NO20001584L - Aminoterminert trunkert MCP-2 som kjemokinantagonister - Google Patents

Aminoterminert trunkert MCP-2 som kjemokinantagonister

Info

Publication number: NO20001584L
Authority: NO; Norway
Prior art keywords: amino; chemokine antagonists; truncated mcp; terminated; terminated truncated
Prior art date: 1997-09-29

Application number

NO20001584A

Other languages

English (en)

Norwegian (no)

Other versions

NO20001584D0 (no

Inventor

Paul Proost

Sofie Struyf

Jo Van Damme

Original Assignee

Applied Research Systems

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-09-29

Filing date

2000-03-27

Publication date

2000-03-27

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8227408&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20001584(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2000-03-27 Application filed by Applied Research Systems filed Critical Applied Research Systems

2000-03-27 Publication of NO20001584D0 publication Critical patent/NO20001584D0/no

2000-03-27 Publication of NO20001584L publication Critical patent/NO20001584L/no

Links

102100034871 C-C motif chemokine 8 Human genes 0.000 title 1
101710155833 C-C motif chemokine 8 Proteins 0.000 title 1
102000019034 Chemokines Human genes 0.000 title 1
108010012236 Chemokines Proteins 0.000 title 1
239000005557 antagonist Substances 0.000 title 1
AEUKDPKXTPNBNY-XEYRWQBLSA-N mcp 2 Chemical compound C([C@@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CS)NC(=O)[C@H](C)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)C1=CC=CC=C1 AEUKDPKXTPNBNY-XEYRWQBLSA-N 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4813—Exopeptidases (3.4.11. to 3.4.19)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/521—Chemokines
- C07K14/523—Beta-chemokines, e.g. RANTES, I-309/TCA-3, MIP-1alpha, MIP-1beta/ACT-2/LD78/SCIF, MCP-1/MCAF, MCP-2, MCP-3, LDCF-1, LDCF-2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Toxicology (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Virology (AREA)
Heart & Thoracic Surgery (AREA)
Epidemiology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Cardiology (AREA)
Tropical Medicine & Parasitology (AREA)
Hematology (AREA)
Diabetes (AREA)
AIDS & HIV (AREA)
Vascular Medicine (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

NO20001584A 1997-09-29 2000-03-27 Aminoterminert trunkert MCP-2 som kjemokinantagonister NO20001584L (no)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
EP97116863A EP0906954A1 (fr)	1997-09-29	1997-09-29	C-C chémokine tronquée à l'aminoterminus comme antagoniste de chémokines
EP97122471A EP0905240A1 (fr)	1997-09-29	1997-12-19	Amino-terminale tronquée C-C chemokin et d'un antagoniste chemokin
EP98104216A EP0905241A1 (fr)	1997-09-29	1998-03-10	Amino-terminale tronquée C-C chemokine et d'un antagoniste de chemokin
PCT/EP1998/006143 WO1999016877A1 (fr)	1997-09-29	1998-09-28	Rantes tronques a acide amine terminal utilises comme antagonistes de la chemokine

Publications (2)

Publication Number	Publication Date
NO20001584D0 NO20001584D0 (no)	2000-03-27
NO20001584L true NO20001584L (no)	2000-03-27

Family

ID=8227408

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
NO20001584A NO20001584L (no)	1997-09-29	2000-03-27	Aminoterminert trunkert MCP-2 som kjemokinantagonister
NO20001609A NO20001609D0 (no)	1997-09-29	2000-03-28	Aminoterminert trunkerte RANTES som kjemokinantagonister

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
NO20001609A NO20001609D0 (no)	1997-09-29	2000-03-28	Aminoterminert trunkerte RANTES som kjemokinantagonister

Country Status (28)

Country	Link
US (5)	US6905676B2 (fr)
EP (6)	EP0906954A1 (fr)
JP (2)	JP4233214B2 (fr)
KR (2)	KR100542934B1 (fr)
CN (3)	CN1148447C (fr)
AR (2)	AR013529A1 (fr)
AT (3)	ATE264390T1 (fr)
AU (2)	AU750606B2 (fr)
BG (2)	BG64679B1 (fr)
BR (2)	BR9812565A (fr)
CA (2)	CA2304827A1 (fr)
CY (1)	CY1110927T1 (fr)
CZ (2)	CZ299479B6 (fr)
DE (3)	DE69823218T2 (fr)
DK (3)	DK1021541T3 (fr)
EA (2)	EA003940B1 (fr)
EE (2)	EE200000152A (fr)
ES (3)	ES2218860T3 (fr)
HU (2)	HU226414B1 (fr)
IL (2)	IL135352A (fr)
NO (2)	NO20001584L (fr)
NZ (3)	NZ516027A (fr)
PL (2)	PL197569B1 (fr)
PT (3)	PT1021541E (fr)
SK (2)	SK286495B6 (fr)
UA (2)	UA73081C2 (fr)
WO (2)	WO1999016876A1 (fr)
ZA (2)	ZA988675B (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6989435B2 (en)	1997-09-11	2006-01-24	Cambridge University Technical Services Ltd.	Compounds and methods to inhibit or augment an inflammatory response
US7067117B1 (en)	1997-09-11	2006-06-27	Cambridge University Technical Services, Ltd.	Compounds and methods to inhibit or augment an inflammatory response
WO1999028474A2 (fr) *	1997-12-01	1999-06-10	The Government Of The United States Of America, Represented By The Secretary Of Health And Human Services	Variants de chemokine et leurs procedes d'utilisation
US7238711B1 (en)	1999-03-17	2007-07-03	Cambridge University Technical Services Ltd.	Compounds and methods to inhibit or augment an inflammatory response
EP1167527A1 (fr) *	2000-06-22	2002-01-02	Euroscreen S.A.	Chemokines humaines tronquées: PHC-1 et PHC-2
CA2387378A1 (fr) *	1999-10-25	2001-05-03	Euroscreen S.A.	Chimiokines humaines phc-1 et phc-2 traitees
AU2505601A (en) *	1999-11-15	2001-05-30	Wolf-Georg Forssmann	Novel use of hcc-2
CA2316405A1 (fr) *	2000-05-26	2001-11-26	Ian Clark-Lewis	Modulation de l'inflammation a l'aide de produits du type protease
EP1176200A3 (fr)	2000-06-20	2005-01-12	Switch Biotech Aktiengesellschaft	Utilisation des polypeptides ou leurs acides nucléiques pour le diagnose ou traitement des maladies de la peau ou de la cicatrisation de blessures et leurs utilisations pour l'identification des substances pharmacologiquement actives
UA77950C2 (en) *	2000-10-04	2007-02-15	Applied Research Systems	Use of mutants of cc chemokines for treatment of multiple sclerosis
GB2373785A (en) *	2001-03-28	2002-10-02	Rega Inst For Medical Res	Truncating chemokines using dipeptidyl peptidase IV
US7553483B2 (en)	2001-12-17	2009-06-30	Merck Serono Sa	Chemokine mutants acting as chemokine antagonists
WO2004104216A2 (fr) *	2003-05-21	2004-12-02	Bayer Healthcare Ag	Diagnostics et agents therapeutiques destines a des maladies liees a une dipeptidylpeptidase iv (dpp4)
DE102005049637A1 (de) *	2005-10-14	2007-04-26	Rheinisch-Westfälische Technische Hochschule Aachen	Antagonisten gegen die Interaktion von PF4 und RANTES
EP2185719B1 (fr)	2007-08-02	2013-11-13	NovImmune SA	Anticorps anti-rantes et leurs procédés d'utilisation
WO2011097567A1 (fr) *	2010-02-08	2011-08-11	Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of Arizona State University	Essai multiplexé du rantes, variants du rantes se rapportant à une maladie, et variants du rantes se rapportant à une activité enzymatique
WO2011112915A2 (fr)	2010-03-11	2011-09-15	Health Research, Inc.	Procédés et compositions contenant des protéines de fusion fc pour le renforcement de réponses immunitaires
TW201718851A (zh) *	2015-09-18	2017-06-01	通用醫院公司	具有抗化學排斥(anti-fugetactic)性質之經修飾自然殺手細胞及其用途
EP3813869B1 (fr)	2018-05-28	2023-10-18	Université de Genève	Inhibiteur du ccr5 pour le traitement d'un trouble neuroinflammatoire impliquant une inflammation cérébrale
US11629196B2 (en)	2020-04-27	2023-04-18	Incelldx, Inc.	Method of treating SARS-CoV-2-associated hypercytokinemia by administering a human monoclonal antibody (PRO-140) that inhibits CCR5/CCL5 binding interactions
US11402391B2 (en)	2020-12-21	2022-08-02	Incelldx, Inc.	Methods of treating a long-hauler subject for chronic COVID-19 by administering a CCR5 or CCL5 antagonist

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH01265099A (ja)	1987-10-08	1989-10-23	Stichting Rega Vzw	抗ｈｉｖ活性をもつ３’，−フルオロプリン−２’，３’−ジデオキシリボシド類
US5739103A (en) *	1993-11-12	1998-04-14	Dana-Farber Cancer Institute	Chemokine N-terminal deletion mutations
HU221089B1 (en) *	1994-12-08	2002-08-28	Glaxo Group Ltd	Rantes peptide derivates with antagonistic effect and uses thereof
WO1997025427A1 (fr) *	1996-01-12	1997-07-17	Genetics Institute, Inc.	Beta-chemokine, h1305 (mpc-2)
WO1997035982A2 (fr) *	1996-03-27	1997-10-02	Icos Corporation	Materiels et procedes de fabrication de proteine-5 chimiotactique monocyte
FR2748938B1 (fr) *	1996-05-22	1998-07-31	Pasteur Institut	Utilisation de molecules antagonistes de chemokines pour leur activite antivirale notamment contre un retrovirus de type vih
US6168784B1 (en) *	1997-09-03	2001-01-02	Gryphon Sciences	N-terminal modifications of RANTES and methods of use

1997
- 1997-09-29 EP EP97116863A patent/EP0906954A1/fr not_active Withdrawn
- 1997-12-19 EP EP97122471A patent/EP0905240A1/fr not_active Withdrawn
1998
- 1998-03-10 EP EP98104216A patent/EP0905241A1/fr not_active Withdrawn
- 1998-09-22 ZA ZA9808675A patent/ZA988675B/xx unknown
- 1998-09-22 ZA ZA9808676A patent/ZA988676B/xx unknown
- 1998-09-28 CA CA002304827A patent/CA2304827A1/fr not_active Abandoned
- 1998-09-28 PT PT98947553T patent/PT1021541E/pt unknown
- 1998-09-28 UA UA2000042499A patent/UA73081C2/uk unknown
- 1998-09-28 JP JP2000513947A patent/JP4233214B2/ja not_active Expired - Fee Related
- 1998-09-28 EE EEP200000152A patent/EE200000152A/xx unknown
- 1998-09-28 AT AT98947553T patent/ATE264390T1/de active
- 1998-09-28 SK SK451-2000A patent/SK286495B6/sk not_active IP Right Cessation
- 1998-09-28 DK DK98947553T patent/DK1021541T3/da active
- 1998-09-28 NZ NZ516027A patent/NZ516027A/en unknown
- 1998-09-28 KR KR1020007003020A patent/KR100542934B1/ko not_active Expired - Fee Related
- 1998-09-28 WO PCT/EP1998/006142 patent/WO1999016876A1/fr not_active Ceased
- 1998-09-28 DK DK98951476T patent/DK1019507T3/da active
- 1998-09-28 CN CNB988095726A patent/CN1148447C/zh not_active Expired - Fee Related
- 1998-09-28 HU HU0003505A patent/HU226414B1/hu not_active IP Right Cessation
- 1998-09-28 EP EP04007579A patent/EP1439231B1/fr not_active Expired - Lifetime
- 1998-09-28 HU HU0003563A patent/HU226468B1/hu not_active IP Right Cessation
- 1998-09-28 AU AU94420/98A patent/AU750606B2/en not_active Ceased
- 1998-09-28 EP EP98947553A patent/EP1021541B1/fr not_active Expired - Lifetime
- 1998-09-28 CZ CZ20001147A patent/CZ299479B6/cs not_active IP Right Cessation
- 1998-09-28 EA EA200000379A patent/EA003940B1/ru not_active IP Right Cessation
- 1998-09-28 DK DK04007579T patent/DK1439231T3/da active
- 1998-09-28 PT PT04007579T patent/PT1439231E/pt unknown
- 1998-09-28 EE EEP200000151A patent/EE200000151A/xx unknown
- 1998-09-28 EA EA200000378A patent/EA003942B1/ru not_active IP Right Cessation
- 1998-09-28 SK SK450-2000A patent/SK286439B6/sk not_active IP Right Cessation
- 1998-09-28 DE DE69823218T patent/DE69823218T2/de not_active Expired - Lifetime
- 1998-09-28 KR KR1020007003019A patent/KR100560275B1/ko not_active Expired - Fee Related
- 1998-09-28 WO PCT/EP1998/006143 patent/WO1999016877A1/fr not_active Ceased
- 1998-09-28 PT PT98951476T patent/PT1019507E/pt unknown
- 1998-09-28 CZ CZ20001146A patent/CZ299478B6/cs not_active IP Right Cessation
- 1998-09-28 ES ES98951476T patent/ES2218860T3/es not_active Expired - Lifetime
- 1998-09-28 PL PL339559A patent/PL197569B1/pl not_active IP Right Cessation
- 1998-09-28 DE DE69838188T patent/DE69838188T2/de not_active Expired - Lifetime
- 1998-09-28 CN CNB988095696A patent/CN1145693C/zh not_active Expired - Fee Related
- 1998-09-28 BR BR9812565-6A patent/BR9812565A/pt not_active Application Discontinuation
- 1998-09-28 AR ARP980104820A patent/AR013529A1/es active IP Right Grant
- 1998-09-28 NZ NZ503234A patent/NZ503234A/en unknown
- 1998-09-28 AU AU97474/98A patent/AU750341B2/en not_active Ceased
- 1998-09-28 BR BR9812394-7A patent/BR9812394A/pt not_active Application Discontinuation
- 1998-09-28 AT AT04007579T patent/ATE368742T1/de active
- 1998-09-28 ES ES04007579T patent/ES2287601T3/es not_active Expired - Lifetime
- 1998-09-28 JP JP2000513946A patent/JP4230659B2/ja not_active Expired - Fee Related
- 1998-09-28 CA CA002305017A patent/CA2305017A1/fr not_active Abandoned
- 1998-09-28 DE DE69822856T patent/DE69822856T2/de not_active Expired - Lifetime
- 1998-09-28 ES ES98947553T patent/ES2215324T3/es not_active Expired - Lifetime
- 1998-09-28 AR ARP980104819A patent/AR013528A1/es active IP Right Grant
- 1998-09-28 EP EP98951476A patent/EP1019507B1/fr not_active Expired - Lifetime
- 1998-09-28 PL PL339545A patent/PL196427B1/pl not_active IP Right Cessation
- 1998-09-28 CN CNB031492991A patent/CN1233415C/zh not_active Expired - Fee Related
- 1998-09-28 NZ NZ503235A patent/NZ503235A/xx unknown
- 1998-09-28 AT AT98951476T patent/ATE263242T1/de active
- 1998-09-28 UA UA2000042496A patent/UA73080C2/uk unknown
2000
- 2000-03-22 BG BG104266A patent/BG64679B1/bg unknown
- 2000-03-22 BG BG104267A patent/BG64757B1/bg unknown
- 2000-03-27 NO NO20001584A patent/NO20001584L/no not_active Application Discontinuation
- 2000-03-28 US US09/537,859 patent/US6905676B2/en not_active Expired - Fee Related
- 2000-03-28 US US09/537,858 patent/US6977071B2/en not_active Expired - Fee Related
- 2000-03-28 NO NO20001609A patent/NO20001609D0/no unknown
- 2000-03-29 IL IL135352A patent/IL135352A/en not_active IP Right Cessation
- 2000-03-29 IL IL135351A patent/IL135351A/en not_active IP Right Cessation
2005
- 2005-03-07 US US11/072,454 patent/US7326411B2/en not_active Expired - Fee Related
- 2005-05-06 US US11/123,089 patent/US7338653B2/en not_active Expired - Fee Related
- 2005-05-18 US US11/131,221 patent/US20050220790A1/en not_active Abandoned
2007
- 2007-10-08 CY CY20071101290T patent/CY1110927T1/el unknown

Also Published As

Publication number	Publication date
NZ503235A (en)	2002-08-28
BG64757B1 (bg)	2006-02-28
US7326411B2 (en)	2008-02-05
WO1999016877A1 (fr)	1999-04-08
EA003940B1 (ru)	2003-10-30
CZ299479B6 (cs)	2008-08-06
DE69838188T2 (de)	2007-11-22
DK1439231T3 (da)	2007-11-05
CY1110927T1 (el)	2015-06-10
EA003942B1 (ru)	2003-10-30
EP1439231A3 (fr)	2004-12-22
NO20001609L (no)	2000-03-28
EP1019507A1 (fr)	2000-07-19
CN1271386A (zh)	2000-10-25
JP4233214B2 (ja)	2009-03-04
EE200000151A (et)	2001-02-15
HK1032426A1 (en)	2001-07-20
EP0905241A1 (fr)	1999-03-31
CN1148447C (zh)	2004-05-05
WO1999016876A1 (fr)	1999-04-08
NO20001584D0 (no)	2000-03-27
KR20010024214A (ko)	2001-03-26
US7338653B2 (en)	2008-03-04
DK1021541T3 (da)	2004-08-02
UA73081C2 (en)	2005-06-15
EP1439231A2 (fr)	2004-07-21
NO20001609D0 (no)	2000-03-28
DE69823218T2 (de)	2004-08-26
SK286439B6 (sk)	2008-10-07
CA2305017A1 (fr)	1999-04-08
AU750341B2 (en)	2002-07-18
US20030124677A1 (en)	2003-07-03
KR20010024213A (ko)	2001-03-26
DE69822856D1 (de)	2004-05-06
SK4502000A3 (en)	2000-09-12
CZ20001146A3 (cs)	2000-09-13
BR9812565A (pt)	2000-08-01
CZ299478B6 (cs)	2008-08-06
US20050164936A1 (en)	2005-07-28
AU750606B2 (en)	2002-07-25
ATE263242T1 (de)	2004-04-15
US6905676B2 (en)	2005-06-14
IL135351A (en)	2006-08-20
ATE368742T1 (de)	2007-08-15
US6977071B2 (en)	2005-12-20
EP1439231B1 (fr)	2007-08-01
CZ20001147A3 (cs)	2000-09-13
JP2001518296A (ja)	2001-10-16
CN1145693C (zh)	2004-04-14
KR100560275B1 (ko)	2006-03-10
IL135352A (en)	2006-08-20
DE69823218D1 (de)	2004-05-19
JP2001518297A (ja)	2001-10-16
EP0906954A1 (fr)	1999-04-07
DE69838188D1 (de)	2007-09-13
DE69822856T2 (de)	2004-08-19
NZ503234A (en)	2002-06-28
HUP0003505A3 (en)	2005-11-28
HUP0003563A3 (en)	2005-11-28
KR100542934B1 (ko)	2006-01-11
PT1019507E (pt)	2004-06-30
ATE264390T1 (de)	2004-04-15
AR013529A1 (es)	2000-12-27
JP4230659B2 (ja)	2009-02-25
HK1032425A1 (en)	2001-07-20
PT1021541E (pt)	2004-07-30
EP1021541B1 (fr)	2004-04-14
AU9747498A (en)	1999-04-23
PL339559A1 (en)	2000-12-18
HUP0003505A2 (hu)	2001-02-28
EA200000379A1 (ru)	2000-10-30
UA73080C2 (en)	2005-06-15
ES2218860T3 (es)	2004-11-16
ES2215324T3 (es)	2004-10-01
BR9812394A (pt)	2000-09-12
EE200000152A (et)	2001-02-15
EP1021541A1 (fr)	2000-07-26
SK286495B6 (sk)	2008-11-06
ZA988676B (en)	1999-12-03
BG64679B1 (bg)	2005-11-30
CN1271385A (zh)	2000-10-25
ZA988675B (en)	1999-11-24
US20050201977A1 (en)	2005-09-15
PL339545A1 (en)	2000-12-18
EP1019507B1 (fr)	2004-03-31
EP0905240A1 (fr)	1999-03-31
DK1019507T3 (da)	2004-07-19
ES2287601T3 (es)	2007-12-16
PL196427B1 (pl)	2008-01-31
HUP0003563A2 (hu)	2001-02-28
BG104267A (en)	2000-11-30
PL197569B1 (pl)	2008-04-30
NZ516027A (en)	2003-05-30
SK4512000A3 (en)	2000-09-12
EA200000378A1 (ru)	2000-10-30
BG104266A (en)	2000-11-30
US20030119148A1 (en)	2003-06-26
CN1233415C (zh)	2005-12-28
HU226468B1 (en)	2008-12-29
CA2304827A1 (fr)	1999-04-08
CN1490049A (zh)	2004-04-21
HK1062637A1 (en)	2004-11-19
AU9442098A (en)	1999-04-23
AR013528A1 (es)	2000-12-27
HU226414B1 (en)	2008-11-28
PT1439231E (pt)	2007-08-20
US20050220790A1 (en)	2005-10-06

Legal Events

Date	Code	Title	Description
2008-01-14	CREP	Change of representative	Representative=s name: ONSAGERS AS, POSTBOKS 6963 ST OLAVS PLASS, 0130 OS
2009-08-24	FC2A	Withdrawal, rejection or dismissal of laid open patent application
2009-09-14	FC2A	Withdrawal, rejection or dismissal of laid open patent application

Publication	Publication Date	Title
NO20001584D0 (no)	2000-03-27	Aminoterminert trunkert MCP-2 som kjemokinantagonister
FI971685A7 (fi)	1997-08-13	Takykiniini-antagonisteja
EP0986385A4 (fr)	2001-05-16	Antagonistes de gonadoliberine
DE69826891D1 (de)	2004-11-11	Piperidinderivate
DE69823694T2 (de)	2005-04-21	Thrombin-rezeptor antagonisten
DK0871623T3 (da)	2003-03-31	3-Azetinidylalkylpiperidiner eller -pyrrolidiner som tachykininantagonister
ID26508A (id)	2001-01-11	Oksim-oksim tersubstitusi sebagai antagonis-antagonis neurokinin
EP0909320A4 (fr)	2004-12-01	CHEMOKINE beta-15
IL135352A0 (en)	2001-05-20	Truncated mcp-2 as chemokine antagonist
DK0964867T3 (da)	2005-06-27	Tachykininantagonister
UA25677A (uk)	1998-12-25	Горілка
FI3380U1 (fi)	1998-04-29	Suojakatos
KR980004088U (ko)	1998-03-30	보일러의 상판구조
IT243110Y1 (it)	2002-02-28	Struttura di tavolo
UA1621S (uk)	1997-10-31	Пляшка
UA1564S (uk)	1997-08-29	Пляшка
UA1566S (uk)	1997-08-29	Флакон
UA1569S (uk)	1997-08-29	Флакон
UA1576S (uk)	1997-08-29	Пляшка
UA1565S (uk)	1997-08-29	Пляшка
UA1567S (uk)	1997-08-29	Флакон
UA1841S (uk)	1998-02-27	Пляшка
UA1560S (uk)	1997-08-29	Пляшка
UA1610S (uk)	1997-08-29	Пляшка
UA1611S (uk)	1997-08-29	Пляшка