NO20006541L - Fremgangsmåte for påvisning av en forbindelse som etterligner, potensierer eller inhiberer den fysiologiske effekten av leptin - Google Patents
Fremgangsmåte for påvisning av en forbindelse som etterligner, potensierer eller inhiberer den fysiologiske effekten av leptinInfo
- Publication number
- NO20006541L NO20006541L NO20006541A NO20006541A NO20006541L NO 20006541 L NO20006541 L NO 20006541L NO 20006541 A NO20006541 A NO 20006541A NO 20006541 A NO20006541 A NO 20006541A NO 20006541 L NO20006541 L NO 20006541L
- Authority
- NO
- Norway
- Prior art keywords
- leptin
- compound
- response element
- potentiates
- inhibits
- Prior art date
Links
- 102000016267 Leptin Human genes 0.000 title abstract 9
- 108010092277 Leptin Proteins 0.000 title abstract 9
- NRYBAZVQPHGZNS-ZSOCWYAHSA-N leptin Chemical compound O=C([C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(C)C)CCSC)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CS)C(O)=O NRYBAZVQPHGZNS-ZSOCWYAHSA-N 0.000 title abstract 9
- 229940039781 leptin Drugs 0.000 title abstract 9
- 150000001875 compounds Chemical class 0.000 title abstract 6
- 230000001766 physiological effect Effects 0.000 title abstract 4
- 108091027981 Response element Proteins 0.000 abstract 5
- 210000004027 cell Anatomy 0.000 abstract 3
- 108700008625 Reporter Genes Proteins 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 102000000887 Transcription factor STAT Human genes 0.000 abstract 1
- 108050007918 Transcription factor STAT Proteins 0.000 abstract 1
- 239000012190 activator Substances 0.000 abstract 1
- 210000001072 colon Anatomy 0.000 abstract 1
- 210000002919 epithelial cell Anatomy 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 230000000638 stimulation Effects 0.000 abstract 1
- 230000002103 transcriptional effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Metode for påvisning av en forbindelse som etterligner, potensierer eller hemmer den fysiologiske effekt av leptin, hvilken metode omfatter: (a) for en forbindelse som etterligner den fysiologiske effekt av leptinet, bedømmelse av effekten av forbindelsen på en leptinaktivert signaloverfører og aktivator av transkripsjons- (STAT) DNA-responselement koblet til et rapportørgen; eller (b) for en forbindelse som potensierer eller hemmer den fysiologiske effekt av leptin, bedømmelse av effekten av forbindelsen på responsen på leptin av et leptinaktivert STAT DNA-responselement koblet til et rapportørgen;. hvor,. responselementet og rapportøren er uttrykt i den humane kaukasiske kolon-epitelcellelinje (CACO-2) eller responselementet og rapportøren er uttrykt i CACO-2-celler, hvilken cellelinje (den konstruerte cellelinje) også er transfektert med et polypeptid som kan mediere eller forsterke stimulering med leptin av et leptinaktivert STAT DNA-responselement og inneholder de passende STAT proteiner.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9814199.7A GB9814199D0 (en) | 1998-06-30 | 1998-06-30 | Novel method |
| PCT/EP1999/004501 WO2000000639A2 (en) | 1998-06-30 | 1999-06-28 | Method for detecting of a compound that mimics, potentiates or inhibits the physiological effect of leptin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20006541D0 NO20006541D0 (no) | 2000-12-21 |
| NO20006541L true NO20006541L (no) | 2000-12-21 |
Family
ID=10834721
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20006541A NO20006541L (no) | 1998-06-30 | 2000-12-21 | Fremgangsmåte for påvisning av en forbindelse som etterligner, potensierer eller inhiberer den fysiologiske effekten av leptin |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP1092048A2 (no) |
| KR (1) | KR20010053331A (no) |
| CN (1) | CN1316015A (no) |
| AR (1) | AR020100A1 (no) |
| AU (1) | AU4902499A (no) |
| BR (1) | BR9911643A (no) |
| CA (1) | CA2335557A1 (no) |
| GB (1) | GB9814199D0 (no) |
| HU (1) | HUP0102809A2 (no) |
| IL (1) | IL140075A0 (no) |
| NO (1) | NO20006541L (no) |
| PL (1) | PL345382A1 (no) |
| TR (1) | TR200003887T2 (no) |
| WO (1) | WO2000000639A2 (no) |
| ZA (1) | ZA200007689B (no) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106636000A (zh) * | 2016-12-23 | 2017-05-10 | 广东圣赛生物科技有限公司 | hESCs‑TK细胞系及其构建方法和应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL323638A1 (en) * | 1995-05-30 | 1998-04-14 | Smithkline Beecham Plc | Method of detecting obesity protein modulating compounds |
| GB9605808D0 (en) * | 1996-03-20 | 1996-05-22 | Isis Innovation | CFTR gene regulator |
| PL333187A1 (en) * | 1996-11-01 | 1999-11-22 | Smithkline Beecham Plc | Method of detecting compounds which modulate the performance of protein of obesity (ob) |
-
1998
- 1998-06-30 GB GBGB9814199.7A patent/GB9814199D0/en not_active Ceased
-
1999
- 1999-06-28 PL PL99345382A patent/PL345382A1/xx not_active Application Discontinuation
- 1999-06-28 TR TR2000/03887T patent/TR200003887T2/xx unknown
- 1999-06-28 BR BR9911643-0A patent/BR9911643A/pt not_active Application Discontinuation
- 1999-06-28 CA CA002335557A patent/CA2335557A1/en not_active Abandoned
- 1999-06-28 AU AU49024/99A patent/AU4902499A/en not_active Abandoned
- 1999-06-28 WO PCT/EP1999/004501 patent/WO2000000639A2/en not_active Ceased
- 1999-06-28 HU HU0102809A patent/HUP0102809A2/hu unknown
- 1999-06-28 IL IL14007599A patent/IL140075A0/xx unknown
- 1999-06-28 CN CN99808215A patent/CN1316015A/zh active Pending
- 1999-06-28 KR KR1020007015081A patent/KR20010053331A/ko not_active Withdrawn
- 1999-06-28 EP EP99932753A patent/EP1092048A2/en not_active Withdrawn
- 1999-06-29 AR ARP990103134A patent/AR020100A1/es unknown
-
2000
- 2000-12-20 ZA ZA200007689A patent/ZA200007689B/en unknown
- 2000-12-21 NO NO20006541A patent/NO20006541L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000000639A3 (en) | 2000-08-17 |
| CN1316015A (zh) | 2001-10-03 |
| NO20006541D0 (no) | 2000-12-21 |
| TR200003887T2 (tr) | 2001-06-21 |
| ZA200007689B (en) | 2001-12-12 |
| EP1092048A2 (en) | 2001-04-18 |
| IL140075A0 (en) | 2002-02-10 |
| AU4902499A (en) | 2000-01-17 |
| HUP0102809A2 (hu) | 2001-12-28 |
| GB9814199D0 (en) | 1998-08-26 |
| PL345382A1 (en) | 2001-12-17 |
| KR20010053331A (ko) | 2001-06-25 |
| AR020100A1 (es) | 2002-04-10 |
| CA2335557A1 (en) | 2000-01-06 |
| BR9911643A (pt) | 2001-03-20 |
| WO2000000639A2 (en) | 2000-01-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |