995-09-28 The Penn State Research Foundation Method for identifying members of combinatorial libraries
US5986076A (en) 1994-05-11 1999-11-16 Trustees Of Boston University Photocleavable agents and conjugates for the detection and isolation of biomolecules
US5643722A (en) 1994-05-11 1997-07-01 Trustees Of Boston University Methods for the detection and isolation of proteins
US5612474A (en) 1994-06-30 1997-03-18 Eli Lilly And Company Acid labile immunoconjugate intermediates
US5545539A (en) 1994-10-18 1996-08-13 Genzyme Corporation Method for nucleotide sequence amplification
US5504326A (en) 1994-10-24 1996-04-02 Indiana University Foundation Spatial-velocity correlation focusing in time-of-flight mass spectrometry
AU5544696A (en) 1995-04-11 1996-10-30 Trustees Of Boston University Solid phase sequencing of biopolymers
AU5576796A (en) 1995-04-26 1996-11-18 Regeneron Pharmaceuticals, Inc. Methods of using neurotrophic factors to enhance neuronal gr afts
US5625184A (en) 1995-05-19 1997-04-29 Perseptive Biosystems, Inc. Time-of-flight mass spectrometry analysis of biomolecules
US5753439A (en) 1995-05-19 1998-05-19 Trustees Of Boston University Nucleic acid detection methods
JP2001500606A (ja) 1995-05-19 2001-01-16 パーセプティブ バイオシステムズ,インコーポレーテッド 質量スペクトル分析を用いた統計的に確実性のあるポリマー配列決定のための方法および装置
US5830655A (en) 1995-05-22 1998-11-03 Sri International Oligonucleotide sizing using cleavable primers
US5700642A (en) 1995-05-22 1997-12-23 Sri International Oligonucleotide sizing using immobilized cleavable primers
US5654150A (en) * 1995-06-07 1997-08-05 President And Fellows Of Harvard College Method of expression cloning
US6146854A (en) 1995-08-31 2000-11-14 Sequenom, Inc. Filtration processes, kits and devices for isolating plasmids
US5869242A (en) 1995-09-18 1999-02-09 Myriad Genetics, Inc. Mass spectrometry to assess DNA sequence polymorphisms
US5654545A (en) 1995-09-19 1997-08-05 Bruker-Franzen Analytik Gmbh Mass resolution in time-of-flight mass spectrometers with reflectors
WO1997016699A1 (en) 1995-10-30 1997-05-09 Trustees Of Boston University Piezoelectric force sensing apparatus and methods for biopolymer sequencing
DE69631540T2 (de) 1995-11-23 2005-01-27 Cancer Research Technology Ltd. Materialien und methoden mit bezug zur identifizierung und sequenzierung des krebs-suszeptilitaetsgens brca2 und dessen anwendungen
US5742049A (en) 1995-12-21 1998-04-21 Bruker-Franzen Analytik Gmbh Method of improving mass resolution in time-of-flight mass spectrometry
US5641959A (en) 1995-12-21 1997-06-24 Bruker-Franzen Analytik Gmbh Method for improved mass resolution with a TOF-LD source
WO1997037041A2 (en) 1996-03-18 1997-10-09 Sequenom, Inc. Dna sequencing by mass spectrometry
US5777325A (en) 1996-05-06 1998-07-07 Hewlett-Packard Company Device for time lag focusing time-of-flight mass spectrometry
US5928906A (en) 1996-05-09 1999-07-27 Sequenom, Inc. Process for direct sequencing during template amplification
US6022688A (en) 1996-05-13 2000-02-08 Sequenom, Inc. Method for dissociating biotin complexes
DE19624802A1 (de) 1996-06-21 1998-01-02 Forssmann Wolf Georg Verfahren zum direkten diagnostischen Nachweis von pathogenen, genetisch bedingten Punktmutationen in Proteinen bei Herzerkrankungen durch chemische und physikalische Methoden, besonders der direkten und indirekten Kopplung der Hochdruck-Flüssigkeitschromatographie und der Massenspektrometrie
EP0931160B1 (de) 1996-09-13 2008-12-17 Alex M. Garvin Nachweis von mutationen mittels in vitro synthetisierten proteinen mit peptid-markierung
US5777324A (en) 1996-09-19 1998-07-07 Sequenom, Inc. Method and apparatus for maldi analysis
US5864137A (en) 1996-10-01 1999-01-26 Genetrace Systems, Inc. Mass spectrometer
US5900481A (en) 1996-11-06 1999-05-04 Sequenom, Inc. Bead linkers for immobilizing nucleic acids to solid supports
US6133436A (en) 1996-11-06 2000-10-17 Sequenom, Inc. Beads bound to a solid support and to nucleic acids
EP1164203B1 (de) 1996-11-06 2007-10-10 Sequenom, Inc. DNA-Diagnostik mittels Massenspektrometrie
WO1998020019A1 (en) 1996-11-06 1998-05-14 Sequenom, Inc. Compositions and methods for immobilizing nucleic acids to solid supports
US6140053A (en) 1996-11-06 2000-10-31 Sequenom, Inc. DNA sequencing by mass spectrometry via exonuclease degradation
DE69735112T2 (de) 1996-11-06 2006-09-07 Sequenom, Inc., San Diego Verfahren zur Analyse und Vorrichtung
US6024925A (en) 1997-01-23 2000-02-15 Sequenom, Inc. Systems and methods for preparing low volume analyte array elements
IL130949A (en) 1997-01-23 2004-12-15 Xzillion Gmbh & Co Kg Method for characterising polypeptides

Also Published As

Publication number Publication date
WO1999012040A2 (en) 1999-03-11
EP1010008A2 (de) 2000-06-21
AU744266B2 (en) 2002-02-21
US6322970B1 (en) 2001-11-27
US6387628B1 (en) 2002-05-14
DE19882657C2 (de) 2003-03-13
ATE346304T1 (de) 2006-12-15
ATE433112T1 (de) 2009-06-15
DE69836488D1 (de) 2007-01-04
US6207370B1 (en) 2001-03-27
EP1296143A2 (de) 2003-03-26
JP2001515209A (ja) 2001-09-18
DE69840878D1 (de) 2009-07-16
NO20001043D0 (no) 2000-03-01
EP1296143B1 (de) 2009-06-03
AU9129898A (en) 1999-03-22
EP1010008B1 (de) 2006-11-22
CA2300356A1 (en) 1999-03-11
DE19882657T1 (de) 2000-08-24
WO1999012040A3 (en) 1999-09-02
EP1296143A3 (de) 2004-02-04
US20030003465A1 (en) 2003-01-02

Similar Documents

Publication Publication Date Title
NO20001043D0 (no) Massespektrometrisk deteksjon av polypeptider
ATE232558T1 (de) Dna-diagnostik mittels massenspektrometrie
WO1998020166A3 (en) Dna diagnostics based on mass spectrometry
ATE100448T1 (de) Substituierte chinazolinone als angiotensin iiantagonisten.
EP1521083A3 (de) Verfahren zur Diagnose und zur Charakterisierung von Schlaganfall
FR2650840B1 (fr) Procede rapide de detection et/ou d'identification d'une seule base sur une sequence d'acide nucleique, et ses applications
CA2193705A1 (en) Merocyanine dye protein stains
ATE340869T1 (de) Massenmarkierte hybridisierungssonden
ES2086405T3 (es) Agonistas de dopamina.
DE69213827D1 (de) Merocynanine als Eiweissfehler-Indikatoren
ES2117855T3 (es) Proteina del ciclo celular de mamifero.
DE69007789D1 (de) Polymerisations-co-katalysator, der organischen sauerstoff enthält.
DE3783851D1 (de) Integrales, mehrschichtiges element fuer analyse.
FR2799281B1 (fr) Procede et dispositif de detection d'une reaction de reconnaissance moleculaire
CA2237817A1 (en) Increasing the fvii sensitivity of a thromboplastin reagent
FI922312L (fi) Direkt fibrinogenbestaemning.
DE69015834D1 (de) 6-Chlor-7,8-dihydroxy-1-(4'-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzodiazepin-carbamate als Pro-Arzneimittel.
DE68913346D1 (de) Bisharnstoffe als Lichtstabilisatoren für organische Polymere.
ES2073495T3 (es) Benzotiazepinas.
DE69015968D1 (de) Spektrometer-Mikroskop für Infrarot.
KR880701886A (ko) 췌장효소원의 유리활성화 펩티드의 면역검정에 의한 질병의 진단, 위중도 예견, 및 모니터링
EA199900683A1 (ru) Тетрагидрофураны
IT8719319A0 (it) Catena per pneumatici nonche'procedimento per la sua fabbricazione.
DK0382268T3 (da) Aminocarboxylsyrederivater
IT9047777A0 (it) Assieme di albero di sterzo con chiavi di fissaggio dei perni precaricate.