NO20004281L - 6,9-disubstituerte 2-[trans-(4-aminocykloheksyl)amino]puriner, farmasoytisk preparat inneholdende disse, og anvendelse derav for fremstilling av et medikament - Google Patents

6,9-disubstituerte 2-[trans-(4-aminocykloheksyl)amino]puriner, farmasoytisk preparat inneholdende disse, og anvendelse derav for fremstilling av et medikament

Info

Publication number: NO20004281L
Authority: NO; Norway
Prior art keywords: present; provides; group; alkyl; formula
Prior art date: 1998-02-26

Application number

NO20004281A

Other languages

English (en)

Norwegian (no)

Other versions

NO20004281D0 (no

Inventor

Jennifer Ann Dumont

Alan Joseph Bitonti

David Roger Borcherding

Harry Randall Munson

Patrick Wai-Kwok Shum

Norton Paul Peet

Original Assignee

Aventis Holdings Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-02-26

Filing date

2000-08-25

Publication date

2000-10-18

2000-08-25 Application filed by Aventis Holdings Inc filed Critical Aventis Holdings Inc

2000-08-25 Publication of NO20004281D0 publication Critical patent/NO20004281D0/no

2000-10-18 Publication of NO20004281L publication Critical patent/NO20004281L/no

Links

239000008194 pharmaceutical composition Substances 0.000 title abstract 2
-1 6,9-disubstituted 2- [trans- (4-aminocyclohexyl) amino] purines Chemical class 0.000 title 1
239000003814 drug Substances 0.000 title 1
230000002401 inhibitory effect Effects 0.000 abstract 4
150000001875 compounds Chemical class 0.000 abstract 3
108091007914 CDKs Proteins 0.000 abstract 1
101100439046 Caenorhabditis elegans cdk-2 gene Proteins 0.000 abstract 1
102000003903 Cyclin-dependent kinases Human genes 0.000 abstract 1
108090000266 Cyclin-dependent kinases Proteins 0.000 abstract 1
230000006907 apoptotic process Effects 0.000 abstract 1
230000006369 cell cycle progression Effects 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 1
239000003937 drug carrier Substances 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
150000004677 hydrates Chemical class 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
210000002569 neuron Anatomy 0.000 abstract 1
230000003287 optical effect Effects 0.000 abstract 1
239000000546 pharmaceutical excipient Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Hematology (AREA)
Oncology (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

NO20004281A 1998-02-26 2000-08-25 6,9-disubstituerte 2-[trans-(4-aminocykloheksyl)amino]puriner, farmasoytisk preparat inneholdende disse, og anvendelse derav for fremstilling av et medikament NO20004281L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US3238198A	1998-02-26	1998-02-26
PCT/US1999/003451 WO1999043676A2 (en)	1998-02-26	1999-02-18	6,9-disubstituted 2-[trans-(4- aminocyclohexyl) amino]purines

Publications (2)

Publication Number	Publication Date
NO20004281D0 NO20004281D0 (no)	2000-08-25
NO20004281L true NO20004281L (no)	2000-10-18

Family

ID=21864658

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20004281A NO20004281L (no)	1998-02-26	2000-08-25	6,9-disubstituerte 2-[trans-(4-aminocykloheksyl)amino]puriner, farmasoytisk preparat inneholdende disse, og anvendelse derav for fremstilling av et medikament

Country Status (30)

Country	Link
EP (1)	EP1056745B1 (da)
JP (1)	JP2002504553A (da)
KR (1)	KR100568658B1 (da)
CN (1)	CN1128149C (da)
AP (1)	AP1258A (da)
AR (1)	AR019822A1 (da)
AT (1)	ATE269332T1 (da)
AU (1)	AU748178B2 (da)
BR (1)	BR9908325A (da)
CA (1)	CA2320448C (da)
CZ (1)	CZ291604B6 (da)
DE (1)	DE69918062T2 (da)
DK (1)	DK1056745T3 (da)
EE (1)	EE04315B1 (da)
ES (1)	ES2219038T3 (da)
HU (1)	HUP0100931A3 (da)
IL (2)	IL138044A0 (da)
NO (1)	NO20004281L (da)
NZ (1)	NZ506234A (da)
OA (1)	OA11480A (da)
PL (1)	PL344021A1 (da)
PT (1)	PT1056745E (da)
RU (1)	RU2191777C2 (da)
SI (1)	SI1056745T1 (da)
SK (1)	SK12912000A3 (da)
TR (1)	TR200002482T2 (da)
TW (1)	TW541308B (da)
UA (1)	UA62996C2 (da)
WO (1)	WO1999043676A2 (da)
ZA (1)	ZA991548B (da)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6627633B2 (en)	1999-03-17	2003-09-30	Albany Molecular Research, Inc.	6-substituted biaryl purine derivatives as potent cyclin/CDK inhibitors and antiproliferative agents
US6969720B2 (en)	1999-03-17	2005-11-29	Amr Technology, Inc.	Biaryl substituted purine derivatives as potent antiproliferative agents
DE60118521T2 (de) *	2000-01-07	2006-10-12	Universitaire Instelling Antwerpen	Purin derivate, ihre herstellung und verwendung
YU54202A (sh)	2000-01-18	2006-01-16	Agouron Pharmaceuticals Inc.	Jedinjenja indazola, farmaceutske smeše i postupci za stimulisanje i inhibiranje ćelijske proliferacije
HN2001000008A (es)	2000-01-21	2003-12-11	Inc Agouron Pharmaceuticals	Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas, y su modo de empleo
FR2806626B1 (fr) *	2000-03-22	2003-11-28	Centre Nat Rech Scient	Utilisation de substances modulatrices de l'expression ou de la fonction d'une proteine impliquee dans le cycle cellulaire pour le traitement ou la prevention des lesions neurales aigues
BR0110302A (pt)	2000-04-18	2003-01-14	Agouron Pharma	Compostos de pirazol para inibição de proteìnas cinase, sal e pró-droga farmaceuticamente aceitável, metabólito farmaceuticamente ativo ou sal farmaceuticamente aceitável de metabólito, composição farmacêutica, método de tratamento de condição doentia em mamìferos mediada pela atividade de proteìna cinase, método de modulação ou inibição da atividade de um receptor de proteìna cinase
BR0113139A (pt)	2000-08-09	2003-06-24	Agouron Pharma	Compostos, seus sais, formas multiméricas, pró-drogas ou metabólitos, composições farmacêuticas, método de tratamento de uma doença ou disfunção mediana através da inibição de cdk4 ou um complexo de cdk4/ciclina, método de tratamento de condição doentia em mamìferos mediada pela atividade de proteìna cinase e método de modulação ou inibição da atividade de um receptor de proteìna cinase
WO2002016326A1 (en)	2000-08-18	2002-02-28	Agouron Pharmaceuticals, Inc.	Heterocyclic-hydroxyimino-fluorenes and their use for inhibiting protein kinases
EP1377579B1 (en) *	2000-10-31	2009-03-25	Aventis Pharmaceuticals Inc.	Acyl and sulfonyl derivatives of 6,9-disubstituted 2-(trans-1,4-diaminocyclohexyl)-purines and their use as antiproliferative agents
GB0117075D0 (en) *	2000-10-31	2001-09-05	Aventis Pharm Prod Inc	Acyl and sulfonyl derivatives of 6, 9-distributed 2-(trans-1, 4-diaminocyclohexyl)-purines and their use as antiproliferative agents
US6756374B2 (en)	2001-01-22	2004-06-29	Hoffmann-La Roche Inc.	Diaminothiazoles having antiproliferative activity
WO2003002565A1 (en) *	2001-06-27	2003-01-09	Cyclacel Limited	2,6,9-substituted purine derivatives and their use n the treatment of proliferative disorders
US6667311B2 (en)	2001-09-11	2003-12-23	Albany Molecular Research, Inc.	Nitrogen substituted biaryl purine derivatives as potent antiproliferative agents
US6812232B2 (en)	2001-09-11	2004-11-02	Amr Technology, Inc.	Heterocycle substituted purine derivatives as potent antiproliferative agents
GB0219054D0 (en)	2002-08-15	2002-09-25	Cyclacel Ltd	New purine derivatives
GB0219052D0 (en)	2002-08-15	2002-09-25	Cyclacel Ltd	New puring derivatives
EP1591112A4 (en) *	2003-02-04	2006-06-14	Yakult Honsha Kk	BREAST CANCER RESISTANT PROTEIN INHIBITOR
US7211576B2 (en)	2004-04-20	2007-05-01	Hoffmann-La Roche Inc.	Diaminothiazoles
IN2014CN04406A (da) *	2006-03-30	2015-09-04	Ptc Therapeutics Inc
DK2209786T3 (da) *	2007-10-05	2013-06-03	Verastem Inc	Pyrimidinsubstituerede purinderivater
CN102241646B (zh) *	2010-05-14	2014-04-09	中国人民解放军军事医学科学院毒物药物研究所	己烯酮类化合物及其医药用途
US9493464B2 (en)	2012-02-29	2016-11-15	The Scripps Research Institute	Wee1 degradation inhibitors
JPWO2015005491A1 (ja) *	2013-07-12	2017-03-02	国立大学法人京都大学	疾病の発症又は進行の一因となる異常スプライシングを抑制できる物質のスクリーニング方法
PL3244891T3 (pl)	2015-01-16	2022-12-27	The General Hospital Corporation	Związki poprawiające splicing mRNA
CN107903274A (zh) *	2017-12-28	2018-04-13	窦玉玲	一种胺类化合物及其在抗肿瘤药物中的应用
US20220251085A1 (en) *	2019-07-21	2022-08-11	University Of Virginia Patent Foundation	Cysteine binding compositions and methods of use thereof
WO2024105159A1 (en) *	2022-11-16	2024-05-23	University Of Zurich	Ligands of the m6a-rna readers

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9301000D0 (en) *	1993-01-20	1993-03-10	Glaxo Group Ltd	Chemical compounds
GB9414208D0 (en) *	1994-07-14	1994-08-31	Glaxo Group Ltd	Compounds
PT874846E (pt) *	1995-11-01	2003-08-29	Novartis Ag	Derivados de purina e processos para a sua preparacao
FR2741881B1 (fr) *	1995-12-01	1999-07-30	Centre Nat Rech Scient	Nouveaux derives de purine possedant notamment des prorietes anti-proliferatives et leurs applications biologiques

1999
- 1999-02-18 UA UA2000095500A patent/UA62996C2/uk unknown
- 1999-02-18 TR TR2000/02482T patent/TR200002482T2/xx unknown
- 1999-02-18 HU HU0100931A patent/HUP0100931A3/hu unknown
- 1999-02-18 CN CN99803395A patent/CN1128149C/zh not_active Expired - Fee Related
- 1999-02-18 SI SI9930621T patent/SI1056745T1/xx unknown
- 1999-02-18 NZ NZ506234A patent/NZ506234A/en active IP Right Revival
- 1999-02-18 RU RU2000124409/04A patent/RU2191777C2/ru active
- 1999-02-18 KR KR1020007009421A patent/KR100568658B1/ko not_active Expired - Fee Related
- 1999-02-18 BR BR9908325-6A patent/BR9908325A/pt not_active IP Right Cessation
- 1999-02-18 JP JP2000533431A patent/JP2002504553A/ja active Pending
- 1999-02-18 PL PL99344021A patent/PL344021A1/xx unknown
- 1999-02-18 DE DE69918062T patent/DE69918062T2/de not_active Expired - Fee Related
- 1999-02-18 PT PT99936074T patent/PT1056745E/pt unknown
- 1999-02-18 WO PCT/US1999/003451 patent/WO1999043676A2/en not_active Ceased
- 1999-02-18 AU AU32990/99A patent/AU748178B2/en not_active Ceased
- 1999-02-18 CA CA002320448A patent/CA2320448C/en not_active Expired - Fee Related
- 1999-02-18 EP EP99936074A patent/EP1056745B1/en not_active Expired - Lifetime
- 1999-02-18 ES ES99936074T patent/ES2219038T3/es not_active Expired - Lifetime
- 1999-02-18 AT AT99936074T patent/ATE269332T1/de not_active IP Right Cessation
- 1999-02-18 SK SK1291-2000A patent/SK12912000A3/sk unknown
- 1999-02-18 DK DK99936074T patent/DK1056745T3/da active
- 1999-02-18 AP APAP/P/2000/001923A patent/AP1258A/en active
- 1999-02-18 CZ CZ20003106A patent/CZ291604B6/cs not_active IP Right Cessation
- 1999-02-18 EE EEP200000501A patent/EE04315B1/xx not_active IP Right Cessation
- 1999-02-18 IL IL13804499A patent/IL138044A0/xx active IP Right Grant
- 1999-02-24 TW TW088102781A patent/TW541308B/zh not_active IP Right Cessation
- 1999-02-25 ZA ZA9901548A patent/ZA991548B/xx unknown
- 1999-02-25 AR ARP990100782A patent/AR019822A1/es active IP Right Grant
2000
- 2000-08-23 IL IL138044A patent/IL138044A/en not_active IP Right Cessation
- 2000-08-25 NO NO20004281A patent/NO20004281L/no not_active Application Discontinuation
- 2000-08-25 OA OA1200000234A patent/OA11480A/en unknown

Also Published As

Publication number	Publication date
AP2000001923A0 (en)	2000-09-30
EE04315B1 (et)	2004-06-15
EE200000501A (et)	2002-02-15
ZA991548B (en)	1999-08-26
HUP0100931A3 (en)	2002-08-28
OA11480A (en)	2004-05-05
PT1056745E (pt)	2004-09-30
IL138044A0 (en)	2001-10-31
JP2002504553A (ja)	2002-02-12
RU2191777C2 (ru)	2002-10-27
ATE269332T1 (de)	2004-07-15
CA2320448C (en)	2005-02-01
TW541308B (en)	2003-07-11
PL344021A1 (en)	2001-09-24
WO1999043676A3 (en)	1999-10-21
AU748178B2 (en)	2002-05-30
TR200002482T2 (tr)	2002-10-21
KR20010041315A (ko)	2001-05-15
CZ291604B6 (cs)	2003-04-16
CA2320448A1 (en)	1999-09-02
AR019822A1 (es)	2002-03-20
NZ506234A (en)	2003-05-30
WO1999043676A2 (en)	1999-09-02
UA62996C2 (en)	2004-01-15
HUP0100931A2 (hu)	2002-04-29
SK12912000A3 (sk)	2001-08-06
DE69918062T2 (de)	2005-06-02
NO20004281D0 (no)	2000-08-25
DE69918062D1 (de)	2004-07-22
AP1258A (en)	2004-03-15
DK1056745T3 (da)	2004-10-25
SI1056745T1 (en)	2004-12-31
ES2219038T3 (es)	2004-11-16
CN1128149C (zh)	2003-11-19
CZ20003106A3 (cs)	2000-12-13
IL138044A (en)	2006-04-10
BR9908325A (pt)	2000-11-07
EP1056745A2 (en)	2000-12-06
AU3299099A (en)	1999-09-15
HK1030948A1 (en)	2001-05-25
CN1291983A (zh)	2001-04-18
EP1056745B1 (en)	2004-06-16
KR100568658B1 (ko)	2006-04-07

Legal Events

Date	Code	Title	Description
2010-04-06	FC2A	Withdrawal, rejection or dismissal of laid open patent application

Publication	Publication Date	Title
WO1999043676A3 (en)	1999-10-21	6,9-disubstituted 2-[trans-(4- aminocyclohexyl) amino]purines
NO20020391L (no)	2002-03-25	8-Fenyl-6,9-dihydro-[1,2,4]-triazolo [3,4-i]-purin-5-on- derivater
DK1406876T3 (da)	2007-04-02	2-anilinopyrimidinderivater som inhibitorer af cyclinafhængige kinaser
NO20061660L (no)	2006-04-11	2-pyridonderivate som neutrofil elasaeinhibitor og deres anvendelse
NO20045099L (no)	2005-01-06	Peptid-derivater omfattende tiazepingruppen for behandling av hyperlipidemiske tilstander
NO20061700L (no)	2006-04-18	2-pyridonderivater som neutrofil elastase inhibitorer og deres anvendelse
NO20063931L (no)	2006-09-04	Nye sammensetninger inneholdende kinolinforbindelser
NO20044599L (no)	2005-02-16	3-amino-tieno[2,3-b]pyridin-2-karboksysyreamid-forbindelser og fremgangsmater for fremstilling og anvendelser av dem
NO20043851L (no)	2004-09-14	Derivater av 4-(imidazol-5-yl)-2-(4-sulfoanilino) pyrimidin med CDK inhibitorisk aktivitet
NO20062692L (no)	2006-08-14	Heterosykliske MEK inhibitorer og fremgangsmater for anvendelse derav
NO992524L (no)	1999-05-26	Konsenserte bicykliske pyrimidin-derivater
NO20063231L (no)	2006-07-11	Pyrido[2,3-D]pyrimidin-2,4-diaminer som PDE 2 inhibitorer
NO994900L (no)	1999-11-19	Forbindelser
JPH0317080A (ja)	1991-01-25	置換ピリドピリミジン誘導体
NO160297C (no)	1989-04-05	Analogifremgangsmaate for fremstilling av terapeutisk virksomme 2-oksoazetidinderivater
NO20023001L (no)	2002-06-21	Substituerte piperazinderivater som MTP inhibitorer
NO982072D0 (no)	1998-05-06	Amidin- og isotioureaderivater som inhibitorer av nitrogenoksydsyntase
NO20026081L (no)	2003-02-04	Nye forbindelser
NO20045132L (no)	1998-07-24	Benzo(c)kinolizinderivater, deres fremstilling og anvendelse som 5alfa- reduktaseinhibitorer
NO992731L (no)	1999-06-04	Nye substituerte tetrahydropyridinforbindelser, fremgangsmÕte ved fremstilling av dem og farmas°ytiske sammensetninger derav
SE0202461D0 (sv)	2002-08-14	Novel compounds
MXPA04003741A (es)	2004-07-23	Derivados novedosos de hidroxialquil indolocarbazol, metodo de preparacion y composiciones farmaceuticas que los contienen.
NO973341L (no)	1997-07-18	Anvendelse av 3,4-difenylkromaner til fremstilling av et farmasöytisk preparat for vasodilatorisk behandling eller profylakse
SE9904676D0 (sv)	1999-12-20	Novel compounds
NO20035026D0 (no)	2003-11-12	Dihydroimidazo [5,1-A]-<beta>-karbolinderivater, fremgangsmåte til deres fremstilling og anvendelse derav som legemiddel