ATE322494T1 - Purin derivate, ihre herstellung und verwendung - Google Patents
Purin derivate, ihre herstellung und verwendungInfo
- Publication number
- ATE322494T1 ATE322494T1 AT01907418T AT01907418T ATE322494T1 AT E322494 T1 ATE322494 T1 AT E322494T1 AT 01907418 T AT01907418 T AT 01907418T AT 01907418 T AT01907418 T AT 01907418T AT E322494 T1 ATE322494 T1 AT E322494T1
- Authority
- AT
- Austria
- Prior art keywords
- purine derivatives
- production
- derivatives
- relates
- methods
- Prior art date
Links
- 229940083251 peripheral vasodilators purine derivative Drugs 0.000 title abstract 3
- 150000003212 purines Chemical class 0.000 title 1
- 125000000561 purinyl group Chemical class N1=C(N=C2N=CNC2=C1)* 0.000 abstract 2
- 102000003903 Cyclin-dependent kinases Human genes 0.000 abstract 1
- 108090000266 Cyclin-dependent kinases Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Virology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00200070 | 2000-01-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE322494T1 true ATE322494T1 (de) | 2006-04-15 |
Family
ID=8170897
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01907418T ATE322494T1 (de) | 2000-01-07 | 2001-01-08 | Purin derivate, ihre herstellung und verwendung |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20030187261A1 (de) |
| EP (1) | EP1244668B1 (de) |
| JP (1) | JP2003519232A (de) |
| AT (1) | ATE322494T1 (de) |
| AU (1) | AU3540101A (de) |
| CA (1) | CA2396276A1 (de) |
| CZ (1) | CZ20022353A3 (de) |
| DE (1) | DE60118521T2 (de) |
| IL (1) | IL150594A0 (de) |
| NO (1) | NO20023247L (de) |
| WO (1) | WO2001049688A1 (de) |
Families Citing this family (100)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ27399A3 (cs) * | 1999-01-26 | 2000-08-16 | Ústav Experimentální Botaniky Av Čr | Substituované dusíkaté heterocyklické deriváty, způsob jejich přípravy, tyto deriváty pro použití jako léčiva, farmaceutická kompozice a kombinovaný farmaceutický přípravek tyto deriváty obsahující a použití těchto derivátů pro výrobu léčiv |
| JP2003531111A (ja) * | 1999-12-17 | 2003-10-21 | アライアッド・ファーマシューティカルズ・インコーポレーテッド | プロトンポンプインヒビター |
| DK1377579T3 (da) * | 2000-10-31 | 2009-08-31 | Aventis Pharma Inc | Acyl- og sulfonylderivater af 6,9-disubstitueret-2(trans-1,4-diaminocyklohexyl)puriner og deres anvendelse som antiproliferative midler |
| CZ294535B6 (cs) * | 2001-08-02 | 2005-01-12 | Ústav Experimentální Botaniky Avčr | Heterocyklické sloučeniny na bázi N6-substituovaného adeninu, způsoby jejich přípravy, jejich použití pro přípravu léčiv, kosmetických přípravků a růstových regulátorů, farmaceutické přípravky, kosmetické přípravky a růstové regulátory tyto sloučeniny obsahující |
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| GB0119249D0 (en) | 2001-08-07 | 2001-10-03 | Novartis Ag | Organic compounds |
| ES2279903T3 (es) | 2001-12-18 | 2007-09-01 | Cv Therapeutics, Inc. | Antagonistas del receptor a2a de adenosina. |
| ES2314224T3 (es) | 2002-03-07 | 2009-03-16 | F. Hoffmann-La Roche Ag | Inhibidores pirimidina y piridina biciclicos de p38 quinasa. |
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| US20080280926A1 (en) * | 2003-12-16 | 2008-11-13 | Palle Venkata P | Phosphodiesterase Inhibitors |
| ATE478082T1 (de) * | 2003-12-30 | 2010-09-15 | Gilead Sciences Inc | Phosphonate, monophosphonamidate, bisphosphonamidate zur behandlung von virenerkrankungen |
| US8012964B2 (en) | 2004-03-26 | 2011-09-06 | Dainippon Sumitomo Pharma Co., Ltd. | 9-substituted 8-oxoadenine compound |
| CA2562251C (en) * | 2004-04-07 | 2009-04-28 | Pfizer Inc. | Pyrazolo'4,3-d pyrimidines |
| ATE374202T1 (de) * | 2004-06-29 | 2007-10-15 | Gruenenthal Gmbh | Neue analoga von nitrobenzylthioinosin |
| KR101261305B1 (ko) | 2004-07-28 | 2013-05-08 | 얀센 파마슈티카 엔.브이. | 히스톤 디아세틸라제의 신규한 저해제로의 치환된 인돌릴알킬 아미노 유도체 |
| US7521446B2 (en) * | 2005-01-13 | 2009-04-21 | Signal Pharmaceuticals, Llc | Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith |
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| EP1846408B1 (de) | 2005-01-14 | 2013-03-20 | Janssen Pharmaceutica NV | 5-gliedrige annelierte heterocyclische pyrimidine als kinaseinhibitoren |
| WO2006074984A1 (en) * | 2005-01-14 | 2006-07-20 | Janssen Pharmaceutica N.V. | Pyrazolopyrimidines as cell cycle kinase inhibitors |
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| US7582634B2 (en) | 2005-02-18 | 2009-09-01 | Wyeth | 7-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor |
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| US12043632B2 (en) | 2020-12-23 | 2024-07-23 | Ajax Therapeutics, Inc. | 6-heteroaryloxy benzimidazoles and azabenzimidazoles as JAK2 inhibitors |
| WO2023086319A1 (en) | 2021-11-09 | 2023-05-19 | Ajax Therapeutics, Inc. | 6-he tero aryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors |
| US12162881B2 (en) | 2021-11-09 | 2024-12-10 | Ajax Therapeutics, Inc. | Forms and compositions of inhibitors of JAK2 |
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|---|---|---|---|---|
| US3506643A (en) * | 1966-12-09 | 1970-04-14 | Max Thiel | N**6-aralkyl-adenosine derivatives |
| NL6717061A (de) * | 1966-12-21 | 1968-06-24 | ||
| DE1670265A1 (de) * | 1967-08-25 | 1971-01-28 | Boehringer Mannheim Gmbh | 2-Amino-Adenosinderivate und Verfahren zu deren Herstellung |
| AT293627B (de) * | 1968-09-10 | 1971-10-25 | Boehringer Mannheim Gmbh | Verfahren zur Herstellung von neuen in 6-Stellung substituierten Purinribonucleosid-3':5'-cyclophosphaten |
| BE789773A (fr) * | 1971-10-08 | 1973-04-06 | Schering Ag | Adenosines n6 -substituees et leur procede de |
| DE2401254A1 (de) * | 1974-01-11 | 1975-11-27 | Boehringer Mannheim Gmbh | Neue derivate von n hoch 6-substituierten adeninen |
| CS233665B1 (en) * | 1983-01-06 | 1985-03-14 | Antonin Holy | Processing of isomere o-phosphonylmethylderivative of anantiomere racemic vicinal diene |
| CS263952B1 (en) * | 1985-04-25 | 1989-05-12 | Holy Antonin | Remedy with antiviral effect |
| JPS61256346A (ja) * | 1985-05-10 | 1986-11-13 | Konishiroku Photo Ind Co Ltd | ハロゲン化銀写真感光材料 |
| CS264222B1 (en) * | 1986-07-18 | 1989-06-13 | Holy Antonin | N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them |
| JPS63165398A (ja) * | 1986-12-15 | 1988-07-08 | サンド・アクチエンゲゼルシャフト | 新規フラヌロン酸誘導体、それらの製造方法およびそれらの用途 |
| US4918075A (en) * | 1988-12-20 | 1990-04-17 | E. R. Squibb & Sons, Inc. | Purinyl and pyrimidinyl cyclobutanes and their use as antiviral agents |
| US5302585A (en) * | 1990-04-20 | 1994-04-12 | Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic | Use of chiral 2-(phosphonomethoxy)propyl guanines as antiviral agents |
| JPH05509307A (ja) * | 1990-07-19 | 1993-12-22 | ビーチャム・グループ・パブリック・リミテッド・カンパニー | プリンの抗ウイルス性ホスホノ―アルケン誘導体 |
| US5124051A (en) * | 1990-11-29 | 1992-06-23 | Solarchem Enterprises Inc. | Process for treatment of contaminated waste water or groundwater |
| US5208221A (en) * | 1990-11-29 | 1993-05-04 | Bristol-Myers Squibb Company | Antiviral (phosphonomethoxy) methoxy purine/pyrimidine derivatives |
| US5276143A (en) * | 1990-12-21 | 1994-01-04 | E. I. Du Pont De Nemours And Company | Dideoxyfructonucleosides and deoxyfructonucleotides |
| CZ284678B6 (cs) * | 1991-05-20 | 1999-01-13 | Ústav Organické Chemie A Biochemie Avčr | Di(2-propyl)estery 1-fluor-2-fosfonomethoxy-3-p -toluensulfonyloxypropanů, způsob jejich přípravy a použití |
| US5849905A (en) * | 1994-11-23 | 1998-12-15 | Centre National De La Recherche Scientifique | Biologically active phosphotriester-type nucleosides and methods for preparing same |
| AU7296896A (en) * | 1995-11-01 | 1997-05-22 | Novartis Ag | Purine derivatives and processes for their preparation |
| FR2741881B1 (fr) * | 1995-12-01 | 1999-07-30 | Centre Nat Rech Scient | Nouveaux derives de purine possedant notamment des prorietes anti-proliferatives et leurs applications biologiques |
| DE69717453T2 (de) * | 1996-06-06 | 2003-07-10 | Otsuka Pharmaceutical Factory, Inc. | Amid derivate |
| US5866702A (en) * | 1996-08-02 | 1999-02-02 | Cv Therapeutics, Incorporation | Purine inhibitors of cyclin dependent kinase 2 |
| US6255485B1 (en) * | 1997-08-07 | 2001-07-03 | The Regents Of The University Of California | Purine inhibitors of protein kinases, G proteins and polymerases |
| TR200002482T2 (tr) * | 1998-02-26 | 2002-10-21 | Aventis Pharmaceuticals Inc. | 6,9-Diikameli 2-(Trans-(4-Aminosiklohekzil) Amino)Pürinler |
| US6479487B1 (en) * | 1998-02-26 | 2002-11-12 | Aventis Pharmaceuticals Inc. | 6, 9-disubstituted 2-[trans-(4-aminocyclohexyl)amino] purines |
| CZ294535B6 (cs) * | 2001-08-02 | 2005-01-12 | Ústav Experimentální Botaniky Avčr | Heterocyklické sloučeniny na bázi N6-substituovaného adeninu, způsoby jejich přípravy, jejich použití pro přípravu léčiv, kosmetických přípravků a růstových regulátorů, farmaceutické přípravky, kosmetické přípravky a růstové regulátory tyto sloučeniny obsahující |
-
2001
- 2001-01-08 IL IL15059401A patent/IL150594A0/xx unknown
- 2001-01-08 DE DE60118521T patent/DE60118521T2/de not_active Expired - Lifetime
- 2001-01-08 CZ CZ20022353A patent/CZ20022353A3/cs unknown
- 2001-01-08 WO PCT/EP2001/000150 patent/WO2001049688A1/en not_active Ceased
- 2001-01-08 AU AU35401/01A patent/AU3540101A/en not_active Abandoned
- 2001-01-08 CA CA002396276A patent/CA2396276A1/en not_active Abandoned
- 2001-01-08 US US10/169,592 patent/US20030187261A1/en not_active Abandoned
- 2001-01-08 EP EP01907418A patent/EP1244668B1/de not_active Expired - Lifetime
- 2001-01-08 AT AT01907418T patent/ATE322494T1/de not_active IP Right Cessation
- 2001-01-08 JP JP2001550228A patent/JP2003519232A/ja active Pending
-
2002
- 2002-07-04 NO NO20023247A patent/NO20023247L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| IL150594A0 (en) | 2003-02-12 |
| DE60118521T2 (de) | 2006-10-12 |
| EP1244668A1 (de) | 2002-10-02 |
| DE60118521D1 (de) | 2006-05-18 |
| CA2396276A1 (en) | 2001-07-12 |
| US20030187261A1 (en) | 2003-10-02 |
| EP1244668B1 (de) | 2006-04-05 |
| CZ20022353A3 (cs) | 2003-02-12 |
| NO20023247L (no) | 2002-09-09 |
| WO2001049688A8 (en) | 2001-10-04 |
| WO2001049688A1 (en) | 2001-07-12 |
| NO20023247D0 (no) | 2002-07-04 |
| AU3540101A (en) | 2001-07-16 |
| JP2003519232A (ja) | 2003-06-17 |
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