NO20032523L - Litiumkomplekser av N-(1-hydroksymetyl-2,3-dihydroksypropyl)- 1,4,7-triskarboksymetyl-1,4,7,10-tetraazasyklododekan, samt deres fremstillingog anvendelse - Google Patents

Litiumkomplekser av N-(1-hydroksymetyl-2,3-dihydroksypropyl)- 1,4,7-triskarboksymetyl-1,4,7,10-tetraazasyklododekan, samt deres fremstillingog anvendelse

Info

Publication number: NO20032523L
Authority: NO; Norway
Prior art keywords: triscarboxymethyl; tetraazacyclododecane; dihydroxypropyl; hydroxymethyl; preparation
Prior art date: 2000-12-15

Application number

NO20032523A

Other languages

English (en)

Other versions

NO324864B1 (no

NO20032523D0 (no

Inventor

Johannes Platzek

Peter Blaszkiewicz

Orlin Petrov

Holger Hoffmann

Original Assignee

Schering Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-12-15

Filing date

2003-06-04

Publication date

2003-06-04

2003-06-04 Application filed by Schering Ag filed Critical Schering Ag

2003-06-04 Publication of NO20032523L publication Critical patent/NO20032523L/no

2003-06-04 Publication of NO20032523D0 publication Critical patent/NO20032523D0/no

2007-12-17 Publication of NO324864B1 publication Critical patent/NO324864B1/no

Links

JZNZSKXIEDHOBD-UHFFFAOYSA-N 2-[4,10-bis(carboxymethyl)-7-(1,3,4-trihydroxybutan-2-yl)-1,4,7,10-tetrazacyclododec-1-yl]acetic acid Chemical compound OCC(O)C(CO)N1CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC1 JZNZSKXIEDHOBD-UHFFFAOYSA-N 0.000 title 1
150000002641 lithium Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
- C07F1/02—Lithium compounds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Materials Engineering (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Epoxy Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

NO20032523A 2000-12-15 2003-06-04 Litiumkomplekser av N-(1-hydroksymetyl-2,3-dihydroksypropyl)-1,4,7-triskarboksymetyl-1,4,7,10-tetraazasyklododekan, samt deres fremstilling og anvendelse NO324864B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE10064467A DE10064467C2 (de)	2000-12-15	2000-12-15	Lithium-Komplexe von N-(1-Hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecan, deren Herstellung und Verwendung
PCT/EP2001/014283 WO2002048119A2 (de)	2000-12-15	2001-12-05	Lithium-komplexe von n-(1-hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecan, deren herstellung und verwendung

Publications (3)

Publication Number	Publication Date
NO20032523L true NO20032523L (no)	2003-06-04
NO20032523D0 NO20032523D0 (no)	2003-06-04
NO324864B1 NO324864B1 (no)	2007-12-17

Family

ID=7668584

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20032523A NO324864B1 (no)	2000-12-15	2003-06-04	Litiumkomplekser av N-(1-hydroksymetyl-2,3-dihydroksypropyl)-1,4,7-triskarboksymetyl-1,4,7,10-tetraazasyklododekan, samt deres fremstilling og anvendelse

Country Status (34)

Country	Link
US (1)	US6894151B2 (no)
EP (1)	EP1343770B1 (no)
JP (1)	JP4399163B2 (no)
KR (1)	KR100869627B1 (no)
CN (1)	CN1229357C (no)
AR (1)	AR035609A1 (no)
AT (1)	ATE430737T1 (no)
AU (2)	AU3165902A (no)
BG (1)	BG66117B1 (no)
BR (1)	BR0116219A (no)
CA (1)	CA2431976C (no)
CY (1)	CY1109280T1 (no)
CZ (1)	CZ304573B6 (no)
DE (2)	DE10064467C2 (no)
DK (1)	DK1343770T3 (no)
EC (1)	ECSP034676A (no)
EE (1)	EE05245B1 (no)
ES (1)	ES2325982T3 (no)
HR (1)	HRP20030576B1 (no)
HU (1)	HU229657B1 (no)
IL (1)	IL156432A0 (no)
ME (1)	ME00157B (no)
MX (1)	MXPA03005240A (no)
NO (1)	NO324864B1 (no)
NZ (1)	NZ526478A (no)
PL (1)	PL204181B1 (no)
PT (1)	PT1343770E (no)
RS (1)	RS51862B (no)
RU (1)	RU2003120513A (no)
SK (1)	SK287424B6 (no)
TW (1)	TWI302531B (no)
UY (1)	UY27056A1 (no)
WO (1)	WO2002048119A2 (no)
ZA (1)	ZA200305421B (no)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2007521254A (ja) *	2003-06-25	2007-08-02	ゲルベ	診断画像用化合物
FR2867473B1 (fr)	2004-03-12	2006-06-23	Guerbet Sa	Compose de porphyrines et utilisation a haut champ en irm
CN101090739B (zh) *	2004-07-02	2012-10-10	伯拉考成像股份公司	磁共振成像中用作高弛豫造影剂配体的1，4-二（羧甲基）氨基-6-甲基-全氢-1，4-二氮杂*（aazta)衍生物
CA2645668A1 (en)	2006-03-14	2007-09-20	Mallinckrodt Inc.	Metal complexes of tetraazamacrocycle derivatives
US7777029B2 (en) *	2006-05-02	2010-08-17	San Diego State University (Sdsu) Foundation	Bifunctional chelators for sequestering lanthanides
DE102009053252B3 (de) *	2009-11-09	2011-09-01	Bayer Schering Pharma Aktiengesellschaft	Gadobutrolherstellung mittels keramischer Membran
WO2011054480A1 (de) *	2009-11-09	2011-05-12	Bayer Schering Pharma Aktiengesellschaft	Gadobutrolherstellung mittels keramischer membran
DE102009057274B4 (de)	2009-12-02	2011-09-01	Bayer Schering Pharma Aktiengesellschaft	Gadobutrolherstellung mittels Trioxobicyclo-octan
DE102010013833A1 (de)	2010-03-29	2011-09-29	Bayer Schering Pharma Aktiengesellschaft	Herstellung von Gadobutrol mittels Dimethylformamiddimethylacetal
DE102010023105A1 (de)	2010-06-04	2011-12-08	Bayer Schering Pharma Aktiengesellschaft	Gadobutrolherstellung im Eintopfverfahren mittels DMF-acetal und N-Methylimidazol
KR20200059319A (ko)	2011-04-21	2020-05-28	바이엘 인텔렉쳐 프로퍼티 게엠베하	고순도 가도부트롤의 제조
CN106543094A (zh) *	2016-11-04	2017-03-29	嘉实（湖南）医药科技有限公司	高纯度钆布醇的制备方法
KR101971435B1 (ko) *	2017-08-29	2019-04-24	주식회사 엔지켐생명과학	가도부트롤 중간체 및 이를 이용한 가도부트롤의 제조 방법
KR102033964B1 (ko) *	2018-01-19	2019-10-18	주식회사 엔지켐생명과학	가도테리돌 중간체 및 이를 이용한 가도테리돌 제조방법
CN111039885B (zh) *	2019-12-06	2021-03-05	广州康瑞泰药业有限公司	一种制备高纯度考布曲钙的方法
KR20210112910A (ko) *	2020-03-06	2021-09-15	주식회사 엔지켐생명과학	가도부트롤 주사제 제조를 위한 부형제인 칼코부트롤의 제조 방법

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4009119A1 (de) *	1990-03-19	1991-09-26	Schering Ag	1,4,7,10-tetraazacyclododecan-butyltriole, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
DE19724186C2 (de) *	1997-06-02	2002-07-18	Schering Ag	Verfahren zur Mono- und 1,7-Bis-N-ß-Hydroxyalkylierung von Cyclen und die entsprechenden N-ß-Hydroxyalkyl-1,4,7,10-tetraazacyclododecan-Li-Salz-Komplexe

2000
- 2000-12-15 DE DE10064467A patent/DE10064467C2/de not_active Expired - Lifetime
2001
- 2001-11-07 TW TW090127671A patent/TWI302531B/zh not_active IP Right Cessation
- 2001-12-05 ME MEP-2008-157A patent/ME00157B/me unknown
- 2001-12-05 MX MXPA03005240A patent/MXPA03005240A/es active IP Right Grant
- 2001-12-05 AU AU3165902A patent/AU3165902A/xx active Pending
- 2001-12-05 DK DK01991788T patent/DK1343770T3/da active
- 2001-12-05 JP JP2002549650A patent/JP4399163B2/ja not_active Expired - Lifetime
- 2001-12-05 HU HU0302563A patent/HU229657B1/hu unknown
- 2001-12-05 EE EEP200300282A patent/EE05245B1/xx unknown
- 2001-12-05 AT AT01991788T patent/ATE430737T1/de active
- 2001-12-05 IL IL15643201A patent/IL156432A0/xx active IP Right Grant
- 2001-12-05 DE DE50114889T patent/DE50114889D1/de not_active Expired - Lifetime
- 2001-12-05 EP EP01991788A patent/EP1343770B1/de not_active Expired - Lifetime
- 2001-12-05 NZ NZ526478A patent/NZ526478A/en not_active IP Right Cessation
- 2001-12-05 RS YU48103A patent/RS51862B/sr unknown
- 2001-12-05 PL PL366141A patent/PL204181B1/pl unknown
- 2001-12-05 CA CA2431976A patent/CA2431976C/en not_active Expired - Lifetime
- 2001-12-05 CZ CZ2003-1641A patent/CZ304573B6/cs not_active IP Right Cessation
- 2001-12-05 BR BRPI0116219-5A patent/BR0116219A/pt not_active IP Right Cessation
- 2001-12-05 RU RU2003120513/04A patent/RU2003120513A/ru not_active Application Discontinuation
- 2001-12-05 WO PCT/EP2001/014283 patent/WO2002048119A2/de not_active Ceased
- 2001-12-05 KR KR1020037008035A patent/KR100869627B1/ko not_active Expired - Lifetime
- 2001-12-05 UY UY27056A patent/UY27056A1/es not_active Application Discontinuation
- 2001-12-05 PT PT01991788T patent/PT1343770E/pt unknown
- 2001-12-05 AU AU2002231659A patent/AU2002231659B2/en not_active Expired
- 2001-12-05 SK SK729-2003A patent/SK287424B6/sk not_active IP Right Cessation
- 2001-12-05 ES ES01991788T patent/ES2325982T3/es not_active Expired - Lifetime
- 2001-12-05 HR HR20030576A patent/HRP20030576B1/xx not_active IP Right Cessation
- 2001-12-05 CN CNB018206808A patent/CN1229357C/zh not_active Expired - Lifetime
- 2001-12-13 US US10/013,840 patent/US6894151B2/en not_active Expired - Lifetime
- 2001-12-14 AR ARP010105797A patent/AR035609A1/es unknown
2003
- 2003-06-04 NO NO20032523A patent/NO324864B1/no not_active IP Right Cessation
- 2003-06-12 BG BG107901A patent/BG66117B1/bg unknown
- 2003-06-26 EC EC2003004676A patent/ECSP034676A/es unknown
- 2003-07-14 ZA ZA200305421A patent/ZA200305421B/en unknown
2009
- 2009-08-06 CY CY20091100837T patent/CY1109280T1/el unknown

Also Published As

Publication number	Publication date
SK7292003A3 (en)	2003-11-04
DE10064467A1 (de)	2002-07-11
AU2002231659B2 (en)	2007-07-05
EE200300282A (et)	2003-10-15
DE10064467C2 (de)	2002-10-31
BG107901A (bg)	2004-06-30
BG66117B1 (bg)	2011-05-31
US20020128472A1 (en)	2002-09-12
TWI302531B (en)	2008-11-01
RU2003120513A (ru)	2004-12-27
CN1481371A (zh)	2004-03-10
HRP20030576A2 (en)	2005-06-30
EE05245B1 (et)	2009-12-15
WO2002048119A2 (de)	2002-06-20
NO324864B1 (no)	2007-12-17
MEP15708A (en)	2010-06-10
AU3165902A (en)	2002-06-24
US6894151B2 (en)	2005-05-17
CA2431976A1 (en)	2002-06-20
UY27056A1 (es)	2002-07-31
IL156432A0 (en)	2004-01-04
ATE430737T1 (de)	2009-05-15
CN1229357C (zh)	2005-11-30
PL366141A1 (en)	2005-01-24
WO2002048119A3 (de)	2002-11-07
NO20032523D0 (no)	2003-06-04
KR100869627B1 (ko)	2008-11-21
NZ526478A (en)	2006-04-28
ECSP034676A (es)	2003-08-29
HU229657B1 (en)	2014-03-28
HUP0302563A2 (hu)	2003-12-29
HUP0302563A3 (en)	2011-04-28
SK287424B6 (sk)	2010-09-07
BR0116219A (pt)	2006-02-21
ES2325982T3 (es)	2009-09-28
EP1343770B1 (de)	2009-05-06
JP2004515545A (ja)	2004-05-27
AR035609A1 (es)	2004-06-16
YU48103A (sh)	2006-05-25
KR20030077555A (ko)	2003-10-01
RS51862B (sr)	2012-02-29
DK1343770T3 (da)	2009-08-10
CY1109280T1 (el)	2014-07-02
CZ20031641A3 (cs)	2003-09-17
CZ304573B6 (cs)	2014-07-16
HRP20030576B1 (en)	2011-09-30
JP4399163B2 (ja)	2010-01-13
PT1343770E (pt)	2009-07-20
CA2431976C (en)	2010-04-13
MXPA03005240A (es)	2003-09-25
EP1343770A2 (de)	2003-09-17
PL204181B1 (pl)	2009-12-31
HK1064098A1 (en)	2005-01-21
DE50114889D1 (de)	2009-06-18
ZA200305421B (en)	2004-08-27
ME00157B (me)	2010-10-10

Legal Events

Date	Code	Title	Description
2012-12-17	CHAD	Change of the owner's name or address (par. 44 patent law, par. patentforskriften)	Owner name: BAYER INTELLECTUAL PROPERTY GMBH, DE
2021-12-13	MK1K	Patent expired

Publication	Publication Date	Title
NO20032523L (no)	2003-06-04	Litiumkomplekser av N-(1-hydroksymetyl-2,3-dihydroksypropyl)- 1,4,7-triskarboksymetyl-1,4,7,10-tetraazasyklododekan, samt deres fremstillingog anvendelse
CY2012009I2 (el)	2015-08-05	Αναστολεις της κυκλοπροπυλ-συντηκωμενης διπεπτυλοπεπτιδασης 4, βασισμενοι σε πυρρολιδινη, και μεθοδοι για την παρασκευη των και την χρηση των
DK1334091T3 (da)	2012-10-15	Thioflavinderivater og deres anvendelse til diagnose og terapi af Alzheimer's sygdom
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DE10083671T1 (de)	2001-11-29	Plug und Play I·2·C Slave
DE60031513D1 (de)	2006-12-07	Phenyl- und pyridinyl-derivate verwendbar als neurokinin-1-antagonisten
DE60136181D1 (de)	2008-11-27	3'-prodrugs von 2'-deoxy-beta-l-nukleosiden
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NO20040469L (no)	2004-04-30	Heterocykliske forbindelser samt fremstilling og anvendelse derav
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